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1. 发明授权

US07796266B2 Optical detection system using electromagnetic radiation to detect presence or quantity of analyte 有权
标题翻译：使用电磁辐射的光学检测系统检测分析物的存在或数量
公开(公告)号：US07796266B2
公开(公告)日：2010-09-14
申请号：US11022287
申请日：2004-12-22
申请人： David Samuel Cohen , Xuedong Song , Michael Knotts , Shawn Ray Feaster , Zdravko Savov Atanassov
发明人： David Samuel Cohen , Xuedong Song , Michael Knotts , Shawn Ray Feaster , Zdravko Savov Atanassov
IPC分类号： G01N21/00
CPC分类号： G01N33/54386 , G01N33/521 , G01N33/558
摘要： A system that employs transmission-based detection techniques to determine the presence or concentration of an analyte within a test sample is provided. Specifically, the optical detection system contains a chromatographic-based assay device that is positioned in the electromagnetic radiation path defined between an illumination source and detector. To enhance the sensitivity and signal-to-noise ratio of the system without significantly increasing costs, the distance between the illumination source and/or detector and the assay device is minimized. The illumination source and/or detector may also be positioned directly adjacent to the assay device. In addition, the system may be selectively controlled to reduce reliance on external optical components, such as optical filters or diffusers.
摘要翻译：提供了一种采用基于传输的检测技术来确定测试样品中分析物的存在或浓度的系统。具体来说，光学检测系统包含位于照射源和检测器之间的电磁辐射路径中的基于色谱的测定装置。为了提高系统的灵敏度和信噪比而不显着增加成本，照明源和/或检测器与测定装置之间的距离最小化。照明源和/或检测器也可以直接邻近测定装置定位。此外，可以选择性地控制系统以减少对诸如光学滤波器或扩散器的外部光学部件的依赖。

2. 发明授权

US07682817B2 Microfluidic assay devices 有权
标题翻译：微流控测定装置
公开(公告)号：US07682817B2
公开(公告)日：2010-03-23
申请号：US11021545
申请日：2004-12-23
申请人： David Samuel Cohen , Shawn Ray Feaster
发明人： David Samuel Cohen , Shawn Ray Feaster
IPC分类号： C12M1/36
CPC分类号： B01L3/502746 , B01L2300/069 , B01L2300/0803 , B01L2300/0816 , B01L2300/0864 , B01L2400/0406
摘要： A microfluidic assay device for determining the presence or absence of an analyte within a fluid test sample is provided. The present invention provides a technique for achieving continuous flow in a microfluidic device by using at least one input channel, an analysis zone, and a plurality of wicking channels disposed about the perimeter of the analysis zone. In one embodiment, for example, the wicking channels extend radially from the analysis zone. As a result of the particular configuration of the microfluidic device, an assay may performed in a “single step” without the need for active forces, such as a pressure source, electrokinetic force, etc., to induce flow of the fluid test sample through the device. Likewise, flow rate is controlled so that the dwell time of the fluid test sample within the analysis zone is long enough to allow for the desired reactions and/or detection.
摘要翻译：提供了用于确定流体测试样品中分析物的存在或不存在的微流控测定装置。本发明提供了一种通过使用至少一个输入通道，分析区和围绕分析区的周边设置的多个芯吸通道来实现微流体装置中的连续流动的技术。在一个实施例中，例如，芯吸通道从分析区域径向延伸。作为微流体装置的特定构造的结果，可以以“单步”进行测定，而不需要诸如压力源，电动力等的主动力来引起流体测试样品通过的流动装置。同样地，控制流速，使得分析区内的流体测试样品的停留时间足够长以允许所需的反应和/或检测。

3. 发明授权

US08173380B2 Metering technique for lateral flow assay devices 有权
标题翻译：侧流测定装置的计量技术
公开(公告)号：US08173380B2
公开(公告)日：2012-05-08
申请号：US12872225
申请日：2010-08-31
申请人： Kaiyuan Yang , Ning Wei , Shawn Ray Feaster
发明人： Kaiyuan Yang , Ning Wei , Shawn Ray Feaster
IPC分类号： G01N33/53
CPC分类号： G01N33/558 , G01N33/54366
摘要： A diagnostic test kit for detecting an analyte residing in a test sample is provided. The kit employs a lateral flow device that contains a membrane. A metering channel is formed in the membrane that is capable of delivering a controlled volume of the test sample to a detection zone upon initiation of the assay. Such a metering channel is particularly effective for embodiments in which the test sample has a relatively low volume, such as less than about 100 microliters, in some embodiments from about 0.5 to about 25 microliters, and in some embodiments, from about 1 to about 10 microliters. For example, whole blood drops obtained from patients with a lancet typically have a volume of less than about 3 microliters. Despite their low volume, the present inventors have discovered that the blood drops may still be accurately analyzed for the presence of an analyte using lateral flow detection techniques.
摘要翻译：提供了用于检测驻留在测试样品中的分析物的诊断测试试剂盒。该套件采用包含膜的侧向流动装置。在膜中形成计量通道，其能够在测定开始时将受控体积的测试样品输送到检测区。这样的计量通道对于其中测试样品具有相对较小的体积，例如小于约100微升，在一些实施方案中为约0.5至约25微升，且在一些实施方案中为约1至约10 微升。例如，从具有刺血针的患者获得的全血滴通常具有小于约3微升的体积。尽管本发明人的体积小，但是本发明人已经发现，使用侧流检测技术仍然可以精确地分析血液滴定分析物的存在。

4. 发明申请

US20110097734A1 Flow Control Technique for Assay Devices 有权
标题翻译：测定装置的流量控制技术
公开(公告)号：US20110097734A1
公开(公告)日：2011-04-28
申请号：US12968366
申请日：2010-12-15
申请人： Shawn Ray Feaster , Kaiyuan Yang
发明人： Shawn Ray Feaster , Kaiyuan Yang
IPC分类号： G01N33/543 , C08B1/00
CPC分类号： G01N33/558 , G01N33/52
摘要： A method for controlling fluid flow in an assay device that employs a membrane is provided. Specifically, one or more recessed regions are formed in the membrane by applying a solvent treatment thereto. The solvent treatment is selected based on its particular dissolving capacity for the material used to form the membrane. For example, an alcohol-based solvent, such as methanol, may be used as a solvent for nitrocellulose membranes. Upon contact with the solvent treatment, a recessed region is formed that may serve a variety of different functions relating to flow control. In one particular embodiment, the recessed region may function as a metering channel that is capable of delivering a controlled volume of the test sample to a detection zone upon initiation of the assay.
摘要翻译：提供了一种用于控制采用膜的测定装置中的流体流动的方法。具体地，通过对膜进行溶剂处理，在膜中形成一个或多个凹陷区域。基于其用于形成膜的材料的特定溶解能力来选择溶剂处理。例如，醇类溶剂如甲醇可用作硝酸纤维素膜的溶剂。在与溶剂处理接触时，形成可以用于与流量控制有关的各种不同功能的凹陷区域。在一个具体实施方案中，凹陷区域可用作计量通道，其能够在测定开始时将受控体积的测试样品递送到检测区域。

5. 发明授权

US07858384B2 Flow control technique for assay devices 有权
标题翻译：测定装置的流量控制技术
公开(公告)号：US07858384B2
公开(公告)日：2010-12-28
申请号：US11119394
申请日：2005-04-29
申请人： Shawn Ray Feaster , Kaiyuan Yang
发明人： Shawn Ray Feaster , Kaiyuan Yang
IPC分类号： G01N31/22 , G01N31/00
CPC分类号： G01N33/558 , G01N33/52
摘要： A method for controlling fluid flow in an assay device that employs a membrane is provided. Specifically, one or more recessed regions are formed in the membrane by applying a solvent treatment thereto. The solvent treatment is selected based on its particular dissolving capacity for the material used to form the membrane. For example, an alcohol-based solvent, such as methanol, may be used as a solvent for nitrocellulose membranes. Upon contact with the solvent treatment, a recessed region is formed that may serve a variety of different functions relating to flow control. In one particular embodiment, the recessed region may function as a metering channel that is capable of delivering a controlled volume of the test sample to a detection zone upon initiation of the assay.
摘要翻译：提供了一种用于控制采用膜的测定装置中的流体流动的方法。具体地，通过对膜进行溶剂处理，在膜中形成一个或多个凹陷区域。基于其用于形成膜的材料的特定溶解能力来选择溶剂处理。例如，醇类溶剂如甲醇可用作硝酸纤维素膜的溶剂。在与溶剂处理接触时，形成可以用于与流量控制有关的各种不同功能的凹陷区域。在一个具体实施方案中，凹陷区域可用作计量通道，其能够在测定开始时将受控体积的测试样品递送到检测区域。

6. 发明申请

US20100323392A1 Metering Technique for Lateral Flow Assay Devices 有权
标题翻译：侧流测试装置的计量技术
公开(公告)号：US20100323392A1
公开(公告)日：2010-12-23
申请号：US12872225
申请日：2010-08-31
申请人： Kaiyuan Yang , Ning Wei , Shawn Ray Feaster
发明人： Kaiyuan Yang , Ning Wei , Shawn Ray Feaster
IPC分类号： C12Q1/04
CPC分类号： G01N33/558 , G01N33/54366
摘要： A diagnostic test kit for detecting an analyte residing in a test sample is provided. The kit employs a lateral flow device that contains a membrane. A metering channel is formed in the membrane that is capable of delivering a controlled volume of the test sample to a detection zone upon initiation of the assay. Such a metering channel is particularly effective for embodiments in which the test sample has a relatively low volume, such as less than about 100 microliters, in some embodiments from about 0.5 to about 25 microliters, and in some embodiments, from about 1 to about 10 microliters. For example, whole blood drops obtained from patients with a lancet typically have a volume of less than about 3 microliters. Despite their low volume, the present inventors have discovered that the blood drops may still be accurately analyzed for the presence of an analyte using lateral flow detection techniques.
摘要翻译：提供了用于检测驻留在测试样品中的分析物的诊断测试试剂盒。该套件采用包含膜的侧向流动装置。在膜中形成计量通道，其能够在测定开始时将受控体积的测试样品输送到检测区。这样的计量通道对于其中测试样品具有相对较小体积（例如小于约100微升），在一些实施方案中为约0.5至约25微升，且在一些实施方案中为约1至约10 微升。例如，从具有柳叶刀的患者获得的全血滴通常具有小于约3微升的体积。尽管本发明人的体积小，但是本发明人已经发现，使用侧流检测技术仍然可以精确地分析血液滴定分析物的存在。

7. 发明授权

US07390674B2 Lateral flow devices using reactive chemistry 失效
标题翻译：使用反应化学的侧流装置
公开(公告)号：US07390674B2
公开(公告)日：2008-06-24
申请号：US11079730
申请日：2005-03-14
申请人： Shawn Ray Feaster , Kaiyuan Yang
发明人： Shawn Ray Feaster , Kaiyuan Yang
IPC分类号： G01N33/53
CPC分类号： G01N33/558 , G01N33/583 , Y10S435/805 , Y10S435/81 , Y10S435/97 , Y10S436/805 , Y10S436/81
摘要： There is provided a lateral flow assay device for detecting the presence or quantity of an analyte residing in a test sample where the lateral flow assay device has a porous membrane in communication with a wicking pad. The porous membrane has a detection zone which has a chromophore configured to chemically react with an analyte or a secondary trigger or a reaction product from the analyte and a trigger generating reagent(s), to generate a visually detectible signal. Additional chrmophore zones may be located downstream from the first chrmophore zone to generate signals of varying color. Scavenging zones may be included between chromophore zones to attenuate the signal by reacting with the analyte without generating a visually detectable signal.
摘要翻译：提供了一种侧流测定装置，用于检测驻留在测试样品中的分析物的存在或数量，其中侧流测定装置具有与芯吸垫连通的多孔膜。多孔膜具有检测区，其具有配置成与分析物或辅助触发剂或来自分析物和触发产生试剂的反应产物发生化学反应的发色团，以产生视觉上可检测的信号。另外的chrmophore区域可以位于第一chrmophore区域的下游，以产生变化颜色的信号。清除区域可以包括在发色团区域之间，以通过与分析物反应来衰减信号，而不产生视觉上可检测的信号。

8. 发明授权

US08124421B2 Flow control technique for assay devices 有权
标题翻译：测定装置的流量控制技术
公开(公告)号：US08124421B2
公开(公告)日：2012-02-28
申请号：US12968366
申请日：2010-12-15
申请人： Shawn Ray Feaster , Kaiyuan Yang
发明人： Shawn Ray Feaster , Kaiyuan Yang
IPC分类号： G01N33/543 , G01N33/00 , C08B1/00
CPC分类号： G01N33/558 , G01N33/52
摘要： A method for controlling fluid flow in an assay device that employs a membrane is provided. Specifically, one or more recessed regions are formed in the membrane by applying a solvent treatment thereto. The solvent treatment is selected based on its particular dissolving capacity for the material used to form the membrane. For example, an alcohol-based solvent, such as methanol, may be used as a solvent for nitrocellulose membranes. Upon contact with the solvent treatment, a recessed region is formed that may serve a variety of different functions relating to flow control. In one particular embodiment, the recessed region may function as a metering channel that is capable of delivering a controlled volume of the test sample to a detection zone upon initiation of the assay.
摘要翻译：提供了一种用于控制采用膜的测定装置中的流体流动的方法。具体地，通过对膜进行溶剂处理，在膜中形成一个或多个凹陷区域。基于其用于形成膜的材料的特定溶解能力来选择溶剂处理。例如，醇类溶剂如甲醇可用作硝酸纤维素膜的溶剂。在与溶剂处理接触时，形成可以用于与流量控制有关的各种不同功能的凹陷区域。在一个具体实施方案中，凹陷区域可用作计量通道，其能够在测定开始时将受控体积的测试样品递送到检测区域。

9. 发明授权

US07803319B2 Metering technique for lateral flow assay devices 有权
标题翻译：侧流测定装置的计量技术
公开(公告)号：US07803319B2
公开(公告)日：2010-09-28
申请号：US11118079
申请日：2005-04-29
申请人： Kaiyuan Yang , Ning Wei , Shawn Ray Feaster
发明人： Kaiyuan Yang , Ning Wei , Shawn Ray Feaster
IPC分类号： G01N21/00 , B01L3/00
CPC分类号： G01N33/558 , G01N33/54366
摘要： A diagnostic test kit for detecting an analyte residing in a test sample is provided. The kit employs a lateral flow device that contains a membrane. A metering channel is formed in the membrane that is capable of delivering a controlled volume of the test sample to a detection zone upon initiation of the assay. Such a metering channel is particularly effective for embodiments in which the test sample has a relatively low volume, such as less than about 100 microliters, in some embodiments less than about 25 microliters, and in some embodiments, less than about 10 microliters. For example, whole blood drops obtained from patients with a lancet from low-pain areas (due to reduced nerve endings than finger), such as the forearm, thigh, or other alternate sites, may have a volume of from about 0.1 to about 5 microliters. Despite their low volume, the present inventors have discovered that the blood drops may still be accurately analyzed for the presence of an analyte using lateral flow detection techniques.
摘要翻译：提供了用于检测驻留在测试样品中的分析物的诊断测试试剂盒。该套件采用包含膜的侧向流动装置。在膜中形成计量通道，其能够在测定开始时将受控体积的测试样品输送到检测区。这样的计量通道对于其中测试样品具有相对较低的体积，例如小于约100微升，在一些实施方案中小于约25微升，在一些实施方案中小于约10微升的实施方案是特别有效的。例如，从患有低疼痛区域的刺血针（由于神经末梢比手指减少）的患者（例如前臂，大腿或其他替代部位）获得的全血滴可具有约0.1至约5的体积微升。尽管本发明人的体积小，但是本发明人已经发现，使用侧流检测技术仍然可以精确地分析血液滴定分析物的存在。

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