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1. 发明授权

US07682817B2 Microfluidic assay devices 有权
标题翻译：微流控测定装置
公开(公告)号：US07682817B2
公开(公告)日：2010-03-23
申请号：US11021545
申请日：2004-12-23
申请人： David Samuel Cohen , Shawn Ray Feaster
发明人： David Samuel Cohen , Shawn Ray Feaster
IPC分类号： C12M1/36
CPC分类号： B01L3/502746 , B01L2300/069 , B01L2300/0803 , B01L2300/0816 , B01L2300/0864 , B01L2400/0406
摘要： A microfluidic assay device for determining the presence or absence of an analyte within a fluid test sample is provided. The present invention provides a technique for achieving continuous flow in a microfluidic device by using at least one input channel, an analysis zone, and a plurality of wicking channels disposed about the perimeter of the analysis zone. In one embodiment, for example, the wicking channels extend radially from the analysis zone. As a result of the particular configuration of the microfluidic device, an assay may performed in a “single step” without the need for active forces, such as a pressure source, electrokinetic force, etc., to induce flow of the fluid test sample through the device. Likewise, flow rate is controlled so that the dwell time of the fluid test sample within the analysis zone is long enough to allow for the desired reactions and/or detection.
摘要翻译：提供了用于确定流体测试样品中分析物的存在或不存在的微流控测定装置。本发明提供了一种通过使用至少一个输入通道，分析区和围绕分析区的周边设置的多个芯吸通道来实现微流体装置中的连续流动的技术。在一个实施例中，例如，芯吸通道从分析区域径向延伸。作为微流体装置的特定构造的结果，可以以“单步”进行测定，而不需要诸如压力源，电动力等的主动力来引起流体测试样品通过的流动装置。同样地，控制流速，使得分析区内的流体测试样品的停留时间足够长以允许所需的反应和/或检测。

2. 发明授权

US07796266B2 Optical detection system using electromagnetic radiation to detect presence or quantity of analyte 有权
标题翻译：使用电磁辐射的光学检测系统检测分析物的存在或数量
公开(公告)号：US07796266B2
公开(公告)日：2010-09-14
申请号：US11022287
申请日：2004-12-22
申请人： David Samuel Cohen , Xuedong Song , Michael Knotts , Shawn Ray Feaster , Zdravko Savov Atanassov
发明人： David Samuel Cohen , Xuedong Song , Michael Knotts , Shawn Ray Feaster , Zdravko Savov Atanassov
IPC分类号： G01N21/00
CPC分类号： G01N33/54386 , G01N33/521 , G01N33/558
摘要： A system that employs transmission-based detection techniques to determine the presence or concentration of an analyte within a test sample is provided. Specifically, the optical detection system contains a chromatographic-based assay device that is positioned in the electromagnetic radiation path defined between an illumination source and detector. To enhance the sensitivity and signal-to-noise ratio of the system without significantly increasing costs, the distance between the illumination source and/or detector and the assay device is minimized. The illumination source and/or detector may also be positioned directly adjacent to the assay device. In addition, the system may be selectively controlled to reduce reliance on external optical components, such as optical filters or diffusers.
摘要翻译：提供了一种采用基于传输的检测技术来确定测试样品中分析物的存在或浓度的系统。具体来说，光学检测系统包含位于照射源和检测器之间的电磁辐射路径中的基于色谱的测定装置。为了提高系统的灵敏度和信噪比而不显着增加成本，照明源和/或检测器与测定装置之间的距离最小化。照明源和/或检测器也可以直接邻近测定装置定位。此外，可以选择性地控制系统以减少对诸如光学滤波器或扩散器的外部光学部件的依赖。

3. 发明授权

US07098040B2 Self-contained swab-based diagnostic systems 有权
标题翻译：独立的基于拭子的诊断系统
公开(公告)号：US07098040B2
公开(公告)日：2006-08-29
申请号：US10744235
申请日：2003-12-23
申请人： Rosann Marie Matthews Kaylor , RameshBabu Boga , Kaiyuan Yang , David Samuel Cohen , Herb Velazquez , Amanda Lee O'Connor
发明人： Rosann Marie Matthews Kaylor , RameshBabu Boga , Kaiyuan Yang , David Samuel Cohen , Herb Velazquez , Amanda Lee O'Connor
IPC分类号： G01N33/558
CPC分类号： G01N1/02 , C12M33/02 , G01N2001/028 , Y10S435/81 , Y10S435/97 , Y10S436/805 , Y10S436/81
摘要： A diagnostic test unit is provided. The test unit comprises a stem having a first end and a second end, the stem defining at least one flow channel extending between the first end and the second end. A swab is disposed at the first end of the stem, the swab being configured to collect a test sample derived from a biological source that is suspected of containing an analyte. The test unit also comprises a fluid chamber configured to contain a fluid, wherein the fluid chamber is in fluid communication with the swab via the flow channel. The test unit also comprises a rupturable seal that inhibits leakage of the fluid from the fluid chamber prior to use, and an assay for detecting the presence or absence of the analyte. The assay is in fluid communication with the swab, the flow channel, and the fluid chamber.
摘要翻译：提供诊断测试单元。测试单元包括具有第一端和第二端的杆，所述杆限定在第一端和第二端之间延伸的至少一个流动通道。拭子设置在茎的第一端，拭子被配置成收集来自怀疑含有分析物的生物来源的测试样品。测试单元还包括被配置为容纳流体的流体室，其中流体室经由流动通道与拭子流体连通。测试单元还包括可破坏的密封，其在使用之前抑制流体从流体室的泄漏，以及用于检测分析物的存在或不存在的测定。测定与拭子，流动通道和流体室流体连通。

4. 发明授权

US07815854B2 Electroluminescent illumination source for optical detection systems 有权
标题翻译：用于光学检测系统的电致发光照明源
公开(公告)号：US07815854B2
公开(公告)日：2010-10-19
申请号：US11022285
申请日：2004-12-22
申请人： David Samuel Cohen
发明人： David Samuel Cohen
IPC分类号： G01N21/00
CPC分类号： G01N21/01 , G01N21/66 , G01N21/76
摘要： An optical detection system that utilizes an electroluminescent (EL) illumination source is provided. Unlike illumination sources used with some conventional optical detection systems, an EL device is relatively homogeneous and diffuse, and thus may provide uniform illumination to the test sample. In addition, the emitted light intensity of the EL device may be easily controlled by simply varying the voltage or the frequency of the applied current. The relatively flexibility of EL devices may also allow them to be readily incorporated into a chromatographic-based assay device for detecting the presence or absence of an analyte within a test sample.
摘要翻译：提供了利用电致发光（EL）照明源的光学检测系统。与一些常规的光学检测系统一起使用的照明源不同，EL器件是相对均匀且漫射的，因此可以向测试样品提供均匀的照明。此外，通过简单地改变施加电流的电压或频率，可以容易地控制EL器件的发射光强度。 EL器件的相对灵活性还可以允许它们容易地并入到基于色谱的测定装置中，用于检测测试样品中分析物的存在或不存在。

5. 发明授权

US07087203B2 Methods and apparatus for blood typing with optical bio-disc 失效
标题翻译：用光学生物盘进行血型分析的方法和装置
公开(公告)号：US07087203B2
公开(公告)日：2006-08-08
申请号：US09988850
申请日：2001-11-19
申请人： John Francis Gordon , Susan Newcomb Hurt , David Samuel Cohen
发明人： John Francis Gordon , Susan Newcomb Hurt , David Samuel Cohen
IPC分类号： C12M1/34
CPC分类号： G01N33/80 , Y10T436/111666
摘要： This invention relates to clinical diagnostic assays and related optical bio-discs and a disc-reading apparatus. The invention is directed to a method for determining the blood cell type of an individual.
摘要翻译：本发明涉及临床诊断测定和相关的光学生物盘和盘读取装置。本发明涉及一种用于确定个体血细胞类型的方法。

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