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1. 发明申请

US20050197369A1 Compounds useful for the synthesis of (+)-discodermolide and methods therefor 有权
标题翻译：用于合成（+） - discodermolide的化合物及其方法
公开(公告)号：US20050197369A1
公开(公告)日：2005-09-08
申请号：US11070705
申请日：2005-03-01
申请人： David Myles , Simon Shaw , Kurt Sundermann
发明人： David Myles , Simon Shaw , Kurt Sundermann
IPC分类号： A61K31/19 , A61K31/421 , C07D263/08 , C07D263/14 , C07D309/30
CPC分类号： C07D309/30 , C07D263/14
摘要： Compounds and methods useful for the synthesis of (+)-discodermolide, a naturally occurring microtubule stabilizing agent useful as an anti-cancer agent.
摘要翻译：可用于合成（+） - discodermolide（天然存在的微管稳定剂，可用作抗癌剂）的化合物和方法。

2. 发明申请

US20050049414A1 Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof 有权
公开(公告)号：US20050049414A1
公开(公告)日：2005-03-03
申请号：US10817532
申请日：2004-04-02
申请人： David Myles , Mark Burlingame , Simon Shaw , Kurt Sundermann , Brian Freeze , Ignacio Martin , Tomoyasu Hirose , Amos Smith
发明人： David Myles , Mark Burlingame , Simon Shaw , Kurt Sundermann , Brian Freeze , Ignacio Martin , Tomoyasu Hirose , Amos Smith
IPC分类号： C07D20060101 , C07D309/10 , C07D309/30 , C07D309/32 , C07F9/28
CPC分类号： C07D309/30 , C07F9/5428 , C07F9/5442
摘要： Synthetic methods and intermediates useful in the preparation of lactone containing compounds such as discodermolide and compounds which mimic the chemical or biological activity of discodermolide are provided.

3. 发明申请

US20090186927A1 TRANS-9,10-DEHYDROEPOTHILONE C AND D, ANALOGS THEREOF AND METHODS OF MAKING THE SAME 审中-公开
标题翻译： TRANS-9,10-去离子水C和D，其模拟物及其制备方法
公开(公告)号：US20090186927A1
公开(公告)日：2009-07-23
申请号：US12172174
申请日：2008-07-11
申请人： Yong Li , Kurt Sundermann , Li Tang , David Myles
发明人： Yong Li , Kurt Sundermann , Li Tang , David Myles
IPC分类号： A61K31/422 , C07D413/06
CPC分类号： C07D405/06 , C07D413/06 , C07D417/06
摘要： The present invention provides new trans-9,10-dehydroepothilone C and trans-9,10-dehydroepothilone D based derivative compounds, compositions and methods of inhibiting cellular hyperproliferation and/or stabilizing microtubules in vitro and of treatment of hyperproliferative diseases in vivo. Also disclosed are methods of making the compounds.
摘要翻译：本发明提供了新的反-9,10-脱氢表皮素C和反式-9,10-脱氢表皮素D衍生物化合物，体外抑制细胞过度增殖和/或稳定微管的组合物和方法以及体内过度增殖性疾病的治疗。还公开了制备该化合物的方法。

4. 发明申请

US20060270616A1 Motilide compounds 有权
标题翻译：化合物
公开(公告)号：US20060270616A1
公开(公告)日：2006-11-30
申请号：US11416519
申请日：2006-05-02
申请人： Yaoquan Liu , Christopher Carreras , David Myles , Yong Li , Simon Shaw , Hong Fu , Yue Chen , Hao Zheng , Yandong Li , Mark Burlingame
发明人： Yaoquan Liu , Christopher Carreras , David Myles , Yong Li , Simon Shaw , Hong Fu , Yue Chen , Hao Zheng , Yandong Li , Mark Burlingame
IPC分类号： A61K31/7048 , C07H17/08
CPC分类号： C07H17/08
摘要： Compounds having a structure according to formula (I) where RA, RB, RC, RD, RE, and RF are as defined herein, are useful as prokinetic agents.
摘要翻译：具有式（I）结构的化合物其中R A，R B，R C，R D，D， R E和R F如本文所定义，可用作促动力剂。

5. 发明申请

US20050272672A1 Ketolide anti-infective compounds 有权
标题翻译：酮类抗感染药物
公开(公告)号：US20050272672A1
公开(公告)日：2005-12-08
申请号：US10883317
申请日：2004-06-30
申请人： Yong Li , Yandong Li , Yan Zhu , Chaitan Khosla , David Myles
发明人： Yong Li , Yandong Li , Yan Zhu , Chaitan Khosla , David Myles
IPC分类号： A61K31/7052 , C07H17/08
CPC分类号： C07H17/08
摘要： Compounds according to formula I wherein m is 0 or 1; X is and R1, R2, R3 R4, and R5 are as defined herein, are useful as anti-infective agents.
摘要翻译：式I化合物，其中m为0或1; X是和R 1，R 2，R 3，R 4和R 5， SUP>如本文所定义，可用作抗感染剂。

6. 发明申请

US20050256064A1 9-Desoxoerythromycin compounds as prokinetic agents 有权
标题翻译： 9-脱氧红霉素化合物作为促动力剂
公开(公告)号：US20050256064A1
公开(公告)日：2005-11-17
申请号：US11016529
申请日：2004-12-15
申请人： Yaoquan Liu , Christopher Carreras , David Myles
发明人： Yaoquan Liu , Christopher Carreras , David Myles
IPC分类号： A61K31/7048 , C07H17/08
CPC分类号： C07H17/08
摘要： 9-Desoxoerythromycin compounds of formula I wherein R1, R2, R3, R4, and R5 are as defined herein, are useful as prokinetic agents for treating disorders of gastric motility.
摘要翻译：其中R 1，R 2，R 3，R 4，R 4和R 4的9-脱氧红霉素化合物，其中R 1，如本文所定义，可用作治疗胃动力障碍的促动力剂。

7. 发明申请

US20050261263A1 Benzoquinone ansamycins 有权
标题翻译：苯并醌安莎霉素
公开(公告)号：US20050261263A1
公开(公告)日：2005-11-24
申请号：US11056470
申请日：2005-02-11
申请人： Daniel Santi , David Myles , Zong-Qiang Tian , C. Hutchinson , Robert Johnson , Yi-Qing Zhou , Li Feng
发明人： Daniel Santi , David Myles , Zong-Qiang Tian , C. Hutchinson , Robert Johnson , Yi-Qing Zhou , Li Feng
IPC分类号： C07D225/06 , C07D491/08 , A61K31/5377 , A61K31/33 , A61K31/4178 , A61K31/452 , A61K31/496
CPC分类号： C07D491/08 , C07D225/06
摘要： The invention relates to benzoquinone ansamycin analogs useful for the treatment of cancer and other diseases or conditions characterized by undesired cellular proliferation or hyperproliferation. Therapies involving the administration of such benzoquinone ansamycin analogs, optionally in combination with an inhibitor of an HSP90 client protein, are useful to treat cancer and non-cancerous disease conditions.
摘要翻译：本发明涉及可用于治疗癌症和其它特征在于不期望的细胞增殖或过度增殖的其它疾病或病症的苯醌安莎霉素类似物。涉及施用这样的苯醌安莎霉素类似物（任选地与HSP90客户蛋白质的抑制剂组合）的治疗可用于治疗癌症和非癌性疾病状况。

8. 发明申请

US20050204599A1 Vehicle alert kit 失效
标题翻译：车辆警示包
公开(公告)号：US20050204599A1
公开(公告)日：2005-09-22
申请号：US10798501
申请日：2004-03-12
申请人： David Myles
发明人： David Myles
IPC分类号： G09F7/04 , G09F21/04
CPC分类号： G09F21/04 , G09F7/04 , G09F2017/0075 , G09F2017/0083
摘要： A vehicle alert kit includes at least one base member having a substantially planar bottom surface and a threaded portion integral therewith. The kit further includes a mechanism for fastening at least one base member to a surface so that same can be maintained at a substantially secure position. The kit further includes an elongated support member having a lower end portion threadably attachable to a select one of at least one base member. The elongated support member extends substantially vertically and upwardly from the base member to a predetermined height, and includes a receiving portion extending substantially vertically along a length thereof and having a bottom surface. The kit further includes a flag having indicia printed thereon and including an edge portion selectively engageable with the receiving portion.
摘要翻译：一种车辆报警套件包括至少一个具有基本平坦的底表面的底座和与其成一体的螺纹部分。该套件还包括用于将至少一个基座构件紧固到表面的机构，使得其能够保持在基本上可靠的位置。套件还包括细长的支撑构件，其具有可螺纹地附接到至少一个基座构件中的选择一个的下端部分。细长的支撑构件从基部构件基本上垂直和向上延伸到预定高度，并且包括沿着其长度基本上垂直延伸并且具有底面的接收部分。套件还包括其上印有标记并包括可选择性地与接收部分接合的边缘部分的标志。

9. 发明申请

US20050101656A1 11-O-METHYLGELDANAMYCIN COMPOUNDS 有权
标题翻译： 11-O-甲基谷氨酰胺化合物
公开(公告)号：US20050101656A1
公开(公告)日：2005-05-12
申请号：US10826445
申请日：2004-04-16
申请人： Zong-Qiang Tian , Yaoquan Liu , David Myles , Zhan Wang
发明人： Zong-Qiang Tian , Yaoquan Liu , David Myles , Zhan Wang
IPC分类号： C07D225/06 , A61K31/4025 , C07D43/02
CPC分类号： C07D225/06
摘要： Compounds having a structure according to formula I wherein the groups R1 and R4 are as defined in the specification, are useful as anti-proliferative agents.
摘要翻译：具有式I结构的化合物，其中基团R 1和R 4如说明书中所定义，可用作抗增殖剂。

10. 发明授权

US08063249B1 Substituted triphenyl butenes 失效
标题翻译：取代的三苯基丁烯
公开(公告)号：US08063249B1
公开(公告)日：2011-11-22
申请号：US12429128
申请日：2009-04-23
申请人： Peter Kushner , Cyrus Harmon , David Myles
发明人： Peter Kushner , Cyrus Harmon , David Myles
IPC分类号： C07C215/46 , C07C217/54 , A61K31/133
CPC分类号： C07C323/12 , C07C317/28
摘要： The present invention is directed to compounds, compositions thereof, and the use of the compounds and compositions for the treatment and prevention of breast cancer. In one embodiment, the present invention relates to the use of a substituted triphenyl butene or prodrug thereof for the treatment of breast cancer in mono-therapy or in combination therapy, or for a reduction in the recurrence rate of previously-treated breast cancer.
摘要翻译：本发明涉及化合物，其组合物，以及用于治疗和预防乳腺癌的化合物和组合物的用途。在一个实施方案中，本发明涉及取代的三苯基丁烯或其前药在单次治疗或联合治疗中用于治疗乳腺癌或降低先前治疗的乳腺癌的复发率的用途。

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