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1. 发明申请

US20090062140A1 METHOD FOR IDENTIFYING CELLS BASED ON DNA REPLICATION DOMAIN TIMING PROFILES 有权
标题翻译：基于DNA复制域定时轮廓识别细胞的方法
公开(公告)号：US20090062140A1
公开(公告)日：2009-03-05
申请号：US12200186
申请日：2008-08-28
申请人： David M. GILBERT , Tyrone Ryba , Ichiro Hiratani
发明人： David M. GILBERT , Tyrone Ryba , Ichiro Hiratani
IPC分类号： C40B30/04 , C12Q1/68
CPC分类号： C12Q1/6837 , C12Q1/6804 , C12Q1/6806 , C12Q1/6809 , G01N33/5005 , C12Q2565/626 , C12Q2565/501 , C12Q2525/101
摘要： Methods for identifying and/or distinguishing a homogeneous population of cells based on their replication domain timing profile using high resolution genomic arrays or sequencing procedures are provided. These methods may be used to compare the replication timing profile for a population of cells to another replication timing profile(s), a replication timing fingerprint, and/or one or more informative segments of a replication timing fingerprint, which may be simultaneously or previously determined and/or contained in a database, to determine whether there is a match between them. Based on such information, the identity of the population of cells may be determined, or the identity of the population of cells may be distinguished from other populations of cells or cell types. Methods for determining a replication timing fingerprint for particular cell types are also provided.
摘要翻译：提供了基于使用高分辨率基因组阵列或测序程序的复制域时序概况来识别和/或区分同源细胞群的方法。这些方法可用于将细胞群体的复制定时概况与复制定时指纹，复制定时指纹和/或复制定时指纹的一个或多个信息段进行比较，其可以同时或先前确定和/或包含在数据库中，以确定它们之间是否存在匹配。基于这样的信息，可以确定细胞群体的身份，或者细胞群体的身份可以与其他细胞群体或细胞类型区分开。还提供了用于确定特定细胞类型的复制定时指纹的方法。

2. 发明申请

US20120322675A1 GENOME-SCALE ANALYSIS OF REPLICATION TIMING 审中-公开
标题翻译：复制时间的基因量化分析
公开(公告)号：US20120322675A1
公开(公告)日：2012-12-20
申请号：US13479686
申请日：2012-05-24
申请人： David M. Gilbert , Tyrone Ryba , Ichiro Hiratani
发明人： David M. Gilbert , Tyrone Ryba , Ichiro Hiratani
IPC分类号： C40B30/04 , G06F19/20
CPC分类号： C12Q1/6809 , C12Q1/6841 , C12Q1/6881 , C12Q2600/158 , C12Q2527/113 , C12Q2531/149 , C12Q2539/115 , C12Q2565/501
摘要： Methods for identifying and/or distinguishing a homogeneous population of cells based on their replication domain timing profile using high resolution genomic arrays or sequencing procedures are provided. These methods may be used to compare the replication timing profile for a population of cells to another replication timing profile(s), a replication timing fingerprint, and/or one or more informative segments of a replication timing fingerprint, which may be simultaneously or previously determined and/or contained in a database, to determine whether there is a match between them. Based on such information, the identity of the population of cells may be determined, or the identity of the population of cells may be distinguished from other populations of cells or cell types. Methods for determining a replication timing fingerprint for particular cell types are also provided.
摘要翻译：提供了基于使用高分辨率基因组阵列或测序程序的复制域时序概况来识别和/或区分同源细胞群的方法。这些方法可用于将细胞群体的复制定时概况与复制定时指纹，复制定时指纹和/或复制定时指纹的一个或多个信息段进行比较，其可以同时或先前确定和/或包含在数据库中，以确定它们之间是否存在匹配。基于这样的信息，可以确定细胞群体的身份，或者细胞群体的身份可以与其他细胞群体或细胞类型区分开。还提供了用于确定特定细胞类型的复制定时指纹的方法。

3. 发明授权

US08728979B2 Method for identifying cells based on DNA replication domain timing profiles 有权
标题翻译：基于DNA复制域定时分布识别细胞的方法
公开(公告)号：US08728979B2
公开(公告)日：2014-05-20
申请号：US12200186
申请日：2008-08-28
申请人： David M. Gilbert , Tyrone Ryba , Ichiro Hiratani
发明人： David M. Gilbert , Tyrone Ryba , Ichiro Hiratani
IPC分类号： C40B30/04 , C12Q1/68
CPC分类号： C12Q1/6837 , C12Q1/6804 , C12Q1/6806 , C12Q1/6809 , G01N33/5005 , C12Q2565/626 , C12Q2565/501 , C12Q2525/101
摘要： Methods for identifying and/or distinguishing a homogeneous population of cells based on their replication domain timing profile using high resolution genomic arrays or sequencing procedures are provided. These methods may be used to compare the replication timing profile for a population of cells to another replication timing profile(s), a replication timing fingerprint, and/or one or more informative segments of a replication timing fingerprint, which may be simultaneously or previously determined and/or contained in a database, to determine whether there is a match between them. Based on such information, the identity of the population of cells may be determined, or the identity of the population of cells may be distinguished from other populations of cells or cell types. Methods for determining a replication timing fingerprint for particular cell types are also provided.
摘要翻译：提供了基于使用高分辨率基因组阵列或测序程序的复制域时序概况来识别和/或区分同源细胞群的方法。这些方法可用于将细胞群体的复制定时概况与复制定时指纹，复制定时指纹和/或复制定时指纹的一个或多个信息段进行比较，其可以同时或先前确定和/或包含在数据库中，以确定它们之间是否存在匹配。基于这样的信息，可以确定细胞群体的身份，或者细胞群体的身份可以与其他细胞群体或细胞类型区分开。还提供了用于确定特定细胞类型的复制定时指纹的方法。

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