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1. 发明申请

US20070128169A1 Inhibition of gene expression by delivery of polynucleotides to animal cells in vivo 审中-公开
标题翻译：通过在体内将多核苷酸递送到动物细胞来抑制基因表达
公开(公告)号：US20070128169A1
公开(公告)日：2007-06-07
申请号：US11649502
申请日：2007-01-04
申请人： David Lewis , Jon Wolff , Vladimir Budker , Hans Herweijer , James Hagstrom
发明人： David Lewis , Jon Wolff , Vladimir Budker , Hans Herweijer , James Hagstrom
IPC分类号： A61K48/00
CPC分类号： C12N15/1137 , A61K31/58 , A61K31/74 , A61K38/00 , A61K48/00 , C12N15/111 , C12N15/88 , C12N2310/14 , C12N2320/32 , C12N2710/24111 , C12Y206/01002 , A61K2300/00
摘要： Described is a process for intravascular delivery of a polynucleotide to an extravascular cell of a mammal to inhibit gene expression. A polynucleotide containing sequence that is similar to a sequence in the gene to be expressed is made and inserted into a vessel in the mammal. The polynucleotide is delivered to a cell wherein expression of the gene is inhibited.
摘要翻译：描述了将多核苷酸血管内递送至哺乳动物血管外细胞以抑制基因表达的方法。制备含有与待表达基因中的序列相似的序列的多核苷酸，并将其插入哺乳动物的血管。将多核苷酸递送至细胞，其中基因的表达被抑制。

2. 发明申请

US20050143332A1 Compositions and processes using siRNA, amphipathic compounds and polycations 有权
标题翻译：使用siRNA，两亲性化合物和聚阳离子的组合物和方法
公开(公告)号：US20050143332A1
公开(公告)日：2005-06-30
申请号：US10845968
申请日：2004-05-14
申请人： Sean Monahan , David Lewis , Hans Herweijer , Jon Wolff , James Hagstrom , Aaron Loomis , Vladimir Trubetskoy , Lori Higgs
发明人： Sean Monahan , David Lewis , Hans Herweijer , Jon Wolff , James Hagstrom , Aaron Loomis , Vladimir Trubetskoy , Lori Higgs
IPC分类号： A61K31/495 , A61K31/58 , A61K31/7105 , A61K31/74 , A61K48/00 , C07H21/04 , C12N15/11 , C12N15/88 , G01N33/53
CPC分类号： C12N15/111 , A61K31/495 , A61K31/58 , A61K31/7105 , A61K31/74 , A61K48/0025 , A61K48/0041 , C07H21/04 , C12N15/88 , C12N2310/14 , C12N2320/32 , A61K2300/00
摘要： Described is a deliverable composition with low toxicity comprising an amphipathic compound, a polycation, and a siRNA. The composition may be used in the process of delivering a siRNA to an animal cell or more particularly, a mammal cell.
摘要翻译：描述了具有低毒性的可递送组合物，其包含两亲性化合物，聚阳离子和siRNA。组合物可以用于将siRNA递送到动物细胞或更特别是哺乳动物细胞的过程中。

3. 发明申请

US20050037989A1 Inhibition of gene function by delivery of polynucleotide-based gene expression inhibitors to mammalian cells in vivo 审中-公开
标题翻译：通过在体内向哺乳动物细胞递送基于多核苷酸的基因表达抑制剂来抑制基因功能
公开(公告)号：US20050037989A1
公开(公告)日：2005-02-17
申请号：US10874528
申请日：2004-06-23
申请人： David Lewis , Jon Wolff , Hans Herweijer , James Hagstrom , Aaron Loomis , Andrew Spencer
发明人： David Lewis , Jon Wolff , Hans Herweijer , James Hagstrom , Aaron Loomis , Andrew Spencer
IPC分类号： A61K38/00 , A61K48/00 , C12N15/11 , C12N15/113 , C12N15/87
CPC分类号： C12N15/111 , A61K38/00 , A61K48/00 , C12N15/1137 , C12N15/87 , C12N2310/14 , C12N2320/32 , C12Y206/01002
摘要： A process is provided to deliver polynucleotide-based gene expression inhibitors to cells in a mammal in vivo for the purpose of inhibiting gene expression in the cells. Inhibition is sequence-specific and relies on sequence similaroty of the polynucleotide-based gene expression inhibitor and the target nucleic acid molecule. Delivery of the polynucleotide-based gene expression inhibitor can enhance the efficacy of co-delivered small molecule drugs.
摘要翻译：为了抑制细胞中的基因表达，提供了一种用于在体内向哺乳动物中的细胞递送基于多核苷酸的基因表达抑制剂的方法。抑制是序列特异性的，并且依赖于基于多核苷酸的基因表达抑制剂和靶核酸分子的序列相似性。基于多核苷酸的基因表达抑制剂的递送可以增强共同递送的小分子药物的功效。

4. 发明申请

US20060063731A1 In vivo inhibition of hepatitis B virus 审中-公开
标题翻译：体内抑制乙型肝炎病毒
公开(公告)号：US20060063731A1
公开(公告)日：2006-03-23
申请号：US11234947
申请日：2005-09-26
申请人： David Lewis , Jon Wolff , Hans Herweijer , James Hagstrom , Aaron Loomis
发明人： David Lewis , Jon Wolff , Hans Herweijer , James Hagstrom , Aaron Loomis
IPC分类号： A61K48/00
CPC分类号： A61K31/07 , C07K14/005 , C12N15/111 , C12N15/1131 , C12N15/1137 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2310/3233 , C12N2320/31 , C12N2320/32 , C12N2730/10122 , C12Y101/01034 , C12Y206/01002
摘要： A process is provided to deliver polynucleotide-based gene expression inhibitors to cells in a mammal in vivo for the purpose of inhibiting gene expression in the cells. Inhibition is sequence-specific and relies on sequence similarity to of the polynucleotide-based gene expression inhibitor and the target nucleic acid molecule. Delivery of the polynucleotide-based gene expression inhibitor can enhance the efficacy of co-delivered small molecule drugs.
摘要翻译：为了抑制细胞中的基因表达，提供了一种用于在体内向哺乳动物中的细胞递送基于多核苷酸的基因表达抑制剂的方法。抑制是序列特异性的，并且依赖于基于多核苷酸的基因表达抑制剂和靶核酸分子的序列相似性。基于多核苷酸的基因表达抑制剂的递送可以增强共同递送的小分子药物的功效。

5. 发明申请

US20050260270A1 Inhibition of gene expression by delivery of small interfering RNA to post-embryonic animal cells in vivo 审中-公开
标题翻译：通过在体内将小干扰RNA递送至胚胎后动物细胞来抑制基因表达
公开(公告)号：US20050260270A1
公开(公告)日：2005-11-24
申请号：US11113586
申请日：2005-04-25
申请人： David Lewis , Hans Herweijer , Jon Wolff , James Hagstrom , Aaron Loomis
发明人： David Lewis , Hans Herweijer , Jon Wolff , James Hagstrom , Aaron Loomis
IPC分类号： A61K9/14 , A61K38/00 , A61K48/00 , C12N15/11
CPC分类号： C12N15/111 , A61K48/0008 , A61K48/0041 , A61K48/0083 , C12N2320/32
摘要： A process is provided to deliver small interfering RNA to cells in vivo for the purpose of inhibiting gene expression in that cell. The small interfering RNA is less than 50 base-pairs in length. This process is practiced on post-embryonic animals. Inhibition is sequence-specific and relies on sequence identity of the small interfering RNA and the target nucleic acid molecule.
摘要翻译：提供了一种方法，用于在体内将小干扰RNA递送至细胞，以抑制该细胞中的基因表达。小干扰RNA的长度小于50个碱基对。这个过程是在胚胎后的动物上进行的。抑制是序列特异性的，并且依赖于小干扰RNA和靶核酸分子的序列同一性。

6. 发明申请

US20130190484A1 In Vivo Polynucleotide Delivery Conjugates Having Enzyme Sensitive Linkages 有权
标题翻译：具有酶敏感连接的体内多核苷酸递送缀合物
公开(公告)号：US20130190484A1
公开(公告)日：2013-07-25
申请号：US13833814
申请日：2013-03-15
申请人： David Rozema , David Lewis , Darren Wakefield , Eric Kitas , Philipp Hadwiger , Jon Wolff , Ingo Roehl , Peter Mohr , Torsten Hoffmann , Kerstin Jahn-Hofmann , Hans Martin Mueller , Guenther Ott , Andrei Blokhin , Jeffrey Carlson , Jonathan Benson
发明人： David Rozema , David Lewis , Darren Wakefield , Eric Kitas , Philipp Hadwiger , Jon Wolff , Ingo Roehl , Peter Mohr , Torsten Hoffmann , Kerstin Jahn-Hofmann , Hans Martin Mueller , Guenther Ott , Andrei Blokhin , Jeffrey Carlson , Jonathan Benson
IPC分类号： C12N15/113 , C07C271/20 , C07C69/96
CPC分类号： A61K38/00 , A61K31/7088 , A61K47/60 , A61K47/65 , A61K48/00 , C07C69/96 , C07C271/20 , C07H15/04 , C07H15/20 , C07H15/26 , C07K7/02 , C07K2317/77 , C12N15/1138 , C12N15/87 , C12N2310/14 , C12N2310/321 , C12N2310/322 , C12N2310/351 , C12N2320/30
摘要： The present invention is directed compositions for delivery of RNA interference (RNAi) polynucleotides to cells in vivo. The compositions comprise amphipathic membrane active polyamines reversibly modified with enzyme cleavable dipeptide-amidobenzyl-carbonate masking agents. Modification masks membrane activity of the polymer while reversibility provides physiological responsiveness. The reversibly modified polyamines (dynamic polyconjugate or DPC) are further covalently linked to an RNAi polynucleotide or co-administered with a targeted RNAi polynucleotide-targeting molecule conjugate.
摘要翻译：本发明涉及用于将RNA干扰（RNAi）多核苷酸递送至细胞体内的组合物。组合物包含用酶切割二肽 - 氨基苄基 - 碳酸酯掩蔽剂可逆地修饰的两亲膜活性多胺。改性掩盖聚合物的膜活性，而可逆性提供生理反应性。可逆修饰的多胺（动态多偶联物或DPC）进一步共价连接到RNAi多核苷酸或与靶向RNAi多核苷酸靶向分子缀合物共同施用。

7. 发明授权

US09697309B1 Metastability-hardened synchronization circuit 有权
公开(公告)号：US09697309B1
公开(公告)日：2017-07-04
申请号：US12563095
申请日：2009-09-18
申请人： Ryan Fung , David Lewis , David Neto
发明人： Ryan Fung , David Lewis , David Neto
IPC分类号： G06F17/50
CPC分类号： G06F17/5031 , G06F17/5036 , G06F17/5054 , H03K3/0375
摘要： An integrated circuit (IC) includes a metastability-hardened synchronization circuit. The metastability-hardened synchronization circuit includes a plurality of sampling circuits, and a multiplexer. The sampling circuits sample an input signal to generate a plurality of sampled signals. The multiplexer generates an output signal from the plurality of sampled signals.

8. 发明授权

US08984367B2 Error detection and correction circuitry 有权
标题翻译：错误检测和校正电路
公开(公告)号：US08984367B2
公开(公告)日：2015-03-17
申请号：US13035826
申请日：2011-02-25
申请人： Paul B. Ekas , David Lewis
发明人： Paul B. Ekas , David Lewis
IPC分类号： G11C29/00 , G11C29/52 , G06F11/10 , H03K19/177 , G11C11/412 , G11C29/04
CPC分类号： G06F11/1076 , G06F11/10 , G06F11/1048 , G11C11/412 , G11C29/52 , G11C2029/0411 , H03K19/17768
摘要： Integrated circuits with memory circuitry may include error detection circuitry and error correction circuitry. The error detection circuitry may be used to detect soft errors in the memory circuitry. The error detection circuitry may include logic gates that are used to perform parity checking. The error detection circuitry may have an interleaved structure to provide interleaved data bit processing, may have a tree structure to reduce logic gate delays, and may be pipelined to optimize performance. The memory circuitry may be loaded with interleaved parity check bits in conjunction with the interleaved structure to provide multi-bit error detection capability. The parity check bits may be precomputed using design tools or computed during device configuration. In response to detection of a memory error, the error correction circuitry may be used to scan desired portions of the memory circuitry and to correct the memory error.
摘要翻译：具有存储器电路的集成电路可以包括错误检测电路和纠错电路。误差检测电路可用于检测存储器电路中的软错误。错误检测电路可以包括用于执行奇偶校验的逻辑门。错误检测电路可以具有交织结构以提供交错数据位处理，可以具有减少逻辑门延迟的树结构，并且可以被流水线化以优化性能。存储器电路可以与交错结构一起加载交错奇偶校验位以提供多位错误检测能力。奇偶校验位可以使用设计工具预先计算或在设备配置期间计算。响应于存储器错误的检测，错误校正电路可用于扫描存储器电路的期望部分并校正存储器错误。

9. 发明授权

US08804295B2 Configurable multi-gate switch circuitry 有权
标题翻译：可配置的多门开关电路
公开(公告)号：US08804295B2
公开(公告)日：2014-08-12
申请号：US12579792
申请日：2009-10-15
申请人： David Lewis
发明人： David Lewis
IPC分类号： H01H47/26 , H01H50/12 , H01H57/00 , H01L29/788
CPC分类号： H01H45/14 , H01H59/00 , H01H59/0009
摘要： Integrated circuits with configurable multi-gate switch circuitry are provided. The switch circuitry may include switch control circuitry and an array of multi-gate switches. Each multi-gate switch may have first and second terminals, first and second gates, and a metal bridge. The metal bridge is attached to the first terminal. The metal bridge may extend over the gates and may hover above the second terminal in the off state. The metal bridge may have a tip that bends down to physically contact the second terminal in the on state. Switch control circuitry may provide row and column control signals to load desired switch states into the switch array. The switch array may be partitioned into groups of switches that form multiplexers. The multiplexers may be used in programmable circuits such as programmable logic device circuits.
摘要翻译：提供了具有可配置的多栅极开关电路的集成电路。开关电路可以包括开关控制电路和多栅极开关阵列。每个多栅极开关可以具有第一和第二端子，第一和第二栅极以及金属桥。金属桥连接到第一个终端。金属桥可以在门上延伸，并且可以在关闭状态下悬停在第二端子上方。金属桥可以具有向下弯曲的尖端，以在接通状态下物理地接触第二端子。开关控制电路可以提供行和列控制信号以将期望的开关状态加载到开关阵列中。开关阵列可以被划分为形成多路复用器的开关组。多路复用器可以用于诸如可编程逻辑器件电路的可编程电路中。

10. 发明授权

US08753696B1 Methods for preparing cannabis and related products 失效
标题翻译：制备大麻及相关产品的方法
公开(公告)号：US08753696B1
公开(公告)日：2014-06-17
申请号：US13652609
申请日：2012-10-16
申请人： David Lewis
发明人： David Lewis
IPC分类号： A01N65/00
CPC分类号： A61K36/185 , A61K9/007
摘要： A method for preparing a medical marijuana mixture includes combining prepared medical marijuana and an alkaline substance in a pulverizing device. The alkaline substance may be coconut, cinnamon, or the like. The pulverizing device may be a coffee grinder, a food processor, a blender, or the like. The mixture may optionally include a sweetener, such as sugar, stevia, or the like.
摘要翻译：制备医用大麻混合物的方法包括将制备的医用大麻和碱性物质混合在粉碎装置中。碱性物质可以是椰子，肉桂等。粉碎装置可以是咖啡研磨机，食品加工机，搅拌机等。混合物可以任选地包括甜味剂，例如糖，甜叶菊等。

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