专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20120123519A1 TUBULAR SILK COMPOSITIONS AND METHODS OF USE THEREOF 有权
标题翻译：管状丝素组合物及其使用方法
公开(公告)号：US20120123519A1
公开(公告)日：2012-05-17
申请号：US12672521
申请日：2008-08-11
申请人： Michael L. Lovett , Xianyan Wang , Christopher M. Cannizzaro , Gordana Vunjak-Novakovic , David L. Kaplan
发明人： Michael L. Lovett , Xianyan Wang , Christopher M. Cannizzaro , Gordana Vunjak-Novakovic , David L. Kaplan
IPC分类号： A61F2/82 , B29C41/14 , B32B1/08
CPC分类号： A61L27/227 , A61F2/07 , A61F2/08 , A61F2/82 , A61L27/26 , A61L27/3604 , D10B2211/22 , Y10T428/13 , C08L89/00
摘要： Described are tubular silk fibroin compositions and methods for their manufacture and use. Tubular compositions as described herein can be produced in a range of high burst strengths, can easily be made in a range of inner diameters, can be derivatized with functional moieties, and can be produced in a range of permeabilities suitable for particularized uses. In one aspect, the tubular compositions can be used in the repair or replacement of damaged or diseased blood vessels, including, but not limited to vessels smaller than about 6 mm.
摘要翻译：描述的是管状丝素蛋白组合物及其制造和使用的方法。如本文所述的管状组合物可以在高爆裂强度的范围内制备，可以容易地在内径范围内制备，可以用官能部分衍生化，并且可以在适合于特定用途的渗透性范围内制备。在一个方面，管状组合物可用于修复或更换受损或患病的血管，包括但不限于小于约6mm的血管。

2. 发明授权

US09808557B2 Tubular silk compositions and methods of use thereof 有权
公开(公告)号：US09808557B2
公开(公告)日：2017-11-07
申请号：US12672521
申请日：2008-08-11
申请人： Michael L. Lovett , Xianyan Wang , Christopher M. Cannizzaro , Gordana Vunjak-Novakovic , David L. Kaplan
发明人： Michael L. Lovett , Xianyan Wang , Christopher M. Cannizzaro , Gordana Vunjak-Novakovic , David L. Kaplan
IPC分类号： A61F2/06 , A61L27/36 , A61L27/22 , A61F2/08 , A61L27/26 , A61F2/07 , A61F2/82
CPC分类号： A61L27/227 , A61F2/07 , A61F2/08 , A61F2/82 , A61L27/26 , A61L27/3604 , D10B2211/22 , Y10T428/13 , C08L89/00
摘要： Described are tubular silk fibroin compositions and methods for their manufacture and use. Tubular compositions as described herein can be produced in a range of high burst strengths, can easily be made in a range of inner diameters, can be derivatized with functional moieties, and can be produced in a range of permeabilities suitable for particularized uses. In one aspect, the tubular compositions can be used in the repair or replacement of damaged or diseased blood vessels, including, but not limited to vessels smaller than about 6 mm.

3. 发明申请

US20090202614A1 METHODS FOR STEPWISE DEPOSITION OF SILK FIBROIN COATINGS 有权
标题翻译：用于步骤沉积硅胶涂层的方法
公开(公告)号：US20090202614A1
公开(公告)日：2009-08-13
申请号：US11997193
申请日：2006-07-28
申请人： David L. Kaplan , Xianyan Wang
发明人： David L. Kaplan , Xianyan Wang
IPC分类号： A61K9/70 , B05D3/04 , B32B9/00 , A61P43/00
CPC分类号： A61L31/10 , A61J3/00 , A61L15/32 , A61L15/44 , A61L27/3604 , A61L27/50 , A61L31/16 , A61L2300/416 , A61L2300/43 , A61L2400/12 , A61L2400/18 , C09D189/00 , Y10T428/31768
摘要： The invention provides a method for the controlled assembly of layered silk fibroin coatings using aqueous silk fibroin material. The methods described herein can be used to coat substrates of any material, shape, or size. Importantly, the described methods enable control of the biomaterial surface chemistry, thickness, morphology and structure using layered thin film coatings, or bulk coatings. Furthermore, the methods can be performed in all water and do not require intensive chemical processing enabling controlled entrapment of labile molecules such as, drugs, cytokines, and even cells or viruses to generate functional coatings that can be used in a variety of applications.
摘要翻译：本发明提供了一种使用水性丝素蛋白材料控制组合层状丝素蛋白涂层的方法。本文所述的方法可用于涂覆任何材料，形状或尺寸的基材。重要的是，所描述的方法使得能够使用分层薄膜涂层或散装涂层来控制生物材料表面化学，厚度，形态和结构。此外，所述方法可以在所有的水中进行，并且不需要强化的化学处理，从而能够控制不稳定的分子例如药物，细胞因子甚至细胞或病毒的捕获，以产生可用于各种应用的功能性涂层。

4. 发明授权

US08354501B2 Methods for stepwise deposition of silk fibroin coatings 有权
标题翻译：丝素蛋白涂层的逐步沉积方法
公开(公告)号：US08354501B2
公开(公告)日：2013-01-15
申请号：US11997193
申请日：2006-07-28
申请人： David L. Kaplan , Xianyan Wang
发明人： David L. Kaplan , Xianyan Wang
IPC分类号： D06M14/24 , A61K38/00
CPC分类号： A61L31/10 , A61J3/00 , A61L15/32 , A61L15/44 , A61L27/3604 , A61L27/50 , A61L31/16 , A61L2300/416 , A61L2300/43 , A61L2400/12 , A61L2400/18 , C09D189/00 , Y10T428/31768
摘要： The invention provides a method for the controlled assembly of layered silk fibroin coatings using aqueous silk fibroin material. The methods described herein can be used to coat substrates of any material, shape, or size. Importantly, the described methods enable control of the biomaterial surface chemistry, thickness, morphology and structure using layered thin film coatings, or bulk coatings. Furthermore, the methods can be performed in all water and do not require intensive chemical processing enabling controlled entrapment of labile molecules such as, drugs, cytokines, and even cells or viruses to generate functional coatings that can be used in a variety of applications.
摘要翻译：本发明提供了一种使用水性丝素蛋白材料控制组合层状丝素蛋白涂层的方法。本文所述的方法可用于涂覆任何材料，形状或尺寸的基材。重要的是，所描述的方法使得能够使用分层薄膜涂层或散装涂层来控制生物材料表面化学，厚度，形态和结构。此外，所述方法可以在所有的水中进行，并且不需要强化的化学处理，从而能够控制不稳定的分子例如药物，细胞因子甚至细胞或病毒的捕获，以产生可用于各种应用的功能性涂层。

5. 发明申请

US20090298139A1 Method for Polymer Synthesis Using Microfluidic Enzymatic Cascade 审中-公开
标题翻译：使用微流控酶级联的聚合物合成方法
公开(公告)号：US20090298139A1
公开(公告)日：2009-12-03
申请号：US12224149
申请日：2007-02-27
申请人： Jin Zou , David L. Kaplan , Jin Zou , Peter Y. Wong , David L. Kaplan
发明人： Jin Zou , David L. Kaplan , Jin Zou , Peter Y. Wong , David L. Kaplan
IPC分类号： C12P17/16 , B01J19/00
CPC分类号： C12P17/04
摘要： The present invention discloses a method for producing polymers in a microscale device. The system utilizes a symmetrically branched system of microchannels interconnecting a plurality of loading decks and re-action chambers. The fluid flow is manipulated by the placement of capillary check valves, mixing areas, and microcomb filters. The system provides for cascading enzymatic biosynthesis pathways wherein any variety of enzymes and reactants can be introduced into the system to produce a final product.
摘要翻译：本发明公开了一种在微型装置中制备聚合物的方法。该系统利用互连多个装载甲板和再作用室的对称分支的微通道系统。通过放置毛细管止回阀，混合区域和微孔过滤器来操纵流体流动。该系统提供级联的酶生物合成途径，其中可以将任何多种酶和反应物引入系统以产生最终产物。

6. 发明授权

US09517357B2 Plasmonic nanoparticle-doped silk materials 有权
标题翻译：掺杂等离子体纳米粒子的丝材料
公开(公告)号：US09517357B2
公开(公告)日：2016-12-13
申请号：US13819419
申请日：2011-09-03
申请人： Fiorenzo Omenetto , David L. Kaplan , Hu Tao
发明人： Fiorenzo Omenetto , David L. Kaplan , Hu Tao
IPC分类号： A61N5/00 , A61N5/06 , A61F7/03 , A61L31/00 , A61L31/12 , A61L31/14 , H01L35/30
CPC分类号： A61N5/0625 , A61F7/03 , A61L31/005 , A61L31/125 , A61L31/14 , A61L2400/12 , A61N5/062 , H01L35/30 , Y10T428/268 , Y10T428/2927
摘要： Provided herein are silk fibroin-based photothermal elements and uses thereof. The silk fibroin-based photothermal elements comprise a plurality of plasmonic nanoparticle distributed in a silk fibroin matrix, and can generate heat when the plasmonic nanoparticles are exposed to electromagnetic radiation. The silk fibroin-based photothermal elements can be adapted to be conformable and biodegradable, and can further be integrated with various electronic components, such as a thermo-electric device for conversion of heat into electricity. The invention is useful for various in vivo applications, such as photothermal therapy, controlled drug-delivery devices or wireless powering of implanted micro-devices.
摘要翻译：本文提供的是丝素蛋白基光热元件及其用途。基于丝素蛋白的光热元件包括分布在丝素蛋白基质中的多个等离子体激元纳米颗粒，当等离子体激元纳米粒子暴露于电磁辐射时可产生热量。丝素蛋白的光热元件可以适应和可生物降解，并且可以进一步与各种电子部件集成，例如用于将热量转换成电的热电装置。本发明可用于各种体内应用，例如光热治疗，受控药物递送装置或植入的微器件的无线供电。

7. 发明授权

US08986380B2 Multilayered silk scaffolds for meniscus tissue engineering 有权
标题翻译：用于半月板组织工程的多层丝绸支架
公开(公告)号：US08986380B2
公开(公告)日：2015-03-24
申请号：US13702606
申请日：2011-06-09
申请人： David L. Kaplan , Biman B. Mandal
发明人： David L. Kaplan , Biman B. Mandal
IPC分类号： A61F2/30 , A61L27/36 , A61L27/38 , A61L27/54 , A61L27/56 , C12N5/00 , C12N5/077
CPC分类号： A61F2/30756 , A61L27/3604 , A61L27/3654 , A61L27/3834 , A61L27/54 , A61L27/56 , A61L2300/252 , A61L2300/30 , A61L2300/414 , C12N5/0068 , C12N5/0655 , C12N2533/50 , C12N2533/90
摘要： Provided herein is a biocompatible implant for meniscus tissue engineering. Particularly, the biocompatible implant comprises a multi-layered crescent-shaped silk fibroin scaffold, in which each layer comprises distinct pore size and/or pore orientation, e.g., to mimic native meniscus complex architecture. Accordingly, the biocompatible implant can be used for repairing any meniscal defect or promoting meniscal regeneration in a subject.
摘要翻译：本文提供了用于弯液面组织工程的生物相容性植入物。特别地，生物相容性植入物包括多层新月形丝素蛋白支架，其中每个层包含不同的孔径和/或孔取向，例如模拟天然半月板复合体系结构。因此，生物相容性植入物可用于修复受试者中的任何半月板缺损或促进半月板再生。

8. 发明授权

US08906444B2 Diazonium salt modification of silk polymer 有权
标题翻译：丝绸聚合物的重氮盐改性
公开(公告)号：US08906444B2
公开(公告)日：2014-12-09
申请号：US13479709
申请日：2012-05-24
申请人： David L. Kaplan , Amanda Murphy
发明人： David L. Kaplan , Amanda Murphy
IPC分类号： B05D3/00 , C12N5/02 , A61K38/17 , C08L89/00 , C08H1/00
CPC分类号： C09D189/00 , C08H1/00 , C08L89/00
摘要： A method for modifying silk polymer by coupling a chemical moiety to a tyrosine residue of a silk polymer is described herein for the purpose of altering the physical properties of the silk protein. Thus, silk proteins with desired physical properties can be produced by the methods described herein. These methods are particularly useful when the introduction of cells to a mammal is desired, since modifications to the silk protein affect the physical properties and thus the adhesion, metabolic activity and cell morphology of the desired cells. The silk protein can be modified to produce, or modify, a structure that provides an optimal environment for the desired cells.
摘要翻译：本文描述了通过将化学部分偶联到丝聚合物的酪氨酸残基来修饰丝聚合物的方法，用于改变丝蛋白的物理性质。因此，可以通过本文所述的方法制备具有所需物理性质的丝蛋白。当需要向哺乳动物引入细胞时，这些方法特别有用，因为对丝蛋白的修饰会影响所需细胞的物理性质，因此影响粘附，代谢活性和细胞形态。可以修饰丝蛋白以产生或修饰为所需细胞提供最佳环境的结构。

9. 发明申请

US20140154788A1 ELECTRONIC COMPONENTS ON PAPER-BASED SUBSTRATES 审中-公开
标题翻译：基于纸张基板的电子元件
公开(公告)号：US20140154788A1
公开(公告)日：2014-06-05
申请号：US13977233
申请日：2012-01-04
申请人： Fiorenzo Omenetto , David L. Kaplan , Hu Tao
发明人： Fiorenzo Omenetto , David L. Kaplan , Hu Tao
IPC分类号： B01L3/00 , C12Q1/54 , G01N22/00 , G01J1/02 , G01J5/02
CPC分类号： B01L3/502707 , C12Q1/54 , G01J1/02 , G01J5/02 , G01N21/3563 , G01N21/3581 , G01N22/00
摘要： The present disclosure relates to paper-based substrates and apparatus comprising such substrates. The apparatus may include a patterned conductive structure coupled to the paper-based substrate, wherein the patterned conductive structure responds to electromagnetic radiation.
摘要翻译：本公开涉及基于纸的基板和包括这种基板的装置。该装置可以包括耦合到纸基基板的图案化导电结构，其中图案化导电结构响应于电磁辐射。

10. 发明授权

US08722067B2 Method for silk fibroin gelation using sonication 有权
标题翻译：使用超声处理丝素蛋白凝胶化方法
公开(公告)号：US08722067B2
公开(公告)日：2014-05-13
申请号：US13457705
申请日：2012-04-27
申请人： Xiaoqin Wang , Jon Kluge , Gary G. Leisk , David L. Kaplan
发明人： Xiaoqin Wang , Jon Kluge , Gary G. Leisk , David L. Kaplan
IPC分类号： A61K9/00 , A61K38/17
CPC分类号： A61K47/42 , A61K9/06 , A61K9/5052 , A61K9/5063 , A61K9/5089 , A61K35/28 , A61K2035/124 , C07K14/43586
摘要： This invention provides for a process of rapidly forming silk fibroin gelation through ultrasonication. Under the appropriate conditions, gelation can be controlled to occur within two hours after the ultrasonication treatment. Biological materials, including viable cells, or therapeutic agents can be encapsulated in the hydrogels formed from the process and be used as delivery vehicles.
摘要翻译：本发明提供了通过超声波快速形成丝素蛋白凝胶化的方法。在适当的条件下，超声波处理后两小时即可控制凝胶化。包括活细胞或治疗剂在内的生物材料可以包封在由该方法形成的水凝胶中并用作输送载体。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式