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    • 3. 发明申请
    • SYSTEM AND METHOD FOR MAKING BIOMATERIAL STRUCTURES
    • 制备生物体结构的系统和方法
    • US20110076384A1
    • 2011-03-31
    • US12934666
    • 2009-04-08
    • Christopher CannizzaroMichael L. LovettGordana Vunjak-NovakovicDavid L. Kaplan
    • Christopher CannizzaroMichael L. LovettGordana Vunjak-NovakovicDavid L. Kaplan
    • B05C11/00A61L33/00
    • D01F4/02D01D5/04D01D5/06D01D5/18D01D7/00
    • A system and method for making a biomaterial device includes a support structure providing a shape for a biomaterial device. At least one applicator has a supply of biomaterial solution and is positioned along the support structure. The at least one applicator forms a biomaterial fiber by applying shear force to the biomaterial solution and delivering the biomaterial fiber to the support structure. A controller causes relative movement between the support structure and the at least one applicator, and the biomaterial fiber is arranged on the support structure according to the relative movement to form the biomaterial device. The biomaterial may be silk fibroin which may be wound onto a reciprocating and rotating mandrel. Control over the properties of the biomaterial device is achieved through appropriate selection of material processing, winding strategy, and post-winding processing.
    • 用于制造生物材料装置的系统和方法包括为生物材料装置提供形状的支撑结构。 至少一个施用器具有生物材料溶液的供应并且沿着支撑结构定位。 所述至少一个施用器通过向所述生物材料溶液施加剪切力并将所述生物材料纤维递送到所述支撑结构来形成生物材料纤维。 控制器引起支撑结构和至少一个施加器之间的相对运动,并且根据相对运动将生物材料纤维布置在支撑结构上以形成生物材料装置。 生物材料可以是可以卷绕到往复和旋转的心轴上的丝素蛋白。 通过适当选择材料加工,卷绕策略和后卷绕处理,可以控制生物材料装置的性能。