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1. 发明授权

US5905032A Electrosynthetic method of modifying biomolecules in particular enzymes 失效
标题翻译：改变生物分子特别是酶的电合成方法
公开(公告)号：US5905032A
公开(公告)日：1999-05-18
申请号：US925870
申请日：1997-09-09
申请人： David John Walton , John Heptinstall , Paul Graham Richards
发明人： David John Walton , John Heptinstall , Paul Graham Richards
IPC分类号： C07K1/00 , C07K1/107 , C12N9/00 , C12N9/16 , C25B3/02 , C12N13/00 , C25B3/00
CPC分类号： C25B3/02 , C07K1/006 , C07K1/1077 , C12N9/00
摘要： Pendant groups in the alpha-amino acid monomer residues comprising a polypeptide molecule are selectively modified by applying an electric potential across an electrochemical cell containing the polypeptide.
摘要翻译：通过在包含该多肽的电化学电池上施加电位来选择性地修饰包含多肽分子的α-氨基酸单体残基中的侧基。

2. 发明申请

US20060292658A1 Fluorescent compound 审中-公开
标题翻译：荧光化合物
公开(公告)号：US20060292658A1
公开(公告)日：2006-12-28
申请号：US10574166
申请日：2004-09-30
申请人： Daniel Lynch , John Heptinstall
发明人： Daniel Lynch , John Heptinstall
IPC分类号： C12Q1/37 , G01N33/00 , C07D403/02
CPC分类号： C09B57/007 , G01N33/582
摘要： A water-soluble photoluminescent compound including a symmetrical skeletal structure of the formula (A) in which x may represent any integer, and in which the phenyl rings may be substituted, is disclosed. A protein detector comprising such a compound and a method of measuring the total dissolved protein content of a fluid sample are also disclosed.
摘要翻译：公开了一种水溶性光致发光化合物，其包括式（A）的对称骨架结构，其中x可以表示任何整数，并且其中苯环可以被取代。还公开了包含这种化合物的蛋白质检测器和测量流体样品的总溶解蛋白质含量的方法。

3. 发明授权

US08214006B2 Devices and methods for detecting β-haematin and haemozoin 有权
标题翻译：用于检测血红蛋白和血红素的装置和方法
公开(公告)号：US08214006B2
公开(公告)日：2012-07-03
申请号：US12513990
申请日：2007-11-09
申请人： David Michael Newman , John Heptinstall
发明人： David Michael Newman , John Heptinstall
IPC分类号： A61B5/1455 , G01N21/00
CPC分类号： G01N21/1717 , A61B5/0059 , A61B5/0095 , A61B5/05 , A61B5/6816 , A61B5/6826 , A61B5/6838 , G01N21/21 , G01N2021/1727 , G01N2021/218 , G01N2201/067 , G01N2201/0697 , G01N2333/445
摘要： In the application, the change in the magnetic state of the haemoglobin caused by the malarial infection is exploited by detecting suitable properties of haemozoin which are dependent on the application of a magnetic field. FIG. 1 shows apparatus, shown generally at (10), for performing magneto-optical detection using photo-acoustic techniques. The apparatus (10) comprises a light source (12), producing a beam of optical radiation (14) which passes through a polarizer (16), a variable LC retarder (0 or 180° retardance) (18), and a (chopper 20), before impinging on a sample (22) held in a sample holder (24). The sample is in direct contact with an acoustic detector (26). The apparatus (10) further comprises an electromagnet (28), and a Gauss meter (30) can be utilized to measure the applied magnetic field strength. Advantages associated with this approach are the—possibility of making in vivo measurements, and the avoidance of problems of optical scattering associated with conventional optical measurements on turbid liquids such as whole blood.
摘要翻译：在应用中，通过检测依赖于磁场的应用的血红素的合适性质来开发由疟疾感染引起的血红蛋白的磁状态的变化。图。图1示出了总体上用（10）示出的用于使用光声技术进行磁光检测的装置。该设备（10）包括光源（12），产生通过偏振器（16），可变LC延迟器（0或180°延迟）（18）和（斩波器）的光辐射束（14） 20），然后撞击保持在样品架（24）中的样品（22）。样品与声学检测器（26）直接接触。装置（10）还包括电磁体（28），并且高斯计（30）可用于测量所施加的磁场强度。与该方法相关的优点是进行体内测量的可能性，以及避免与诸如全血的混浊液体的常规光学测量相关联的光学散射问题。

4. 发明申请

US20090318784A1 Devices and Methods for Detecting B-Haematin and Haemozoin 有权
标题翻译：用于检测B-Haematin和Haemozoin的装置和方法
公开(公告)号：US20090318784A1
公开(公告)日：2009-12-24
申请号：US12513990
申请日：2007-11-09
申请人： David Michael Newman , John Heptinstall
发明人： David Michael Newman , John Heptinstall
IPC分类号： A61B5/145 , G01N27/00 , B01J19/12 , G01N21/00 , C12M1/34 , C12Q1/04
CPC分类号： G01N21/1717 , A61B5/0059 , A61B5/0095 , A61B5/05 , A61B5/6816 , A61B5/6826 , A61B5/6838 , G01N21/21 , G01N2021/1727 , G01N2021/218 , G01N2201/067 , G01N2201/0697 , G01N2333/445
摘要： In the application, the change in the magnetic state of the haemoglobin caused by the malarial infection is exploited by detecting suitable properties of haemozoin which are dependent on the application of a magnetic field. FIG. 1 shows apparatus, shown generally at (10), for performing magneto-optical detection using photo-acoustic techniques. The apparatus (10) comprises a light source (12), producing a beam of optical radiation (14) which passes through a polariser (16), a variable LC retarder (0 or 180° retardance) (18), and a (chopper 20), before impinging on a sample (22) held in a sample holder (24). The sample is in direct contact with an acoustic detector (26). The apparatus (10) further comprises an electromagnet (28), and a Gauss meter (30) can be utilised to measure the applied magnetic field strength. Advantages associated with this approach are the—possibility of making in vivo measurements, and the avoidance of problems of optical scattering associated with conventional optical measurements on turbid liquids such as whole blood.
摘要翻译：在应用中，通过检测依赖于磁场的应用的血红素的合适性质来开发由疟疾感染引起的血红蛋白的磁状态的变化。图。图1示出了总体上用（10）示出的用于使用光声技术进行磁光检测的装置。该设备（10）包括一个光源（12），产生通过偏振器（16），可变LC延迟器（0或180°延迟）（18）和（斩波器）的光辐射束（14） 20），然后撞击保持在样品架（24）中的样品（22）。样品与声学检测器（26）直接接触。装置（10）还包括电磁体（28），并且高斯计（30）可用于测量所施加的磁场强度。与该方法相关的优点是进行体内测量的可能性，以及避免与诸如全血的混浊液体的常规光学测量相关联的光学散射问题。

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