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1. 发明申请

US20090201499A1 Spectroscopic Imaging Microscopy 有权
标题翻译：光谱成像显微镜
公开(公告)号：US20090201499A1
公开(公告)日：2009-08-13
申请号：US12239628
申请日：2008-09-26
申请人： David J. Monk , David R. Walt
发明人： David J. Monk , David R. Walt
IPC分类号： G01J3/04
CPC分类号： G01J3/18 , G01J3/02 , G01J3/0208 , G01J3/0229 , G01J3/0237 , G01J3/0264 , G01J3/14 , G01J3/32 , G02B21/06 , G02B21/367
摘要： Disclosed herein are systems that include: (a) an objective lens system configured to collect light from a sample; (b) a first aperture positioned to allow a portion of the collected light received from the objective lens system to pass as input light; (c) a first lens positioned to transmit the input light received from the first aperture; (d) a dispersive element configured to spatially disperse the input light received from the first lens in a first plane; (e) a second lens positioned to transmit the spatially dispersed light; (f) a second aperture positioned to allow a portion of the spatially dispersed light received from the second lens to pass as detection light; and (g) a detector positioned to receive the detection light and configured to form at least one image of the sample.
摘要翻译：这里公开的系统包括：（a）被配置为收集来自样品的光的物镜系统; （b）第一孔，定位成允许从物镜系统接收的一部分收集的光作为输入光通过; （c）第一透镜，定位成透射从第一孔接收的输入光; （d）分散元件，被配置为在第一平面中将从第一透镜接收的输入光空间分散; （e）定位成透射空间分散的光的第二透镜; （f）第二孔，定位成允许从第二透镜接收的部分空间分散的光作为检测光通过; 和（g）定位成接收检测光并被配置成形成样品的至少一个图像的检测器。

2. 发明申请

US20090215143A1 Controlled alteration of pores using fluid flow and fabrication of articles thereby 有权
标题翻译：使用流体流动控制孔隙的改变，从而制造制品
公开(公告)号：US20090215143A1
公开(公告)日：2009-08-27
申请号：US11658515
申请日：2005-07-26
申请人： David J. Monk , David R. Walt
发明人： David J. Monk , David R. Walt
IPC分类号： C12N13/00 , B05D1/36 , B05D7/22 , B05D5/12 , G01N27/00 , B32B1/08 , G02B27/10
CPC分类号： G01N33/5438 , B01J2219/00439 , B01J2219/0045 , B01J2219/00524 , B01J2219/00653 , Y10T428/13
摘要： The invention relates to microscopic structures and methods of making and using the structures. A method of forming a microscopic structure of a material includes obtaining a solution (310) containing the material, establishing a flowing stream of the solution (310) in a capillary (104), wherein the capillary (104) has an inner dimension that is smaller than about 300 micrometers, and maintaining the stream until a layer is built up along an inner wall of the capillary (104) from material deposited from the flowing stream, thereby forming a microscopic structure.
摘要翻译：本发明涉及微观结构及其制造和使用方法。形成材料的微观结构的方法包括获得含有该材料的溶液（310），在毛细管（104）中形成溶液（310）的流动流，其中毛细管（104）的内部尺寸为小于约300微米，并且保持流，直到沿着毛细管（104）的内壁从流动物料沉积的材料构建层，从而形成微观结构。

3. 发明授权

US08663973B2 Controlled alteration of pores using fluid flow and fabrication of articles thereby 有权
标题翻译：使用流体流动控制孔隙的改变，从而制造制品
公开(公告)号：US08663973B2
公开(公告)日：2014-03-04
申请号：US11658515
申请日：2005-07-26
申请人： David J. Monk , David R. Walt
发明人： David J. Monk , David R. Walt
IPC分类号： B05D1/36 , B05D5/12 , B05D7/22
CPC分类号： G01N33/5438 , B01J2219/00439 , B01J2219/0045 , B01J2219/00524 , B01J2219/00653 , Y10T428/13
摘要： The invention relates to microscopic structures and methods of making and using the structures. A method of forming a microscopic structure of a material includes obtaining a solution (310) containing the material, establishing a flowing stream of the solution (310) in a capillary (104), wherein the capillary (104) has an inner dimension that is smaller than about 300 micrometers, and maintaining the stream until a layer is built up along an inner wall of the capillary (104) from material deposited from the flowing stream, thereby forming a microscopic structure.
摘要翻译：本发明涉及微观结构及其制造和使用方法。形成材料的微观结构的方法包括获得含有该材料的溶液（310），在毛细管（104）中形成溶液（310）的流动流，其中毛细管（104）的内部尺寸为小于约300微米，并且保持流，直到沿着毛细管（104）的内壁从流动物料沉积的材料构建层，从而形成微观结构。

4. 发明授权

US09482662B2 Ultra-sensitive detection of molecules or particles using beads or other capture objects 有权
标题翻译：使用珠粒或其他捕获物体对分子或颗粒进行超敏感检测
公开(公告)号：US09482662B2
公开(公告)日：2016-11-01
申请号：US13530979
申请日：2012-06-22
申请人： David C. Duffy , David M. Rissin , David R. Walt , David Fournier , Cheuk Kan
发明人： David C. Duffy , David M. Rissin , David R. Walt , David Fournier , Cheuk Kan
IPC分类号： G01N33/543
CPC分类号： G01N33/54393 , G01N33/54306 , G01N33/54313
摘要： The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles with respect to a plurality of capture objects. At least a portion of the plurality of capture objects may be spatially separated into a plurality of locations. A measure of the concentration of analyte molecules in a fluid sample may be determined, at least in part, on the number of reaction vessels comprising an analyte molecule immobilized with respect to a capture object. In some cases, the assay may additionally comprise steps including binding ligands, precursor labeling agents, and/or enzymatic components.
摘要翻译：本发明涉及用于检测流体样品中的分析物分子或颗粒的系统和方法，并且在某些情况下，确定流体样品中分子或颗粒的浓度的量度。本发明的方法可以包括相对于多个捕获物体固定多个分析物分子或颗粒。多个捕获对象的至少一部分可以在空间上分离成多个位置。可以至少部分地确定包含相对于捕获对象固定的分析物分子的反应容器的数量，来测量流体样品中分析物分子的浓度。在一些情况下，该测定可另外包括包括结合配体，前体标记试剂和/或酶组分的步骤。

5. 发明授权

US09310360B2 Ultra-sensitive detection of molecules or particles using beads or other capture objects 有权
公开(公告)号：US09310360B2
公开(公告)日：2016-04-12
申请号：US13531061
申请日：2012-06-22
申请人： David C. Duffy , David M. Rissin , David R. Walt , David Fournier , Cheuk Kan
发明人： David C. Duffy , David M. Rissin , David R. Walt , David Fournier , Cheuk Kan
IPC分类号： C12Q1/00 , G01N33/543
CPC分类号： G01N33/54393 , G01N33/54306 , G01N33/54313
摘要： The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles with respect to a plurality of capture objects. At least a portion of the plurality of capture objects may be spatially separated into a plurality of locations. A measure of the concentration of analyte molecules in a fluid sample may be determined, at least in part, on the number of reaction vessels comprising an analyte molecule immobilized with respect to a capture object. In some cases, the assay may additionally comprise steps including binding ligands, precursor labeling agents, and/or enzymatic components.

6. 发明授权

US08932869B2 Chemical switches for detecting reactive chemical agents 有权
标题翻译：用于检测反应性化学试剂的化学开关
公开(公告)号：US08932869B2
公开(公告)日：2015-01-13
申请号：US12279899
申请日：2007-02-22
申请人： David R. Walt , Sandra Bencic-Nagale
发明人： David R. Walt , Sandra Bencic-Nagale
IPC分类号： G01N21/64 , C07D311/82 , G01N33/00 , C07D219/06
CPC分类号： G01N33/0057 , C07D219/06 , G01N21/643 , Y10T436/16 , Y10T436/163333
摘要： Certain embodiments of the present invention relate to the preparation of microbeads that exhibit a “turn on” fluorescence response within seconds of exposure to an analyte vapor (e.g., a chemical warfare agent or a reactive stimulant). This sensing approach is modeled after the mechanism for inhibition of acetylcholinesterase enzyme activity, and utilizes a specific and irreversible reaction between phosphonyl halides and a fluorescent indicator. The present invention also relates to a sensor and a method for sensing an analyte through detection of changes in the fluorescing properties of the inventive microbeads.
摘要翻译：本发明的某些实施方案涉及在暴露于分析物蒸汽（例如化学战剂或反应兴奋剂）的几秒钟内显示出“开启”荧光响应的微珠的制备。该感测方法在抑制乙酰胆碱酯酶活性的机制之后被建模，并利用膦酰卤与荧光指示剂之间的特异性和不可逆反应。本发明还涉及通过检测本发明微珠的荧光特性变化来检测分析物的传感器和方法。

7. 发明授权

US08030094B2 Self-encoding sensor with microspheres 有权
标题翻译：具有微球的自编码传感器
公开(公告)号：US08030094B2
公开(公告)日：2011-10-04
申请号：US12834422
申请日：2010-07-12
申请人： David R. Walt , Todd A. Dickinson
发明人： David R. Walt , Todd A. Dickinson
IPC分类号： G01N33/543 , G01N21/00 , G01N21/75
CPC分类号： C12Q1/682 , B01J2219/00317 , B01J2219/0045 , B01J2219/00466 , B01J2219/005 , B01J2219/00524 , B01J2219/00585 , B01J2219/00648 , B01J2219/00659 , C12Q1/6834 , C40B60/14 , G01N21/6428 , G01N21/6452 , G01N21/7703 , G01N33/0031 , G01N33/54313 , G01N2201/0846 , Y10T436/101666 , Y10T436/109163
摘要： A microsphere-based analytic chemistry system is disclosed in which self-encoding microspheres having distinct characteristic optical response signatures to specific target analytes may be mixed together while the ability is retained to identify the sensor type and location of each sensor in a random dispersion of large numbers of such sensors in a sensor array using an optically interrogatable encoding scheme. An optical fiber bundle sensor is also disclosed in which individual microsphere sensors are disposed in microwells at a distal end of the fiber bundle and are optically coupled to discrete fibers or groups of fibers within the bundle. The identities of the individual sensors in the array are self-encoded by exposing the array to a reference analyte while illuminating the array with excitation light energy. A single sensor array may carry thousands of discrete sensing elements whose combined signal provides for substantial improvements in sensor detection limits, response times and signal-to-noise ratios.
摘要翻译：公开了一种基于微球的分析化学系统，其中具有针对特定目标分析物的不同特征光学响应特征的自编码微球可以混合在一起，同时保留能力以识别大尺度随机色散中的每个传感器的传感器类型和位置使用光学可询问编码方案的传感器阵列中的这种传感器的数量。还公开了一种光纤束传感器，其中单个微球传感器设置在纤维束的远端处的微孔中，并且光束耦合到束内的离散纤维或纤维组。阵列中各个传感器的身份通过将阵列暴露于参考分析物而进行自编码，同时用激发光能照射阵列。单个传感器阵列可携带数千个离散感测元件，其组合信号提供传感器检测限，响应时间和信噪比方面的实质性改进。

8. 发明申请

US20100256465A1 DEVICES AND TECHNIQUES ASSOCIATED WITH DIAGNOSTICS, THERAPIES, AND OTHER APPLICATIONS, INCLUDING SKIN-ASSOCIATED APPLICATIONS 有权
标题翻译：与诊断，治疗和其他应用相关的设备和技术，包括皮肤相关应用
公开(公告)号：US20100256465A1
公开(公告)日：2010-10-07
申请号：US12716229
申请日：2010-03-02
申请人： Howard Bernstein , Donald E. Chickering, III , Douglas A. Levinson , David R. Walt , Shawn Davis , Ramin Haghgooie , Robert S. Langer , Timothy M. Blicharz
发明人： Howard Bernstein , Donald E. Chickering, III , Douglas A. Levinson , David R. Walt , Shawn Davis , Ramin Haghgooie , Robert S. Langer , Timothy M. Blicharz
IPC分类号： A61B5/00 , A61B5/145 , G01N21/00
CPC分类号： A61B5/150099 , A61B5/0013 , A61B5/0022 , A61B5/0077 , A61B5/1438 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/1459 , A61B5/14865 , A61B5/150022 , A61B5/150221 , A61B5/150358 , A61B5/150389 , A61B5/150412 , A61B5/150442 , A61B5/150503 , A61B5/150969 , A61B5/150984 , A61B5/151 , A61B5/15125 , A61B5/157 , A61B5/411 , A61B5/4839 , A61B5/4845 , A61B5/486 , A61B5/685 , A61B5/6898 , A61B5/743
摘要： The present invention generally relates to devices and techniques associated with diagnostics, therapies, and other applications, including skin-associated applications, for example, devices for delivering and/or withdrawing fluid from subjects, e.g., through the skin. In some embodiments, the device includes a system for accessing an extractable medium from and/or through the skin of the subject at an access site, and a pressure regulator supported by a support structure, able to create a pressure differential across the skin at least a portion of the access site. The device may also include, in some cases, a sensor supported by the support structure for determining at least one condition of the extractable medium from the subject, and optionally a signal generator supported by the support structure for generating a signal relating to the condition of the medium determined by the sensor.
摘要翻译：本发明一般涉及与诊断，治疗和其它应用相关联的装置和技术，包括皮肤相关应用，例如用于递送和/或从主体（例如通过皮肤）排出流体的装置。在一些实施例中，所述装置包括用于在进入位置从所述受试者的皮肤和/或穿过所述受试者的皮肤接入可提取介质的系统，以及由支撑结构支撑的压力调节器，所述压力调节器能够至少在所述皮肤上形成压差访问站点的一部分。在一些情况下，该装置还可以包括由支撑结构支持的传感器，用于确定来自主体的可提取介质的至少一个状况，以及可选地由支撑结构支撑的信号发生器，用于产生与介质由传感器确定。

9. 发明申请

US20100075355A1 ULTRA-SENSITIVE DETECTION OF ENZYMES BY CAPTURE-AND-RELEASE FOLLOWED BY QUANTIFICATION 审中-公开
标题翻译：通过定量检测和释放对酶的超敏感检测
公开(公告)号：US20100075355A1
公开(公告)日：2010-03-25
申请号：US12236490
申请日：2008-09-23
申请人： David C. Duffy , Evan Ferrell , Jeffrey D. Randall , David M. Rissin , David R. Walt
发明人： David C. Duffy , Evan Ferrell , Jeffrey D. Randall , David M. Rissin , David R. Walt
IPC分类号： C12Q1/34 , C12Q1/28
CPC分类号： G01N33/543 , G01N33/54306 , G01N33/54393
摘要： The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles to form a plurality of complexes, releasing at least a portion of some of the plurality of complexes, determining at least a portion of the plurality of complexes released, and determining a measure of the concentration of the analyte molecules or particles in a fluid sample.
摘要翻译：本发明涉及用于检测流体样品中的分析物分子或颗粒的系统和方法，并且在某些情况下，确定流体样品中分子或颗粒的浓度的量度。本发明的方法可以包括固定多个分析物分子或颗粒以形成多个复合物，释放所述多个复合物中的至少一部分，确定所述多个复合物的至少一部分被释放，并且确定测量流体样品中分析物分子或颗粒的浓度。

10. 发明授权

US07622294B2 Methods for detecting target analytes and enzymatic reactions 失效
标题翻译：检测目标分析物和酶反应的方法
公开(公告)号：US07622294B2
公开(公告)日：2009-11-24
申请号：US10920637
申请日：2004-08-17
申请人： David R. Walt , Karri Lynn Ballard
发明人： David R. Walt , Karri Lynn Ballard
IPC分类号： C12M1/34
CPC分类号： G01N15/1456 , B01J19/0046 , B01J2219/00317 , B01J2219/00459 , B01J2219/00466 , B01J2219/005 , B01J2219/00524 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00677 , B01J2219/00704 , B01J2219/00722 , B01J2219/00725 , B01J2219/0074 , B82Y30/00 , C12Q1/6837 , C40B40/06 , C40B40/10 , G01N21/6428 , G01N21/6452 , G01N21/6456 , G01N21/7703 , G01N21/78 , G01N33/543 , G01N33/54313 , G01N2015/1438 , G01N2021/6441 , G01N2021/6484 , G01N2035/0097 , G01N2201/0826 , Y02A50/55 , Y10S435/808 , Y10S436/805
摘要： A microsphere-based analytic chemistry system and method for making the same is disclosed in which microspheres or particles carrying bioactive agents may be combined randomly or in ordered fashion and dispersed on a substrate to form an array while maintaining the ability to identify the location of bioactive agents and particles within the array using an optically interrogatable, optical signature encoding scheme. A wide variety of modified substrates may be employed which provide either discrete or non-discrete sites for accommodating the microspheres in either random or patterned distributions. The substrates may be constructed from a variety of materials to form either two-dimensional or three-dimensional configurations. In a preferred embodiment, a modified fiber optic bundle or array is employed as a substrate to produce a high density array. The disclosed system and method have utility for detecting target analytes and screening large libraries of bioactive agents.
摘要翻译：公开了一种基于微球的分析化学体系及其制备方法，其中携带生物活性剂的微球或颗粒可以随机或以有序的方式组合并分散在基质上以形成阵列，同时保持识别生物活性物质的位置的能力阵列内的代理和粒子，使用光学可询问的光学签名编码方案。可以使用各种各样的改性底物，其提供用于以随机或图案分布容纳微球体的离散或非离散位点。衬底可以由各种材料构成以形成二维或三维构型。在优选的实施方案中，采用改性的光纤束或阵列作为基底以产生高密度阵列。所公开的系统和方法具有检测目标分析物和筛选大型生物活性剂库的效用。

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