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1. 发明授权

US08426217B2 Self-encoding sensor with microspheres 有权
公开(公告)号：US08426217B2
公开(公告)日：2013-04-23
申请号：US13215749
申请日：2011-08-23
申请人： David R. Walt , Todd A. Dickinson
发明人： David R. Walt , Todd A. Dickinson
IPC分类号： G01N21/00 , G01N33/543 , G01N21/75
CPC分类号： C12Q1/682 , B01J2219/00317 , B01J2219/0045 , B01J2219/00466 , B01J2219/005 , B01J2219/00524 , B01J2219/00585 , B01J2219/00648 , B01J2219/00659 , C12Q1/6834 , C40B60/14 , G01N21/6428 , G01N21/6452 , G01N21/7703 , G01N33/0031 , G01N33/54313 , G01N2201/0846 , Y10T436/101666 , Y10T436/109163
摘要： Disclosed herein are compositions and methods for combining the output obtained from redundant sensor elements in a sensor array.

2. 发明申请

US20120129716A1 USE OF MICROFLUIDIC SYSTEMS IN THE DETECTION OF TARGET ANALYTES USING MICROSPHERE ARRAYS 有权
标题翻译：微流感系统在使用微波阵列检测目标分析仪时的应用
公开(公告)号：US20120129716A1
公开(公告)日：2012-05-24
申请号：US13299235
申请日：2011-11-17
申请人： Mark S. Chee , Todd A. Dickinson , Kevin Gunderson , Don O'Neil , John R. Stuelpnagel
发明人： Mark S. Chee , Todd A. Dickinson , Kevin Gunderson , Don O'Neil , John R. Stuelpnagel
IPC分类号： C40B30/04 , C40B60/12
CPC分类号： B01L3/502761 , B01L2200/0668 , B01L2300/0816 , B01L2300/0867 , B01L2400/0415 , C12Q1/68 , C12Q1/6816 , C12Q1/6869 , C12Q1/6874 , C12Q2565/629 , C12Q2563/149
摘要： The invention relates generally to methods and apparatus for conducting analyses, particularly microfluidic devices for the detection of target analytes.
摘要翻译：本发明一般涉及用于进行分析的方法和装置，特别是用于检测目标分析物的微流体装置。

3. 发明授权

US07115884B1 Self-encoding fiber optic sensor 失效
标题翻译：自编光纤传感器
公开(公告)号：US07115884B1
公开(公告)日：2006-10-03
申请号：US08944850
申请日：1997-10-06
申请人： David R. Walt , Todd A. Dickinson
发明人： David R. Walt , Todd A. Dickinson
IPC分类号： G01N21/64
CPC分类号： G01N21/6452 , B01J2219/00317 , B01J2219/00524 , B01J2219/00648 , B01J2219/00659 , C40B60/14 , G01N21/6428 , G01N21/7703 , G01N33/0031 , G01N33/54313 , G01N33/54373 , G01N33/54393 , G01N2021/6484 , G01N2021/7786
摘要： Self-encoding microspheres having distinct characteristic optical response signatures to specific target analytes may be mixed together while the ability is retained to identify the sensor type and location of each sensor in a random dispersion of large numbers of such sensors in a sensor array using an optically interrogatable encoding scheme, resulting in a microsphere-based analytic chemistry system. Individual microsphere sensors are disposed in microwells at a distal end of a fiber bundle and are optically coupled to discrete fibers or groups of fibers within the bundle to form an optical fiber bundle sensor. The identities of the individual sensors in the array are self-encoded by exposing the array to a reference analyte while illuminating the array with excitation light energy. A single sensor array may carry thousands of discrete sensing elements whose combined signal provides for substantial improvements in sensor detection limits, response times and signal-to-noise ratios.
摘要翻译：具有针对特定目标分析物的特征性光学响应特征的自编码微球可以混合在一起，同时保留能力以在传感器阵列中使用光学方法识别大量这种传感器的随机色散中的每个传感器的传感器类型和位置可询问的编码方案，导致基于微球的分析化学系统。单个微球传感器设置在纤维束的远端处的微孔中，并且光学耦合到束内的离散纤维或纤维组，以形成光纤束传感器。阵列中各个传感器的身份通过将阵列暴露于参考分析物而进行自编码，同时用激发光能照射阵列。单个传感器阵列可以携带数千个离散感测元件，其组合信号提供传感器检测限，响应时间和信噪比方面的实质性改进。

4. 发明申请

US20120004120A1 SELF-ENCODING SENSOR WITH MICROSPHERES 有权
标题翻译：具有微结构的自编码传感器
公开(公告)号：US20120004120A1
公开(公告)日：2012-01-05
申请号：US13215749
申请日：2011-08-23
申请人： David R. Walt , Todd A. Dickinson
发明人： David R. Walt , Todd A. Dickinson
IPC分类号： C40B30/00 , G06F19/00
CPC分类号： C12Q1/682 , B01J2219/00317 , B01J2219/0045 , B01J2219/00466 , B01J2219/005 , B01J2219/00524 , B01J2219/00585 , B01J2219/00648 , B01J2219/00659 , C12Q1/6834 , C40B60/14 , G01N21/6428 , G01N21/6452 , G01N21/7703 , G01N33/0031 , G01N33/54313 , G01N2201/0846 , Y10T436/101666 , Y10T436/109163
摘要： Disclosed herein are compositions and methods for combining the output obtained from redundant sensor elements in a sensor array.
摘要翻译：这里公开了用于组合从传感器阵列中的冗余传感器元件获得的输出的组合物和方法。

5. 发明申请

US20100279880A1 SELF-ENCODING SENSOR WITH MICROSPHERES 有权
标题翻译：具有微结构的自编码传感器
公开(公告)号：US20100279880A1
公开(公告)日：2010-11-04
申请号：US12834422
申请日：2010-07-12
申请人： DAVID R. WALT , TODD A. DICKINSON
发明人： DAVID R. WALT , TODD A. DICKINSON
IPC分类号： C40B30/00
CPC分类号： C12Q1/682 , B01J2219/00317 , B01J2219/0045 , B01J2219/00466 , B01J2219/005 , B01J2219/00524 , B01J2219/00585 , B01J2219/00648 , B01J2219/00659 , C12Q1/6834 , C40B60/14 , G01N21/6428 , G01N21/6452 , G01N21/7703 , G01N33/0031 , G01N33/54313 , G01N2201/0846 , Y10T436/101666 , Y10T436/109163
摘要： A microsphere-based analytic chemistry system is disclosed in which self-encoding microspheres having distinct characteristic optical response signatures to specific target analytes may be mixed together while the ability is retained to identify the sensor type and location of each sensor in a random dispersion of large numbers of such sensors in a sensor array using an optically interrogatable encoding scheme. An optical fiber bundle sensor is also disclosed in which individual microsphere sensors are disposed in microwells at a distal end of the fiber bundle and are optically coupled to discrete fibers or groups of fibers within the bundle. The identities of the individual sensors in the array are self-encoded by exposing the array to a reference analyte while illuminating the array with excitation light energy. A single sensor array may carry thousands of discrete sensing elements whose combined signal provides for substantial improvements in sensor detection limits, response times and signal-to-noise ratios.
摘要翻译：公开了一种基于微球的分析化学系统，其中具有针对特定目标分析物的不同特征光学响应特征的自编码微球可以混合在一起，同时保留能力以识别大尺度随机色散中的每个传感器的传感器类型和位置使用光学可询问编码方案的传感器阵列中的这种传感器的数量。还公开了一种光纤束传感器，其中单个微球传感器设置在纤维束的远端处的微孔中，并且光束耦合到束内的离散纤维或纤维组。阵列中各个传感器的身份通过将阵列暴露于参考分析物而进行自编码，同时用激发光能照射阵列。单个传感器阵列可携带数千个离散感测元件，其组合信号提供传感器检测限，响应时间和信噪比方面的实质性改进。

6. 发明授权

US07754498B2 Self-encoding sensor with microspheres 失效
标题翻译：具有微球的自编码传感器
公开(公告)号：US07754498B2
公开(公告)日：2010-07-13
申请号：US11040504
申请日：2005-01-21
申请人： David R. Walt , Todd A. Dickinson
发明人： David R. Walt , Todd A. Dickinson
IPC分类号： G01N33/543 , G01N21/00 , G01N21/75
CPC分类号： C12Q1/682 , B01J2219/00317 , B01J2219/0045 , B01J2219/00466 , B01J2219/005 , B01J2219/00524 , B01J2219/00585 , B01J2219/00648 , B01J2219/00659 , C12Q1/6834 , C40B60/14 , G01N21/6428 , G01N21/6452 , G01N21/7703 , G01N33/0031 , G01N33/54313 , G01N2201/0846 , Y10T436/101666 , Y10T436/109163
摘要： A microsphere-based analytic chemistry system is disclosed in which self-encoding microspheres having distinct characteristic optical response signatures to specific target analytes may be mixed together while the ability is retained to identify the sensor type and location of each sensor in a random dispersion of large numbers of such sensors in a sensor array using an optically interrogatable encoding scheme. An optical fiber bundle sensor is also disclosed in which individual microsphere sensors are disposed in microwells at a distal end of the fiber bundle and are optically coupled to discrete fibers or groups of fibers within the bundle. The identities of the individual sensors in the array are self-encoded by exposing the array to a reference analyte while illuminating the array with excitation light energy. A single sensor array may carry thousands of discrete sensing elements whose combined signal provides for substantial improvements in sensor detection limits, response times and signal-to-noise ratios.
摘要翻译：公开了一种基于微球的分析化学系统，其中具有针对特定目标分析物的不同特征光学响应特征的自编码微球可以混合在一起，同时保留能力以识别大尺度随机色散中的每个传感器的传感器类型和位置使用光学可询问编码方案的传感器阵列中的这种传感器的数量。还公开了一种光纤束传感器，其中单个微球传感器设置在纤维束的远端处的微孔中，并且光束耦合到束内的离散纤维或纤维组。阵列中各个传感器的身份通过将阵列暴露于参考分析物而进行自编码，同时用激发光能照射阵列。单个传感器阵列可携带数千个离散感测元件，其组合信号提供传感器检测限，响应时间和信噪比方面的实质性改进。

7. 发明授权

US07348181B2 Self-encoding sensor with microspheres 有权
标题翻译：具有微球的自编码传感器
公开(公告)号：US07348181B2
公开(公告)日：2008-03-25
申请号：US09287573
申请日：1999-04-06
申请人： David R. Walt , Todd A. Dickinson
发明人： David R. Walt , Todd A. Dickinson
IPC分类号： G01N21/76
CPC分类号： C12Q1/682 , B01J2219/00317 , B01J2219/0045 , B01J2219/00466 , B01J2219/005 , B01J2219/00524 , B01J2219/00585 , B01J2219/00648 , B01J2219/00659 , C12Q1/6834 , C40B60/14 , G01N21/6428 , G01N21/6452 , G01N21/7703 , G01N33/0031 , G01N33/54313 , G01N2201/0846 , Y10T436/101666 , Y10T436/109163
摘要： A microsphere-based analytic chemistry system is disclosed in which self-encoding microspheres having distinct characteristic optical response signatures to specific target analytes may be mixed together while the ability is retained to identify the sensor type and location of each sensor in a random dispersion of large numbers of such sensors in a sensor array using an optically interrogatable encoding scheme. An optical fiber bundle sensor is also disclosed in which individual microsphere sensors are disposed in microwells at a distal end of the fiber bundle and are optically coupled to discrete fibers or groups of fibers within the bundle. The identities of the individual sensors in the array are self-encoded by exposing the array to a reference analyte while illuminating the array with excitation light energy. A single sensor array may carry thousands of discrete sensing elements whose combined signal provides for substantial improvements in sensor detection limits, response times and signal-to-noise ratios.
摘要翻译：公开了一种基于微球的分析化学系统，其中具有针对特定目标分析物的不同特征光学响应特征的自编码微球可以混合在一起，同时保留能力以识别大尺度随机色散中的每个传感器的传感器类型和位置使用光学可询问编码方案的传感器阵列中的这种传感器的数量。还公开了一种光纤束传感器，其中单个微球传感器设置在纤维束的远端处的微孔中，并且光束耦合到束内的离散纤维或纤维组。阵列中各个传感器的身份通过将阵列暴露于参考分析物而进行自编码，同时用激发光能照射阵列。单个传感器阵列可携带数千个离散感测元件，其组合信号提供传感器检测限，响应时间和信噪比方面的实质性改进。

8. 发明授权

US06942968B1 Array compositions for improved signal detection 有权
标题翻译：用于改善信号检测的阵列组合物
公开(公告)号：US06942968B1
公开(公告)日：2005-09-13
申请号：US09651181
申请日：2000-08-30
申请人： Todd A. Dickinson , Shawn Meade , Steven M. Barnard , Anthony W. Czarnik , James Bierle , Bahram G. Kermani , Mark S. Chee
发明人： Todd A. Dickinson , Shawn Meade , Steven M. Barnard , Anthony W. Czarnik , James Bierle , Bahram G. Kermani , Mark S. Chee
IPC分类号： B01J19/00 , C07H21/04 , C12M1/00 , C12Q1/68 , C40B40/06 , C40B60/14 , C40B70/00 , G01N21/25 , G01N21/64 , G01N33/543
CPC分类号： G01N21/6452 , B01J19/0046 , B01J2219/00317 , B01J2219/005 , B01J2219/0054 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00639 , B01J2219/00648 , B01J2219/00659 , B01J2219/00702 , B01J2219/00722 , C40B40/06 , C40B60/14 , C40B70/00 , G01N21/6428 , G01N33/54373
摘要： The invention relates methods of improving signal detection from an array and methods for background subtraction in an array. The invention provides for novel array compositions including arrays with wells with different shapes, or surfaces coated with reflective or selectively absorptive coatings. In addition, the array include a signal transducer element.
摘要翻译：本发明涉及从阵列改善信号检测的方法以及用于阵列中背景减法的方法。本发明提供了新颖的阵列组合物，包括具有不同形状的孔的阵列，或涂覆有反射或选择性吸收涂层的表面。另外，该阵列包括信号传感器元件。

9. 发明授权

US08481268B2 Use of microfluidic systems in the detection of target analytes using microsphere arrays 有权
标题翻译：使用微流体系统检测目标分析物使用微球阵列
公开(公告)号：US08481268B2
公开(公告)日：2013-07-09
申请号：US13299235
申请日：2011-11-17
申请人： Mark S. Chee , Todd A. Dickinson , Kevin Gunderson , Don O'Neil , John R. Stuelpnagel
发明人： Mark S. Chee , Todd A. Dickinson , Kevin Gunderson , Don O'Neil , John R. Stuelpnagel
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： B01L3/502761 , B01L2200/0668 , B01L2300/0816 , B01L2300/0867 , B01L2400/0415 , C12Q1/68 , C12Q1/6816 , C12Q1/6869 , C12Q1/6874 , C12Q2565/629 , C12Q2563/149
摘要： The invention relates generally to methods and apparatus for conducting analyses, particularly microfluidic devices for the detection of target analytes.
摘要翻译：本发明一般涉及用于进行分析的方法和装置，特别是用于检测目标分析物的微流体装置。

10. 发明授权

US08080380B2 Use of microfluidic systems in the detection of target analytes using microsphere arrays 有权
标题翻译：使用微流体系统检测目标分析物使用微球阵列
公开(公告)号：US08080380B2
公开(公告)日：2011-12-20
申请号：US10897899
申请日：2004-07-23
申请人： Mark S. Chee , Todd A. Dickinson , Kevin Gunderson , Don O'Neil , John R. Stuelpnagel
发明人： Mark S. Chee , Todd A. Dickinson , Kevin Gunderson , Don O'Neil , John R. Stuelpnagel
IPC分类号： C12Q1/68 , G01N33/53 , C07H21/04
CPC分类号： C12Q1/6816 , B01L3/502761 , B01L2200/0668 , B01L2300/0816 , B01L2300/0867 , B01L2400/0415 , C12Q2565/629 , C12Q2563/149
摘要： The invention relates generally to methods and apparatus for conducting analyses, particularly microfluidic devices for the detection of target analytes.
摘要翻译：本发明一般涉及用于进行分析的方法和装置，特别是用于检测目标分析物的微流体装置。

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