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    • 4. 发明授权
    • Apparatus, system and method for applying optical gradient forces
    • 用于应用光学梯度力的装置,系统和方法
    • US07324282B2
    • 2008-01-29
    • US10701324
    • 2003-11-04
    • David GrierWard LopesEric Dufresne
    • David GrierWard LopesEric Dufresne
    • G02B5/18
    • G02B26/0808
    • The present invention relates to a system of applying optical gradient forces to form a plurality of optical traps to manipulate small particles. The system includes a light source for generating a focused beam of light which is directed along an optical axis though a phase patterning optical element having a variable optical surface and which has a virtual lens encoded thereon. The optical element produces a plurality of beamlets that are coverged at a position between the optical element and a single transfer lens, and directed through the transfer lens to overlap at the back aperture of a focusing lens. The focusing lens coverges the beamlets to form a plurality of optical traps in the working focal region where particles to be examined, manipulated, or measured, are disposed.
    • 本发明涉及一种应用光学梯度力以形成多个光学阱以操纵小颗粒的系统。 该系统包括用于产生聚焦光束的光源,其通过具有可变光学表面的相位图案化光学元件沿着光轴定向并且具有编码在其上的虚拟透镜。 光学元件产生多个子束,其被覆盖在光学元件和单个转印透镜之间的位置处,并且被引导通过转印透镜在聚焦透镜的后孔处重叠。 聚焦透镜覆盖子束以在工作焦点区域中形成多个光学陷阱,其中设置要被检查,操纵或测量的颗粒。
    • 5. 发明申请
    • TRANSVERSE OPTICAL ACCELERATOR AND GENERALIZED OPTICAL VORTICES
    • 横向光学加速器和广义光学VORTICES
    • US20070084993A1
    • 2007-04-19
    • US11522665
    • 2006-09-18
    • David GrierJennifer Curtis
    • David GrierJennifer Curtis
    • H05H3/02
    • G02B21/32G03H1/08G03H1/2294G03H2001/0077G03H2001/085G03H2225/32
    • A method and system for generating modulated optical vortices. Optical vortices can be used for a variety of applications, such as applying controlled torque or controlled force patterns to objects from a few nanometers to hundreds of micrometers in size. Numerous optical modes of optical vortices can be created to meet virtually any desired need in manipulating of objects. Furthermore, one can modify the wavefront of a beam of light in a specific way to create a new type of optical trap useful for manipulating mesoscopic materials. When the modified beam is brought to a focus, the resulting optical trap exerts forces transverse to the optical axis that can be used to transport mesoscopic matter such as nanoclusters, colloidal particles, and biological cells.
    • 一种用于产生调制光学旋涡的方法和系统。 光学旋涡可用于各种应用,例如将受控扭矩或受控力图案应用于尺寸从几纳米到几百微米的物体。 可以创建光学旋涡的许多光学模式,以满足在操作物体时几乎任何所需的需要。 此外,可以以特定方式修改光束的波前,以产生用于操纵介观材料的新型光阱。 当修改的光束被聚焦时,所产生的光阱被施加横向于光轴的力,该光轴可用于传输诸如纳米团簇,胶体粒子和生物细胞的介观物质。
    • 10. 发明申请
    • Optical fractionation methods and apparatus
    • 光学分级方法和装置
    • US20050078343A1
    • 2005-04-14
    • US10845758
    • 2004-05-14
    • David Grier
    • David Grier
    • G01N15/02G01N15/14G02B1/00G02B5/18G02B5/32G02B27/44G21K1/00
    • H05H3/04G01N15/1484G01N2015/0288G01N2015/1075G01N2015/149G01N2015/1493G03H2001/0077Y10S359/90
    • Static arrays of optical traps can be used to sort microscopic objects with exponential sensitivity to size. Such optical fractionation relies on competition between an externally applied force and the moving objects' differing affinities for optical gradient traps. In a reverse fractionation method, objects that are more strongly influenced by the traps tend to become kinetically locked in to the array and are systematically deflected back into an input flow. In a thermal ratcheting method, patterns are spaced to allow particle diffusion, thus providing the opportunity for forward or reverse movement through the patterns. Unlike other sorting techniques, optical fractionation can operate continuously and can be continuously optimized. The exponential sensitivity arises quite generally from the particle size dependence of the potential wells' apparent widths.
    • 光阱的静态阵列可用于对具有指数敏感度的微小物体进行分类。 这种光学分级依赖于外部施加的力与运动物体对光学梯度陷阱的不同亲和力之间的竞争。 在反向分馏方法中,受陷阱更强烈影响的物体趋向于动力学地锁定到阵列中,并被系统地偏转回到输入流中。 在热棘轮方法中,图案间隔开以允许颗粒扩散,从而提供通过图案的正向或反向移动的机会。 与其他分选技术不同,光学分级可以连续工作,可以不断优化。 指数敏感性通常来自潜在井的表观宽度的粒子尺寸依赖性。