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1. 发明申请

US20050152039A1 Apparatus and method for fabricating, sorting, and integrating materials with holographic optical traps 失效
标题翻译：用于制造，分选和整合材料与全息光学陷阱的装置和方法
公开(公告)号：US20050152039A1
公开(公告)日：2005-07-14
申请号：US11029396
申请日：2005-01-06
申请人： David Grier , Eric Dufresne
发明人： David Grier , Eric Dufresne
IPC分类号： G02B5/18 , C12N13/00 , C12N15/09 , C12N15/87 , C12N15/88 , G02B5/32 , G02B27/42 , G21K1/00 , H01H3/04
CPC分类号： C12N13/00 , C12M35/02 , C12N15/87 , C12N15/88 , G02B5/32 , G02B21/32
摘要： An apparatus and method for manipulating, effecting interaction of, photochemically transforming and/or sorting small dielectric particles or other materials. The apparatus and method involves use of one or more diffractive optical elements which each receive a laser beam and form a plurality of laser beams. These laser beams are operated on by a telescope lens system and then an objective lens element to create an array of optical traps for manipulating, effecting interaction of, photochemically transforming and/or sorting small dielectric particles or other materials.
摘要翻译：用于操纵，实现光电化学转换和/或分选小电介质颗粒或其它材料的相互作用的装置和方法。该装置和方法包括使用一个或多个衍射光学元件，每个衍射光学元件接收激光束并形成多个激光束。这些激光束通过望远镜透镜系统然后是物镜元件来操作，以产生用于操纵，实现光电化学转换和/或分选小电介质颗粒或其它材料的光学阱的阵列。

2. 发明申请

US20050098717A1 Apparatus for using optical tweezers to manipulate materials 有权
公开(公告)号：US20050098717A1
公开(公告)日：2005-05-12
申请号：US11010004
申请日：2004-12-10
申请人： David Grier , Eric Dufresne , Jennifer Curtis , Brian Koss
发明人： David Grier , Eric Dufresne , Jennifer Curtis , Brian Koss
IPC分类号： G02B21/32 , C12M1/00 , C12N1/00 , G02B27/42 , H01S1/00
CPC分类号： G02B21/32 , G02B27/1086 , G02B27/42 , G02B27/4244 , G02B27/425
摘要： A method and apparatus for control of optical trap arrays and formation of particle arrays using light that is in the visible portion of the spectrum. The method and apparatus provides a laser and a time variable diffractive optical element to allow dynamic control of optical trap arrays and consequent control of particle arrays and also the ability to manipulate singular objects using a plurality of optical traps. By avoiding wavelengths associated with strong absorption in the underlying material, creating optical traps with a continuous-wave laser, optimizing the efficiency of individual traps, and trapping extended samples at multiple points, the rate of deleterious nonlinear optical processes can be minimized.

3. 发明授权

US08128242B2 Apparatus and method for fabricating, sorting, and integrating materials with holographic optical traps 失效
标题翻译：用于制造，分选和整合材料与全息光学陷阱的装置和方法
公开(公告)号：US08128242B2
公开(公告)日：2012-03-06
申请号：US12385202
申请日：2009-04-01
申请人： David Grier , Eric Dufresne
发明人： David Grier , Eric Dufresne
IPC分类号： H01S3/00 , G01B26/00 , G01B27/00
CPC分类号： C12N13/00 , C12M35/02 , C12N15/87 , C12N15/88 , G02B5/32 , G02B21/32
摘要： A method of manufacturing a semiconductor device able to reduce the number of manufacturing steps and attain the rationalization of a manufacturing line is disclosed. The semiconductor device is a high-frequency module assembled by mounting chip parts (22) and semiconductor pellets (21) onto each of wiring substrates (2) formed on a matrix substrate (27) after inspection. A defect mark (2e) is affixed to a wiring substrate (2) as a block judged to be defective in the inspection of the matrix substrate (27), then in a series of subsequent assembling steps the defect mark (e) is recognized and the assembling work for the wiring substrate (2) with the defect mark (2e) thereon is omitted to attain the rationalization of a manufacturing line.
摘要翻译：用于操纵，实现光电化学转换和/或分选小电介质颗粒或其它材料的相互作用的装置和方法。该装置和方法包括使用一个或多个衍射光学元件，每个衍射光学元件接收激光束并形成多个激光束。这些激光束通过望远镜透镜系统然后是物镜元件来操作，以产生用于操纵，实现光电化学转换和/或分选小电介质颗粒或其它材料的光学阱的阵列。

4. 发明授权

US07324282B2 Apparatus, system and method for applying optical gradient forces 失效
标题翻译：用于应用光学梯度力的装置，系统和方法
公开(公告)号：US07324282B2
公开(公告)日：2008-01-29
申请号：US10701324
申请日：2003-11-04
申请人： David Grier , Ward Lopes , Eric Dufresne
发明人： David Grier , Ward Lopes , Eric Dufresne
IPC分类号： G02B5/18
CPC分类号： G02B26/0808
摘要： The present invention relates to a system of applying optical gradient forces to form a plurality of optical traps to manipulate small particles. The system includes a light source for generating a focused beam of light which is directed along an optical axis though a phase patterning optical element having a variable optical surface and which has a virtual lens encoded thereon. The optical element produces a plurality of beamlets that are coverged at a position between the optical element and a single transfer lens, and directed through the transfer lens to overlap at the back aperture of a focusing lens. The focusing lens coverges the beamlets to form a plurality of optical traps in the working focal region where particles to be examined, manipulated, or measured, are disposed.
摘要翻译：本发明涉及一种应用光学梯度力以形成多个光学阱以操纵小颗粒的系统。该系统包括用于产生聚焦光束的光源，其通过具有可变光学表面的相位图案化光学元件沿着光轴定向并且具有编码在其上的虚拟透镜。光学元件产生多个子束，其被覆盖在光学元件和单个转印透镜之间的位置处，并且被引导通过转印透镜在聚焦透镜的后孔处重叠。聚焦透镜覆盖子束以在工作焦点区域中形成多个光学陷阱，其中设置要被检查，操纵或测量的颗粒。

5. 发明申请

US20070084993A1 TRANSVERSE OPTICAL ACCELERATOR AND GENERALIZED OPTICAL VORTICES 失效
标题翻译：横向光学加速器和广义光学VORTICES
公开(公告)号：US20070084993A1
公开(公告)日：2007-04-19
申请号：US11522665
申请日：2006-09-18
申请人： David Grier , Jennifer Curtis
发明人： David Grier , Jennifer Curtis
IPC分类号： H05H3/02
CPC分类号： G02B21/32 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2001/085 , G03H2225/32
摘要： A method and system for generating modulated optical vortices. Optical vortices can be used for a variety of applications, such as applying controlled torque or controlled force patterns to objects from a few nanometers to hundreds of micrometers in size. Numerous optical modes of optical vortices can be created to meet virtually any desired need in manipulating of objects. Furthermore, one can modify the wavefront of a beam of light in a specific way to create a new type of optical trap useful for manipulating mesoscopic materials. When the modified beam is brought to a focus, the resulting optical trap exerts forces transverse to the optical axis that can be used to transport mesoscopic matter such as nanoclusters, colloidal particles, and biological cells.
摘要翻译：一种用于产生调制光学旋涡的方法和系统。光学旋涡可用于各种应用，例如将受控扭矩或受控力图案应用于尺寸从几纳米到几百微米的物体。可以创建光学旋涡的许多光学模式，以满足在操作物体时几乎任何所需的需要。此外，可以以特定方式修改光束的波前，以产生用于操纵介观材料的新型光阱。当修改的光束被聚焦时，所产生的光阱被施加横向于光轴的力，该光轴可用于传输诸如纳米团簇，胶体粒子和生物细胞的介观物质。

6. 发明申请

US20060240591A1 System and method for processing nanowires with holographic optical tweezers 有权
标题翻译：用全息光学镊子处理纳米线的系统和方法
公开(公告)号：US20060240591A1
公开(公告)日：2006-10-26
申请号：US11329579
申请日：2006-01-11
申请人： David Grier , Ritesh Agarwal , Guihua Yu , Charles Lieber , Kosta Ladavac , Yael Roichman
发明人： David Grier , Ritesh Agarwal , Guihua Yu , Charles Lieber , Kosta Ladavac , Yael Roichman
IPC分类号： H01L51/40 , H01L21/00
CPC分类号： B82B3/00 , B82Y10/00 , B82Y20/00 , B82Y30/00 , B82Y40/00 , C23C14/3407 , G03H1/2294 , G03H2001/0077 , G03H2210/30 , H01J37/3423 , H01L51/0002 , H01L51/0048 , H01L51/0052
摘要： A system and method for manipulating and processing nanowires in solution with arrays of holographic optical traps. The system and method of the present invention is capable of creating hundreds of individually controlled optical traps with the ability to manipulate objects in three dimensions. Individual nanowires with cross-sections as small as 20 nm and lengths exceeding 20 μm are capable of being isolated, translated, rotated and deposited onto a substrate with holographic optical trap arrays under conditions where single traps have no discernible influence. Spatially localized photothermal and photochemical processes induced by the well-focused traps can also be used to melt localized domains on individual nanowires and to fuse nanowire junctions.
摘要翻译：一种用于在全息光阱中阵列处理和处理溶液中的纳米线的系统和方法。本发明的系统和方法能够创建数百个具有三维操纵对象能力的单独控制的光学陷阱。具有小于20nm且长度超过20μm的横截面的单个纳米线能够在单陷阱没有明显影响的条件下被分离，平移，旋转并沉积到具有全息光阱阵列的基板上。由聚焦陷阱诱导的空间定位的光热和光化学过程也可用于熔化单个纳米线上的局部结构域并融合纳米线结。

7. 发明申请

US20050145785A1 Optical peristaltic pumping with optical traps 失效
标题翻译：带有光学陷阱的光学蠕动泵送
公开(公告)号：US20050145785A1
公开(公告)日：2005-07-07
申请号：US11041640
申请日：2005-01-24
申请人： David Grier , Sven Behrens
发明人： David Grier , Sven Behrens
IPC分类号： H01S3/00 , G21K1/00 , H05H3/02
CPC分类号： G03H1/0005 , F04B19/006 , G02B21/32 , G03H1/08 , G03H1/2294 , G03H1/30 , G03H2001/0077 , G03H2001/085 , G03H2225/32 , G03H2227/03 , H05H3/04
摘要： A method of use for holographic optical traps or gradients in which repetitive cycling of a small number of appropriately designed arrays of traps are used for general and very complex manipulations of particles and volumes of matter. Material transport results from a process resembling peristaltic pumping, with the sequence of holographically-defined trapping or holding manifolds resembling the states of a physical peristaltic pump.
摘要翻译：用于全息光学陷阱或梯度的方法，其中使用少量适当设计的捕集阱阵列的重复循环用于颗粒和物质体积的一般和非常复杂的操作。材料运输的结果来自类似于蠕动泵送的过程，具有类似于物理蠕动泵的状态的全息定义的捕集或保持歧管的顺序。

8. 发明申请

US20050001063A1 Apparatus and process for the lateral deflection and separation of flowing particles by a static array of optical tweezers 失效
标题翻译：用于通过光学镊子的静态阵列横向偏转和分离流动颗粒的装置和方法
公开(公告)号：US20050001063A1
公开(公告)日：2005-01-06
申请号：US10878797
申请日：2004-06-28
申请人： David Grier , Pamela Korda
发明人： David Grier , Pamela Korda
IPC分类号： G02B21/32 , B82B3/00 , G01N15/14 , G01N30/00 , G01N30/02 , G21K1/00 , B05B5/025 , A01G23/10 , B05B1/32
CPC分类号： G01N30/00 , G01N30/02 , G01N2015/149 , G03H2001/0077 , B01D2015/3895
摘要： A method and apparatus for laterally deflecting and/or separating a flow of particles using a static array of optical tweezers. In an array of optical tweezers with a lattice constant larger than the size of a particle of interest, particles driven past the array by an external force experience an additional interaction with the array of traps. By altering the angle of the array of traps relative to the external force, the particles' movement from trap to trap inside the array can be biased away from the direction of the external force, thereby enabling selective deflection and/or separation of particles.
摘要翻译：一种使用光学镊子的静态阵列横向偏转和/或分离颗粒流的方法和装置。在具有大于感兴趣的粒子的大小的晶格常数的光学镊子的阵列中，通过外力驱动通过阵列的颗粒经历与陷阱阵列的额外的相互作用。通过改变陷阱阵列相对于外力的角度，颗粒从阵列内的陷阱到陷阱的移动可以被偏离远离外力的方向，从而使得能够选择性地偏转和/或分离颗粒。

9. 发明申请

US20060163463A1 Modulated optical tweezers 有权
标题翻译：调制光学镊子
公开(公告)号：US20060163463A1
公开(公告)日：2006-07-27
申请号：US11040665
申请日：2005-01-21
申请人： David Grier
发明人： David Grier
IPC分类号： H05H3/02
CPC分类号： B01L3/502761 , B01L3/502715 , B01L2200/0636 , B01L2200/0647 , B01L2300/0864 , B01L2400/0454 , G01N30/00 , G01N30/02 , G01N2015/0288 , G03H1/0808 , G03H2001/0077 , G03H2001/0816 , G03H2210/30 , B01D2015/3895
摘要： A method and apparatus for selecting a specific fraction from a heterogeneous fluid-borne sample using optical gradient forces in a microfluidic or fluidic system are presented. Samples may range in size from a few nanometers to at least tens of micrometers, may be dispersed in any fluid medium, and may be sorted on the basis of size, shape, optical characteristics, charge, and other physical properties. The selection process involves passive transport through optical intensity field driven by flowing fluid, and so offers several advantages over competing techniques. These include continuous rather than batch-mode operation, continuous and dynamic tunability, operation over a wide range of samples, compactness, and low cost.
摘要翻译：提出了一种用于在微流体或流体系统中使用光学梯度力从异质流体样品中选择特定部分的方法和装置。样品的尺寸可以从几纳米至至少几十微米，可以分散在任何流体介质中，并且可以根据尺寸，形状，光学特性，电荷和其它物理性质进行分类。选择过程涉及通过由流动流体驱动的光强度场的被动传输，因此提供了优于竞争技术的几个优点。这些包括连续而不是批模式操作，连续和动态可调性，在各种样品中的操作，紧凑性和低成本。

10. 发明申请

US20050078343A1 Optical fractionation methods and apparatus 失效
$Optical fractionation methods and apparatus$
标题翻译：光学分级方法和装置
公开(公告)号：US20050078343A1
公开(公告)日：2005-04-14
申请号：US10845758
申请日：2004-05-14
申请人： David Grier
发明人： David Grier
IPC分类号： G01N15/02 , G01N15/14 , G02B1/00 , G02B5/18 , G02B5/32 , G02B27/44 , G21K1/00
CPC分类号： H05H3/04 , G01N15/1484 , G01N2015/0288 , G01N2015/1075 , G01N2015/149 , G01N2015/1493 , G03H2001/0077 , Y10S359/90
摘要： Static arrays of optical traps can be used to sort microscopic objects with exponential sensitivity to size. Such optical fractionation relies on competition between an externally applied force and the moving objects' differing affinities for optical gradient traps. In a reverse fractionation method, objects that are more strongly influenced by the traps tend to become kinetically locked in to the array and are systematically deflected back into an input flow. In a thermal ratcheting method, patterns are spaced to allow particle diffusion, thus providing the opportunity for forward or reverse movement through the patterns. Unlike other sorting techniques, optical fractionation can operate continuously and can be continuously optimized. The exponential sensitivity arises quite generally from the particle size dependence of the potential wells' apparent widths.
摘要翻译：光阱的静态阵列可用于对具有指数敏感度的微小物体进行分类。这种光学分级依赖于外部施加的力与运动物体对光学梯度陷阱的不同亲和力之间的竞争。在反向分馏方法中，受陷阱更强烈影响的物体趋向于动力学地锁定到阵列中，并被系统地偏转回到输入流中。在热棘轮方法中，图案间隔开以允许颗粒扩散，从而提供通过图案的正向或反向移动的机会。与其他分选技术不同，光学分级可以连续工作，可以不断优化。指数敏感性通常来自潜在井的表观宽度的粒子尺寸依赖性。

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