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1. 发明授权

US07324282B2 Apparatus, system and method for applying optical gradient forces 失效
标题翻译：用于应用光学梯度力的装置，系统和方法
公开(公告)号：US07324282B2
公开(公告)日：2008-01-29
申请号：US10701324
申请日：2003-11-04
申请人： David Grier , Ward Lopes , Eric Dufresne
发明人： David Grier , Ward Lopes , Eric Dufresne
IPC分类号： G02B5/18
CPC分类号： G02B26/0808
摘要： The present invention relates to a system of applying optical gradient forces to form a plurality of optical traps to manipulate small particles. The system includes a light source for generating a focused beam of light which is directed along an optical axis though a phase patterning optical element having a variable optical surface and which has a virtual lens encoded thereon. The optical element produces a plurality of beamlets that are coverged at a position between the optical element and a single transfer lens, and directed through the transfer lens to overlap at the back aperture of a focusing lens. The focusing lens coverges the beamlets to form a plurality of optical traps in the working focal region where particles to be examined, manipulated, or measured, are disposed.
摘要翻译：本发明涉及一种应用光学梯度力以形成多个光学阱以操纵小颗粒的系统。该系统包括用于产生聚焦光束的光源，其通过具有可变光学表面的相位图案化光学元件沿着光轴定向并且具有编码在其上的虚拟透镜。光学元件产生多个子束，其被覆盖在光学元件和单个转印透镜之间的位置处，并且被引导通过转印透镜在聚焦透镜的后孔处重叠。聚焦透镜覆盖子束以在工作焦点区域中形成多个光学陷阱，其中设置要被检查，操纵或测量的颗粒。

2. 发明授权

US07161140B2 Apparatus and method to generate and control optical traps to manipulate small particles 失效
标题翻译：用于产生和控制光阱以操纵小颗粒的装置和方法
公开(公告)号：US07161140B2
公开(公告)日：2007-01-09
申请号：US10510529
申请日：2003-04-10
申请人： David Grier , Ward Lopes
发明人： David Grier , Ward Lopes
IPC分类号： H05H3/04 , G02B15/32
CPC分类号： G03H1/0005 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2225/32
摘要： The present invention relates generally to an apparatus and method to generate and control optical traps (1000, 1002) for manipulation of small particles. An upstream modification of an input laser beam (12, 22) provides a beam with a square or other preselected, cross section of intensity which can be used to form optical traps (1000, 1002) with a corresponding cross section of intensity.
摘要翻译：本发明一般涉及一种用于产生和控制用于操纵小粒子的光阱（1000,1002）的装置和方法。输入激光束（12,22）的上游修改为光束提供具有正方形或其它预选的强度横截面，其可用于形成具有对应的强度横截面的光学陷阱（1000,1002）。

3. 发明授权

US07351953B2 Apparatus and method to generate and control optical traps to manipulate small particles 失效
标题翻译：用于产生和控制光阱以操纵小颗粒的装置和方法
公开(公告)号：US07351953B2
公开(公告)日：2008-04-01
申请号：US11522975
申请日：2006-09-19
申请人： David Grier , Ward Lopes
发明人： David Grier , Ward Lopes
IPC分类号： H05H3/02 , G02B5/18 , G02B5/32
CPC分类号： G03H1/0005 , G03H1/08 , G03H2001/0077
摘要： The present invention relates generally to an apparatus and method to generating and controlling optical traps for manipulation of small particles. An upstream modification of an input laser beam provides a beam with a square or other preselected, cross section of intensity which can be used to form optical traps with a corresponding cross section of intensity.
摘要翻译：本发明一般涉及一种用于产生和控制用于操纵小粒子的光阱的装置和方法。输入激光束的上游修改提供具有正方形或其它预选的强度横截面的光束，其可用于形成具有对应的强度横截面的光学陷阱。

4. 发明申请

US20070023622A1 Apparatus and method to generate and control optical traps to manipulate small particles 失效
标题翻译：用于产生和控制光阱以操纵小颗粒的装置和方法
公开(公告)号：US20070023622A1
公开(公告)日：2007-02-01
申请号：US11522975
申请日：2006-09-19
申请人： David Grier , Ward Lopes
发明人： David Grier , Ward Lopes
IPC分类号： H05H3/02
CPC分类号： G03H1/0005 , G03H1/08 , G03H2001/0077
摘要： The present invention relates generally to an apparatus and method to generating and controlling optical traps for manipulation of small particles. An upstream modification of an input laser beam provides a beam with a square or other preselected, cross section of intensity which can be used to form optical traps with a corresponding cross section of intensity.
摘要翻译：本发明一般涉及一种用于产生和控制用于操纵小粒子的光阱的装置和方法。输入激光束的上游修改提供具有正方形或其它预选的强度横截面的光束，其可用于形成具有对应的强度横截面的光学陷阱。

5. 发明授权

US07482577B2 System and method of sorting materials using holographic laser steering 有权
标题翻译：使用全息激光转向分选材料的系统和方法
公开(公告)号：US07482577B2
公开(公告)日：2009-01-27
申请号：US11808677
申请日：2007-06-12
申请人： Lewis Gruber , Kenneth Bradley , Ward Lopes , Robert Lancelot , Joseph Plewa , David Grier
发明人： Lewis Gruber , Kenneth Bradley , Ward Lopes , Robert Lancelot , Joseph Plewa , David Grier
IPC分类号： H01S1/00 , B01D21/01
CPC分类号： G01N15/1459 , B01L3/5027 , G01N2015/149 , G02B21/32 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2001/085 , G03H2225/32 , H05H3/04
摘要： The present invention employs a beam steering apparatus to isolate valuable cells from other cells, tissues, and contaminants. In one embodiment, the system balances optical trapping against biasing flow to parallelize cell sorting under the flexible control of computer program-directed traps which differentially manipulate cells based on their composition or labels to direct separation.
摘要翻译：本发明采用光束转向装置来将有价值的细胞与其它细胞，组织和污染物分离。在一个实施例中，系统平衡光学捕获与偏置流平衡，以在计算机程序导向的陷阱的灵活控制下平行化细胞分选，其基于它们的组成或标签差异地操纵细胞以引导分离。

6. 发明申请

US20070235640A1 Systems and method of sorting materials using holographic laser steering 有权
标题翻译：使用全息激光转向分选材料的系统和方法
公开(公告)号：US20070235640A1
公开(公告)日：2007-10-11
申请号：US11808677
申请日：2007-06-12
申请人： Lewis Gruber , Kenneth Bradley , Ward Lopes , Robert Lancelot , Joseph Plewa , David Grier
发明人： Lewis Gruber , Kenneth Bradley , Ward Lopes , Robert Lancelot , Joseph Plewa , David Grier
IPC分类号： H05H3/04
CPC分类号： G01N15/1459 , B01L3/5027 , G01N2015/149 , G02B21/32 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2001/085 , G03H2225/32 , H05H3/04
摘要： The present invention employs a beam steering apparatus to isolate valuable cells from other cells, tissues, and contaminants. In one embodiment, the system balances optical trapping against biasing flow to parallelize cell sorting under the flexible control of computer program-directed traps which differentially manipulate cells based on their composition or labels to direct separation.
摘要翻译：本发明采用光束转向装置来将有价值的细胞与其它细胞，组织和污染物分离。在一个实施例中，系统平衡光学捕获与偏置流平衡，以在计算机程序导向的陷阱的灵活控制下平行化细胞分选，其基于它们的组成或标签差异地操纵细胞以引导分离。

7. 发明申请

US20050176134A1 Apparatus and method to generate and control optical traps to manipulate small particles 失效
标题翻译：用于产生和控制光阱以操纵小颗粒的装置和方法
公开(公告)号：US20050176134A1
公开(公告)日：2005-08-11
申请号：US10510529
申请日：2003-04-10
申请人： David Grier , Ward Lopes
发明人： David Grier , Ward Lopes
IPC分类号： G02B21/32 , B01J19/12 , G21K1/00 , G06F19/00 , C12M1/34 , G01N33/48 , G01N33/50
CPC分类号： G03H1/0005 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2225/32
摘要： The present invention relates generally to an apparatus and method to generate and control optical traps (1000, 1002) for manipulation of small particles. An upstream modification of an input laser beam (12, 22) provides a beam with a square or other preselected, cross section of intensity which can be used to form optical traps (1000, 1002) with a corresponding cross section of intensity.
摘要翻译：本发明一般涉及一种用于产生和控制用于操纵小粒子的光阱（1000,1002）的装置和方法。输入激光束（12,22）的上游修改为光束提供具有正方形或其它预选的强度横截面，其可用于形成具有对应的强度横截面的光学陷阱（1000,1002）。

8. 发明申请

US20050152039A1 Apparatus and method for fabricating, sorting, and integrating materials with holographic optical traps 失效
标题翻译：用于制造，分选和整合材料与全息光学陷阱的装置和方法
公开(公告)号：US20050152039A1
公开(公告)日：2005-07-14
申请号：US11029396
申请日：2005-01-06
申请人： David Grier , Eric Dufresne
发明人： David Grier , Eric Dufresne
IPC分类号： G02B5/18 , C12N13/00 , C12N15/09 , C12N15/87 , C12N15/88 , G02B5/32 , G02B27/42 , G21K1/00 , H01H3/04
CPC分类号： C12N13/00 , C12M35/02 , C12N15/87 , C12N15/88 , G02B5/32 , G02B21/32
摘要： An apparatus and method for manipulating, effecting interaction of, photochemically transforming and/or sorting small dielectric particles or other materials. The apparatus and method involves use of one or more diffractive optical elements which each receive a laser beam and form a plurality of laser beams. These laser beams are operated on by a telescope lens system and then an objective lens element to create an array of optical traps for manipulating, effecting interaction of, photochemically transforming and/or sorting small dielectric particles or other materials.
摘要翻译：用于操纵，实现光电化学转换和/或分选小电介质颗粒或其它材料的相互作用的装置和方法。该装置和方法包括使用一个或多个衍射光学元件，每个衍射光学元件接收激光束并形成多个激光束。这些激光束通过望远镜透镜系统然后是物镜元件来操作，以产生用于操纵，实现光电化学转换和/或分选小电介质颗粒或其它材料的光学阱的阵列。

9. 发明申请

US20050098717A1 Apparatus for using optical tweezers to manipulate materials 有权
公开(公告)号：US20050098717A1
公开(公告)日：2005-05-12
申请号：US11010004
申请日：2004-12-10
申请人： David Grier , Eric Dufresne , Jennifer Curtis , Brian Koss
发明人： David Grier , Eric Dufresne , Jennifer Curtis , Brian Koss
IPC分类号： G02B21/32 , C12M1/00 , C12N1/00 , G02B27/42 , H01S1/00
CPC分类号： G02B21/32 , G02B27/1086 , G02B27/42 , G02B27/4244 , G02B27/425
摘要： A method and apparatus for control of optical trap arrays and formation of particle arrays using light that is in the visible portion of the spectrum. The method and apparatus provides a laser and a time variable diffractive optical element to allow dynamic control of optical trap arrays and consequent control of particle arrays and also the ability to manipulate singular objects using a plurality of optical traps. By avoiding wavelengths associated with strong absorption in the underlying material, creating optical traps with a continuous-wave laser, optimizing the efficiency of individual traps, and trapping extended samples at multiple points, the rate of deleterious nonlinear optical processes can be minimized.

10. 发明授权

US08128242B2 Apparatus and method for fabricating, sorting, and integrating materials with holographic optical traps 失效
标题翻译：用于制造，分选和整合材料与全息光学陷阱的装置和方法
公开(公告)号：US08128242B2
公开(公告)日：2012-03-06
申请号：US12385202
申请日：2009-04-01
申请人： David Grier , Eric Dufresne
发明人： David Grier , Eric Dufresne
IPC分类号： H01S3/00 , G01B26/00 , G01B27/00
CPC分类号： C12N13/00 , C12M35/02 , C12N15/87 , C12N15/88 , G02B5/32 , G02B21/32
摘要： A method of manufacturing a semiconductor device able to reduce the number of manufacturing steps and attain the rationalization of a manufacturing line is disclosed. The semiconductor device is a high-frequency module assembled by mounting chip parts (22) and semiconductor pellets (21) onto each of wiring substrates (2) formed on a matrix substrate (27) after inspection. A defect mark (2e) is affixed to a wiring substrate (2) as a block judged to be defective in the inspection of the matrix substrate (27), then in a series of subsequent assembling steps the defect mark (e) is recognized and the assembling work for the wiring substrate (2) with the defect mark (2e) thereon is omitted to attain the rationalization of a manufacturing line.
摘要翻译：用于操纵，实现光电化学转换和/或分选小电介质颗粒或其它材料的相互作用的装置和方法。该装置和方法包括使用一个或多个衍射光学元件，每个衍射光学元件接收激光束并形成多个激光束。这些激光束通过望远镜透镜系统然后是物镜元件来操作，以产生用于操纵，实现光电化学转换和/或分选小电介质颗粒或其它材料的光学阱的阵列。

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