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1. 发明申请

US20150056300A1 THERAPEUTIC NANOPARTICLES WITH HIGH MOLECULAR WEIGHT COPOLYMERS 审中-公开
标题翻译：具有高分子量共聚物的治疗纳米颗粒
公开(公告)号：US20150056300A1
公开(公告)日：2015-02-26
申请号：US13880853
申请日：2011-10-24
申请人： David Dewitt , Maria Figueiredo , Hong Wang , Greg Troiano , Young-Ho Song
发明人： David Dewitt , Maria Figueiredo , Hong Wang , Greg Troiano , Young-Ho Song
IPC分类号： A61K38/05 , A61K31/4375 , A61K31/4184 , A61K31/196 , A61K47/48 , A61K31/365 , A61K31/635 , A61K31/555 , A61K33/24 , A61K31/337 , A61K31/407
CPC分类号： A61K38/05 , A61K9/0019 , A61K9/5153 , A61K31/196 , A61K31/337 , A61K31/365 , A61K31/407 , A61K31/4184 , A61K31/4375 , A61K31/555 , A61K31/635 , A61K33/24 , A61K47/593 , A61K47/60
摘要： The present disclosure generally relates to therapeutic nanoparticles. Exemplary nanoparticles disclosed herein may include about 0.1 to about 40 weight percent of a therapeutic agent and about 10 to about 90 weight percent a diblock poly(lactic) acid-poly(ethylene)glycol copolymer or a diblock poly(lactic)-co-poly(glycolic) acid-poly(ethylene)glycol copolymer, wherein the diblock poly(lactic) acid-poly(ethylene)glycol copolymer comprises poly(lactic) acid having a number average molecule weight of about 30 kDa to about 90 kDa or the diblock poly(lactic)-co-poly(glycolic) acid-poly(ethylene)glycol copolymer comprises poly(lactic)-co-poly(glycolic) acid having a number average molecule weight of about 30 kDa to about 90 kDa.
摘要翻译：本公开一般涉及治疗性纳米颗粒。本文公开的示例性纳米颗粒可包括约0.1至约40重量％的治疗剂和约10至约90重量％的二嵌段聚（乳酸） - 聚（乙二醇）二醇共聚物或二嵌段聚（乳酸） - 共 - 聚（乙二醇）酸 - 聚（乙二醇）二醇共聚物，其中二嵌段聚（乳酸） - 聚（乙二醇）二醇共聚物包含数均分子量为约30kDa至约90kDa的聚（乳酸）或二嵌段聚（乳酸） - 共聚（乙醇酸） - 聚（乙二醇）二醇共聚物包含数均分子量为约30kDa至约90kDa的聚（乳酸） - 共聚（乙醇酸）酸。

2. 发明授权

US10420166B2 Method for avoiding handover failure 有权
公开(公告)号：US10420166B2
公开(公告)日：2019-09-17
申请号：US13542247
申请日：2012-07-05
申请人： Lixiang Xu , Hong Wang , Huarui Liang
发明人： Lixiang Xu , Hong Wang , Huarui Liang
IPC分类号： H04W76/30 , H04W8/08 , H04W36/00
摘要： Methods for avoiding handover failure are provided. The method includes determining, by a source Base Station (BS), to perform a handover of a User Equipment (UE); determining, by the source BS, whether a target BS connects with a user plane node serving the UE at the source BS; and releasing resources, when the target BS does not connect with the user plane node serving the UE at the source BS.

3. 发明授权

US10089263B2 Synchronization of interrupt processing to reduce power consumption 有权
公开(公告)号：US10089263B2
公开(公告)日：2018-10-02
申请号：US15118501
申请日：2014-03-24
申请人： INTEL CORPORATION , Thiam Wah Loh , Gautham N. Chinya , Per Hammarlund , Reza Fortas , Hong Wang , Huajin Sun
发明人： Thiam Wah Loh , Gautham N. Chinya , Per Hammarlund , Reza Fortas , Hong Wang , Huajin Sun
IPC分类号： G06F13/24
摘要： A processor is disclosed and includes at least one core including a first core, and interrupt delay logic. The interrupt delay logic is to receive a first interrupt at a first time and delay the first interrupt from being processed by a first time delay that begins at the first time, unless the first interrupt is pending at a second time when a second interrupt is processed by the first core. If the first interrupt is pending at the second time, the interrupt delay logic is to indicate to the first core to begin to process the first interrupt prior to completion of the first time delay. Other embodiments are disclosed and claimed.

4. 发明申请

US20180225118A1 METHOD AND SYSTEM TO PROVIDE USER-LEVEL MULTITHREADING 审中-公开
公开(公告)号：US20180225118A1
公开(公告)日：2018-08-09
申请号：US15943614
申请日：2018-04-02
申请人： Ed Grochowski , Hong Wang , John P. Shen , Perry H. Wang , Jamison D. Collins , James Held , Partha Kundu , Raya Leviathan , Tin-Fook Ngai
发明人： Ed Grochowski , Hong Wang , John P. Shen , Perry H. Wang , Jamison D. Collins , James Held , Partha Kundu , Raya Leviathan , Tin-Fook Ngai
IPC分类号： G06F9/30 , G06F9/38
CPC分类号： G06F9/30003 , G06F9/30087 , G06F9/3009 , G06F9/30101 , G06F9/3013 , G06F9/384 , G06F9/3851
摘要： A method and system to provide user-level multithreading are disclosed. The method according to the present techniques comprises receiving programming instructions to execute one or more shared resource threads (shreds) via an instruction set architecture (ISA). One or more instruction pointers are configured via the ISA; and the one or more shreds are executed simultaneously with a microprocessor, wherein the microprocessor includes multiple instruction sequencers.

5. 发明授权

US09867157B2 Method for detachment of MS moving between communication systems 有权
公开(公告)号：US09867157B2
公开(公告)日：2018-01-09
申请号：US12527328
申请日：2008-02-13
申请人： Bing Bu , Xiaoqiang Li , Chunying Sun , Hong Wang , Lixiang Xu , Yanmin Zhu
发明人： Bing Bu , Xiaoqiang Li , Chunying Sun , Hong Wang , Lixiang Xu , Yanmin Zhu
IPC分类号： H04W60/06 , H04W76/06
CPC分类号： H04W60/06 , H04W76/32
摘要： A method for detachment of a mobile set within the equivalent route area moving between the communication systems comprising steps of: during the detachment process is implemented between a mobile set and a service node in one communication system, the service node generates one or more messages and transmits it to the service nodes in one or more communication system within the ERA. If the message is transmitted to the service node within the ERA of only one communication system, this service node transmits this message or the message generated according to this message to the service nodes within the ERA of the other communication system. With the method proposed in present invention, when a mobile is detached from two or more communication systems which share the same ERA, the service nodes in all communication systems within the ERA can still correctly manage the relevant information on this mobile set.

6. 发明申请

US20170020717A1 Condom with Side Portals 审中-公开
标题翻译：安全套与侧门
公开(公告)号：US20170020717A1
公开(公告)日：2017-01-26
申请号：US15273117
申请日：2016-09-22
申请人： Hong Wang
发明人： Hong Wang
IPC分类号： A61F6/04
CPC分类号： A61F6/04
摘要： A condom of embodiments of the disclosed technology has a tip and base with cords connecting the two, creating portals where the urethra is exposed and fully capable of feeling abrasion with other objects. The base ring is oppositely disposed from the tip and an extreme other end of the condom. The base ring also extends circumferentially and in parallel to a largest circumference of the solid tip, when the cord extends perpendicularly to the largest circumference of the solid tip and the base ring. The largest circumference of the circle referred to herein, in embodiments of the disclosed technology, is a portion of the tip which is closest to the base ring.
摘要翻译：所公开技术的实施例的避孕套具有尖端和底部，其具有连接两者的线，创建出口的位置，其中尿道被暴露并且完全能够感受到与其它物体的磨损。基座环从尖端和避孕套的极端另一端相对设置。当绳索垂直于固体末端和基环的最大圆周延伸时，基环也周向地并且平行于固体末端的最大圆周延伸。在所公开的技术的实施例中，这里提到的圆的最大圆周是尖端的最靠近基环的部分。

7. 发明授权

US09198891B2 Method of treating cancer by inhibition of protein kinase-like endoplasmic reticulum protein kinase 有权
标题翻译：通过抑制蛋白激酶样内质网蛋白激酶治疗癌症的方法
公开(公告)号：US09198891B2
公开(公告)日：2015-12-01
申请号：US13111769
申请日：2011-05-19
申请人： Timothy Cardozo , Hong Wang , David Ron
发明人： Timothy Cardozo , Hong Wang , David Ron
IPC分类号： A61K49/00 , A61K31/225 , A61K31/24 , A61K31/4166 , A61K31/4245 , A61K31/428 , A61K31/433 , A61K31/496 , A61K31/519 , A61K31/536 , C07D207/416 , C07D239/42 , C07D249/12 , C07D265/22 , C07D277/44 , C07D277/54 , C07D277/66 , C07D307/54 , C07D317/60 , C07D403/04 , C07D403/06 , C07D403/12 , C07D409/12 , C07D417/14 , C07D487/04 , C12Q1/48 , G06F19/00 , G06F19/16
CPC分类号： A61K31/225 , A61K31/24 , A61K31/4166 , A61K31/4245 , A61K31/428 , A61K31/433 , A61K31/496 , A61K31/519 , A61K31/536 , C07D207/416 , C07D239/42 , C07D249/12 , C07D265/22 , C07D277/44 , C07D277/54 , C07D277/66 , C07D307/54 , C07D317/60 , C07D403/04 , C07D403/06 , C07D403/12 , C07D409/12 , C07D417/14 , C07D487/04 , C12Q1/485 , G06F19/16 , G06F19/706
摘要： The present invention relates to a method of identifying compounds useful in inhibiting protein kinase-like endoplasmic reticulum protein kinase (PERK). The method comprises providing a first model comprising PERK active domains, where the said active domains are selected from the group consisting of the peptide spanning from amino acid residue Asp144 to amino acid residue Ser191 of SEQ ID NO: 1 and a peptide comprising the amino acid residue at position 7 of SEQ ID NO: 1, providing one or more candidate compounds, evaluating contact between the candidate compounds and the first model to determine which of the one or more candidate compounds have an ability to bind to and/or fit in the first model, and identifying the compounds which, based on said evaluating, have the ability to bind to and/or fit in the first model as compounds potentially useful for inhibiting PERK. The present invention further relates to compounds that can be used for inhibition of PERK, for example human PERK, and methods related to treatment of PERK-mediated diseases.
摘要翻译：本发明涉及鉴定可用于抑制蛋白激酶样内质网蛋白激酶（PERK）的化合物的方法。该方法包括提供包含PERK活性结构域的第一模型，其中所述活性域选自跨越SEQ ID NO：1的氨基酸残基Asp144至氨基酸残基Ser191的肽和包含氨基酸的肽提供一种或多种候选化合物，评估候选化合物与第一模型之间的接触，以确定一种或多种候选化合物中的哪一种具有结合和/或适合的能力第一模型，以及鉴定基于所述评估具有结合和/或适合第一模型的能力的化合物，作为潜在地可用于抑制PERK的化合物。本发明还涉及可用于抑制PERK的化合物，例如人PERK，以及与治疗PERK介导的疾病有关的方法。

8. 发明申请

US20150153329A1 ASSAY SYSTEM FOR GLP-2 RECEPTOR LIGANDS 审中-公开
标题翻译： GLP-2受体配体的测定系统
公开(公告)号：US20150153329A1
公开(公告)日：2015-06-04
申请号：US14616295
申请日：2015-02-06
申请人： Lidia L. Demchyshyn , Hong Wang
发明人： Lidia L. Demchyshyn , Hong Wang
IPC分类号： G01N33/50 , G01N33/74
CPC分类号： G01N33/5082 , G01N33/5088 , G01N33/74 , G01N2333/605 , G01N2333/726 , G01N2500/04 , G01N2500/10
摘要： Disclosed herein is a method for measuring the contractility of intestinal tissue upon treatment with GLP-2 or a GLP-2 ligand. Also disclosed is an assay which directly measures the activity of GLP-2 or GLP-2 ligands ex vivo and permits the screening of putative GLP-2 ligands in native tissue.
摘要翻译：本文公开了一种用于在用GLP-2或GLP-2配体处理时测量肠组织的收缩性的方法。还公开了一种直接测量GLP-2或GLP-2配体活性的测定法，并允许在天然组织中筛选推定的GLP-2配体。

9. 发明授权

US08971290B2 Handover method supporting terminal mobility 有权
标题翻译：切换方式支持终端移动性
公开(公告)号：US08971290B2
公开(公告)日：2015-03-03
申请号：US13103314
申请日：2011-05-09
申请人： Huarui Liang , Hong Wang , Lixiang Xu
发明人： Huarui Liang , Hong Wang , Lixiang Xu
IPC分类号： H04W36/00 , H04W76/06 , H04W28/04 , H04W28/06 , H04W36/08 , H04W72/00 , H04W76/02
CPC分类号： H04W76/064 , H04W8/082 , H04W28/04 , H04W28/06 , H04W36/08 , H04W48/02 , H04W72/00 , H04W76/19 , H04W76/34
摘要： A handover method for supporting terminal mobility is provided, wherein, before a target core network node updates bearer information, an access control determination procedure is added. According to the access control determination information provided by the target base station, if it is determined that the bearer supporting a SIPTO or LIPA service is permitted to perform the handover, the target core network node updates the bearer information. If it is determined that the bearer supporting the SIPTO or LIPA service is not allowed to perform the handover, the handover failure is notified as per the bearer not performing the handover, and the bearer information is not updated. Alternatively, during or after the handover to the target network, the bearer release or deactivation is performed for the bearer not performing the handover, so that the UE may re-initiate the bearer establishment process with respect to the bearer not performing the handover.
摘要翻译：提供了一种用于支持终端移动性的切换方法，其中，在目标核心网节点更新承载信息之前，添加访问控制确定过程。根据目标基站提供的访问控制确定信息，如果确定支持SIPTO或LIPA服务的承载被允许执行切换，则目标核心网节点更新承载信息。如果确定不支持SIPTO或LIPA服务的承载不允许执行切换，则根据不执行切换的承载来通知切换失败，并且不更新承载信息。或者，在切换到目标网络期间或之后，对不执行切换的承载执行承载释放或去激活，使得UE可以针对不执行切换的承载重新发起承载建立过程。

10. 发明授权

US08868887B2 Programmable event driven yield mechanism which may activate other threads 有权
标题翻译：可编程事件驱动的产生机制，可以激活其他线程
公开(公告)号：US08868887B2
公开(公告)日：2014-10-21
申请号：US10982261
申请日：2004-11-05
申请人： Hong Wang , Per Hammarlund , Xiang Zou , John Shen , Xinmin Tian , Milind Girkar , Perry Wang , Piyush Desai
发明人： Hong Wang , Per Hammarlund , Xiang Zou , John Shen , Xinmin Tian , Milind Girkar , Perry Wang , Piyush Desai
IPC分类号： G06F9/00
CPC分类号： G06F13/24 , G06F9/3005 , G06F9/3009 , G06F9/30145 , G06F9/3851 , G06F9/4843 , G06F11/3024 , G06F11/348 , G06F12/0875 , G06F2201/86 , G06F2201/88 , G06F2201/885 , G06F2212/452
摘要： Method, apparatus, and program means for a programmable event driven yield mechanism that may activate other threads. In one embodiment, an apparatus includes execution resources to execute a plurality of instructions and a monitor to detect a condition indicating a low level of progress. The monitor can disrupt processing of a program by transferring to a handler in response to detecting the condition indicating a low level of progress. In another embodiment, thread switch logic may be coupled to a plurality of event monitors which monitor events within the multithreading execution logic. The thread switch logic switches threads based at least partially on a programmable condition of one or more of the performance monitors.
摘要翻译：用于可激活其他线程的可编程事件驱动产量机制的方法，装置和程序装置。在一个实施例中，一种装置包括执行多个指令的执行资源和用于检测指示低水平进展的状况的监视器。响应于检测到指示低水平进展的状况，监视器可以通过传送到处理程序来中断程序的处理。在另一个实施例中，线程切换逻辑可以耦合到监视多线程执行逻辑内的事件的多个事件监视器。线程开关逻辑至少部分地基于一个或多个性能监视器的可编程状态来切换线程。

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