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1. 发明公开

US20240233573A1 AUDIOVISUAL CONTENT SELECTION 审中-公开
公开(公告)号：US20240233573A1
公开(公告)日：2024-07-11
申请号：US18416857
申请日：2024-01-18
申请人： DAN SACHS , Dwight E. Nelson
发明人： DAN SACHS , Dwight E. Nelson
IPC分类号： G09B19/00 , A61B5/00 , A61B5/16 , A61M21/00 , G09B5/02 , G16H20/70 , H04N21/466 , H04N21/472 , H04N21/81
CPC分类号： G09B19/00 , A61B5/165 , A61B5/7264 , A61B5/7267 , A61M21/00 , G09B5/02 , G16H20/70 , H04N21/4667 , H04N21/472 , H04N21/8106 , A61M2021/0027 , A61M2021/0044
摘要： Systems and techniques are disclosed for aspects of audiovisual content selection based on collecting and processing physiological data. In an example, a system comprises: a sensor device with at one physiological sensor to capture physiological data from a human subject; an output device with a display device to output video and a speaker to output audio to the human subject; and a computing device with at least one processor to control an output of digital audiovisual data to a human subject via the output device, based on data processing operations including a comparison of an observed pattern of autonomic nervous system activity to a target pattern of autonomic nervous system activity.

2. 发明授权

US11917250B1 Audiovisual content selection 有权
公开(公告)号：US11917250B1
公开(公告)日：2024-02-27
申请号：US17935499
申请日：2022-09-26
申请人： Dan Sachs , Dwight E. Nelson
发明人： Dan Sachs , Dwight E. Nelson
IPC分类号： H04N21/472 , H04N21/466 , H04N21/81 , G16H20/70 , A61B5/16 , A61M21/00 , A61B5/00
CPC分类号： H04N21/472 , A61B5/165 , A61B5/7267 , A61M21/00 , G16H20/70 , H04N21/4667 , H04N21/8106 , A61M2021/0027 , A61M2021/0044
摘要： Systems and techniques are disclosed for aspects of audiovisual content selection based on collecting and processing physiological data. In an example, a system comprises: a sensor device with at one physiological sensor to capture physiological data from a human subject; an output device with a display device to output video and a speaker to output audio to the human subject; and a computing device with at least one processor to control an output of digital audiovisual data to a human subject via the output device, based on data processing operations including a comparison of an observed pattern of autonomic nervous system activity to a target pattern of autonomic nervous system activity.

3. 发明申请

US20200302825A1 AUTOMATED SELECTION AND TITRATION OF SENSORY STIMULI TO INDUCE A TARGET PATTERN OF AUTONOMIC NERVOUS SYSTEM ACTIVITY 审中-公开
公开(公告)号：US20200302825A1
公开(公告)日：2020-09-24
申请号：US16824078
申请日：2020-03-19
申请人： Dan Sachs , Dwight E. Nelson
发明人： Dan Sachs , Dwight E. Nelson
IPC分类号： G09B19/00 , A61B5/16 , A61B5/00 , G09B5/02
摘要： Systems and techniques are disclosed for aspects of processing physiological signals in connection with the selection and output of sensory stimuli. In an example, a system for modulating the cognitive state or physiological activity of a human subject may be used in a variety of settings, such as for offering exposure therapy or other forms of guided psychological treatment, based on the presentation and control of a sensory stimulus to a human subject. In another example, a system for generating or training a physiological response model may be established to classify or identify a cognitive response state from sensory stimulus, such as media content, based on the identification of a physiologic or cognitive response state produced from physiological response signals during exposure to the sensory stimulus.

4. 发明授权

US09878161B2 Entrainment of bioelectrical brain signals 有权
公开(公告)号：US09878161B2
公开(公告)日：2018-01-30
申请号：US13446801
申请日：2012-04-13
申请人： Jianping Wu , Steven L. Jensen , Dwight E. Nelson
发明人： Jianping Wu , Steven L. Jensen , Dwight E. Nelson
IPC分类号： A61N1/00 , A61N1/36
CPC分类号： A61N1/36171 , A61N1/36067 , A61N1/36139
摘要： The disclosure relates to the delivery of electrical stimulation therapy to the brain of a patient, e.g., to treat or otherwise manage a patient disorder. In one example, the disclosure relates to a method comprising generating electrical stimulation via a medical device; delivering the electrical stimulation at a first frequency to a brain of a patient when the bioelectrical brain signals of the patient oscillate at a second frequency, where the second frequency corresponds to pathological brain signals of the patient, where the electrical stimulation is selected to entrain the bioeiectrical brain signals of the patient; and adjusting the delivered electrical stimulation from the first frequency to a third frequency, where adjusting the delivered electrical stimulation changes the bioelectrical brain signal oscillations to a fourth frequency different from the second frequency. The fourth frequency may correspond to an oscillation frequency of non-pathological brain signals of the patient.

5. 发明授权

US09724509B2 Selective termination of stimulation to deliver post-stimulation therapeutic effect 有权
公开(公告)号：US09724509B2
公开(公告)日：2017-08-08
申请号：US13701654
申请日：2011-06-06
申请人： Xin Su , Dwight E. Nelson
发明人： Xin Su , Dwight E. Nelson
IPC分类号： A61N1/36 , A61B5/0488 , A61B5/20 , A61B5/00 , A61B5/04 , A61B5/11 , A61N1/05
CPC分类号： A61N1/36007 , A61B5/0031 , A61B5/04001 , A61B5/04882 , A61B5/1116 , A61B5/205 , A61B5/4047 , A61B5/4836 , A61N1/0514
摘要： In some examples, electrical stimulation is delivered to a patient such that selective termination of the stimulation causes a therapeutic effect in the patient after termination of the electrical stimulation to the patient. The electrical stimulation may be insufficient to produce a desired therapeutic effect in the patient during stimulation, but sufficient to induce a post-stimulation desired therapeutic effect following termination of the stimulation. In some examples, the electrical stimulation may be sub-threshold electrical stimulation. In some examples, the desired therapeutic effect may alleviate bladder dysfunction, bowel dysfunction, or other disorders. The stimulation may be selectively terminated in response to one or more therapy trigger events to induce the post-stimulation therapeutic effect.

6. 发明授权

US09289607B2 Urgency therapy with neuromodulation and C-afferent nerve desensitization 有权
标题翻译：紧急治疗与神经调节和C传入神经脱敏
公开(公告)号：US09289607B2
公开(公告)日：2016-03-22
申请号：US13817486
申请日：2011-08-16
申请人： Xin Su , Gregory F. Molnar , Dwight E. Nelson
发明人： Xin Su , Gregory F. Molnar , Dwight E. Nelson
IPC分类号： A61N1/02 , A61N1/36 , A61M5/142 , A61M5/172 , G06F19/00 , A61K31/165
CPC分类号： A61N1/36007 , A61K31/165 , A61M5/14276 , A61M5/1723 , A61M2205/054 , A61M2210/1085 , A61N1/36057 , A61N1/3606 , A61N1/36071 , A61N1/36171 , G06F19/00 , G06F19/3468 , G06F19/3481
摘要： Systems (10), devices (16), and methods may be used for treating bladder dysfunction, such as urgency and pelvic pain. In one example, a method includes administering a pharmacological agent to a patient (14) in a dosage sufficient to desensitize a C-afferent nerve fiber of the patient. Additionally, the method includes delivering stimulation to activate a nerve fiber proximate to the C-afferent nerve fiber via an electrode (19A, 19B, 21A, 21B, 29A-29D) electrically coupled to an implantable medical device (16). In some examples, the nerve fiber may be different than the C-afferent nerve fiber, the stimulation of the nerve fiber may elicit an inhibitory physiological response related to voiding in the patient, and/or the stimulation substantially may not activate the C-afferent nerve fiber after desensitization of the nerve fiber via the administration of the pharmacological agent.
摘要翻译：系统（10），装置（16）和方法可用于治疗膀胱功能障碍，如紧急和盆腔疼痛。在一个实例中，一种方法包括以足以使患者的C型传入神经纤维脱敏的剂量向患者（14）施用药理学试剂。另外，该方法包括递送刺激以通过电耦合到可植入医疗装置（16）的电极（19A，19B，21A，21B，29A-29D）激活靠近C型传入神经纤维的神经纤维。在一些实例中，神经纤维可能与C传入神经纤维不同，神经纤维的刺激可能引起与患者排尿有关的抑制性生理反应，和/或刺激基本上不能激活C传入神经纤维通过施用药理学神经纤维脱敏后。

7. 发明授权

US09211411B2 Therapy for rapid eye movement behavior disorder (RBD) 有权
标题翻译：治疗快速眼球运动障碍（RBD）
公开(公告)号：US09211411B2
公开(公告)日：2015-12-15
申请号：US13211904
申请日：2011-08-17
申请人： Jianping Wu , Dwight E. Nelson
发明人： Jianping Wu , Dwight E. Nelson
IPC分类号： A61N1/36 , A61B5/04 , A61B5/0476 , A61B5/00 , A61B5/11 , A61B5/0488
CPC分类号： A61N1/36067 , A61B5/04001 , A61B5/0476 , A61B5/0488 , A61B5/1104 , A61B5/1116 , A61B5/4812 , A61B5/4815 , A61B5/4836 , A61B5/6868 , A61B2562/0219 , A61N1/36003 , A61N1/36078
摘要： Examples for delivering electrical stimulation to a patient via a medical device to manage or treat rapid eye movement behavior disorder (RBD) are described. In one example, a method comprises determining a patient is in a rapid eye movement (REM) sleep stage, and delivering electrical stimulation therapy to the patient based on the determination that the patient is in the REM sleep stage, where the electrical stimulation therapy is delivered to inhibit movement of the patient during the REM sleep stage. In some examples, the electrical stimulation therapy may be delivered to the brain of the patient.
摘要翻译：描述了通过医疗装置向患者传送电刺激以管理或治疗快速眼睛运动行为障碍（RBD）的实例。在一个示例中，一种方法包括确定患者处于快速眼动（REM）睡眠阶段，并且基于确定患者处于REM睡眠阶段中的电刺激疗法，其中电刺激治疗是输送以在REM睡眠阶段期间抑制患者的运动。在一些实例中，电刺激治疗可以递送到患者的大脑。

8. 发明授权

US08886323B2 Electrical brain stimulation in gamma band 有权
标题翻译： γ波段电脑刺激
公开(公告)号：US08886323B2
公开(公告)日：2014-11-11
申请号：US12701099
申请日：2010-02-05
申请人： Jianping Wu , Dwight E. Nelson , Rahul Gupta
发明人： Jianping Wu , Dwight E. Nelson , Rahul Gupta
IPC分类号： A61N1/05 , A61N1/36 , A61B5/048
CPC分类号： A61N1/36067 , A61B5/048 , A61N1/0534 , A61N1/36171
摘要： This disclosure describes techniques for delivering electrical stimulation to the brain of a patient at a frequency greater than a selected frequency. The techniques may reestablish gamma frequency band activity within the brain of a patient, and thus improve the patient's movements and cognitive states. In one example, the disclosure is directed to a method that includes selecting a frequency within a gamma frequency band and delivering electrical stimulation at a frequency greater than the selected frequency.
摘要翻译：本公开描述了以大于所选频率的频率向患者的大脑递送电刺激的技术。这些技术可能会重新建立患者脑内的伽马频带活动，从而改善患者的运动和认知状态。在一个示例中，本公开涉及一种方法，其包括选择伽马频带内的频率并以大于所选频率的频率递送电刺激。

9. 发明申请

US20130072998A1 STIMULATION THERAPY FOR BLADDER DYSFUNCTION 有权
标题翻译：用于刀片功能的刺激治疗
公开(公告)号：US20130072998A1
公开(公告)日：2013-03-21
申请号：US13701603
申请日：2011-06-06
申请人： Xin Su , Dwight E. Nelson
发明人： Xin Su , Dwight E. Nelson
IPC分类号： A61N1/36
CPC分类号： A61N1/36007 , A61B5/0031 , A61B5/04001 , A61B5/04882 , A61B5/1116 , A61B5/205 , A61B5/4047 , A61B5/4836 , A61N1/0514
摘要： A medical system may include a control module and a therapy delivery module configured to generate and deliver electrical stimulation therapy to a patient. The control module may be configured to control the therapy delivery module to deliver electrical stimulation at a first stimulation intensity for a first time period, to deliver electrical stimulation at a second stimulation intensity for a second time period immediately following the first time period, and to deliver electrical stimulation at the first stimulation intensity for a third time period immediately following the second time period. The second stimulation intensity may be less than the first stimulation intensity. The electrical stimulation may elicit a first inhibitory physiological response during the first time period and a second inhibitory physiological response during the second time period. The second inhibitory physiological response may be greater than the first inhibitory physiological response.
摘要翻译：医疗系统可以包括控制模块和治疗递送模块，其被配置为产生并向患者递送电刺激治疗。控制模块可以被配置为控制治疗递送模块在第一时间段内以第一刺激强度递送电刺激，以在第一时间段之后的第二时间段中以第二刺激强度递送电刺激，以及在第二时间段之后的第三时间段内以第一刺激强度递送电刺激。第二刺激强度可能小于第一刺激强度。电刺激可以在第一时间段期间引起第一抑制性生理反应，并在第二时间段期间引起第二抑制性生理反应。第二抑制生理反应可能大于第一抑制生理反应。

10. 发明申请

US20120277820A1 ENTRAINMENT OF BIOELECTRICAL BRAIN SIGNALS 有权
标题翻译：生物电信号的识别
公开(公告)号：US20120277820A1
公开(公告)日：2012-11-01
申请号：US13446801
申请日：2012-04-13
申请人： Jianping Wu , Steven L. Jensen , Dwight E. Nelson
发明人： Jianping Wu , Steven L. Jensen , Dwight E. Nelson
IPC分类号： A61N1/36
CPC分类号： A61N1/36171 , A61N1/36067 , A61N1/36139
摘要： The disclosure relates to the delivery of electrical stimulation therapy to the brain of a patient, e.g., to treat or otherwise manage a patient disorder. In one example, the disclosure relates to a method comprising generating electrical stimulation via a medical device; delivering the electrical stimulation at a first frequency to a brain of a patient when the bioelectrical brain signals of the patient oscillate at a second frequency, where the second frequency corresponds to pathological brain signals of the patient, where the electrical stimulation is selected to entrain the bioeiectrical brain signals of the patient; and adjusting the delivered electrical stimulation from the first frequency to a third frequency, where adjusting the delivered electrical stimulation changes the bioelectrical brain signal oscillations to a fourth frequency different from the second frequency. The fourth frequency may correspond to an oscillation frequency of non-pathological brain signals of the patient.
摘要翻译：本公开涉及将电刺激治疗递送到患者的大脑，例如治疗或以其他方式治疗患者病症。在一个示例中，本公开涉及一种包括经由医疗装置产生电刺激的方法; 当患者的生物电脑信号以第二频率振荡时，将第一频率的电刺激递送到患者的大脑，其中第二频率对应于患者的病理性脑信号，其中选择电刺激以夹带患者生物大脑信号; 以及将所递送的电刺激从所述第一频率调整到第三频率，其中调节所输送的电刺激将所述生物电脑信号振荡改变到与所述第二频率不同的第四频率。第四频率可以对应于患者的非病理性脑信号的振荡频率。

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