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1. 发明授权

US10143553B2 Heart valve repair device 有权
公开(公告)号：US10143553B2
公开(公告)日：2018-12-04
申请号：US14364060
申请日：2012-12-10
申请人： David Alon , Karl-Heinz Kuck
发明人： David Alon , Karl-Heinz Kuck
IPC分类号： A61F2/24 , A61B17/068 , A61B17/04 , A61B17/115 , A61B17/00 , A61B17/064 , A61B17/22
摘要： A heart valve annulus repair device having a tissue engaging member and a plurality of anchors. The tissue engaging member includes a loop of wire. Each of the anchors has a pointy front end and a back end and a slot that runs in a front-to-back direction. The anchors are distributed about the loop of wire with the front ends of the plurality of anchors facing the heart valve annulus and with the loop of wire passing through the slots. The device further includes means for implanting the anchors into the heart valve annulus tissue so that the tissue engaging member becomes affixed to the heart valve annulus.

2. 发明申请

US20140309730A1 Heart Valve Repair Device 审中-公开
标题翻译：心脏瓣膜修复装置
公开(公告)号：US20140309730A1
公开(公告)日：2014-10-16
申请号：US14364060
申请日：2012-12-10
申请人： David ALON , Karl-Heinz KUCK
发明人： David Alon , Karl-Heinz Kuck
IPC分类号： A61F2/24
CPC分类号： A61F2/2466 , A61B17/068 , A61B17/1155 , A61B2017/00243 , A61B2017/00557 , A61B2017/00783 , A61B2017/0403 , A61B2017/0409 , A61B2017/0414 , A61B2017/0427 , A61B2017/0438 , A61B2017/0464 , A61B2017/0647 , A61B2017/22068 , A61F2/2409 , A61F2/2418 , A61F2/2445 , A61F2/2448 , F04C2270/0421
摘要： A heart valve annulus repair device having a tissue engaging member and a plurality of anchors. The tissue engaging member includes a loop of wire. Each of the anchors has a pointy front end and a back end and a slot that runs in a front-to-back direction. The anchors are distributed about the loop of wire with the front ends of the plurality of anchors facing the heart valve annulus and with the loop of wire passing through the slots. The device further includes means for implanting the anchors into the heart valve annulus tissue so that the tissue engaging member becomes affixed to the heart valve annulus.
摘要翻译：一种具有组织接合构件和多个锚固件的心脏瓣膜环形修复装置。组织接合构件包括线环。每个锚具有尖的前端和后端以及沿着前后方向延伸的槽。锚固件围绕电线环分布，多个锚的前端面向心脏瓣膜环，并且电线环穿过槽。该装置还包括用于将锚固件植入心脏瓣膜环形组织中的装置，使得组织接合构件固定在心脏瓣膜环上。

3. 发明申请

US20070282429A1 PROSTHETIC INSERT FOR IMPROVING HEART VALVE FUNCTION 审中-公开
标题翻译：用于改善心脏瓣膜功能的前置插件
公开(公告)号：US20070282429A1
公开(公告)日：2007-12-06
申请号：US11756530
申请日：2007-05-31
申请人： David L. Hauser , Jan Otto Solem , David Alon
发明人： David L. Hauser , Jan Otto Solem , David Alon
IPC分类号： A61F2/24 , A61F2/94
CPC分类号： A61F2/246 , A61F2/2412 , A61F2/2418 , A61F2/2436 , A61F2/2445 , A61F2/2466 , A61F2210/0014 , A61F2220/0008 , A61F2220/0016
摘要： A device and methods for improving the function of a heart valve, such as an aortic valve, is disclosed. In one embodiment, the device includes an insert member configured for insertion between leaflets of an aortic valve. The insert member preferably includes three radial arms extending outwardly from a central portion. The device also includes an anchoring member which is coupled to the insert member and configured for maintaining the insert member within the heart valve. In operation, each of the arms fills gaps between heart valve leaflets, thereby minimizing or preventing regurgitation through the heart valve.
摘要翻译：公开了一种用于改善诸如主动脉瓣的心脏瓣膜功能的装置和方法。在一个实施例中，该装置包括构造成用于插入主动脉瓣的小叶之间的插入构件。插入构件优选地包括从中心部分向外延伸的三个径向臂。该装置还包括锚固构件，该锚固构件联接到插入构件并且构造成用于将插入构件保持在心脏瓣膜内。在操作中，每个臂填充心脏瓣膜小叶之间的间隙，从而最小化或防止通过心脏瓣膜的反流。

4. 发明申请

US20060058871A1 Device and method for treatment of heart valve regurgitation 有权
公开(公告)号：US20060058871A1
公开(公告)日：2006-03-16
申请号：US11227642
申请日：2005-09-14
申请人： Avraham Zakay , Dan Rottenberg , David Mishaly , David Alon
发明人： Avraham Zakay , Dan Rottenberg , David Mishaly , David Alon
IPC分类号： A61F2/24
CPC分类号： A61F2/246 , A61B17/00234 , A61B17/12013 , A61B2017/00783 , A61B2017/00867 , A61F2/2412 , A61F2/2466 , A61F2210/0014 , A61F2210/0061 , A61F2210/0066
摘要： In one embodiment, the present invention provides a prosthesis that can be implanted within a heart to at least partially block gaps that may be present between the two mitral valve leaflets. In one preferred embodiment, the prosthesis includes an anchoring ring that expands within the left atrium to anchor the prosthesis and a pocket member fixed to the anchoring ring. The pocket member is positioned within the mitral valve, between the leaflets so that an open end of the pocket member is positioned within the left ventricle. When the mitral valve is open, blood flows past the pocket member, maintaining the pocket member in a collapsed state. When the mitral valve closes, the backpressure of the blood pushes into the pocket member, expanding the pocket member to an inflated shape. The mitral valve leaflets contact the expanded pocket member, allowing the prosthesis to block at least a portion of the openings between the leaflets, thereby minimizing regurgitated blood flow into the left atrium.

5. 发明授权

US09155619B2 Prosthetic heart valve delivery apparatus 有权
标题翻译：假心脏瓣膜输送装置
公开(公告)号：US09155619B2
公开(公告)日：2015-10-13
申请号：US13405119
申请日：2012-02-24
申请人： Jun Liu , Luca Pesce , Michael Popp , David Alon , Mohammad Jafari , Sergio Delgado
发明人： Jun Liu , Luca Pesce , Michael Popp , David Alon , Mohammad Jafari , Sergio Delgado
IPC分类号： A61F2/24 , A61F2/00 , A61F2/95 , A61F2/966 , A61M25/00
CPC分类号： A61F2/2427 , A61F2/0095 , A61F2/2418 , A61F2/2436 , A61F2002/9517 , A61F2002/9522 , A61F2002/9665 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/0054 , A61F2230/0069 , A61M25/0051
摘要： Certain embodiments of the present disclosure provide a prosthetic valve (e.g., prosthetic heart valve) and a valve delivery apparatus for delivery of the prosthetic valve to a native valve site via the human vasculature. The delivery apparatus is particularly suited for advancing a prosthetic heart valve through the aorta (i.e., in a retrograde approach) for replacing a diseased native aortic valve. The delivery apparatus in particular embodiments is configured to deploy a prosthetic valve from a delivery sheath in a precise and controlled manner at the target location within the body.
摘要翻译：本公开的某些实施例提供了一种人造瓣膜（例如，假体心脏瓣膜）和用于经由人类脉管系统将人工瓣膜输送到自然瓣膜部位的瓣膜输送装置。输送装置特别适合于通过主动脉推进假体心脏瓣膜（即逆行方法），以更换患病的天然主动脉瓣。在特定实施例中的输送装置被配置成以精确和受控的方式将人造瓣膜从输送护套部署到体内的目标位置。

6. 发明授权

US08932348B2 Device and method for improving heart valve function 有权
标题翻译：改善心脏瓣膜功能的装置和方法
公开(公告)号：US08932348B2
公开(公告)日：2015-01-13
申请号：US11750272
申请日：2007-05-17
申请人： Jan Otto Solem , David Alon
发明人： Jan Otto Solem , David Alon
IPC分类号： A61F2/24 , A61B17/04 , A61B17/00
CPC分类号： A61F2/246 , A61B17/0401 , A61B2017/00243 , A61B2017/0437 , A61B2017/0445 , A61B2017/0453 , A61F2/2466 , A61F2220/0016 , A61F2230/0093 , A61F2240/002
摘要： The invention is device and method for reducing regurgitation through a mitral valve. The device and method is directed to an anchor portion for engagement with the heart wall and an expandable valve portion configured for deployment between the mitral valve leaflets. The valve portion is expandable for preventing regurgitation through the mitral valve while allowing blood to circulate through the heart. The expandable valve portion may include apertures for reducing the stagnation of blood. In a preferred configuration, the device is configured to be delivered in two-stages wherein an anchor portion is first delivered and the valve structure is then coupled to the anchor portion. In yet another embodiment, the present invention provides a method of forming an anchor portion wherein a disposable jig is used to mold the anchor portion into a three-dimensional shape for conforming to a heart chamber.
摘要翻译：本发明是通过二尖瓣减少反流的装置和方法。该装置和方法被引导到用于与心脏壁接合的锚定部分和构造成在二尖瓣传单之间展开的可膨胀阀部分。阀部分是可扩张的，用于通过二尖瓣防止反流，同时允许血液循环通过心脏。可膨胀阀部分可以包括用于减少血液停滞的孔。在优选的构造中，该装置构造成以两级递送，其中首先输送锚定部分，然后将阀结构连接到锚定部分。在另一个实施例中，本发明提供一种形成锚定部分的方法，其中使用一次性夹具将锚固部分模制成三维形状以与心室一致。

7. 发明授权

US07704277B2 Device and method for treatment of heart valve regurgitation 有权
标题翻译：用于治疗心脏瓣膜反流的装置和方法
公开(公告)号：US07704277B2
公开(公告)日：2010-04-27
申请号：US11227642
申请日：2005-09-14
申请人： Avraham Zakay , Dan Rottenberg , David Mishaly , David Alon
发明人： Avraham Zakay , Dan Rottenberg , David Mishaly , David Alon
IPC分类号： A61F2/24
CPC分类号： A61F2/246 , A61B17/00234 , A61B17/12013 , A61B2017/00783 , A61B2017/00867 , A61F2/2412 , A61F2/2466 , A61F2210/0014 , A61F2210/0061 , A61F2210/0066
摘要： In one embodiment, the present invention provides a prosthesis that can be implanted within a heart to at least partially block gaps that may be present between the two mitral valve leaflets. In one preferred embodiment, the prosthesis includes an anchoring ring that expands within the left atrium to anchor the prosthesis and a pocket member fixed to the anchoring ring. The pocket member is positioned within the mitral valve, between the leaflets so that an open end of the pocket member is positioned within the left ventricle. When the mitral valve is open, blood flows past the pocket member, maintaining the pocket member in a collapsed state. When the mitral valve closes, the backpressure of the blood pushes into the pocket member, expanding the pocket member to an inflated shape. The mitral valve leaflets contact the expanded pocket member, allowing the prosthesis to block at least a portion of the openings between the leaflets, thereby minimizing regurgitated blood flow into the left atrium.
摘要翻译：在一个实施例中，本发明提供了一种假体，其可植入心脏内以至少部分阻止可能存在于两个二尖瓣瓣叶之间的间隙。在一个优选实施例中，假体包括锚定环，其在左心房内扩张以锚定假体和固定到锚定环的口袋构件。口袋构件位于二尖瓣之间，在小叶之间，使得口袋构件的开口端位于左心室内。当二尖瓣打开时，血液流过口袋构件，保持口袋构件处于折叠状态。当二尖瓣关闭时，血液的背压推入口袋构件，将口袋构件膨胀成膨胀的形状。二尖瓣小叶接触膨胀的口袋构件，允许假体阻挡小叶之间的至少一部分开口，从而最小化进入左心房的反流血液。

8. 发明申请

US20100049313A1 PROSTHETIC HEART VALVE AND DELIVERY APPARATUS 有权
标题翻译：先天性心脏瓣膜和输送装置
公开(公告)号：US20100049313A1
公开(公告)日：2010-02-25
申请号：US12429040
申请日：2009-04-23
申请人： David Alon , Netanel Benichou , Oded Meiri
发明人： David Alon , Netanel Benichou , Oded Meiri
IPC分类号： A61F2/24
CPC分类号： A61F2/2436 , A61F2/2418 , A61F2/2439 , A61F2002/9517 , A61F2002/9522 , A61F2002/9528 , A61F2002/9534 , A61F2210/0076 , A61F2220/005 , A61F2220/0075 , A61F2230/0054 , A61F2230/0076 , A61F2250/0039
摘要： Embodiments of the present disclosure provide a prosthetic heart valve and a heart valve delivery apparatus for delivery of the prosthetic heart valve to a native valve site via the human vasculature. The delivery apparatus is particularly suited for advancing a prosthetic valve through the aorta (i. e., in a retrograde approach) for replacing a diseased native aortic valve. In one embodiment, a self-expanding valve comprises an expandable stent that is shaped to maintain the valve in the aortic annulus against axial without anchors or retaining devices that engage the surrounding tissue. A delivery apparatus for delivering s self-expanding prosthetic valve can be configured to allow controlled and precise deployment of the valve from a valve sheath so as to minimize or prevent jumping of the valve from the valve sheath.
摘要翻译：本公开的实施例提供了一种假体心脏瓣膜和心脏瓣膜输送装置，用于经由人类脉管系统将假体心脏瓣膜输送到天然瓣膜部位。输送装置特别适用于通过主动脉推进人工瓣膜（即，在逆行方法中），用于替换患病的天然主动脉瓣。在一个实施例中，自膨胀阀包括可扩张支架，其被成形为在不具有接合周围组织的锚固件或保持装置的情况下将阀保持在主动脉环中以抵抗轴向。用于输送自膨胀假体瓣膜的输送装置可以构造成允许阀从阀套被控制和精确地展开，以便最小化或防止阀从阀套跳跃。

9. 发明授权

US10299928B2 Heart ventricle remodeling 有权
公开(公告)号：US10299928B2
公开(公告)日：2019-05-28
申请号：US15540974
申请日：2015-12-23
申请人： David Alon
发明人： David Alon
IPC分类号： A61F2/24 , A61B17/00 , A61N1/05
摘要： The ventricle of a heart can be reshaped by passing a plurality of catheters from inside the ventricle to outside the ventricle through holes in the ventricle wall. Fluid-tight bags are then delivered through the catheters and expanded outside the ventricle to a diameter that is larger than the holes. A fluid substance is introduced into the bags, and the fluid substance is configured to solidify into solid pads that are also larger than the holes. The solid pads are then pulled towards each other and locked in position in order to reshape the ventricle.

10. 发明授权

US08460370B2 Device and method for treatment of heart valve regurgitation 有权
标题翻译：用于治疗心脏瓣膜反流的装置和方法
公开(公告)号：US08460370B2
公开(公告)日：2013-06-11
申请号：US12761225
申请日：2010-04-15
申请人： Avraham Zakay , Dan Rottenberg , David Michaly , David Alon
发明人： Avraham Zakay , Dan Rottenberg , David Michaly , David Alon
IPC分类号： A61F2/24
CPC分类号： A61F2/246 , A61B17/00234 , A61B17/12013 , A61B2017/00783 , A61B2017/00867 , A61F2/2412 , A61F2/2466 , A61F2210/0014 , A61F2210/0061 , A61F2210/0066
摘要： In one embodiment, the present invention provides a prosthesis that can be implanted within a heart to at least partially block gaps that may be present between the two mitral valve leaflets. In one preferred embodiment, the prosthesis includes an anchoring ring that expands within the left atrium to anchor the prosthesis and a pocket member fixed to the anchoring ring. The pocket member is positioned within the mitral valve, between the leaflets so that an open end of the pocket member is positioned within the left ventricle. When the mitral valve is open, blood flows past the pocket member, maintaining the pocket member in a collapsed state. When the mitral valve closes, the backpressure of the blood pushes into the pocket member, expanding the pocket member to an inflated shape. The mitral valve leaflets contact the expanded pocket member, allowing the prosthesis to block at least a portion of the openings between the leaflets, thereby minimizing regurgitated blood flow into the left atrium.
摘要翻译：在一个实施例中，本发明提供了一种假体，其可植入心脏内以至少部分阻止可能存在于两个二尖瓣瓣叶之间的间隙。在一个优选实施例中，假体包括锚定环，其在左心房内扩张以锚定假体和固定到锚定环的口袋构件。口袋构件位于二尖瓣之间，在小叶之间，使得口袋构件的开口端位于左心室内。当二尖瓣打开时，血液流过口袋构件，保持口袋构件处于折叠状态。当二尖瓣关闭时，血液的背压推入口袋构件，将口袋构件膨胀成膨胀的形状。二尖瓣小叶接触膨胀的口袋构件，允许假体阻挡小叶之间的至少一部分开口，从而最小化进入左心房的反流血液。

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