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1. 发明授权

US08932348B2 Device and method for improving heart valve function 有权
标题翻译：改善心脏瓣膜功能的装置和方法
公开(公告)号：US08932348B2
公开(公告)日：2015-01-13
申请号：US11750272
申请日：2007-05-17
申请人： Jan Otto Solem , David Alon
发明人： Jan Otto Solem , David Alon
IPC分类号： A61F2/24 , A61B17/04 , A61B17/00
CPC分类号： A61F2/246 , A61B17/0401 , A61B2017/00243 , A61B2017/0437 , A61B2017/0445 , A61B2017/0453 , A61F2/2466 , A61F2220/0016 , A61F2230/0093 , A61F2240/002
摘要： The invention is device and method for reducing regurgitation through a mitral valve. The device and method is directed to an anchor portion for engagement with the heart wall and an expandable valve portion configured for deployment between the mitral valve leaflets. The valve portion is expandable for preventing regurgitation through the mitral valve while allowing blood to circulate through the heart. The expandable valve portion may include apertures for reducing the stagnation of blood. In a preferred configuration, the device is configured to be delivered in two-stages wherein an anchor portion is first delivered and the valve structure is then coupled to the anchor portion. In yet another embodiment, the present invention provides a method of forming an anchor portion wherein a disposable jig is used to mold the anchor portion into a three-dimensional shape for conforming to a heart chamber.
摘要翻译：本发明是通过二尖瓣减少反流的装置和方法。该装置和方法被引导到用于与心脏壁接合的锚定部分和构造成在二尖瓣传单之间展开的可膨胀阀部分。阀部分是可扩张的，用于通过二尖瓣防止反流，同时允许血液循环通过心脏。可膨胀阀部分可以包括用于减少血液停滞的孔。在优选的构造中，该装置构造成以两级递送，其中首先输送锚定部分，然后将阀结构连接到锚定部分。在另一个实施例中，本发明提供一种形成锚定部分的方法，其中使用一次性夹具将锚固部分模制成三维形状以与心室一致。

2. 发明申请

US20120191182A1 PROSTHETIC INSERT FOR TREATING A MITRAL VALVE 有权
标题翻译：用于治疗麻醉阀的前置插件
公开(公告)号：US20120191182A1
公开(公告)日：2012-07-26
申请号：US13439336
申请日：2012-04-04
申请人： David L. Hauser , Jan Otto Solem , David Alon
发明人： David L. Hauser , Jan Otto Solem , David Alon
IPC分类号： A61F2/24
CPC分类号： A61F2/246 , A61F2/2412 , A61F2/2418 , A61F2/2436 , A61F2/2445 , A61F2/2466 , A61F2210/0014 , A61F2220/0008 , A61F2220/0016
摘要： A prosthetic insert member for improving the function of a mitral valve is disclosed. The insert member is configured for insertion between leaflets of mitral valve. The insert member has an elongated cross-sectional profile for conforming to the opening in the mitral valve. The device also includes an anchoring member for attachment to heart tissue for maintaining the insert member in the mitral valve. In operation, the insert member fills the opening between the leaflets of the mitral valve and reduces regurgitation while preferably allowing the leaflets to function in a substantially normal manner. In one embodiment, the insert member is formed with a valve member disposed in a passageway for allowing blood to pass through the insert member in one direction.
摘要翻译：公开了一种用于改善二尖瓣功能的假体插入件。插入构件被构造成用于在二尖瓣的小叶之间插入。插入构件具有用于与二尖瓣中的开口一致的细长横截面轮廓。该装置还包括用于附接到心脏组织的锚固构件，用于将插入构件保持在二尖瓣中。在操作中，插入构件填充二尖瓣的小叶之间的开口并且减少反流，同时优选地允许小叶以基本上正常的方式起作用。在一个实施例中，插入构件形成有设置在通道中的阀构件，用于允许血液沿一个方向穿过插入构件。

3. 发明申请

US20070270943A1 DEVICE AND METHOD FOR IMPROVING HEART VALVE FUNCTION 有权
标题翻译：改进心瓣功能的装置和方法
公开(公告)号：US20070270943A1
公开(公告)日：2007-11-22
申请号：US11750272
申请日：2007-05-17
申请人： Jan Otto Solem , David Alon
发明人： Jan Otto Solem , David Alon
IPC分类号： A61F2/24
CPC分类号： A61F2/246 , A61B17/0401 , A61B2017/00243 , A61B2017/0437 , A61B2017/0445 , A61B2017/0453 , A61F2/2466 , A61F2220/0016 , A61F2230/0093 , A61F2240/002
摘要： The invention is device and method for reducing regurgitation through a mitral valve. The device and method is directed to an anchor portion for engagement with the heart wall and an expandable valve portion configured for deployment between the mitral valve leaflets. The valve portion is expandable for preventing regurgitation through the mitral valve while allowing blood to circulate through the heart. The expandable valve portion may include apertures for reducing the stagnation of blood. In a preferred configuration, the device is configured to be delivered in two-stages wherein an anchor portion is first delivered and the valve structure is then coupled to the anchor portion. In yet another embodiment, the present invention provides a method of forming an anchor portion wherein a disposable jig is used to mold the anchor portion into a three-dimensional shape for conforming to a heart chamber.
摘要翻译：本发明是通过二尖瓣减少反流的装置和方法。该装置和方法被引导到用于与心脏壁接合的锚定部分和构造成在二尖瓣传单之间展开的可膨胀阀部分。阀部分是可扩张的，用于通过二尖瓣防止反流，同时允许血液循环通过心脏。可膨胀阀部分可以包括用于减少血液停滞的孔。在优选的构造中，该装置构造成以两级递送，其中首先输送锚定部分，然后将阀结构连接到锚定部分。在另一个实施例中，本发明提供一种形成锚定部分的方法，其中使用一次性夹具将锚固部分模制成三维形状以与心室一致。

4. 发明申请

US20070282429A1 PROSTHETIC INSERT FOR IMPROVING HEART VALVE FUNCTION 审中-公开
标题翻译：用于改善心脏瓣膜功能的前置插件
公开(公告)号：US20070282429A1
公开(公告)日：2007-12-06
申请号：US11756530
申请日：2007-05-31
申请人： David L. Hauser , Jan Otto Solem , David Alon
发明人： David L. Hauser , Jan Otto Solem , David Alon
IPC分类号： A61F2/24 , A61F2/94
CPC分类号： A61F2/246 , A61F2/2412 , A61F2/2418 , A61F2/2436 , A61F2/2445 , A61F2/2466 , A61F2210/0014 , A61F2220/0008 , A61F2220/0016
摘要： A device and methods for improving the function of a heart valve, such as an aortic valve, is disclosed. In one embodiment, the device includes an insert member configured for insertion between leaflets of an aortic valve. The insert member preferably includes three radial arms extending outwardly from a central portion. The device also includes an anchoring member which is coupled to the insert member and configured for maintaining the insert member within the heart valve. In operation, each of the arms fills gaps between heart valve leaflets, thereby minimizing or preventing regurgitation through the heart valve.
摘要翻译：公开了一种用于改善诸如主动脉瓣的心脏瓣膜功能的装置和方法。在一个实施例中，该装置包括构造成用于插入主动脉瓣的小叶之间的插入构件。插入构件优选地包括从中心部分向外延伸的三个径向臂。该装置还包括锚固构件，该锚固构件联接到插入构件并且构造成用于将插入构件保持在心脏瓣膜内。在操作中，每个臂填充心脏瓣膜小叶之间的间隙，从而最小化或防止通过心脏瓣膜的反流。

5. 发明授权

US08968395B2 Prosthetic insert for treating a mitral valve 有权
标题翻译：用于治疗二尖瓣的假体插入物
公开(公告)号：US08968395B2
公开(公告)日：2015-03-03
申请号：US13439336
申请日：2012-04-04
申请人： David L. Hauser , Jan Otto Solem , David Alon
发明人： David L. Hauser , Jan Otto Solem , David Alon
IPC分类号： A61F2/24
CPC分类号： A61F2/246 , A61F2/2412 , A61F2/2418 , A61F2/2436 , A61F2/2445 , A61F2/2466 , A61F2210/0014 , A61F2220/0008 , A61F2220/0016
摘要： A prosthetic insert member for improving the function of a mitral valve is disclosed. The insert member is configured for insertion between leaflets of mitral valve. The insert member has an elongated cross-sectional profile for conforming to the opening in the mitral valve. The device also includes an anchoring member for attachment to heart tissue for maintaining the insert member in the mitral valve. In operation, the insert member fills the opening between the leaflets of the mitral valve and reduces regurgitation while preferably allowing the leaflets to function in a substantially normal manner. In one embodiment, the insert member is formed with a valve member disposed in a passageway for allowing blood to pass through the insert member in one direction.
摘要翻译：公开了一种用于改善二尖瓣功能的假体插入件。插入构件被构造成用于在二尖瓣的小叶之间插入。插入构件具有用于与二尖瓣中的开口一致的细长横截面轮廓。该装置还包括用于附接到心脏组织的锚固构件，用于将插入构件保持在二尖瓣中。在操作中，插入构件填充二尖瓣的小叶之间的开口并且减少反流，同时优选地允许小叶以基本上正常的方式起作用。在一个实施例中，插入构件形成有设置在通道中的阀构件，用于允许血液沿一个方向穿过插入构件。

6. 发明授权

US08257376B2 Device, a kit and a method for treatment of disorders in the heart rhythm regulation system 有权
标题翻译：装置，试剂盒和治疗心律调节系统疾病的方法
公开(公告)号：US08257376B2
公开(公告)日：2012-09-04
申请号：US12486690
申请日：2009-06-17
申请人： Jan Otto Solem
发明人： Jan Otto Solem
IPC分类号： A61B17/32
CPC分类号： A61B17/32 , A61B17/320016 , A61B17/3205 , A61B2017/00243 , A61B2017/00247 , A61B2017/00292 , A61B2017/00867 , A61B2018/00392 , A61F2/2493 , A61F2/91 , A61F2002/249
摘要： A tissue lesion creating device is structured and arranged to be inserted through the vascular system into a body vessel adjacent the heart and to be subsequently subjected to a change of shape in order to penetrate into the heart tissue. The tissue lesion creating device may thus be used for treating disorders to the heart rhythm regulation system. A kit of devices provides a plurality of devices for creating a lesion pattern for treating such disorders.
摘要翻译：组织损伤产生装置被构造和布置成通过血管系统插入与心脏相邻的身体容器中并且随后经受形状变化以便穿透入心脏组织。因此，组织损伤产生装置可用于治疗心律调节系统的障碍。一套装置提供多个用于创建用于治疗这种疾病的损伤模式的装置。

7. 发明授权

US08100820B2 Implantable device for treatment of ventricular dilation 有权
标题翻译：用于治疗心室扩张的植入式装置
公开(公告)号：US08100820B2
公开(公告)日：2012-01-24
申请号：US11843628
申请日：2007-08-22
申请人： David L. Hauser , Jan Otto Solem
发明人： David L. Hauser , Jan Otto Solem
IPC分类号： A61F2/00
CPC分类号： A61F2/2451 , A61F2/2481 , A61F2250/0007 , A61F2250/0031
摘要： A device and method for reducing ventricular dilation by placing one or more cardiac bridges into vessels extending along a length of the ventricle. Each cardiac bridge preferably includes a pair of anchors and a bridge member secured therebetween. The tension in the bridge member is increased to compress the ventricle and thereby reduce the dilation. In another embodiment, the bridge member is tensioned to reshape the left ventricle for reducing tension on the chordae tendinae in the heart to improve valve function.
摘要翻译：一种通过将一个或多个心脏桥放置在沿着心室长度延伸的血管中来减少心室扩张的装置和方法。每个心桥优选地包括一对固定器和固定在它们之间的桥构件。增加桥梁构件的张力以压缩心室，从而减少扩张。在另一个实施例中，桥构件被张紧以重塑左心室，以减轻心脏中腱索的张力，以改善瓣膜功能。

8. 发明申请

US20110077733A1 LEAFLET CONTACTING APPARATUS AND METHOD 审中-公开
标题翻译： LEAFLET接触装置和方法
公开(公告)号：US20110077733A1
公开(公告)日：2011-03-31
申请号：US12567047
申请日：2009-09-25
申请人： Jan Otto Solem
发明人： Jan Otto Solem
IPC分类号： A61F2/24 , A61M29/00
CPC分类号： A61F2/24 , A61F2/246 , A61N1/056
摘要： A prosthesis can include a leaflet contacting member and an anchoring member. The leaflet contacting member can have an outer surface and an aperture that extends through at least a portion of the leaflet contacting member. The outer surface of the leaflet contacting member can be configured to contact one or more leaflets of the heart valve during coaptation of the leaflets, and the contact of the leaflets with the outer surface can prevent the leaflets from contacting one or more wires that extend through the aperture of the leaflet contacting member.
摘要翻译：假体可以包括小叶接触构件和锚定构件。小叶接触构件可以具有延伸穿过小叶接触构件的至少一部分的外表面和孔。小叶接触构件的外表面可以构造成在小叶接合期间接触心脏瓣膜的一个或多个小叶，并且小叶与外表面的接触可以防止小叶接触一根或多根延伸穿过的线小叶接触构件的孔径。

9. 发明授权

US07717954B2 Device and method for treatment of mitral insufficiency 有权
标题翻译：治疗二尖瓣功能不全的装置和方法
公开(公告)号：US07717954B2
公开(公告)日：2010-05-18
申请号：US11841782
申请日：2007-08-20
申请人： Jan Otto Solem , Per Ola Kimblad
发明人： Jan Otto Solem , Per Ola Kimblad
IPC分类号： A61F2/24
CPC分类号： A61F2/2451 , A61B17/00234 , A61B2017/00243 , A61B2017/00867 , A61F2002/826 , Y10S623/903
摘要： A device for treatment of mitral annulus dilatation comprises an elongate body having two states. In a first of these states the elongate body is insertable into the coronary sinus and has a shape adapting to the shape of the coronary sinus. When positioned in the coronary sinus, the elongate body is transferable to the second state assuming a reduced radius of curvature, whereby the radius of curvature of the coronary sinus and the radius of curvature as well as the circumference of the mitral annulus is reduced.
摘要翻译：用于治疗二尖瓣环扩张的装置包括具有两种状态的细长体。在这些状态中的第一个状态下，细长体可插入冠状窦，并且具有适应冠状窦形状的形状。当定位在冠状窦中时，假设缩小的曲率半径，细长体可转移到第二状态，由此降低冠状窦的曲率半径和曲率半径以及二尖瓣环的圆周。

10. 发明授权

US07637945B2 Device and method for treatment of mitral insufficiency 有权
标题翻译：治疗二尖瓣功能不全的装置和方法
公开(公告)号：US07637945B2
公开(公告)日：2009-12-29
申请号：US11643352
申请日：2006-12-20
申请人： Jan Otto Solem , Per Ola Kimblad
发明人： Jan Otto Solem , Per Ola Kimblad
IPC分类号： A61F2/24
CPC分类号： A61F2/2451 , A61B17/00234 , A61B2017/00243 , A61B2017/00867 , A61F2002/826 , Y10S623/903
摘要： A device for treatment of mitral annulus dilatation comprises an elongate body having two states. In a first of these states the elongate body is insertable into the coronary sinus and has a shape adapting to the shape of the coronary sinus. When positioned in the coronary sinus, the elongate body is transferable to the second state assuming a reduced radius of curvature, whereby the radius of curvature of the coronary sinus and the radius of curvature as well as the circumference of the mitral annulus is reduced.
摘要翻译：用于治疗二尖瓣环扩张的装置包括具有两种状态的细长体。在这些状态中的第一个状态下，细长体可插入冠状窦，并且具有适应冠状窦形状的形状。当定位在冠状窦中时，假设缩小的曲率半径，细长体可转移到第二状态，由此降低冠状窦的曲率半径和曲率半径以及二尖瓣环的圆周。

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