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1. 发明授权

US5349691A Programming process for 3-level programming logic devices 失效
标题翻译： 3级可编程逻辑器件的编程过程
公开(公告)号：US5349691A
公开(公告)日：1994-09-20
申请号：US058679
申请日：1993-05-04
申请人： David A. Harrison , Abdul Malik
发明人： David A. Harrison , Abdul Malik
IPC分类号： G06F17/50 , H03K19/177 , G06F9/302
CPC分类号： G06F17/5054 , H03K19/17704
摘要： A process of programming a programmable logic device (PLD) to carry out a specified logic function. The PLD contains three levels of logic implemented as a plurality of functional blocks, each with AND and OR planes, and a programmable interconnect matrix or logic expander carrying out AND logic. After providing such a PLD with specified size constraints and after specifying a logic function, the function is split or factored into subfunctions or factors. A Boolean factorization procedure chooses factors by replacing pairs of product terms in the first factor with their supercube and minimizing the number input terms and product terms required. Subfunctions or factors which are too large can be simplified by combining pairs of inputs in the interconnect matrix. The product terms of a subfunction or factor can be ordered according to the number of input terms they have and assigned to the functional blocks one at a time. Functional blocks which use many inputs or product terms per output can have some of their assigned subfunctions split so as to pack the PLD more densely. Split subfunctions or factors are recombined in the interconnect matrix. After assigning terms to functional blocks and the matrix, they are loaded into the PLD using a device programmer to configure the logic arrays in the PLD.
摘要翻译：编程可编程逻辑器件（PLD）以执行指定逻辑功能的过程。 PLD包含实现为多个功能块的三个级别的逻辑，每个具有AND和OR平面，以及执行AND逻辑的可编程互连矩阵或逻辑扩展器。在提供具有规定大小约束的PLD之后，并且在指定逻辑功能之后，该功能被分割或分解为子功能或因子。布尔因式分解程序通过用第一个因子替换成对的超立方体来选择因素，并最小化所需数量的输入项和产品术语。子功能或太大的因素可以通过组合互连矩阵中的输入对来简化。子功能或因子的产品术语可以根据他们已经输入的功能块的数量和功能块一次一个地排序。每个输出使用多个输入或产品项的功能块可以将其一些分配的子功能分开，以便更密集地封装PLD。分裂子功能或因素在互连矩阵中重新组合。在将术语分配给功能块和矩阵后，使用设备编程器将其加载到PLD中，以配置PLD中的逻辑阵列。

2. 发明申请

US20070172960A1 Capillary column and method of making 审中-公开
标题翻译：毛细管柱和制造方法
公开(公告)号：US20070172960A1
公开(公告)日：2007-07-26
申请号：US11499258
申请日：2006-08-03
申请人： Abdul Malik , Dongxin Wang
发明人： Abdul Malik , Dongxin Wang
IPC分类号： G01N30/02
CPC分类号： G01N30/56 , B01J2220/86 , G01N30/6073 , G01N2030/025 , G01N2030/567
摘要： The present invention concerns a new and useful structure for forming a capillary tube, e.g. for gas chromatography, and methods for forming the capillary tube are described. The capillary tube comprises a tube structure, and a deactivated surface-bonded sol-gel coating on a surface of the tube structure to form a stationary phase coating on that surface of the tube structure. According to the present invention the deactivated stationary phase sol-gel coating enables separation of analytes while minimizing adsorption of analytes on the separation column structure.
摘要翻译：本发明涉及用于形成毛细管的新的和有用的结构，例如，用于气相色谱法和形成毛细管的方法。毛细管包括管结构和在管结构的表面上的失活的表面键合的溶胶 - 凝胶涂层，以在管结构的该表面上形成固定相涂层。根据本发明，失活的固定相溶胶 - 凝胶涂层能够分离分析物，同时最小化分析物在分离柱结构上的吸附。

3. 发明申请

US20060013981A1 Polytetrahydrofuran-Based Coating for Capillary Microextraction 审中-公开
标题翻译：用于毛细管微萃取的聚四氢呋喃基涂层
公开(公告)号：US20060013981A1
公开(公告)日：2006-01-19
申请号：US11161004
申请日：2005-07-19
申请人： Abdul Malik , Abuzar Kabir
发明人： Abdul Malik , Abuzar Kabir
IPC分类号： B29D22/00
CPC分类号： B01J13/0065 , B01J20/26 , B01J20/28014 , B01J20/28047 , B01J20/285 , B01J2220/86 , C08G65/36 , G01N1/40 , G01N1/405 , Y10T428/1393
摘要： A sol-gel poly-THF coating was developed for high-performance capillary microextraction to facilitate ultra-trace analysis of polar and nonpolar organic compounds. Parts per quadrillion level detection limits were achieved using Poly-THF coated microextraction capillaries in conjunction with GC-FID. Sol-gel Poly-THF coatings showed extraordinarily high sorption efficiency for both polar and nonpolar compounds, and proved to be highly effective in providing simultaneous extraction of nonpolar, moderately polar, and highly polar analytes from aqueous media. Sol-gel poly-THF coated microextraction capillaries showed excellent thermal and solvent stability, making them very suitable for hyphenation with both gas-phase and liquid-phase separation techniques, including GC, HPLC, and CEC. In CME-HPLC and CME-CEC hyphenations, sol-gel poly-THF coated microextraction capillaries have the potential to provide new levels of detection sensitivity in liquid-phase trace analysis, and to extend the analytical scope of CME to thermally labile-, high molecular weight-, and other types of compounds that are not amenable to GC.
摘要翻译：开发了用于高性能毛细管微萃取的溶胶 - 凝胶多THF涂层，以促进极性和非极性有机化合物的超痕量分析。使用聚四氢呋喃涂布的微萃取毛细管与GC-FID结合，实现了每千兆级检测限的部分。溶胶 - 凝胶聚-THF涂层对极性和非极性化合物的吸附效率非常高，并被证明在从水性介质中同时提取非极性，中等极性和高极性的分析物方面非常有效。溶胶 - 凝胶状聚四氢呋喃涂布的微萃取毛细管显示出优异的热和溶剂稳定性，使其非常适合气相和液相分离技术（包括GC，HPLC和CEC）的连字。在CME-HPLC和CME-CEC连字中，溶胶 - 凝胶聚-THF涂覆的微萃取毛细血管具有在液相痕量分析中提供新水平的检测灵敏度的潜力，并将CME的分析范围扩展到热不稳定性分子量和其他类型的不适合GC的化合物。

4. 发明授权

US08597508B2 Sol-gel monolithic column with optical window and method of making 有权
标题翻译：具有光学窗口的溶胶 - 凝胶整体柱和制造方法
公开(公告)号：US08597508B2
公开(公告)日：2013-12-03
申请号：US13102651
申请日：2011-05-06
申请人： Abdul Malik , James D. Hayes
发明人： Abdul Malik , James D. Hayes
IPC分类号： B01D15/08
CPC分类号： B01J20/291 , B01D15/08 , B01D15/206 , B01J20/28042 , B01J20/282 , B01J2220/52 , B01J2220/54 , B01J2220/82 , G01N27/44721 , G01N27/44747 , G01N30/6082 , G01N2030/528
摘要： A method of preparing a sol-gel monolithic column includes the step of forming a separation bed (14) from a sol-gel solution in a single process step. This column has improved characteristics for CEC based on its incorporated surface charge and ease of operation due to a lack of or need for end frits. Also, a second type of column includes an optical window (30) for on-column detection.
摘要翻译：制备溶胶 - 凝胶整体柱的方法包括在单一工艺步骤中从溶胶 - 凝胶溶液形成分离床（14）的步骤。由于缺少或需要末端玻璃料，该色谱柱基于其结合的表面电荷和易于操作，具有改进的CEC特性。此外，第二类型的列包括用于列列检测的光学窗口（30）。

5. 发明申请

US20070095736A1 Tube structure with sol-gel zirconia coating 审中-公开
标题翻译：管结构用溶胶 - 凝胶氧化锆涂层
公开(公告)号：US20070095736A1
公开(公告)日：2007-05-03
申请号：US11491786
申请日：2006-07-24
申请人： Abdul Malik , Khalid Alhooshani
发明人： Abdul Malik , Khalid Alhooshani
IPC分类号： B01D15/08
CPC分类号： B01J20/286 , B01J20/28047 , B01J20/285 , B01J20/3242 , B01J20/3268 , B01J2220/86 , C23C18/1216 , C23C18/1254
摘要： The subject invention concerns zirconia-based hybrid organic-inorganic sol-gel coating for optional use as a stationary phase in capillary microextraction (CME), gas chromatographic (GC), high performance liquid chromatography (HPLC), capillary electrophoresis (CE), capillary electrochromatography (CEC) and related analytical techniques. Sol-gel chemistry is employed to chemically bind a hydroxy-terminated silicone polymer (polydimethyldiphenylsiloxane, PDMDPS) to a sol-gel zirconia network. In one embodiment, a fused silica capillary is filled with a properly designed sol solution to allow for the sol-gel reactions to take place within the capillary. In the course of this process, a layer of the evolving hybrid organic-inorganic sol-gel polymer becomes chemically bonded to the silanol groups on the inner capillary walls. The unbonded part of the sol solution is expelled from the capillary under helium pressure, leaving behind a chemically bonded sol-gel zirconia —PDMDPS coating on the inner walls of the capillary. Polycyclic aromatic hydrocarbons, ketones, and aldehydes are efficiently extracted and preconcentrated from dilute aqueous samples followed by GC separation of the extracted analytes.
摘要翻译：本发明涉及在毛细管微萃取（CME），气相色谱（GC），高效液相色谱（HPLC），毛细管电泳（CE），毛细管电泳（GC），毛细管电泳电色谱（CEC）和相关分析技术。使用溶胶 - 凝胶化学法将羟基封端的有机硅聚合物（聚二甲基二苯基硅氧烷，PDMDPS）化学结合到溶胶 - 凝胶氧化锆网络。在一个实施方案中，熔融石英毛细管填充有适当设计的溶胶溶液以允许溶胶 - 凝胶反应发生在毛细管内。在该过程的过程中，逐渐变化的混合有机 - 无机溶胶 - 凝胶聚合物层与内毛细管壁上的硅烷醇基化学键合。溶胶溶液的未粘合部分在氦气压力下从毛细管中排出，留下毛细管内壁上化学键合的溶胶 - 凝胶氧化锆-PDMDPS涂层。有机萃取多环芳香烃，酮类和醛类，并从稀释的水样中预先浓缩，然后进行GC分离提取的分析物。

6. 发明授权

US06759126B1 Solid phase microextraction fiber structure and method of making 有权
标题翻译：固相微萃取纤维结构及其制备方法
公开(公告)号：US06759126B1
公开(公告)日：2004-07-06
申请号：US09806443
申请日：2001-07-13
申请人： Abdul Malik , Dongxin Wang
发明人： Abdul Malik , Dongxin Wang
IPC分类号： D02G300
CPC分类号： B01J20/28023 , B01J20/28014 , B01J20/28021 , B01J20/28047 , B01J20/3204 , B01J20/3253 , B01J20/3259 , B01J20/3263 , B01J20/3265 , B01J20/3272 , B01J20/3274 , B01J20/3285 , B01J20/3293 , G01N1/405 , G01N2030/009 , Y10T428/2933 , Y10T428/2962 , Y10T428/2964 , Y10T428/2975
摘要： A solid phase microextraction (SPME) fiber including a fiber and a deactivated surface-bonded sol-gel coating on a portion of the fiber to form a solid phase microextraction coating on the portion of the fiber, wherein the solid-phase microextraction coating is capable of preconcentrating trace organic compounds in various matrices. A sol-gel method of preparing SPME fibers with chemically bonded stationary phase coatings that serve as solvent-free extraction media including the step of chemically bonding the sol-gel stationary phase with the SPME fiber surface during its creation through sol-gel reactions.
摘要翻译：一种固相微萃取（SPME）纤维，其包括在纤维的一部分上的纤维和失活的表面键合的溶胶 - 凝胶涂层，以在纤维的该部分上形成固相微萃取涂层，其中固相微萃取涂层能够的各种基质中的预浓缩微量有机化合物。制备具有化学键合的固定相涂层的SPME纤维的溶胶 - 凝胶法，其用作无溶剂萃取介质，包括在溶胶 - 凝胶反应产生期间，通过化学方法将溶胶 - 凝胶固定相与SPME纤维表面化学键合。

7. 发明授权

US4531957A Filtering material and filtration apparatus employing the filtering material 失效
标题翻译：使用过滤材料的过滤材料和过滤装置
公开(公告)号：US4531957A
公开(公告)日：1985-07-30
申请号：US570379
申请日：1984-01-13
申请人： Abdul Malik
发明人： Abdul Malik
IPC分类号： B01D39/08 , B01D39/10 , B01D39/16 , B01D46/02 , B32B27/12
CPC分类号： B01D46/4209 , B01D39/083 , B01D39/10 , B01D39/1692 , B01D46/02 , B32B27/12 , B01D2239/0478 , B01D2239/065 , B01D2239/0654 , Y10S55/43 , Y10S55/44 , Y10T428/31681
摘要： Filtering material and filtration apparatus employing the filtering material. The filtering material includes a perforated laminate of a plastic sheeting and a metalized coating adhesively attached to a fabric backing. A filter bag formed from this filtering material is mounted within a support structure so that the metalized coating is electrically connected to the support structure.
摘要翻译：使用过滤材料的过滤材料和过滤装置。过滤材料包括塑料薄片和金属化涂层的穿孔层压板，其粘附到织物背衬上。由该过滤材料形成的过滤袋安装在支撑结构内，使得金属化涂层电连接到支撑结构。

8. 发明授权

US09528921B2 Materials and methods for capillary microextraction in combination with high-performance liquid chromatography comprising a sol-gel germania triblock polymer 有权
标题翻译：与高效液相色谱组合的毛细管微萃取的材料和方法，其包括溶胶 - 凝胶锗纳三烯聚合物
公开(公告)号：US09528921B2
公开(公告)日：2016-12-27
申请号：US13641640
申请日：2011-04-18
申请人： Abdul Malik , Scott S. Segro
发明人： Abdul Malik , Scott S. Segro
IPC分类号： G01N1/40 , G01N30/08 , B01J20/26 , B01J20/285 , B01J20/286 , G01N30/74
CPC分类号： G01N1/405 , B01J20/262 , B01J20/285 , B01J20/286 , B01J2220/86 , G01N30/08 , G01N30/74 , Y10T436/255 , G01N21/33 , G01N2030/009 , G01N2030/062
摘要： Germania-based sol-gel organic-inorganic hybrid coatings were prepared for on-line coupling of capillary microextraction with high-performance liquid chromatography. A germania-based sol-gel precursor, tetra-n-butoxygermane and a hydroxy-terminated triblock copolymer, poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide), were chemically anchored to the inner walls of a fused silica capillary (0.25 mm I.D.). Scanning electron microscopy images of the sol-gel germania triblock polymer coating were obtained to estimate the coating thickness. The analyte distribution constants between a sol-gel germania organic-inorganic hybrid coating and the samples (Kcs) were determined. For a variety of analytes from different chemical classes, including polycyclic aromatic hydrocarbons (PAHs), ketones, alcohols, phenols, and amines, the Kcs values ranged from 1.8×101 to 2.0×104. The sol-gel germania triblock polymer coatings survived exposure to high temperature solvent conditions (200° C.) with little change in extraction capabilities. Reproducibility of the method for preparation of the sol-gel germania triblock polymer coatings was also evaluated, and the capillary-to-capillary RSD values ranged from 5.3% to 6.5%. The use of higher flow rates in extraction was found to significantly reduce the time required (from 30-40 minutes to 10-15 minutes) to reach equilibrium between the sol-gel germania triblock polymer coating and the analytes in the sample solution.
摘要翻译：制备了基于Germania的溶胶凝胶有机 - 无机杂化涂层，用于毛细管微萃取与高效液相色谱的在线偶联。将基于锗酸盐的溶胶 - 凝胶前体，四正丁氧基锗烷和羟基封端的三嵌段共聚物，聚（环氧乙烷） - 嵌段 - 聚（环氧丙烷） - 嵌段 - 聚（环氧乙烷）化学地锚定到内部熔融石英毛细管的壁（0.25mm ID）。获得溶胶 - 凝胶锗三嵌段聚合物涂层的扫描电子显微镜图像以估计涂层厚度。测定溶胶 - 凝胶锗有机 - 无机杂化涂层和样品（Kcs）之间的分析物分布常数。对于不同化学类别的各种分析物，包括多环芳烃（PAHs），酮类，醇类，酚类和胺类，Kcs值范围为1.8×101〜2.0×104。溶胶 - 凝胶锗三嵌段聚合物涂层在暴露于高温溶剂条件（200℃）下存活，萃取能力几乎没有变化。还评估了溶胶 - 凝胶锗三嵌段聚合物涂层的制备方法的重现性，毛细管与毛细管的RSD值为5.3％至6.5％。发现在提取中使用更高的流速显着地减少了所需的时间（从30-40分钟到10-15分钟）以达到溶胶 - 凝胶锗三嵌段聚合物涂层和样品溶液中分析物之间的平衡。

9. 发明授权

US08685240B2 High efficiency sol-gel gas chromatography column 有权
标题翻译：高效溶胶凝胶气相色谱柱
公开(公告)号：US08685240B2
公开(公告)日：2014-04-01
申请号：US11599497
申请日：2006-11-13
申请人： Abdul Malik , Abuzar Kabir , Chetan Shende
发明人： Abdul Malik , Abuzar Kabir , Chetan Shende
IPC分类号： B01J20/285 , B01J20/28 , B01D15/26 , G01N30/56 , G01N30/60
CPC分类号： B01J20/285 , B01D15/206 , B01D15/265 , B01J20/28047 , B01J20/286 , B01J2220/54 , B01J2220/86 , G01N30/56 , G01N30/6078 , G01N2030/567
摘要： A capillary column (10) includes a tube structure having inner walls (14) and a sol-gel substrate (16) coated on a portion of inner walls (14) to form a stationary phase coating (18) on inner walls (14). The sol solution used to prepare the sol-gel substrate (16) has at least one baseline stabilizing reagent and at least one surface deactivation reagent resulting in the sol-gel substrate (16) having at least one baseline stabilizing reagent residual and at least one surface deactivating reagent residual. A method of making the sol-gel solution is by mixing suitable sol-gel precursors to form the solution, stabilizing the solution by adding at least one baseline stabilization reagent, deactivating the solution by adding at least one surface deactivation reagent to the solution, and reacting the solution in the presence of at least one catalyst.
摘要翻译：毛细管柱（10）包括具有内壁（14）的管结构和涂覆在内壁（14）的一部分上以在内壁（14）上形成固定相涂层（18）的溶胶 - 凝胶基质（16）。用于制备溶胶 - 凝胶基质（16）的溶胶溶液具有至少一种基线稳定剂和至少一种表面去活化试剂，导致溶胶 - 凝胶底物（16）具有至少一种基线稳定剂残留物和至少一种表面钝化试剂残留。制备溶胶 - 凝胶溶液的方法是通过混合合适的溶胶 - 凝胶前体形成溶液，通过加入至少一种基线稳定剂来稳定溶液，通过向溶液中加入至少一种表面失活试剂来使溶液失活，以及在至少一种催化剂存在下使溶液反应。

10. 发明申请

US20130071945A1 MATERIALS AND METHODS FOR CAPILLARY MICROEXTRACTION IN COMBINATION WITH HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY 有权
标题翻译：与高性能液相色谱联用的毛细微萃取的材料和方法
公开(公告)号：US20130071945A1
公开(公告)日：2013-03-21
申请号：US13641640
申请日：2011-04-18
申请人： Abdul Malik , Scott S. Segro
发明人： Abdul Malik , Scott S. Segro
IPC分类号： G01N1/40
CPC分类号： G01N1/405 , B01J20/262 , B01J20/285 , B01J20/286 , B01J2220/86 , G01N30/08 , G01N30/74 , Y10T436/255 , G01N21/33 , G01N2030/009 , G01N2030/062
摘要： Germania-based sol-gel organic-inorganic hybrid coatings were prepared for on-line coupling of capillary microextraction with high-performance liquid chromatography. A germania-based sol-gel precursor, tetra-n-butoxygermane and a hydroxy-terminated triblock copolymer, poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide), were chemically anchored to the inner walls of a fused silica capillary (0.25 mm I.D.). Scanning electron microscopy images of the sol-gel germania triblock polymer coating were obtained to estimate the coating thickness. The analyte distribution constants between a sol-gel germania organic-inorganic hybrid coating and the samples (Kcs) were determined. For a variety of analytes from different chemical classes, including polycyclic aromatic hydrocarbons (PAHs), ketones, alcohols, phenols, and amines, the Kcs values ranged from 1.8×101 to 2.0×104. The sol-gel germania triblock polymer coatings survived exposure to high temperature solvent conditions (200° C.) with little change in extraction capabilities. Reproducibility of the method for preparation of the sol-gel germania triblock polymer coatings was also evaluated, and the capillary-to-capillary RSD values ranged from 5.3% to 6.5%. The use of higher flow rates in extraction was found to significantly reduce the time required (from 30-40 minutes to 10-15 minutes) to reach equilibrium between the sol-gel germania triblock polymer coating and the analytes in the sample solution.
摘要翻译：制备了基于Germania的溶胶凝胶有机 - 无机杂化涂层，用于毛细管微萃取与高效液相色谱的在线偶联。将基于锗酸盐的溶胶 - 凝胶前体，四正丁氧基锗烷和羟基封端的三嵌段共聚物，聚（环氧乙烷） - 嵌段 - 聚（环氧丙烷） - 嵌段 - 聚（环氧乙烷）化学地锚定到内部熔融石英毛细管的壁（0.25mm ID）。获得溶胶 - 凝胶锗三嵌段聚合物涂层的扫描电子显微镜图像以估计涂层厚度。测定溶胶 - 凝胶锗有机 - 无机杂化涂层和样品（Kcs）之间的分析物分布常数。对于不同化学类别的各种分析物，包括多环芳烃（PAHs），酮类，醇类，酚类和胺类，Kcs值范围为1.8×101〜2.0×104。溶胶 - 凝胶锗三嵌段聚合物涂层在暴露于高温溶剂条件（200℃）下存活，萃取能力几乎没有变化。还评估了溶胶 - 凝胶锗三嵌段聚合物涂层的制备方法的重现性，毛细管与毛细管的RSD值为5.3％至6.5％。发现在提取中使用更高的流速显着地减少了所需的时间（从30-40分钟到10-15分钟）以达到溶胶 - 凝胶锗三嵌段聚合物涂层和样品溶液中分析物之间的平衡。

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