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1. 发明申请

US20130217583A1 MICROFLUIDIC DEVICES AND METHODS OF USE IN THE FORMATION AND CONTROL OF NANOREACTORS 有权
标题翻译：微流体装置及其在纳米复合材料的形成与控制中的应用
公开(公告)号：US20130217583A1
公开(公告)日：2013-08-22
申请号：US13759660
申请日：2013-02-05
申请人： Darren Link , Laurent Boitard , Jeffrey Branciforte , Yves Charles , Gilbert Feke , John Q. Lu , David Marran , Ahmadali Tabatabai , Michael Weiner , Wolfgang Hinz , Jonathan M. Rothberg
发明人： Darren Link , Laurent Boitard , Jeffrey Branciforte , Yves Charles , Gilbert Feke , John Q. Lu , David Marran , Ahmadali Tabatabai , Michael Weiner , Wolfgang Hinz , Jonathan M. Rothberg
IPC分类号： C12Q1/68 , G01N33/543
CPC分类号： C12N15/1075 , B01F3/0807 , B01F13/0071 , B01F13/0076 , B01J19/0046 , B01J2219/00286 , B01J2219/00459 , B01J2219/00466 , B01J2219/00468 , B01J2219/00479 , B01J2219/005 , B01J2219/00576 , B01J2219/00599 , B01J2219/00702 , B01J2219/0072 , B01J2219/00743 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L3/502761 , B01L3/502784 , B01L3/502792 , B01L3/565 , B01L7/52 , B01L2200/027 , B01L2200/0621 , B01L2200/0647 , B01L2200/0652 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0896 , B01L2400/0415 , B01L2400/0424 , B01L2400/0487 , B01L2400/084 , B82Y5/00 , B82Y30/00 , C07K1/047 , C12Q1/6804 , C12Q1/6816 , C12Q1/6825 , C12Q1/6834 , C12Q1/686 , C12Q1/6869 , C12Q1/6874 , C12Q1/6876 , C12Q2525/161 , C12Q2561/119 , C12Q2563/103 , C12Q2563/107 , C12Q2563/159 , C12Q2565/537 , C12Q2565/629 , C12Q2600/16 , C40B30/04 , C40B40/04 , C40B50/08 , C40B60/08 , C40B60/12 , C40B70/00 , G01N21/6428 , G01N21/6445 , G01N21/6458 , G01N33/536 , G01N33/542 , G01N33/543 , G01N33/6845 , G01N33/6854 , G01N2500/10
摘要： The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. Such methods can include labeling a library of compounds by emulsifying aqueous solutions of the compounds and aqueous solutions of unique liquid labels on a microfluidic device, which includes a plurality of electrically addressable, channel bearing fluidic modules integrally arranged on a microfabricated substrate such that a continuous channel is provided for flow of immiscible fluids, whereby each compound is labeled with a unique liquid label, pooling the labeled emulsions, coalescing the labeled emulsions with emulsions containing a specific cell or enzyme, thereby forming a nanoreactor, screening the nanoreactors for a desirable reaction between the contents of the nanoreactor, and decoding the liquid label, thereby identifying a single compound from a library of compounds.
摘要翻译：本发明提供了可用于进行高通量筛选测定和组合化学的新型微流体装置和方法。这样的方法可以包括通过将化合物的水溶液和独特的液体标签的水溶液乳化在微流体装置上来标记化合物文库，所述微流体装置包括整体地布置在微细加工的基底上的多个可电寻址的通道支承的流体模块，提供了用于不混溶流体流动的通道，由此每种化合物用独特的液体标记标记，汇集标记的乳液，将标记的乳液与含有特定细胞或酶的乳液聚结，从而形成纳米反应器，筛选纳米反应器以获得所需的反应在纳米反应器的内容物之间，并解码液体标签，从而从化合物文库鉴定单一化合物。

2. 发明申请

US20100137163A1 Microfluidic Devices and Methods of Use in The Formation and Control of Nanoreactors 审中-公开
标题翻译：微流体装置及其在纳米反应器的形成与控制中的应用
公开(公告)号：US20100137163A1
公开(公告)日：2010-06-03
申请号：US12087713
申请日：2006-06-01
申请人： Darren R. Link , Laurent Boitard , Jeffrey Branciforte , Yves Charles , Gilbert Feke , John Q. Lu , David Marran , Ahmadali Tabatabai , Michael Weiner , Wolfgang Hinz , Jonathan M. Rothberg
发明人： Darren R. Link , Laurent Boitard , Jeffrey Branciforte , Yves Charles , Gilbert Feke , John Q. Lu , David Marran , Ahmadali Tabatabai , Michael Weiner , Wolfgang Hinz , Jonathan M. Rothberg
IPC分类号： C40B40/06 , C40B60/14 , C40B60/08 , C40B50/14
CPC分类号： B01F3/0807 , B01F13/0071 , B01F13/0076 , B01J19/0046 , B01J2219/00286 , B01J2219/00459 , B01J2219/00466 , B01J2219/00468 , B01J2219/00479 , B01J2219/005 , B01J2219/00576 , B01J2219/00599 , B01J2219/00702 , B01J2219/0072 , B01J2219/00743 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L3/502761 , B01L3/502784 , B01L3/502792 , B01L3/565 , B01L7/52 , B01L2200/027 , B01L2200/0621 , B01L2200/0647 , B01L2200/0652 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0896 , B01L2400/0415 , B01L2400/0424 , B01L2400/0487 , B01L2400/084 , B82Y5/00 , B82Y30/00 , C07K1/047 , C12N15/1075 , C12Q1/6804 , C12Q1/6816 , C12Q1/6825 , C12Q1/6834 , C12Q1/686 , C12Q1/6869 , C12Q1/6874 , C12Q1/6876 , C12Q2525/161 , C12Q2561/119 , C12Q2563/103 , C12Q2563/107 , C12Q2563/159 , C12Q2565/537 , C12Q2565/629 , C12Q2600/16 , C40B30/04 , C40B40/04 , C40B50/08 , C40B60/08 , C40B60/12 , C40B70/00 , G01N21/6428 , G01N21/6445 , G01N21/6458 , G01N33/536 , G01N33/542 , G01N33/543 , G01N33/6845 , G01N33/6854 , G01N2500/10
摘要： The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. Such methods can include labeling a library of compounds by emulsifying aqueous solutions of the compounds and aqueous solutions of unique liquid labels on a microfluidic device, which includes a plurality of electrically addressable, channel bearing fluidic modules integrally arranged on a microfabricated substrate such that a continuous channel is provided for flow of immiscible fluids, whereby each compound is labeled with a unique liquid label, pooling the labeled emulsions, coalescing the labeled emulsions with emulsions containing a specific cell or enzyme, thereby forming a nanoreactor, screening the nanoreactors for a desirable reaction between the contents of the nanoreactor, and decoding the liquid label, thereby identifying a single compound from a library of compounds.
摘要翻译：本发明提供了可用于进行高通量筛选测定和组合化学的新型微流体装置和方法。这样的方法可以包括通过将化合物的水溶液和独特的液体标签的水溶液乳化在微流体装置上来标记化合物文库，所述微流体装置包括整体地布置在微细加工的基底上的多个可电寻址的通道支承的流体模块，提供了用于不混溶流体流动的通道，由此每种化合物用独特的液体标记标记，汇集标记的乳液，将标记的乳液与含有特定细胞或酶的乳液聚结，从而形成纳米反应器，筛选纳米反应器以获得所需的反应在纳米反应器的内容物之间，并解码液体标签，从而从化合物文库鉴定单一化合物。

3. 发明申请

US20140069865A1 METHOD FOR HIGH-THROUGHPUT SCREENING OF DROPS BY OSMOTIC EXCHANGE AND DENSITY VARIATION 有权
标题翻译：通过OSMOTIC交换和密度变化进行高渗透性筛选的方法
公开(公告)号：US20140069865A1
公开(公告)日：2014-03-13
申请号：US14006347
申请日：2012-03-21
申请人： Gaël Yvert , Jérôme Bibette , Jean-Marie Baudry , Laurent Boitard , Nicolas Bremond , Denis Cottinet
发明人： Gaël Yvert , Jérôme Bibette , Jean-Marie Baudry , Laurent Boitard , Nicolas Bremond , Denis Cottinet
IPC分类号： B01D61/00 , B01D61/38
CPC分类号： B01D61/002 , B01D19/0036 , B01D61/38 , C12N1/00 , G01N15/0255 , G01N15/04 , G01N2015/1081
摘要： This method comprises bringing drops to be separated into contact with an interface (40) suitable for allowing an osmotic equilibrium between the content of each drop to be separated. The method comprises an osmotic flow between the drops (20A) of the first group of drops through the interface (40) in order to modify the density of each drop (20A) of the first group of drops and the separation of the drops (20A, 20B) according to the density thereof or a combination of the density and the volume in order to isolate the drops (20A) of the first group of drops from the drops (20B) of a second group of drops.
摘要翻译：该方法包括将液滴分离成与适于允许每个液滴的内容物之间的渗透平衡分离的界面（40）接触。该方法包括在通过界面（40）的第一组液滴的液滴（20A）之间的渗透流，以便改变第一组液滴的每个液滴（20A）的密度和液滴的分离（20A ，20B），以便将第一组液滴的液滴（20A）与第二组液滴的液滴（20B）隔离开来，根据密度或密度和体积的组合。

4. 发明授权

US09327242B2 Method for high-throughput screening of drops by osmotic exchange and density variation 有权
标题翻译：通过渗透交换和密度变化对液滴进行高通量筛选的方法
公开(公告)号：US09327242B2
公开(公告)日：2016-05-03
申请号：US14006347
申请日：2012-03-21
申请人： Gaël Yvert , Jérôme Bibette , Jean-Marie Baudry , Laurent Boitard , Nicolas Bremond , Denis Cottinet
发明人： Gaël Yvert , Jérôme Bibette , Jean-Marie Baudry , Laurent Boitard , Nicolas Bremond , Denis Cottinet
IPC分类号： B01D61/00 , G01N15/04 , B01D19/00 , C12N1/00 , G01N15/02 , B01D61/38 , G01N15/10
CPC分类号： B01D61/002 , B01D19/0036 , B01D61/38 , C12N1/00 , G01N15/0255 , G01N15/04 , G01N2015/1081
摘要： This method comprises bringing drops to be separated into contact with an interface (40) suitable for allowing an osmotic equilibrium between the content of each drop to be separated. The method comprises an osmotic flow between the drops (20A) of the first group of drops through the interface (40) in order to modify the density of each drop (20A) of the first group of drops and the separation of the drops (20A, 20B) according to the density thereof or a combination of the density and the volume in order to isolate the drops (20A) of the first group of drops from the drops (20B) of a second group of drops.
摘要翻译：该方法包括将液滴分离成与适于允许每个液滴的内容物之间的渗透平衡分离的界面（40）接触。该方法包括在通过界面（40）的第一组液滴的液滴（20A）之间的渗透流，以便改变第一组液滴的每个液滴（20A）的密度和液滴的分离（20A ，20B），以便将第一组液滴的液滴（20A）与第二组液滴的液滴（20B）隔离开来，根据密度或密度和体积的组合。

5. 发明授权

US08798341B2 Method and device for reading an emulsion 有权
标题翻译：读取乳液的方法和装置
公开(公告)号：US08798341B2
公开(公告)日：2014-08-05
申请号：US13054194
申请日：2009-07-13
申请人： Jean Baudry , Julien Sylvestre , Jerome Bibette , Laurent Boitard , Nicolas Bremond
发明人： Jean Baudry , Julien Sylvestre , Jerome Bibette , Laurent Boitard , Nicolas Bremond
IPC分类号： G06K9/00
CPC分类号： G01N15/1475 , G01N2015/003 , G01N2015/0092
摘要： A method for reading an emulsion (3) including droplets and a continuous phase surrounding the droplets, the method includes: two-dimensional scanning of the emulsion (3), and construction of a two-dimensional image of the emulsion (3) based on the scanning. Preferably, the droplets do not move during scanning, for example by solidifying the continuous phase or by using a two-dimensional compact or semi-compact network of droplets. The method can further include time-based monitoring of a chemical or biological reaction taking place in at least one of the droplets. A device implementing this method is also described. The method is applicable for the detection and/or sorting of microdroplets performing the role of microreactors or containing specific cells or molecules, in fields such as gene expression or diagnosis.
摘要翻译：一种用于读取包括液滴和围绕液滴的连续相的乳液（3）的方法，所述方法包括：乳液（3）的二维扫描，以及基于乳液（3）的二维图像的构建扫描。优选地，液滴在扫描期间不移动，例如通过固化连续相或通过使用二维紧凑或半紧凑的液滴网络。该方法还可以包括在至少一个液滴中发生的化学或生物反应的基于时间的监测。还描述了实现该方法的设备。该方法适用于在诸如基因表达或诊断的领域中进行微量反应器或包含特定细胞或分子的作用的微滴的检测和/或分选。

6. 发明申请

US20110188717A1 METHOD AND DEVICE FOR READING AN EMULSION 有权
标题翻译：用于读取乳液的方法和装置
公开(公告)号：US20110188717A1
公开(公告)日：2011-08-04
申请号：US13054194
申请日：2009-07-13
申请人： Jean Baudry , Julien Sylvestre , Jerome Bibette , Laurent Boitard , Nicolas Bremond
发明人： Jean Baudry , Julien Sylvestre , Jerome Bibette , Laurent Boitard , Nicolas Bremond
IPC分类号： G06K9/00
CPC分类号： G01N15/1475 , G01N2015/003 , G01N2015/0092
摘要： A method for reading an emulsion (3) including droplets and a continuous phase surrounding the droplets, the method includes: two-dimensional scanning of the emulsion (3), and construction of a two-dimensional image of the emulsion (3) based on the scanning. Preferably, the droplets do not move during scanning, for example by solidifying the continuous phase or by using a two-dimensional compact or semi-compact network of droplets. The method can further include time-based monitoring of a chemical or biological reaction taking place in at least one of the droplets. A device implementing this method is also described. The method is applicable for the detection and/or sorting of microdroplets performing the role of microreactors or containing specific cells or molecules, in fields such as gene expression or diagnosis.
摘要翻译：一种用于读取包括液滴和围绕液滴的连续相的乳液（3）的方法，所述方法包括：乳液（3）的二维扫描，以及基于乳液（3）的二维图像的构建扫描。优选地，液滴在扫描期间不移动，例如通过固化连续相或通过使用二维紧凑或半紧凑的液滴网络。该方法还可以包括在至少一个液滴中发生的化学或生物反应的基于时间的监测。还描述了实现该方法的装置。该方法适用于在诸如基因表达或诊断的领域中进行微量反应器或包含特定细胞或分子的作用的微滴的检测和/或分选。

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