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1. 发明授权

US07553943B2 Polynucleotide arrays 有权
标题翻译：多核苷酸阵列
公开(公告)号：US07553943B2
公开(公告)日：2009-06-30
申请号：US10578460
申请日：2004-11-08
申请人： Darren James Ellis , Colin Lloyd Barnes , Harold Philip Swerdlow , Tom Brown
发明人： Darren James Ellis , Colin Lloyd Barnes , Harold Philip Swerdlow , Tom Brown
IPC分类号： C07H21/00 , C07H21/02 , C07H21/04 , C12Q1/68 , C12P19/34
CPC分类号： C07H21/00 , C12Q1/6837 , C12Q2525/301 , C12Q2525/113
摘要： The invention provides a hairpin polynucleotide, having a loop and a stem region, characterised in that a sulfur-based nucleophile is attached to an internal nucleotide in the hairpin through a linker to enable binding to a solid support.
摘要翻译：本发明提供了具有环和茎区的发夹多核苷酸，其特征在于通过连接体将硫基亲核试剂连接到发夹中的内部核苷酸以使得能够结合固体支持物。

2. 发明授权

US10187496B2 Apparatus, system and method for resolving bandwidth constriction 有权
公开(公告)号：US10187496B2
公开(公告)日：2019-01-22
申请号：US12967714
申请日：2010-12-14
申请人： Amit Garg , Tom Brown
发明人： Amit Garg , Tom Brown
IPC分类号： H04L29/06 , H04L29/08 , H04N21/24 , H04N21/63 , H04N21/433 , H04N21/462 , H04N21/472
摘要： An apparatus, system and method are disclosed for resolving bandwidth constriction using multiple bandwidths and/or multiple content delivery paths. The apparatus, system and method may include recording requested video content and/or delivering the recorded video content to resolve bandwidth constriction using alternate bandwidths or delivery paths.

3. 发明授权

US09167310B2 Optimized delivery techniques 有权
标题翻译：优化交付技术
公开(公告)号：US09167310B2
公开(公告)日：2015-10-20
申请号：US13619264
申请日：2012-09-14
申请人： Tom Brown , Rick Gasloli
发明人： Tom Brown , Rick Gasloli
IPC分类号： H04L12/66 , H04N21/647
CPC分类号： H04N21/64738 , H04L12/66 , H04L43/0876 , H04L43/16 , H04N21/2385 , H04N21/64723
摘要： Systems and methods are described that relate to on-demand compression for electronic data, such as media content, through a communication pathway. The communication pathway may be a configured to multicast media content to a plurality of end-users in a service group. In certain embodiments, the service group may comprise a service group node having a quadrature amplitude modulation device. In one exemplary method, it may be determined whether the amount of media content being transmitted meets a first utilization threshold. The determination may be based on, at least in part, by measurements taken at one or more electronic devices located throughout a network or system. If the first bandwidth utilization threshold is not met, media content may be transmitted in a first format. If the first bandwidth utilization threshold is met, at least a portion of the media content may be transmitted in a first optimized delivery technique.
摘要翻译：描述了通过通信路径与电子数据的按需压缩相关的系统和方法，诸如媒体内容。通信路径可以被配置为将媒体内容多播到服务组中的多个最终用户。在某些实施例中，服务组可以包括具有正交幅度调制装置的服务组节点。在一个示例性方法中，可以确定被发送的媒体内容的数量是否满足第一利用阈值。该确定可以至少部分地基于通过网络或系统的一个或多个电子设备进行的测量。如果不满足第一带宽利用率阈值，则媒体内容可以以第一格式发送。如果满足第一带宽利用率阈值，则媒体内容的至少一部分可以在第一优化传递技术中传输。

4. 发明授权

US08797891B2 System and method for capacity planning on a high speed data network 有权
标题翻译：高速数据网络容量规划的系统和方法
公开(公告)号：US08797891B2
公开(公告)日：2014-08-05
申请号：US12706455
申请日：2010-02-16
申请人： Nishant Agarwal , Tom Brown , John Paclik
发明人： Nishant Agarwal , Tom Brown , John Paclik
IPC分类号： G01R31/08
CPC分类号： H04L41/0681 , H04L41/32 , H04L41/5035 , H04L43/062 , H04L43/0882 , H04L43/106 , H04L43/16
摘要： The present disclosure describes a method and system for monitoring the bandwidth utilization on a high speed data network port over time. According to the method described herein, measurements of the bandwidth utilization on the port may be taken over a predetermined time interval and analyzed to determine whether the utilization measurement equals or exceeds a predetermined upper threshold. If the port exhibits high bandwidth utilization within the time interval, an alert may be set for further monitoring of the port or for port augmentation.
摘要翻译：本公开描述了一种用于在一段时间内监视高速数据网络端口上的带宽利用率的方法和系统。根据本文描述的方法，端口上的带宽利用率的测量可以在预定的时间间隔内进行，并且被分析以确定应用测量是否等于或超过预定的上限阈值。如果端口在时间间隔内显示高带宽利用率，则可以设置警报以进一步监视端口或端口扩充。

5. 发明申请

US20120311093A1 DYNAMIC MANAGEMENT OF AUDIOVISUAL AND DATA COMMUNICATIONS 有权
标题翻译：视听与数据通信动态管理
公开(公告)号：US20120311093A1
公开(公告)日：2012-12-06
申请号：US13153632
申请日：2011-06-06
申请人： Amit Garg , Tom Brown
发明人： Amit Garg , Tom Brown
IPC分类号： G06F15/16
CPC分类号： H04N21/4621 , H04L12/185 , H04N21/6168
摘要： A device, system and method are provided to dynamically manage bandwidth for audiovisual communications and content distribution. The device, system and method may include dynamic qualification of content or channels for distribution in accordance with one or more distribution models, such as a broadcast distribution model and a narrowcast distribution model (e.g., a multicast distribution model and/or a unicast distribution model). In some embodiments, the qualification may be based on demand as reflected in requests for, or access to, content from user terminals. In some embodiments, based on changes in demand for content, a requalification of the content in terms of one or more distribution models may take place.
摘要翻译：提供了一种设备，系统和方法来动态管理视听通信和内容分发的带宽。设备，系统和方法可以包括根据一个或多个分布模型（例如，广播分发模型和窄播放分布模型（例如，组播分布模型和/或单播分发模型））分发的内容或信道的动态鉴定）。在一些实施例中，该资格可以基于对来自用户终端的请求或访问内容所反映的需求。在一些实施例中，基于对内容的需求的变化，可以进行关于一个或多个分发模型的内容的重新鉴定。

6. 发明授权

US07348141B2 Hybridization beacon and method of rapid sequence detection and discrimination 有权
标题翻译：杂交信标和快速序列检测和鉴别方法
公开(公告)号：US07348141B2
公开(公告)日：2008-03-25
申请号：US10239913
申请日：2001-03-28
申请人： David John French , David Gordon McDowell , Tom Brown
发明人： David John French , David Gordon McDowell , Tom Brown
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04 , C07H21/00
CPC分类号： C12Q1/6818 , C12Q1/6816 , C12Q1/6851 , C12Q1/686 , C12Q2565/107 , C12Q2525/185 , C12Q2561/101 , C12Q2535/131 , C12Q2527/101
摘要： A method for detecting specific DNA sequences and discriminating single nucleotide polymorphisms (SNPs) using fluorescently labelled oligonucleotide probes is disclosed. Oligonucleotide probes are labelled with a reporter molecule preferentially attached to an internal nucleotide residue. The fluorescence emission of oligonucleotide probes varies significantly when in single-stranded and double-stranded states despite the absence of quencher moieties, allowing reliable detection of complementary DNA targets. The melting temperature of probe/target duplexes permits discrimination of targets that differ by as little as a single nucleotide residue, such that polymorphic targets may be discriminated by fluorescence quantitation and Tm. The hybridisation probes of this invention have been demonstrated to accurately identify homozygous and heterozygous samples using a single fluorescent oligonucleotide and direct investigation of saliva with hybridisation probes permits ultra-rapid genotypic analysis within 35-40 minutes. Target detection and SNP discrimination assays have been achieved in homogeneous, heterogeneous, ‘real-time’ and solid-phase formats.
摘要翻译：公开了使用荧光标记的寡核苷酸探针检测特异性DNA序列和区分单核苷酸多态性（SNP）的方法。寡核苷酸探针用优先连接到内部核苷酸残基的报道分子标记。尽管不存在猝灭剂部分，但在单链和双链状态下，寡核苷酸探针的荧光发射显着变化，允许可靠检测互补DNA靶标。探针/目标双链体的解链温度允许区分不同于单个核苷酸残基的靶标，从而可以通过荧光定量和Tm鉴别多态性靶标。已经证明本发明的杂交探针可以使用单一的荧光寡核苷酸准确地鉴定纯合和杂合样品，并且可以在35-40分钟内使用杂交探针直接研究唾液进行超快速基因分析。目标检测和SNP鉴别测定已经在均匀，异质，“实时”和固相格式中实现。

7. 发明申请

US20130046084A1 OLIGONUCLEOTIDE LIGATION 有权
标题翻译：寡核苷酸
公开(公告)号：US20130046084A1
公开(公告)日：2013-02-21
申请号：US13409927
申请日：2012-03-01
申请人： Tom Brown , Afaf Helmy El-Sagheer
发明人： Tom Brown , Afaf Helmy El-Sagheer
IPC分类号： C07H1/00 , C07H21/02
CPC分类号： C07H1/00 , C07H21/02 , C07H21/04
摘要： Oligonucleotide chemistry is central to the advancement of core technologies such as DNA sequencing, forensic and genetic analysis and has impacted greatly on the discipline of molecular biology. Oligonucleotides and their analogues are essential tools in these areas. They are often produced by automated solid-phase phosphoramidite synthesis but it is difficult to synthesize long DNA and RNA sequences by this method. Methods are proposed for ligating oligonucleotides together, in particular the use of an azide-alkyne coupling reaction to ligate the backbones of oligonucleotides together to form longer oligonucleotides that can be synthesized using current phosphoramidite synthesis methods.
摘要翻译：寡核苷酸化学是DNA测序，法医学和遗传分析等核心技术进步的核心，也对分子生物学的学科有很大的影响。寡核苷酸及其类似物是这些领域必不可少的工具。它们通常由自动化固相亚磷酰胺合成制备，但是通过该方法难以合成长的DNA和RNA序列。提出了将寡核苷酸结合在一起的方法，特别是使用叠氮化物 - 炔炔偶联反应将寡核苷酸的骨架连接在一起形成可以使用当前亚磷酰胺合成方法合成的更长的寡核苷酸。

8. 外观设计

USD666949S1 Independent rear suspension kit 有权
标题翻译：独立后悬挂套件
公开(公告)号：USD666949S1
公开(公告)日：2012-09-11
申请号：US29390740
申请日：2011-04-28
申请人： Vaughn E. D. West , Tom Brown
设计人： Vaughn E. D. West , Tom Brown

9. 发明申请

US20120159558A1 Cache Management In A Video Content Distribution Network 有权
标题翻译：视频内容分发网络中的缓存管理
公开(公告)号：US20120159558A1
公开(公告)日：2012-06-21
申请号：US12973156
申请日：2010-12-20
申请人： Volnie Whyte , Amit Garg , Tom Brown , Robert Gaydos , Mark Muehl
发明人： Volnie Whyte , Amit Garg , Tom Brown , Robert Gaydos , Mark Muehl
IPC分类号： H04N7/173
CPC分类号： H04N21/23103 , G06F12/0871 , G06F12/0888 , G06F12/121 , G06F2212/263 , G06F2212/284 , H04N7/17336 , H04N21/222 , H04N21/23106 , H04N21/23113 , H04N21/2393 , H04N21/2402 , H04N21/2407 , H04N21/2408 , H04N21/47202
摘要： Cache management techniques are described for a content distribution network (CDN), for example, a video on demand (VOD) system supporting user requests and delivery of video content. A preferred cache size may be calculated for one or more cache devices in the CDN, for example, based on a maximum cache memory size, a bandwidth availability associated with the CDN, and a title dispersion calculation determined by the user requests within the CDN. After establishing the cache with a set of assets (e.g., video content), an asset replacement algorithm may be executed at one or more cache devices in the CDN. When a determination is made that a new asset should be added to a full cache, a multi-factor comparative analysis may be performed on the assets currently residing in the cache, comparing the popularity and size of assets and combinations of assets, along with other factors to determine which assets should be replaced in the cache device.
摘要翻译：描述了用于内容分发网络（CDN）的缓存管理技术，例如支持用户请求和视频内容传送的视频点播（VOD）系统。可以例如基于最大高速缓冲存储器大小，与CDN相关联的带宽可用性以及由CDN内的用户请求确定的标题色散计算，为CDN中的一个或多个高速缓存设备计算优选高速缓存大小。在用一组资产（例如，视频内容）建立高速缓存之后，可以在CDN中的一个或多个高速缓存设备上执行资产置换算法。当确定将新资产添加到完整缓存时，可以对当前驻留在缓存中的资产执行多因素比较分析，比较资产的流行度和大小以及资产组合以及其他确定在缓存设备中应该替换哪些资产的因素。

10. 外观设计

USD607122S1 Door panel 有权
公开(公告)号：USD607122S1
公开(公告)日：2009-12-29
申请号：US29339530
申请日：2009-07-01
申请人： Glenn A. Davina , Tom Brown , James S. Hackett , Rodney C. Harlin , Daniel S. Malicki , John Monfore , Craig R. Turner
设计人： Glenn A. Davina , Tom Brown , James S. Hackett , Rodney C. Harlin , Daniel S. Malicki , John Monfore , Craig R. Turner

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