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1. 发明申请

US20110059865A1 Modified Molecular Arrays 审中-公开
标题翻译：改性分子数组
公开(公告)号：US20110059865A1
公开(公告)日：2011-03-10
申请号：US10585373
申请日：2005-01-07
申请人： Mark Edward Brennan Smith , Andrea Sabot , Isabelle Marie Julia Rasalonjatovo , Jean-Ernest Sohna Sohna , Adrian Martin Horgan , Harold Philip Swerdlow
发明人： Mark Edward Brennan Smith , Andrea Sabot , Isabelle Marie Julia Rasalonjatovo , Jean-Ernest Sohna Sohna , Adrian Martin Horgan , Harold Philip Swerdlow
IPC分类号： C40B40/06 , C40B50/18 , C40B50/06 , C08L37/00 , C08L33/06 , B32B27/36 , B32B27/28
CPC分类号： B01J19/0046 , B01J2219/00351 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00639 , B01J2219/00641 , B01J2219/00716 , B01J2219/0072 , B01J2219/00722 , C08F222/38 , C12Q1/6806 , C12Q1/6834 , C12Q1/6837 , C12Q1/6876 , C40B40/06 , C40B50/18 , Y10T428/265
摘要： The invention relates to the preparation of a hydrogel surface useful in the formation and manipulation of arrays of molecules, particularly polynucleotides and to the chemical modification of these and other arrays. In particular, the invention relates to a method of preparing a hydrogel immobilised to a solid support comprising polymerising on the support a mixture of a first comonomer which is acrylamide, methacrylamide, hydroxyethyl methacrylate or N-vinyl pyrrolidinone and a second comonomer which is a functionalised acrylamide or acrylate.
摘要翻译：本发明涉及可用于形成和操纵分子阵列，特别是多核苷酸以及这些和其它阵列的化学修饰的水凝胶表面的制备。特别地，本发明涉及一种制备固定在固体支持物上的水凝胶的方法，其包括在载体上聚合第一共聚单体的混合物，第一共聚单体是丙烯酰胺，甲基丙烯酰胺，甲基丙烯酸羟乙酯或N-乙烯基吡咯烷酮，和第二共聚单体是官能化的丙烯酰胺或丙烯酸酯。

2. 发明授权

US08563477B2 Modified molecular arrays 有权
标题翻译：改性分子阵列
公开(公告)号：US08563477B2
公开(公告)日：2013-10-22
申请号：US13548558
申请日：2012-07-13
申请人： Mark Edward Brennan Smith , Andrea Sabot , Isabelle Marie Julia Rasalonjatovo , Jean-Ernest Sohna Sohna , Adrian Martin Horgan , Harold Philip Swerdlow
发明人： Mark Edward Brennan Smith , Andrea Sabot , Isabelle Marie Julia Rasalonjatovo , Jean-Ernest Sohna Sohna , Adrian Martin Horgan , Harold Philip Swerdlow
IPC分类号： C40B40/02 , C40B40/00
CPC分类号： B01J19/0046 , B01J2219/00351 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00639 , B01J2219/00641 , B01J2219/00716 , B01J2219/0072 , B01J2219/00722 , C08F222/38 , C12Q1/6806 , C12Q1/6834 , C12Q1/6837 , C12Q1/6876 , C40B40/06 , C40B50/18 , Y10T428/265
摘要： A composition including (a) a solid support having a surface; (b) a first plurality of nucleic acids immobilized on the surface, wherein the nucleic acids in the first plurality each include the P7 primer sequence (5′-CAAGCAGAAGACGGCATACGA-3′; SEQ ID NO: 3); and (c) a second plurality of nucleic acids immobilized on the surface, wherein the nucleic acids in the second plurality each include the P5 primer sequence (5′-AATGATACGGCGACCACCGA-3′; SEQ ID NO: 4).
摘要翻译：一种组合物，其包含（a）具有表面的固体支持体; （b）固定在所述表面上的第一组多个核酸，其中，所述第一多个核酸各自包含P7引物序列（5'-CAAGCAGAAGACGGCATACGA-3'; SEQ ID NO：3）。和（c）固定在表面上的第二多个核酸，其中第二多个核酸分别包含P5引物序列（5'-AATGATACGGCGACCACCGA-3'; SEQ ID NO：4）。

3. 发明申请

US20100311597A1 METHODS FOR SEQUENCE A POLYNUCLEOTIDE TEMPLATE 有权
标题翻译：序列多核苷酸模板的方法
公开(公告)号：US20100311597A1
公开(公告)日：2010-12-09
申请号：US11989170
申请日：2006-07-20
申请人： Harold Philip Swerdlow
发明人： Harold Philip Swerdlow
IPC分类号： C40B20/00 , C12Q1/68
CPC分类号： C12Q1/6869 , C12Q1/6853 , C12Q2565/525 , C12Q2533/101 , C12Q2525/119 , C12Q2525/301 , C12Q2535/119 , C12Q2565/537
摘要： The invention relates to methods for pairwise sequencing of a polynucleotide template which result in the sequential determination of nucleotide sequence in two distinct and separate regions of the polynucleotide template.
摘要翻译：本发明涉及多核苷酸模板的成对测序方法，其导致多核苷酸模板的两个不同和分离的区域中的核苷酸序列的顺序测定。

4. 发明授权

US09765391B2 Methods for sequencing a polynucleotide template 有权
公开(公告)号：US09765391B2
公开(公告)日：2017-09-19
申请号：US11989170
申请日：2006-07-20
申请人： Harold Philip Swerdlow
发明人： Harold Philip Swerdlow
IPC分类号： C12P19/34 , C12Q1/68 , C12M1/34 , C12M3/00 , C07H21/02 , C07H21/04 , C07H21/00
CPC分类号： C12Q1/6869 , C12Q1/6853 , C12Q2565/525 , C12Q2533/101 , C12Q2525/119 , C12Q2525/301 , C12Q2535/119 , C12Q2565/537
摘要： The invention relates to methods for pairwise sequencing of a polynucleotide template which result in the sequential determination of nucleotide sequence in two distinct and separate regions of the polynucleotide template.

5. 发明申请

US20130085084A1 Modified Molecular Arrays 有权
标题翻译：改性分子数组
公开(公告)号：US20130085084A1
公开(公告)日：2013-04-04
申请号：US13548558
申请日：2012-07-13
申请人： Mark Edward Brennan Smith , Andrea Sabot , Isabelle Marie Julia Rasolonjatovo , Jean-Ernest Sohna Sohna , Adrian Martin Horgan , Harold Philip Swerdlow
发明人： Mark Edward Brennan Smith , Andrea Sabot , Isabelle Marie Julia Rasolonjatovo , Jean-Ernest Sohna Sohna , Adrian Martin Horgan , Harold Philip Swerdlow
IPC分类号： C40B40/06
CPC分类号： B01J19/0046 , B01J2219/00351 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00639 , B01J2219/00641 , B01J2219/00716 , B01J2219/0072 , B01J2219/00722 , C08F222/38 , C12Q1/6806 , C12Q1/6834 , C12Q1/6837 , C12Q1/6876 , C40B40/06 , C40B50/18 , Y10T428/265
摘要： A composition including (a) a solid support having a surface; (b) a first plurality of nucleic acids immobilized on the surface, wherein the nucleic acids in the first plurality each include the P7 primer sequence (5′-CAAGCAGAAGACGGCATACGA-3′); and (c) a second plurality of nucleic acids immobilized on the surface, wherein the nucleic acids in the second plurality each include the P5 primer sequence (5′-AATGATACGGCGACCACCGA-3′).
摘要翻译：一种组合物，其包含（a）具有表面的固体支持体; （b）固定在所述表面上的第一组多个核酸，其中所述第一多个核酸包含P7引物序列（5'-CAAGCAGAAGACGGCATACGA-3'）; 和（c）固定在表面上的第二组多个核酸，其中第二组多个核酸包含P5引物序列（5'-AATGATACGGCGACCACCGA-3'）。

6. 发明授权

US07351532B2 DNA sequence analysis 有权
标题翻译： DNA序列分析
公开(公告)号：US07351532B2
公开(公告)日：2008-04-01
申请号：US10547062
申请日：2004-02-26
申请人： Harold Philip Swerdlow , Colin Barnes , John Andrew Todd , Richard Michael Durbin
发明人： Harold Philip Swerdlow , Colin Barnes , John Andrew Todd , Richard Michael Durbin
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6827 , C12Q2525/301 , C12Q2561/125
摘要： There is disclosed a method for determining the identity of one or more mutations or single nucleotide polymorphisms (SNPs) in a genome, comprising: a contacting a sample genome, under conditions which permit template dependant oligonucleotide ligation, with a plurality of different oligonucleotide molecules which comprise (i) a first set of oligonucleotides each comprising a sequence of nucleotides that is complementary to a region on said genome that includes a known SNP site and which oligonucleotides are complementary to said region other than at a base at or near the 5′ end of said oligonucleotides that is to be tested for complementarity to a base at the SNP site, each of said oligonucleotides comprising a unique label to identify both the base to be tested and the position of the SNP to be scored, (ii) a second set of oligonucleotides each comprising a sequence of nucleotides complementary to a region on said target genome for hybridisation with said target genome adjacent the 5′ end of an oligonucleotide of said first oligonucleotide set, and a surface capture moiety, a phosphate moiety being located at any of either the 5′ end of said first set of oligonucleotides or the 3′ end of said second set of oligonucleotides, any resulting ligated oligonucleotide being immobilised on a solid support via the surface capture moiety, b. analysing said solid support for the identity of one or more of said unique labels and comparing the defined bases in any of said immobilised oligonucleotides to those of the reference one or more SNPs.
摘要翻译：公开了一种用于确定基因组中一个或多个突变或单核苷酸多态性（SNP）的身份的方法，其包括：在允许模板依赖性寡核苷酸连接的条件下使样品基因组与多种不同的寡核苷酸分子接触，所述寡核苷酸分子包括（i）第一组寡核苷酸，每组寡核苷酸包含与所述基因组上包含已知SNP位点的区域互补的核苷酸序列，并且哪些寡核苷酸除了在5'端或附近的碱基处与所述区域互补待测试的与SNP位点的碱基互补的所述寡核苷酸，每个所述寡核苷酸包含唯一的标记，以鉴别要测试的碱基和待评估的SNP的位置，（ii）第二组的寡核苷酸，其各自包含与所述靶基因组上的区域互补的核苷酸序列，用于与所述靶基因组相邻5相杂交末端的所述第一寡核苷酸组的寡核苷酸，以及表面捕获部分，磷酸酯部分位于所述第一组寡核苷酸的5'端或所述第二组寡核苷酸的3'末端中的任一个，任何所得连接的寡核苷酸通过表面捕获部分固定在固体支持物上，b。分析所述固体支持物中的一种或多种所述独特标记的身份，并将任何所述固定的寡核苷酸中的所定义的碱基与所述参考的一个或多个SNP的那些进行比较。

7. 发明授权

US07553943B2 Polynucleotide arrays 有权
标题翻译：多核苷酸阵列
公开(公告)号：US07553943B2
公开(公告)日：2009-06-30
申请号：US10578460
申请日：2004-11-08
申请人： Darren James Ellis , Colin Lloyd Barnes , Harold Philip Swerdlow , Tom Brown
发明人： Darren James Ellis , Colin Lloyd Barnes , Harold Philip Swerdlow , Tom Brown
IPC分类号： C07H21/00 , C07H21/02 , C07H21/04 , C12Q1/68 , C12P19/34
CPC分类号： C07H21/00 , C12Q1/6837 , C12Q2525/301 , C12Q2525/113
摘要： The invention provides a hairpin polynucleotide, having a loop and a stem region, characterised in that a sulfur-based nucleophile is attached to an internal nucleotide in the hairpin through a linker to enable binding to a solid support.
摘要翻译：本发明提供了具有环和茎区的发夹多核苷酸，其特征在于通过连接体将硫基亲核试剂连接到发夹中的内部核苷酸以使得能够结合固体支持物。

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