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    • 7. 发明授权
    • Optimized delivery techniques
    • 优化交付技术
    • US09167310B2
    • 2015-10-20
    • US13619264
    • 2012-09-14
    • Tom BrownRick Gasloli
    • Tom BrownRick Gasloli
    • H04L12/66H04N21/647
    • H04N21/64738H04L12/66H04L43/0876H04L43/16H04N21/2385H04N21/64723
    • Systems and methods are described that relate to on-demand compression for electronic data, such as media content, through a communication pathway. The communication pathway may be a configured to multicast media content to a plurality of end-users in a service group. In certain embodiments, the service group may comprise a service group node having a quadrature amplitude modulation device. In one exemplary method, it may be determined whether the amount of media content being transmitted meets a first utilization threshold. The determination may be based on, at least in part, by measurements taken at one or more electronic devices located throughout a network or system. If the first bandwidth utilization threshold is not met, media content may be transmitted in a first format. If the first bandwidth utilization threshold is met, at least a portion of the media content may be transmitted in a first optimized delivery technique.
    • 描述了通过通信路径与电子数据的按需压缩相关的系统和方法,诸如媒体内容。 通信路径可以被配置为将媒体内容多播到服务组中的多个最终用户。 在某些实施例中,服务组可以包括具有正交幅度调制装置的服务组节点。 在一个示例性方法中,可以确定被发送的媒体内容的数量是否满足第一利用阈值。 该确定可以至少部分地基于通过网络或系统的一个或多个电子设备进行的测量。 如果不满足第一带宽利用率阈值,则媒体内容可以以第一格式发送。 如果满足第一带宽利用率阈值,则媒体内容的至少一部分可以在第一优化传递技术中传输。
    • 9. 发明申请
    • DYNAMIC MANAGEMENT OF AUDIOVISUAL AND DATA COMMUNICATIONS
    • 视听与数据通信动态管理
    • US20120311093A1
    • 2012-12-06
    • US13153632
    • 2011-06-06
    • Amit GargTom Brown
    • Amit GargTom Brown
    • G06F15/16
    • H04N21/4621H04L12/185H04N21/6168
    • A device, system and method are provided to dynamically manage bandwidth for audiovisual communications and content distribution. The device, system and method may include dynamic qualification of content or channels for distribution in accordance with one or more distribution models, such as a broadcast distribution model and a narrowcast distribution model (e.g., a multicast distribution model and/or a unicast distribution model). In some embodiments, the qualification may be based on demand as reflected in requests for, or access to, content from user terminals. In some embodiments, based on changes in demand for content, a requalification of the content in terms of one or more distribution models may take place.
    • 提供了一种设备,系统和方法来动态管理视听通信和内容分发的带宽。 设备,系统和方法可以包括根据一个或多个分布模型(例如,广播分发模型和窄播放分布模型(例如,组播分布模型和/或单播分发模型))分发的内容或信道的动态鉴定 )。 在一些实施例中,该资格可以基于对来自用户终端的请求或访问内容所反映的需求。 在一些实施例中,基于对内容的需求的变化,可以进行关于一个或多个分发模型的内容的重新鉴定。
    • 10. 发明授权
    • Hybridization beacon and method of rapid sequence detection and discrimination
    • 杂交信标和快速序列检测和鉴别方法
    • US07348141B2
    • 2008-03-25
    • US10239913
    • 2001-03-28
    • David John FrenchDavid Gordon McDowellTom Brown
    • David John FrenchDavid Gordon McDowellTom Brown
    • C12Q1/68C07H21/02C07H21/04C07H21/00
    • C12Q1/6818C12Q1/6816C12Q1/6851C12Q1/686C12Q2565/107C12Q2525/185C12Q2561/101C12Q2535/131C12Q2527/101
    • A method for detecting specific DNA sequences and discriminating single nucleotide polymorphisms (SNPs) using fluorescently labelled oligonucleotide probes is disclosed. Oligonucleotide probes are labelled with a reporter molecule preferentially attached to an internal nucleotide residue. The fluorescence emission of oligonucleotide probes varies significantly when in single-stranded and double-stranded states despite the absence of quencher moieties, allowing reliable detection of complementary DNA targets. The melting temperature of probe/target duplexes permits discrimination of targets that differ by as little as a single nucleotide residue, such that polymorphic targets may be discriminated by fluorescence quantitation and Tm. The hybridisation probes of this invention have been demonstrated to accurately identify homozygous and heterozygous samples using a single fluorescent oligonucleotide and direct investigation of saliva with hybridisation probes permits ultra-rapid genotypic analysis within 35-40 minutes. Target detection and SNP discrimination assays have been achieved in homogeneous, heterogeneous, ‘real-time’ and solid-phase formats.
    • 公开了使用荧光标记的寡核苷酸探针检测特异性DNA序列和区分单核苷酸多态性(SNP)的方法。 寡核苷酸探针用优先连接到内部核苷酸残基的报道分子标记。 尽管不存在猝灭剂部分,但在单链和双链状态下,寡核苷酸探针的荧光发射显着变化,允许可靠检测互补DNA靶标。 探针/目标双链体的解链温度允许区分不同于单个核苷酸残基的靶标,从而可以通过荧光定量和Tm鉴别多态性靶标。 已经证明本发明的杂交探针可以使用单一的荧光寡核苷酸准确地鉴定纯合和杂合样品,并且可以在35-40分钟内使用杂交探针直接研究唾液进行超快速基因分析。 目标检测和SNP鉴别测定已经在均匀,异质,“实时”和固相格式中实现。