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1. 发明授权

US06382526B1 Process and apparatus for the production of nanofibers 有权
标题翻译：用于生产纳米纤维的方法和设备
公开(公告)号：US06382526B1
公开(公告)日：2002-05-07
申请号：US09410808
申请日：1999-10-01
申请人： Darrell H. Reneker , Iksoo Chun , Dale Ertley
发明人： Darrell H. Reneker , Iksoo Chun , Dale Ertley
IPC分类号： B05B128
CPC分类号： D01D5/0985 , D01D4/022 , D01D4/025 , D01D5/0069
摘要： A process for forming nanofibers comprising the steps of feeding a fiber-forming material into an annular column, the column having an exit orifice, directing the fiber-forming material into an gas jet space, thereby forming an annular film of fiber-forming material, the annular film having an inner circumference, simultaneously forcing gas through a gas column, which is concentrically positioned within the annular column, and into the gas jet space, thereby causing the gas to contact the inner circumference of the annular film, and ejects the fiber-forming material from the exit orifice of the annular column in the form of a plurality of strands of fiber-forming material that solidify and form nanofibers having a diameter up to about 3,000 nanometers.
摘要翻译：一种用于形成纳米纤维的方法，包括以下步骤：将纤维形成材料进料到环形柱中，所述塔具有出口孔，将纤维形成材料引导到气体喷射空间中，由此形成纤维形成材料的环形膜，环状膜具有内圆周，同时迫使气体通过同心地定位在环形柱内的气柱，并进入气体喷射空间，从而使气体与环形膜的内圆周接触并喷出纤维形成材料以多根纤维形成材料的形式从环形柱的出口孔固化并形成直径高达约3000纳米的纳米纤维。

2. 发明授权

US07927676B2 Plasma-treated vascular occlusion devices and methods 有权
标题翻译：血浆治疗血管闭塞装置及方法
公开(公告)号：US07927676B2
公开(公告)日：2011-04-19
申请号：US11395474
申请日：2006-03-31
申请人： Chunlin Yang , Yufu Li , Hiep Do , Matthew Gounis , Iksoo Chun , Richard Champion Davis, III , Darren R. Sherman
发明人： Chunlin Yang , Yufu Li , Hiep Do , Matthew Gounis , Iksoo Chun , Richard Champion Davis, III , Darren R. Sherman
IPC分类号： B65D39/00 , B32B15/08 , A61D1/00
CPC分类号： A61L31/14 , A61L31/10 , A61L31/146 , A61L2400/18 , A61L2430/36 , Y10T428/1355 , Y10T428/1376 , C08L27/20
摘要： Vaso-occlusive devices are provided that have a polymer foam disposed about them. The polymer is treated with a plasma to facilitate thrombogenicity. A method for making and using such devices also is provided. The preferred polymer is a copolymer of a halogenated vinylidene and a halogenated alkene.
摘要翻译：提供具有围绕它们设置聚合物泡沫的血管闭塞装置。用等离子体处理聚合物以促进血栓形成。还提供了制造和使用这种装置的方法。优选的聚合物是卤代亚乙烯基和卤代烯烃的共聚物。

3. 发明申请

US20100082064A1 METHOD FOR COATING METALLIC SURFACES OF MEDICAL DEVICES WITH AN ANTI-INFECTIVE AGENT 审中-公开
标题翻译：用抗感染药物涂覆医疗器械的金属表面的方法
公开(公告)号：US20100082064A1
公开(公告)日：2010-04-01
申请号：US12241503
申请日：2008-09-30
申请人： Iksoo Chun , Thoppil Mathew John , Raymond S. Shissias , Bruce A. Lowenhaupt , Uri Herzberg
发明人： Iksoo Chun , Thoppil Mathew John , Raymond S. Shissias , Bruce A. Lowenhaupt , Uri Herzberg
IPC分类号： A61B17/70 , A61L27/54
CPC分类号： A61L27/54 , A61L27/04 , A61L31/022 , A61L31/16 , A61L2300/404
摘要： A method of coating metallic surfaces of medical devices with an anti-infective agent is disclosed. Specifically, a method of providing a discontinuous coating of triclosan on the metallic surface of a medical device is disclosed.
摘要翻译：公开了一种用抗感染剂涂覆医疗器械的金属表面的方法。具体地，公开了在医疗装置的金属表面上提供三氯生不连续涂层的方法。

4. 发明申请

US20060069435A1 Channeled biomedical foams an method for producing same 有权
公开(公告)号：US20060069435A1
公开(公告)日：2006-03-30
申请号：US11230220
申请日：2005-09-19
申请人： Kelly Brown , Mora Melican , Iksoo Chun
发明人： Kelly Brown , Mora Melican , Iksoo Chun
IPC分类号： A61F2/02 , B29C65/00
CPC分类号： A61L31/146 , A61F2/0077 , A61F2/28 , A61F2/30756 , A61F2/30767 , A61F2002/0086 , A61F2002/2817 , A61F2002/30062 , A61F2002/30199 , A61F2002/30677 , A61F2002/30762 , A61F2002/30766 , A61F2002/30785 , A61F2002/30787 , A61F2002/3093 , A61F2002/4648 , A61F2210/0004 , A61F2230/0063 , A61F2250/0067 , A61L27/18 , A61L27/56 , A61L31/06 , C08L67/04
摘要： The present invention provides a biomedical, biocompatible, polymeric foam scaffold suitable for use in the repair and regeneration of tissue and which contains located therein a network of, branched channels that are effective to encourage and facilitate vascularization and tissue growth within the scaffold and to methods for making such biomedical scaffolds.

5. 发明申请

US20050214377A1 Microparticles for cell delivery 审中-公开
标题翻译：用于细胞传递的微粒
公开(公告)号：US20050214377A1
公开(公告)日：2005-09-29
申请号：US11081247
申请日：2005-03-16
申请人： Sanjay Mistry , Iksoo Chun , Darin Messina , Anna Gosiewska
发明人： Sanjay Mistry , Iksoo Chun , Darin Messina , Anna Gosiewska
IPC分类号： A61K9/14 , A61K9/16 , A61K9/50 , A61K35/12 , A61K35/30 , A61K35/51
CPC分类号： A61K9/0024 , A61K9/1647 , A61K9/167 , A61K35/12 , A61K35/30 , A61K35/51 , A61K38/1858 , A61K2300/00
摘要： The invention relates to microparticles and compositions containing the microparticles for use in delivering viable cells to specific regions in the body for treatment of diseases in the body, and to methods of treatment of such diseases, where the microparticles include a core containing an effective amount of a biologically active agent distributed there through, and a cell attached to the surface of the core, and where the compositions contain the microparticles and a vehicle for the microparticles.
摘要翻译：本发明涉及含有用于将活细胞递送到体内特定区域以用于治疗身体疾病的微粒和组合物的微粒和组合物，以及治疗这些疾病的方法，其中微粒包括含有有效量通过其分布的生物活性剂和附着于芯表面的细胞，组合物含有微粒和微粒载体。

6. 发明授权

US08895045B2 Method of preparation of bioabsorbable porous reinforced tissue implants and implants thereof 有权
标题翻译：生物可吸收多孔增强组织植入物及其植入物的制备方法
公开(公告)号：US08895045B2
公开(公告)日：2014-11-25
申请号：US13466448
申请日：2012-05-08
申请人： Dennis D. Jamiolkowski , Kelly R. Brown , Iksoo Chun , Mora Carolynne Melican
发明人： Dennis D. Jamiolkowski , Kelly R. Brown , Iksoo Chun , Mora Carolynne Melican
IPC分类号： A61F13/00 , A61L27/56 , A61F2/08 , A61F2/02 , A61L27/44 , A61L27/48 , A61L27/46 , A61F2/00
CPC分类号： A61F2/02 , A61F2/0063 , A61F2/08 , A61F2210/0004 , A61L27/446 , A61L27/46 , A61L27/48 , A61L27/56 , A61L2430/34 , C08L67/04
摘要： A biocompatible tissue implant. The tissue implant may be bioabsorbable, consists of a biocompatible polymeric foam. The tissue implant also includes a biocompatible reinforcement member. The polymeric foam and the reinforcement member are soluble in a lyophilizing solvent. The reinforcement may be annealed and/or coated.
摘要翻译：生物相容性组织植入物。组织植入物可以是生物可吸收的，由生物相容的聚合物泡沫组成。组织植入物还包括生物相容性加强构件。聚合物泡沫和增强构件可溶于冻干溶剂中。钢筋可以退火和/或涂覆。

7. 发明申请

US20130123937A1 METHOD OF PREPARATION OF BIOABSORBABLE POROUS REINFORCED TISSUE IMPLANTS AND IMPLANTS THEREOF 有权
标题翻译：可生物多孔增强组织植入物及其植入物的制备方法
公开(公告)号：US20130123937A1
公开(公告)日：2013-05-16
申请号：US13466448
申请日：2012-05-08
申请人： Dennis D. Jamiolkowski , Kelly R. Brown , Iksoo Chun , Mora Carolynne Melican
发明人： Dennis D. Jamiolkowski , Kelly R. Brown , Iksoo Chun , Mora Carolynne Melican
IPC分类号： A61F2/02
CPC分类号： A61F2/02 , A61F2/0063 , A61F2/08 , A61F2210/0004 , A61L27/446 , A61L27/46 , A61L27/48 , A61L27/56 , A61L2430/34 , C08L67/04
摘要： A biocompatible tissue implant. The tissue implant may be bioabsorbable, consists of a biocompatible polymeric foam. The tissue implant also includes a biocompatible reinforcement member. The polymeric foam and the reinforcement member are soluble in a lyophilizing solvent. The reinforcement may be annealed and/or coated.
摘要翻译：生物相容性组织植入物。组织植入物可以是生物可吸收的，由生物相容的聚合物泡沫组成。组织植入物还包括生物相容性加强构件。聚合物泡沫和增强构件可溶于冻干溶剂中。钢筋可以退火和/或涂覆。

8. 发明授权

US08366787B2 Hybrid biologic-synthetic bioabsorbable scaffolds 有权
标题翻译：混合生物合成生物可吸收支架
公开(公告)号：US08366787B2
公开(公告)日：2013-02-05
申请号：US10172347
申请日：2002-06-14
申请人： Laura Jean Brown , Iksoo Chun , Sridevi Dhanaraj , Prasanna Malaviya , Mora C. Melican , Alireza Rezania , Li Zhang
发明人： Laura Jean Brown , Iksoo Chun , Sridevi Dhanaraj , Prasanna Malaviya , Mora C. Melican , Alireza Rezania , Li Zhang
IPC分类号： A61F2/02
CPC分类号： A61F2/0063 , A61B2017/0495 , A61F2/08 , A61L27/18 , A61L27/3629 , A61L27/3633 , A61L27/3641 , A61L27/3683 , A61L27/40 , C08L67/04
摘要： A bioprosthetic device is provided for soft tissue attachment, reinforcement, and or reconstruction. The device comprises a naturally occurring extracellular matrix portion and a three-dimensional synthetic portion. In illustrated embodiments, the naturally occurring extracellular matrix portion comprises layers of small intestine submucosa, and the three-dimensional synthetic portion comprises a foam or a three-dimensional mesh, textile, or felt.
摘要翻译：提供了用于软组织附着，加强和/或重建的生物假体装置。该装置包括天然存在的细胞外基质部分和三维合成部分。在所示实施例中，天然存在的细胞外基质部分包括小肠粘膜下层，并且三维合成部分包括泡沫或三维网，织物或毡。

9. 发明申请

US20120241496A1 TISSUE THICKNESS COMPENSATOR COMPRISING A PLURALITY OF CAPSULES 有权
标题翻译：组合厚度补偿器包括多孔的胶囊
公开(公告)号：US20120241496A1
公开(公告)日：2012-09-27
申请号：US13433096
申请日：2012-03-28
申请人： Venkataramanan Mandakolathur Vasudevan , Taylor W. Aronhalt , Jeffrey L. Aldridge , Charles J. Scheib , Chunlin Yang , Christopher J. Schall , Chester O. Baxter, III , Iksoo Chun , Rao S. Bezwada , Sean P. Conlon , Michael S. Cropper , Joshua R. Uth , Richard L. Leimbach , Donna L. Korvick
发明人： Venkataramanan Mandakolathur Vasudevan , Taylor W. Aronhalt , Jeffrey L. Aldridge , Charles J. Scheib , Chunlin Yang , Christopher J. Schall , Chester O. Baxter, III , Iksoo Chun , Rao S. Bezwada , Sean P. Conlon , Michael S. Cropper , Joshua R. Uth , Richard L. Leimbach , Donna L. Korvick
IPC分类号： A61B17/068
CPC分类号： A61B17/0643 , A61B17/00491 , A61B17/0644 , A61B17/0684 , A61B17/072 , A61B17/07207 , A61B17/07292 , A61B17/1155 , A61B17/2909 , A61B2017/00004 , A61B2017/00314 , A61B2017/00327 , A61B2017/00477 , A61B2017/00526 , A61B2017/0053 , A61B2017/00818 , A61B2017/00884 , A61B2017/00889 , A61B2017/00893 , A61B2017/00898 , A61B2017/00938 , A61B2017/00942 , A61B2017/00951 , A61B2017/07228 , A61B2017/07235 , A61B2017/07242 , A61B2017/07264 , A61B2017/07271 , A61B2017/07278 , A61B2017/07285 , A61B2017/2908 , A61B2017/2919 , A61B2017/2923 , A61B2017/2927 , A61B2017/2933 , A61B2017/2936 , A61B2017/2946 , A61B2017/320052 , A61B2090/037 , A61B2090/0811 , A61L31/042 , A61L31/129 , A61L31/14 , A61L31/148 , A61L31/16 , C08L1/04
摘要： A tissue thickness compensator can comprise a plurality of layers. Various embodiments are disclosed herein for manufacturing a tissue thickness compensator. In certain embodiments, a tissue thickness compensator can comprise at least one medicament tube, capsule, and/or packet contained therein
摘要翻译：组织厚度补偿器可以包括多个层。本文公开了用于制造组织厚度补偿器的各种实施例。在某些实施例中，组织厚度补偿器可以包括其中包含的至少一个药物管，胶囊和/或包装

10. 发明授权

US07192604B2 Implantable biodegradable devices for musculoskeletal repair or regeneration 有权
标题翻译：用于肌肉骨骼修复或再生的植入式可生物降解装置
公开(公告)号：US07192604B2
公开(公告)日：2007-03-20
申请号：US10020021
申请日：2001-12-07
申请人： Kelly R. Brown , Iksoo Chun , Joseph J. Hammer , Victor F. Janas , Jennifer Mandanas , Mora C Melican , Alireza Rezania , Mark C. Zimmerman
发明人： Kelly R. Brown , Iksoo Chun , Joseph J. Hammer , Victor F. Janas , Jennifer Mandanas , Mora C Melican , Alireza Rezania , Mark C. Zimmerman
IPC分类号： A61K9/70 , A61L15/64
CPC分类号： A61L27/58 , A61L27/48 , C08L67/04
摘要： An implantable biodegradable device is disclosed containing a fibrous matrix, the fibrous matrix being constructed from fibers A and fibers B, wherein fibers A biodegrade faster than fibers B, fibers A and fibers B are present in relative amounts and are organized such that the fibrous matrix is provided with properties useful in repair and/or regeneration of mammalian tissue.
摘要翻译：公开了一种可植入的可生物降解的装置，其包含纤维基质，该纤维基质由纤维A和纤维B构成，其中纤维A比纤维B，纤维A和纤维B生物降解得更快，并以组织使纤维基质具有可用于哺乳动物组织的修复和/或再生的性质。

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