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1. 发明申请

US20220008923A1 MULTI FUNCTION SPINNING PLATFORM 有权
公开(公告)号：US20220008923A1
公开(公告)日：2022-01-13
申请号：US17288152
申请日：2019-10-24
申请人： Danmarks Tekniske Universitet
发明人： Anja Boisen , En-Te Hwu , Kinga Iudith Zor , Sriram Thoppe Ranjendran , Laura Serioli
IPC分类号： B01L3/00 , G01N27/27 , G01N27/327 , B04B5/12 , G01N21/65
摘要： A rotatable platform is provided for use in Lab-on-disc (LoD) applications. A LoD microfluidic device has the rotatable platform and is suitable for analysis of a fluid sample. Real-time monitoring of cells is also provided, using a centrifugal microfluidic platform. A mobile LoD device is provided, which can be used in remote destinations and for point of care applications. A method for monitoring microorganisms under the constant supply of nutrients includes the step of inoculating the cells in a culture chamber in a rotatable microfluidic platform, rotating the platform such that liquid in a reservoir connected to or located on the platform, the liquid comprising nutrients for the cells, is constantly supplied to the cells in the culture chamber by means of shear/centrifugal force resulting from rotating the platform, and continuously monitoring the cells during rotation of the platform by means of imaging, electrochemical and/or electrical measurements.

2. 发明授权

US09395343B2 Resonant fiber based aerosol particle sensor and method 有权
标题翻译：基于共振光纤的气溶胶粒子传感器及方法
公开(公告)号：US09395343B2
公开(公告)日：2016-07-19
申请号：US14356059
申请日：2012-11-02
申请人： DANMARKS TEKNISKE UNIVERSITET
发明人： Silvan Schmid , Anja Boisen
IPC分类号： G01N29/02 , G01N33/00 , G01N29/036 , G01N5/02 , G01N9/00 , G01N15/02
CPC分类号： G01N33/0004 , G01N5/02 , G01N9/002 , G01N15/0255 , G01N29/022 , G01N29/036 , G01N2291/0256 , G01N2291/0427
摘要： The present invention relates to methods and devices for determining the weight of small particles, typically being nano-sized particles by use of resonating fibers in the form of elongate members being driven into resonance by an actuator or e.g. thermal noise/fluctuation. The frequency shift in resonance frequency due to depositing of nano-sized particles is correlated with the mass deposited on the elongate member and the vibration frequency of the elongate member is determined by a detector. The read-out from the detector is transformed into a mass deposited on the elongate member. Particles are deposited by letting a fluid with the particles flow past the elongate member.
摘要翻译：本发明涉及用于确定小颗粒重量的方法和装置，通常是通过使用由细长构件形式的共振纤维通过致动器驱动到共振中的纳米尺寸颗粒。热噪声/波动。由于沉积纳米尺寸颗粒的共振频率的频率偏移与沉积在细长构件上的质量相关，细长构件的振动频率由检测器确定。从检测器的读出被转换成沉积在细长构件上的物质。通过使流体与颗粒流过细长构件来沉积颗粒。

3. 发明公开

US20230210994A1 CELL-PENETRATING CONJUGATE SYSTEMS 审中-公开
公开(公告)号：US20230210994A1
公开(公告)日：2023-07-06
申请号：US17594289
申请日：2020-04-06
申请人： Danmarks Tekniske Universitet
发明人： Sarvesh Kumar Srivastava , Gael Clergeaud Veiga , Anja Boisen
IPC分类号： A61K47/26 , A61K47/18 , A61K31/4745 , A61K31/337 , A61K31/282 , A61P35/00
CPC分类号： A61K47/26 , A61K47/183 , A61K31/4745 , A61K31/337 , A61K31/282 , A61P35/00
摘要： The present invention relates to the in vitro use of a group of cell-penetrating conjugate systems or a formulation incorporating the same for transporting e.g. therapeutically active agents, such as chemotherapeutics, insulin and immunosuppressants across the cellular membranes of mammalian cells, including human cells. The invention also relates to an in vitro methods of transporting physiologically active agents, such as therapeutics, across cell-membranes by using the cell-penetrating conjugate systems according to the present invention as well as the cell-penetrating conjugate systems for use in treatment of cancer, diabetes and for use in immunotherapy.

4. 发明申请

US20160240703A1 NANOSTRUCTURED SILICON BASED SOLAR CELLS AND METHODS TO PRODUCE NANOSTRUCTURED SILICON BASED SOLAR CELLS 有权
标题翻译：基于纳米结构的硅基太阳能电池和生产纳米结构的硅基太阳能电池的方法
公开(公告)号：US20160240703A1
公开(公告)日：2016-08-18
申请号：US15022137
申请日：2014-09-26
申请人： DANMARKS TEKNISKE UNIVERSITET
发明人： Rasmus Schmidt Davidsen , Ole Hansen , Anja Boisen , Michael Stenbæk Schmidt
IPC分类号： H01L31/0236 , H01L31/18
CPC分类号： H01L31/02363 , H01L31/068 , H01L31/1804 , H01L31/186 , H01L31/1868 , Y02E10/547 , Y02P70/521
摘要： The present invention relates to a plasma texturing method for silicon based solar cells and the nanostructured silicon solar cells produced thereof. The silicon based solar cell comprises a silicon substrate having in at least part of its surface conical shaped nanostructures having an average height between 200 and 450 nm and a pitch between 100 and 200 nm, thereby achieving low reflectance and minimizing surface charge recombination.
摘要翻译：本发明涉及一种用于硅基太阳能电池的等离子体纹理化方法及其制造的纳米结构硅太阳能电池。硅基太阳能电池包括硅基板，其至少部分表面具有锥形纳米结构，其平均高度在200和450nm之间，间距在100和200nm之间，从而实现低反射率和最小化表面电荷复合。

5. 发明申请

US20140305191A1 RESONANT FIBER BASED AEROSOL PARTICLE SENSOR AND METHOD 有权
标题翻译：基于共聚纤维的气溶胶颗粒传感器和方法
公开(公告)号：US20140305191A1
公开(公告)日：2014-10-16
申请号：US14356059
申请日：2012-11-02
申请人： DANMARKS TEKNISKE UNIVERSITET
发明人： Silvan Schmid , Anja Boisen
IPC分类号： G01N33/00 , G01N15/02
CPC分类号： G01N33/0004 , G01N5/02 , G01N9/002 , G01N15/0255 , G01N29/022 , G01N29/036 , G01N2291/0256 , G01N2291/0427
摘要： The present invention relates to methods and devices for determining the weight of small particles, typically being nano-sized particles by use of resonating fibers in the form of elongate members being driven into resonance by an actuator or e.g. thermal noise/fluctuation. The frequency shift in resonance frequency due to depositing of nano-sized particles is correlated with the mass deposited on the elongate member and the vibration frequency of the elongate member is determined by a detector. The read-out from the detector is transformed into a mass deposited on the elongate member. Particles are deposited by letting a fluid with the particles flow past the elongate member.
摘要翻译：本发明涉及用于确定小颗粒重量的方法和装置，通常是通过使用由细长构件形式的共振纤维通过致动器驱动到共振中的纳米尺寸颗粒。热噪声/波动。由于沉积纳米尺寸颗粒的共振频率的频率偏移与沉积在细长构件上的质量相关，细长构件的振动频率由检测器确定。从检测器的读出被转换成沉积在细长构件上的物质。通过使流体与颗粒流过细长构件来沉积颗粒。

6. 发明授权

US09784735B2 Biosensor based on the measurements of clustering dynamics of magnetic particles using a double pass setup 有权
公开(公告)号：US09784735B2
公开(公告)日：2017-10-10
申请号：US14900339
申请日：2014-03-24
申请人： Danmarks Tekniske Universitet
发明人： Marco Donolato , Filippo Bosco , Mikkel Fougt Hansen , Anja Boisen , En-Te Hwu
IPC分类号： G01N33/543 , G01N21/17 , G01N33/50
CPC分类号： G01N33/54333 , G01N21/1717 , G01N33/50 , G01N33/54373 , G01N2021/1727
摘要： Disclosed herein is a biosensor for optical detection of Brownian relaxation dynamics of magnetic particles measured by light transmission. The magnetic particles can be functionalized with biological ligands for the detection of target analytes in a sample. The setup may be implemented in a disc and optical pick-up head configuration.

7. 发明申请

US20160138908A1 MICROMECHANICAL PHOTOTHERMAL ANALYSER OF MICROFLUIDIC SAMPLES 审中-公开
标题翻译：微生物样品的微生物光热分析仪
公开(公告)号：US20160138908A1
公开(公告)日：2016-05-19
申请号：US14899457
申请日：2014-06-26
申请人： DANMARKS TEKNISKE UNIVERSITET
发明人： Muhammad Faheem Khan , Silvan Schmid , Anja Boisen , Seonghwan Kim , Thomas Thundat
IPC分类号： G01B11/16 , G01N21/31
CPC分类号： G01B11/16 , B01L3/5027 , B01L3/502715 , B01L2300/0636 , B01L2300/0663 , B01L2300/0877 , B01L2300/1838 , G01N21/0303 , G01N21/171 , G01N21/31 , G01N2021/036 , G01N2021/0389 , G01N2201/06113
摘要： The present invention relates to a micromechanical photothermal analyser of microfluidic samples comprising an oblong micro-channel extending longitudinally from a support element, the micro-channel is made from at least two materials with different thermal expansion coefficients, wherein the materials are arranged relatively to each other so that heating of the micro-channel results in a bending of the micro-channel, the first material has a first thermal expansion coefficient and is made from an light-specific transparent penetrable material so that when exposed to ultraviolet, visible, or infrared light, the specific light radiates into the channel through said light transparent material, the second material has a second thermal expansion coefficient being different from the first thermal expansion coefficient. The micromechanical photothermal analyser also comprises an irradiation source being adapted to controlled radiate ultraviolet, visible, or infrared light towards and through the transparent micro-channel, and a deflection detector being adapted to detect the amount of deflection of the micro-channel. The wavelength-deflection plot provides a spectrum of an analyte inside the oblong microchannel. To characterize the analyte the plot is compared with the standard database of spectroscopy.
摘要翻译：本发明涉及微流体样品的微机械光热分析仪，其包括从支撑元件纵向延伸的长圆形微通道，微通道由具有不同热膨胀系数的至少两种材料制成，其中材料相对于每个另一个使得微通道的加热导致微通道的弯曲，第一材料具有第一热膨胀系数，并且由光特异性透明可穿透材料制成，使得当暴露于紫外线，可见光或红外线光，特定的光通过所述透光材料辐射到通道中，第二材料具有与第一热膨胀系数不同的第二热膨胀系数。微机械光热分析仪还包括辐射源，其适于控制朝向和穿过透明微通道的辐射紫外线，可见光或红外光，以及偏转检测器，其适于检测微通道的偏转量。波长偏转图提供长方形微通道内的分析物的光谱。为了表征分析物，将该图与光谱学的标准数据库进行比较。

8. 发明申请

US20150293017A1 PHOTOTHERMAL RESONANCE 审中-公开
标题翻译：光热共振
公开(公告)号：US20150293017A1
公开(公告)日：2015-10-15
申请号：US14438094
申请日：2013-10-25
申请人： DANMARKS TEKNISKE UNIVERSITET
发明人： Shoko Yamada , Silvan Schmid , Anja Boisen , Tom Larsen
IPC分类号： G01N21/39 , G01N29/24 , G01N21/17
CPC分类号： G01N21/39 , G01N21/1702 , G01N29/022 , G01N29/036 , G01N29/2418 , G01N2201/06113 , G01N2291/014 , G01N2291/0256 , G01N2291/0427
摘要： The present invention relates to a method for detecting photo-thermal absorbance of a material utilising a mechanically temperature sensitive resonator (20) and a sample being arrange in thermal communication with the temperature sensitive resonator. The present invention further relates to an apparatus for detecting photo-thermal absorbance of a sample.
摘要翻译：本发明涉及利用机械感温谐振器（20）和与温度敏感型谐振器热连通的样品来检测材料的光吸收的方法。本发明还涉及一种用于检测样品的光热吸收的装置。

9. 发明授权

US11815440B2 Method for preparing a substrate by applying a sample to be analysed 有权
公开(公告)号：US11815440B2
公开(公告)日：2023-11-14
申请号：US16097939
申请日：2017-05-01
申请人： Danmarks Tekniske Universitet
发明人： Onur Durucan , Michael Stenbaek Schmidt , Tomas Rindzevicius , Anja Boisen
IPC分类号： G01N1/40 , B01L3/00 , G01N21/07 , G01N35/00 , G01N21/65 , G01N33/49
CPC分类号： G01N1/4077 , B01L3/50273 , B01L3/502753 , G01N21/07 , G01N21/658 , G01N33/491 , G01N35/00069 , B01L2200/0684 , B01L2300/0803 , B01L2300/087 , B01L2400/0406 , B01L2400/0409 , G01N2035/00158 , G01N2035/00495
摘要： The invention relates to a method for preparing a substrate (105a) comprising a sample reception area (110) and a sensing area (111). The method comprises the steps of: 1) applying a sample on the sample reception area; 2) rotating the substrate around a predetermined axis; 3) during rotation, at least part of the liquid travels from the sample reception area to the sensing area due to capillary forces acting between the liquid and the substrate; and 4) removing the wave of particles and liquid formed at one end of the substrate. The sensing area is closer to the predetermined axis than the sample reception area. The sample comprises a liquid part and particles suspended therein.

10. 发明申请

US20160377609A1 TEST SYSTEM AND METHOD 审中-公开
公开(公告)号：US20160377609A1
公开(公告)日：2016-12-29
申请号：US14944062
申请日：2015-11-17
申请人： Danmarks Tekniske Universitet
发明人： Anja Boisen , Filippo Giacomo Bosco , En-Te Hwu
IPC分类号： G01N33/543 , G01N29/02 , G01N21/65 , G01N29/036 , B01L3/00 , G01N35/00
CPC分类号： G01N33/54373 , B01L3/502715 , B01L3/502761 , B01L2200/148 , B01L2300/0654 , B01L2300/0806 , B01L2300/0861 , G01N21/07 , G01N21/658 , G01N29/022 , G01N29/036 , G01N29/2418 , G01N33/53 , G01N35/00069 , G01N2291/0256 , G01N2291/0427
摘要： The present invention relates to an apparatus for detecting compounds, the apparatus having a device defining a disk-shaped geometry, the device having a centre, a plurality of fluid channels each comprising a fluid inlet positioned at a first distance from the centre and a fluid channel end at a second distance from the centre, the second distance being larger than the first distance, one or more sensors arranged at each fluid channel, wherein the sensors each comprise at least one optical detectable member, the test apparatus further comprising one or more optical sensing devices arranged for sensing the at least one optical detectable member of the one or more sensors, and a rotation device adapted for rotating the device so that the sensors pass over the one or more optical sensing devices. Further the present invention relates to a method for determining compounds comprising providing an apparatus for detecting compounds having a device defining a disk-shaped geometry, the device having a centre, a plurality of fluid channels each comprising a fluid inlet positioned at a first distance from the centre and a fluid channel end at a second distance from the centre, the second distance being larger than the first distance, one or more sensors arranged at each fluid channel, wherein the sensors each comprise at least one optical detectable member, the test apparatus further comprising one or more optical sensing devices arranged for sensing the at least one optical detectable member of the one or more sensors, and a rotation device adapted for rotating the device so that the sensors pass over the one or more optical sensing devices, the method comprising: providing a fluid at an inlet near the centre of the device, rotating the device, and obtaining properties of the sensors using the optical sensing devices.

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