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1. 发明申请

US20060153898A1 Nocturnal muscle enhancing composition and method 失效
标题翻译：夜间肌肉增强成分及方法
公开(公告)号：US20060153898A1
公开(公告)日：2006-07-13
申请号：US11374872
申请日：2006-03-14
申请人： Daniel Mowrey , Mauro DiPasquale , Donald Layman , David Holmes
发明人： Daniel Mowrey , Mauro DiPasquale , Donald Layman , David Holmes
IPC分类号： A61K47/00 , A61K9/22
CPC分类号： A23L33/19 , A23L33/105 , A23L33/175 , A23L33/185 , A23V2002/00 , A23V2200/224 , A23V2250/5424 , A23V2250/54252 , A23V2250/0628 , A23V2250/0626 , A23V2250/0654 , A23V2250/062 , A23V2250/5486 , A23V2250/606 , A23V2250/28 , A23V2250/70 , A23V2250/0644 , A23V2250/0612 , A23V2250/026
摘要： A method and nutrient supplement composition for nocturnal administration to human subjects where the nutrient supplement composition includes both a sustained timed release portion and a rapid release portion, both portions containing a mixture of edible food proteins and edible amino acid building blocks with a portion of these key components being microencapsulated for sustained timed release in a the human body during the growth hormone spikes that generally occur during nocturnal sleep.
摘要翻译：一种用于夜间给予人类受试者的方法和营养补充剂组合物，其中营养补充剂组合物包括持续定时释放部分和快速释放部分，两部分含有食用食物蛋白质和可食用氨基酸结构单元的混合物，其中一部分在通常在夜间睡眠期间发生的生长激素尖峰期间，关键组分被微囊化以在人体内持续定时释放。

2. 发明授权

US07300665B2 Nocturnal muscle enhancing composition and method 失效
标题翻译：夜间肌肉增强成分及方法
公开(公告)号：US07300665B2
公开(公告)日：2007-11-27
申请号：US11374872
申请日：2006-03-14
申请人： Daniel B. Mowrey , Mauro DiPasquale , Donald K. Layman , David Holmes
发明人： Daniel B. Mowrey , Mauro DiPasquale , Donald K. Layman , David Holmes
IPC分类号： A61K47/00
CPC分类号： A23L33/19 , A23L33/105 , A23L33/175 , A23L33/185 , A23V2002/00 , A23V2200/224 , A23V2250/5424 , A23V2250/54252 , A23V2250/0628 , A23V2250/0626 , A23V2250/0654 , A23V2250/062 , A23V2250/5486 , A23V2250/606 , A23V2250/28 , A23V2250/70 , A23V2250/0644 , A23V2250/0612 , A23V2250/026
摘要： A method and nutrient supplement composition for nocturnal administration to human subjects where the nutrient supplement composition includes both a sustained timed release portion and a rapid release portion, both portions containing a mixture of edible food proteins and edible amino acid building blocks with a portion of these key components being microencapsulated for sustained timed release in a the human body during the growth hormone spikes that generally occur during nocturnal sleep.
摘要翻译：一种用于夜间给予人类受试者的方法和营养补充剂组合物，其中营养补充剂组合物包括持续定时释放部分和快速释放部分，两部分含有食用食物蛋白质和可食用氨基酸结构单元的混合物，其中一部分在通常在夜间睡眠期间发生的生长激素尖峰期间，关键组分被微囊化以在人体内持续定时释放。

3. 发明授权

US07037522B2 Nocturnal muscle enhancing composition and method 失效
标题翻译：夜间肌肉增强成分及方法
公开(公告)号：US07037522B2
公开(公告)日：2006-05-02
申请号：US10256997
申请日：2002-09-27
申请人： Daniel B. Mowrey , Mauro DiPasquale , Donald K. Layman , David Holmes
发明人： Daniel B. Mowrey , Mauro DiPasquale , Donald K. Layman , David Holmes
IPC分类号： A61K47/00 , A61K9/20 , A61K9/22 , A23J1/00
CPC分类号： A23L33/19 , A23L33/105 , A23L33/175 , A23L33/185 , A23V2002/00 , A23V2200/224 , A23V2250/5424 , A23V2250/54252 , A23V2250/0628 , A23V2250/0626 , A23V2250/0654 , A23V2250/062 , A23V2250/5486 , A23V2250/606 , A23V2250/28 , A23V2250/70 , A23V2250/0644 , A23V2250/0612 , A23V2250/026
摘要： A method and nutrient supplement composition for nocturnal administration to human subjects where the nutrient supplement composition includes both a sustained timed release portion and a rapid release portion, both portions containing a mixture of edible food proteins and edible amino acid building blocks with a portion of these key components being micro encapsulated for sustained timed release in a the human body during the growth hormone spikes that generally occur during nocturnal sleep.
摘要翻译：一种用于夜间给予人类受试者的方法和营养补充剂组合物，其中营养补充剂组合物包括持续定时释放部分和快速释放部分，两部分含有食用食物蛋白质和可食用氨基酸结构单元的混合物，其中一部分关键组分是微囊化的，用于在通常在夜间睡眠期间发生的生长激素尖峰期间在人体中持续定时释放。

4. 发明申请

US20140236691A1 METHODS AND SYSTEMS FOR A DYNAMIC NETWORKED COMMERCE ARCHITECTURE 审中-公开
标题翻译：动态网络商业架构的方法与系统
公开(公告)号：US20140236691A1
公开(公告)日：2014-08-21
申请号：US14184127
申请日：2014-02-19
申请人： Heath B. Clarke , David Holmes , Theodore Tanner
发明人： Heath B. Clarke , David Holmes , Theodore Tanner
IPC分类号： G06Q30/02
CPC分类号： G06Q30/0222 , G06Q30/0207 , G06Q30/0214 , G06Q30/06 , G06Q30/0625 , G06Q30/0633 , G06Q30/0635 , G06Q30/0641
摘要： One embodiment of the present invention provides systems and methods, which allow a more efficient shopping experience. A cascading commerce menu provides access to a plurality of product, service, and/or content categories. In one embodiment, the cascading commerce menu is stored on a client computer, thereby providing quick access to the menu.
摘要翻译：本发明的一个实施例提供了允许更有效的购物体验的系统和方法。级联商业菜单提供对多个产品，服务和/或内容类别的访问。在一个实施例中，级联商务菜单存储在客户端计算机上，从而提供对菜单的快速访问。

5. 发明授权

US07727189B2 Filter apparatus for ostium of left atrial appendage 有权
标题翻译：左心耳口滤器
公开(公告)号：US07727189B2
公开(公告)日：2010-06-01
申请号：US10644388
申请日：2003-08-19
申请人： Robert A VanTassel , Robert G Hauser , Robert Schwartz , David Holmes , Gregg S Sutton , Thomas E Borillo , Jeffrey Welch
发明人： Robert A VanTassel , Robert G Hauser , Robert Schwartz , David Holmes , Gregg S Sutton , Thomas E Borillo , Jeffrey Welch
IPC分类号： A61M29/00
CPC分类号： A61F2/01 , A61B17/00234 , A61B17/0057 , A61B17/12122 , A61B17/12136 , A61B17/12159 , A61B17/12172 , A61B2017/00243 , A61B2017/00597 , A61B2017/00619 , A61B2017/00632 , A61B2017/1205 , A61F2002/018 , A61F2230/0006 , A61F2230/005 , A61F2230/0067 , A61F2230/0069 , A61F2230/0076 , A61F2230/0078 , A61F2230/008 , A61F2230/0093
摘要： Apparatus for permanent placement across an ostium of a left atrial appendage in a patient, which includes a filtering membrane configured to extend across the ostium of the left atrial appendage. The filtering membrane has a permeable structure which allows blood to flow through but substantially inhibits thrombus from passing therethrough. The apparatus also includes a support structure comprising a plurality of fingers which are radially outwardly expandable with respect to a longitudinal axis to permanently engage the interior wall of the left atrial appendage, wherein the filtering membrane is attached to the support structure extending across the ostium of the left atrial appendage.
摘要翻译：用于永久性放置在患者左心耳的口上的装置，其包括配置成延伸穿过左心耳的口的过滤膜。过滤膜具有允许血液流过但可以基本上抑制血栓通过的可渗透结构。所述装置还包括支撑结构，所述支撑结构包括多个指状物，所述多个指状物相对于纵向轴线径向向外可膨胀，以永久地接合左心耳内壁，其中所述过滤膜连接到所述支撑结构，左心耳。

6. 发明申请

US20100003033A1 Transmission of Audio Signals Via Fibre Optic 审中-公开
标题翻译：通过光纤传输音频信号
公开(公告)号：US20100003033A1
公开(公告)日：2010-01-07
申请号：US11992004
申请日：2006-09-12
申请人： David Holmes
发明人： David Holmes
IPC分类号： H04B10/12 , H04B3/00
CPC分类号： H04B10/00
摘要： A system received an analogue electrical signal having content between 20 Hz and 20 kHz representing an analogue audio signal; amplitude modulates the analogue electrical signal onto an optical signal; transmits the modulated optical signal over an optical waveguide; receives. The modulated optical signal; and demodulates the modulated optical signal to reproduce the analogue electrical signal. The system may be incorporated within a cable arrangement.
摘要翻译：系统接收到具有20Hz和20kHz之间的内容的模拟电信号，表示模拟音频信号; 将模拟电信号的幅度调制到光信号上; 通过光波导传输经调制的光信号; 收到。调制光信号; 并解调调制的光信号以再现模拟电信号。该系统可以结合在电缆装置中。

7. 发明申请

US20080076811A1 COMBINATIONS COMPRISING DEPEPTIDYPEPTIDASE-IV INHIBITORS AND ANTIDIABETIC AGENTS 审中-公开
标题翻译：包含抑肽酶IV抑制剂和抗生素的组合
公开(公告)号：US20080076811A1
公开(公告)日：2008-03-27
申请号：US11868129
申请日：2007-10-05
申请人： Bork Balkan , Thomas Hughes , David Holmes , Edwin Villhauer
发明人： Bork Balkan , Thomas Hughes , David Holmes , Edwin Villhauer
IPC分类号： A61K31/427 , A61K31/40 , A61P3/04 , A61P3/10
CPC分类号： A61K31/40 , A61K31/421 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K45/06 , A61K2300/00
摘要： The invention relates to a combination which comprises a DPP-IV inhibitor and at least one further antidiabetic compound, preferably selected from the group consisting of insulin signalling pathway modulators, like inhibitors of protein tyrosine phosphatases (PTPases), non-small molecule mimetic compounds and inhibitors of glutamine-fructose-6-phosphate amidotransferase (GFAT), compounds influencing a dysregulated hepatic glucose production, like inhibitors of glucose-6-phosphatase (G6Pase), inhibitors of fructose-1,6-bisphosphatase (F-1,6-BPase), inhibitors of glycogen phosphorylase (GP), glucagon receptor antagonists and inhibitors of phosphoenolpyruvate carboxykinase (PEPCK), pyruvate dehydrogenase kinase (PDHK) inhibitors, insulin sensitivity enhancers, insulin secretion enhancers, α-glucosidase inhibitors, inhibitors of gastric emptying, insulin, and α2-adrenergic antagonists, for simultaneous, separate or sequential use in the prevention, delay of progression or treatment of conditions mediated by dipeptidylpeptidase-IV (DPP-IV), in particular diabetes, more especially type 2 diabetes mellitus, conditions of impaired glucose tolerance (IGT), conditions of impaired fasting plasma glucose, metabolic acidosis, ketosis, arthritis, obesity and osteoporosis; and the use of such combination for the cosmetic treatment of a mammal in order to effect a cosmetically beneficial loss of body weight.
摘要翻译：本发明涉及包含DPP-IV抑制剂和至少一种另外的抗糖尿病化合物的组合，其优选选自胰岛素信号通路调节剂，如蛋白酪氨酸磷酸酶（PTPases）的抑制剂，非小分子模拟化合物和谷氨酰胺 - 果糖-6-磷酸酰胺转移酶（GFAT）的抑制剂，影响失调的肝脏葡萄糖产生的化合物，如葡萄糖-6-磷酸酶（G6Pase）的抑制剂，果糖-1,6-二磷酸酶抑制剂（F-1,6- BPA），糖原磷酸化酶（GP）的抑制剂，胰高血糖素受体拮抗剂和磷酸烯醇丙酮酸羧激酶（PEPCK），丙酮酸脱氢酶激酶（PDHK）抑制剂，胰岛素敏感性增强剂，胰岛素分泌增强剂，α-葡糖苷酶抑制剂，胃排空抑制剂，胰岛素和α2 - 肾上腺素能拮抗剂，用于同时，分开或顺序使用以预防，延迟进展o 治疗由二肽基肽酶-IV（DPP-IV）介导的病症，特别是糖尿病，特别是2型糖尿病，葡萄糖耐量降低的病症（IGT），空腹血浆葡萄糖受损的病症，代谢性酸中毒，酮症，关节炎，肥胖和骨质疏松症; 以及使用这种组合来进行哺乳动物的美容治疗，以实现美容上有益的体重损失。

8. 发明申请

US20070065879A1 Marker for inflammatory conditions 审中-公开
标题翻译：炎症症状的标记
公开(公告)号：US20070065879A1
公开(公告)日：2007-03-22
申请号：US11516020
申请日：2006-09-05
申请人： Cheryl Conover , Antonio Bayes-Genis , David Holmes , Robert Schwartz
发明人： Cheryl Conover , Antonio Bayes-Genis , David Holmes , Robert Schwartz
IPC分类号： G01N33/53
CPC分类号： G01N33/5091 , C07K14/4715 , G01N33/564 , G01N33/689 , G01N33/6893 , G01N2800/324 , G01N2800/368
摘要： Use of pregnancy-associated plasma protein-A as a marker for inflammatory conditions, and in particular, for acute coronary syndromes is described.
摘要翻译：描述了使用怀孕相关血浆蛋白-A作为炎性病症的标志物，特别是用于急性冠状动脉综合征。

9. 发明申请

US20060019112A1 Use of branched polyethylenes in multilayer films and resealable closures 审中-公开
标题翻译：支链聚乙烯在多层薄膜和可重复密封的封闭中的应用
公开(公告)号：US20060019112A1
公开(公告)日：2006-01-26
申请号：US11080759
申请日：2005-03-15
申请人： David Holmes , Dewey Kerbow , Slawomir Opuszko , Tina Lorenzo-Moore
发明人： David Holmes , Dewey Kerbow , Slawomir Opuszko , Tina Lorenzo-Moore
IPC分类号： B32B27/00
CPC分类号： B32B27/32 , Y10T428/31855
摘要： Branched polyethylenes of density up to about 0.875 g/cc are used as a component in articles that can be pressure-sealed and unsealed repeatedly. Such articles include multilayer films that contain the branched polyethylene and another thermoplastic and pressure-resealable closures comprising a sealing surface that comprises the branched polyethylene and a sealing surface that comprises a thermoplastic. The multilayer film and closures are particularly useful in packaging, especially plastic packaging, such as bags, pouches, and vacuum skin packaging, to package a large variety of goods.
摘要翻译：密度高达约0.875g / cc的分支聚乙烯可用作可以重复压力密封和开封的制品中的组分。这样的制品包括含有支化聚乙烯的多层膜和另一种热塑性和可重压密封的封闭件，其包括包含支化聚乙烯的密封表面和包含热塑性塑料的密封表面。多层膜和封闭物在包装，特别是塑料包装，例如袋，袋和真空皮肤包装中特别有用，可以包装各种各样的商品。

10. 发明申请

US20050136498A1 Marker for inflammatory conditions 审中-公开
标题翻译：炎症症状的标记
公开(公告)号：US20050136498A1
公开(公告)日：2005-06-23
申请号：US11062400
申请日：2005-02-22
申请人： Cheryl Conover , Antonio Bayes-Genis , David Holmes , Robert Schwartz
发明人： Cheryl Conover , Antonio Bayes-Genis , David Holmes , Robert Schwartz
IPC分类号： G01N33/53 , A61B5/055 , A61B8/12 , A61K51/00 , C07K14/47 , C12Q1/48 , C12Q1/56 , G01N33/564 , G01N33/577 , G01N33/68 , G01T1/00 , G01T1/161 , G01N33/537 , G01N33/543
CPC分类号： G01N33/5091 , C07K14/4715 , G01N33/564 , G01N33/689 , G01N33/6893 , G01N2800/324 , G01N2800/368
摘要： Use of pregnancy-associated plasma protein-A as a marker for inflammatory conditions, and in particular, for acute coronary syndromes is described.
摘要翻译：描述了使用怀孕相关血浆蛋白-A作为炎性病症的标志物，特别是用于急性冠状动脉综合征。

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