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1. 发明授权

US08685055B2 Filter apparatus for ostium of left atrial appendage 有权
标题翻译：左心耳口滤器
公开(公告)号：US08685055B2
公开(公告)日：2014-04-01
申请号：US10656647
申请日：2003-09-04
申请人： Robert A VanTassel , Robert G Hauser , Robert Schwartz , David Holmes , Gregg S Sutton , Thomas E Borillo , Jeffrey Welch
发明人： Robert A VanTassel , Robert G Hauser , Robert Schwartz , David Holmes , Gregg S Sutton , Thomas E Borillo , Jeffrey Welch
IPC分类号： A61M29/00
CPC分类号： A61F2/01 , A61B17/00234 , A61B17/0057 , A61B17/12122 , A61B17/12136 , A61B17/12159 , A61B17/12172 , A61B2017/00243 , A61B2017/00597 , A61B2017/00619 , A61B2017/00632 , A61B2017/1205 , A61F2002/018 , A61F2230/0006 , A61F2230/005 , A61F2230/0067 , A61F2230/0069 , A61F2230/0076 , A61F2230/0078 , A61F2230/008 , A61F2230/0093
摘要： Apparatus for permanent placement across an ostium of a left atrial appendage in a patient, which includes a filtering membrane configured to extend across the ostium of the left atrial appendage. The filtering membrane has a permeable structure which allows blood to flow through but substantially inhibits thrombus from passing therethrough. The apparatus also includes a support structure attached to the filtering membrane which retains the filtering membrane in position across the ostium of the left atrial appendage by permanently engaging a portion of the interior wall of the left atrial appendage. The support structure may be radially expandable from a first configuration to a second configuration which engages the ostium or the interior wall of the left atrial appendage. The filtering membrane may define an opening therethrough that is configured to expand from a first size which inhibits the passage of thrombus therethrough to a second size which allows an interventional device, e.g., an expansion balloon, to pass therethrough, and wherein the opening is resiliently biased towards the first size.
摘要翻译：用于永久性放置在患者左心耳的口上的装置，其包括配置成延伸穿过左心耳的口的过滤膜。过滤膜具有允许血液流过但可以基本上抑制血栓通过的可渗透结构。该装置还包括附接到过滤膜的支撑结构，其通过永久地接合左心耳内壁的一部分而将过滤膜保持在左心耳的口处的适当位置。支撑结构可以从第一构型径向扩张到接合左心耳的口或内壁的第二构型。过滤膜可以限定穿过其中的开口，其被构造成从阻止血栓通过的第一尺寸膨胀到允许介入装置例如膨胀气囊通过的第二尺寸，并且其中开口是弹性的偏向于第一大小。

2. 发明授权

US6126649A Steerable catheter with external guidewire as catheter tip deflector 有权
标题翻译：可导向导管，外导管作为导管尖端导流器
公开(公告)号：US6126649A
公开(公告)日：2000-10-03
申请号：US329386
申请日：1999-06-10
申请人： Robert A. VanTassel , Robert S. Schwartz , David R. Holmes
发明人： Robert A. VanTassel , Robert S. Schwartz , David R. Holmes
IPC分类号： A61M25/01 , A61M25/09
CPC分类号： A61M25/0138 , A61M25/0147 , A61B2017/22041 , A61B2017/22045 , A61M2025/0177
摘要： A steerable catheter in which a guidewire can serve a dual purpose of deflecting a bendable element at a distal end of the steerable catheter and as a guidewire to facilitate the placement of a working catheter within the vascular system. The guidewire is adapted to be slidingly received within routing eyelets or the like where one of such eyelets is disposed at a distal end of the bendable element and another near the proximal end thereof. The guidewire can be readily advanced in the distal direction relative to the steerable catheter, but tensioning of the guidewire at its proximal end serves to deflect and bend the bendable element.
摘要翻译：可导向的导管，其中导丝可以用于在可操纵导管的远端处偏转可弯曲元件的双重目的，并且用作导丝，以便于在血管系统内放置工作导管。导丝适于滑动地容纳在布置孔眼等内，其中这些孔眼之一设置在可弯曲元件的远端，另一个靠近其近端。导丝可以相对于可导向导管在远端方向上容易地前进，但是导丝在其近端处的张紧用于使可弯曲元件偏转和弯曲。

3. 发明授权

US06652556B1 Filter apparatus for ostium of left atrial appendage 有权
标题翻译：左心耳口滤器
公开(公告)号：US06652556B1
公开(公告)日：2003-11-25
申请号：US09697628
申请日：2000-10-26
申请人： Robert A. VanTassel , Robert G. Hauser , Robert Schwartz , David Holmes , Gregg S. Sutton , Thomas E. Borillo , Jeffrey Welch
发明人： Robert A. VanTassel , Robert G. Hauser , Robert Schwartz , David Holmes , Gregg S. Sutton , Thomas E. Borillo , Jeffrey Welch
IPC分类号： A61M2900
CPC分类号： A61F2/01 , A61B17/00234 , A61B17/0057 , A61B17/12122 , A61B17/12136 , A61B17/12159 , A61B17/12172 , A61B2017/00243 , A61B2017/00597 , A61B2017/00619 , A61B2017/00632 , A61B2017/1205 , A61F2002/018 , A61F2230/0006 , A61F2230/005 , A61F2230/0067 , A61F2230/0069 , A61F2230/0076 , A61F2230/0078 , A61F2230/008 , A61F2230/0093
摘要： Apparatus for permanent placement across an ostium of a left atrial appendage in a patient, which includes a filtering membrane configured to extend across the ostium of the left atrial appendage. The filtering membrane has a permeable structure which allows blood to flow through but substantially inhibits thrombus from passing therethrough. The apparatus also includes a support structure comprising a plurality of fingers which are radially outwardly expandable with respect to a longitudinal axis to permanently engage the interior wall of the left atrial appendage, wherein the filtering membrane is attached to the support structure extending across the ostium of the left atrial appendage.
摘要翻译：用于永久性放置在患者左心耳的口上的装置，其包括配置成延伸穿过左心耳的口的过滤膜。过滤膜具有允许血液流过但可以基本上抑制血栓通过的可渗透结构。所述装置还包括支撑结构，所述支撑结构包括多个指状物，所述多个指状物相对于纵向轴线径向向外可膨胀，以永久地接合左心耳内壁，其中所述过滤膜连接到所述支撑结构，左心耳。

4. 发明授权

US06241710B1 Hypodermic needle with weeping tip and method of use 失效
标题翻译：皮下注射针头及其使用方法
公开(公告)号：US06241710B1
公开(公告)日：2001-06-05
申请号：US09468688
申请日：1999-12-20
申请人： Robert A. VanTassel , David R. Holmes, Jr. , Robert S. Schwartz
发明人： Robert A. VanTassel , David R. Holmes, Jr. , Robert S. Schwartz
IPC分类号： A61M532
CPC分类号： A61M5/3286 , A61M5/3291 , A61M25/0068 , A61M2025/0057 , A61M2025/0073
摘要： The invention provides surgical needles with a porous distal portion from which a liquid injectate will weep or ooze multidirectionally under injection pressure while the porous distal portion of the needle is inserted into a body surface. The porous distal portion of the needle can be fabricated from a porous carbon, metal, ceramic or polymer and preferably has a decreasing gradient of impedance to fluid flowing to the point of the needle to compensate for the falling off of injection pressure as fluid moves towards the point, thereby ensuring uniform weeping of the injectate along the injection course. The needle is adapted for attachment to a catheter or syringe. In another embodiment, a surgical assemblage is provided wherein a porous distal portion having similar fluid flow characteristics is located along the distal end of a catheter, and a needle point is attached to the distal end of the catheter (e.g., a steerable catheter) for piercing tissue. A guidance catheter can be used to direct the invention devices to a remote internal injection site. The invention devices and methods can be used to inject fluids (including those containing nucleic acids for gene therapy) into interior body walls or tissue, such as a beating heart, without substantial loss of fluid and without substantial damage to tissue caused by injectate.
摘要翻译：本发明提供具有多孔远端部分的手术针头，其中注射的液体将在注射压力下多次渗漏或渗出，同时针的多孔远端部分插入体表面。针的多孔远端部分可以由多孔碳，金属，陶瓷或聚合物制成，并且优选地具有减小的流向梯度的流体流向针的位置以补偿注射压力随着流体朝向这点，从而确保注射过程中注射剂的均匀渗漏。该针适于附接到导管或注射器。在另一个实施例中，提供了一种手术组合件，其中具有类似流体流动特征的多孔远侧部分沿着导管的远端定位，并且针尖附接到导管的远端（例如，可导向的导管），用于刺穿组织。引导导管可用于将本发明装置引导到远程内部注射部位。本发明的装置和方法可用于将流体（包括含有用于基因治疗的核酸的那些）注射到内部体壁或组织（例如打浆心脏）中，而没有明显的流体损失，并且对注射造成的组织没有实质的损害。

5. 发明授权

US06949087B2 Apparatus with weeping tip and method of use 失效
公开(公告)号：US06949087B2
公开(公告)日：2005-09-27
申请号：US10855026
申请日：2004-05-26
申请人： Robert A. VanTassel , David R. Holmes, Jr. , Robert S. Schwartz
发明人： Robert A. VanTassel , David R. Holmes, Jr. , Robert S. Schwartz
IPC分类号： C12N15/09 , A61K31/711 , A61K48/00 , A61M5/158 , A61M5/32 , A61M25/00 , A61M31/00 , A61P43/00
CPC分类号： A61M5/3286 , A61M5/3291 , A61M25/0068 , A61M2025/0057 , A61M2025/0073
摘要： The invention provides surgical needles with a porous distal portion from which a liquid injectate will weep or ooze multidirectionally under injection pressure while the porous distal portion of the needle is inserted into a body surface. The porous distal portion of the needle can be fabricated from a porous carbon, metal, ceramic or polymer and preferably has a decreasing gradient of impedance to fluid flowing to the point of the needle to compensate for the falling off of injection pressure as fluid moves towards the point, thereby ensuring uniform weeping of the injectate along the injection course. The needle is adapted for attachment to a catheter or syringe. In another embodiment, a surgical assemblage is provided wherein a porous distal portion having similar fluid flow characteristics is located along the distal end of a catheter, and a needle point is attached to the distal end of the catheter (e.g., a steerable catheter) for piercing tissue. A guidance catheter can be used to direct the invention devices to a remote internal injection site. The invention devices and methods can be used to inject fluids (including those containing nucleic acids for gene therapy) into interior body walls or tissue, such as a beating heart, without substantial loss of fluid and without substantial damage to tissue caused by injectate.

6. 发明授权

US06689150B1 Filter apparatus for ostium of left atrial appendage 有权
公开(公告)号：US06689150B1
公开(公告)日：2004-02-10
申请号：US09614091
申请日：2000-07-11
申请人： Robert A. VanTassel , Robert G. Hauser , Robert Schwartz , David Holmes , Gregg S. Sutton , Thomas E. Borillo , Jeffrey Welch
发明人： Robert A. VanTassel , Robert G. Hauser , Robert Schwartz , David Holmes , Gregg S. Sutton , Thomas E. Borillo , Jeffrey Welch
IPC分类号： A61M2900
CPC分类号： A61F2/01 , A61B17/00234 , A61B17/0057 , A61B17/12122 , A61B17/12136 , A61B17/12159 , A61B17/12172 , A61B2017/00243 , A61B2017/00597 , A61B2017/00619 , A61B2017/00632 , A61B2017/1205 , A61F2002/018 , A61F2230/0006 , A61F2230/005 , A61F2230/0067 , A61F2230/0069 , A61F2230/0076 , A61F2230/0078 , A61F2230/008 , A61F2230/0093
摘要： Apparatus for permanent placement across an ostium of a left atrial appendage in a patient, which includes a filtering membrane configured to extend across the ostium of the left atrial appendage. The filtering membrane has a permeable structure which allows blood to flow through but substantially inhibits thrombus from passing therethrough. The apparatus also includes a support structure attached to the filtering membrane which retains the filtering membrane in position across the ostium of the left atrial appendage by permanently engaging a portion of the interior wall of the left atrial appendage. The support structure may be radially expandable from a first configuration to a second configuration which engages the ostium or the interior wall of the left atrial appendage. The filtering membrane may define an opening therethrough that is configured to expand from a first size which inhibits the passage of thrombus therethrough to a second size which allows an interventional device, e.g., an expansion balloon, to pass therethrough, and wherein the opening is resiliently biased towards the first size.

7. 发明授权

US06652555B1 Barrier device for covering the ostium of left atrial appendage 有权
标题翻译：用于覆盖左心耳口的屏障装置
公开(公告)号：US06652555B1
公开(公告)日：2003-11-25
申请号：US09642291
申请日：2000-08-18
申请人： Robert A. VanTassel , Robert G. Hauser , Robert Schwartz , David Holmes , Gregg S. Sutton , Thomas E. Borillo , Jeffrey Welch
发明人： Robert A. VanTassel , Robert G. Hauser , Robert Schwartz , David Holmes , Gregg S. Sutton , Thomas E. Borillo , Jeffrey Welch
IPC分类号： A61M2900
CPC分类号： A61B17/12136 , A61B17/00234 , A61B17/0057 , A61B17/0643 , A61B17/12022 , A61B17/12122 , A61B17/12131 , A61B17/12159 , A61B17/12172 , A61B17/122 , A61B2017/00243 , A61B2017/00628 , A61B2017/0641 , A61B2017/081 , A61B2017/1205 , A61F2/01 , A61F2002/018 , A61F2230/0006 , A61F2230/0069 , A61F2230/008
摘要： A membrane applied to the ostium of an atrial appendage is disclosed. The membrane prevents blood clots in the atrial appendage from escaping therefrom and entering the blood stream which can result in a blocked blood vessel, leading to strokes and heart attacks. The membrane may be permeable or impermeable with respect to blood flow. The membrane is configured to extend over the ostium of the left atrial appendage. The membrane has an outer periphery with a dimension larger than a corresponding dimension of the ostium. Securement means is provided to secure the outer periphery of the membrane in direct engagement with the atrial wall surrounding the ostium. The securement means may located between the membrane and the atrial wall, or the securement means may extend distally from the membrane through the ostium.
摘要翻译：公开了应用于心房的口的膜。膜防止心耳中的血块从其中逸出并进入血流，导致血管阻塞，导致中风和心脏病发作。膜可以相对于血液流动是可渗透的或不可渗透的。膜被配置为延伸超过左心耳的口。膜具有尺寸大于口的相应尺寸的外周。提供安全装置以固定膜的外周与围绕口的心房壁直接接合。固定装置可以位于膜和心房壁之间，或者固定装置可以从膜向远侧延伸通过口。

8. 发明授权

US06855132B2 Apparatus with weeping tip and method of use 失效
标题翻译：具有啜饮尖端和使用方法的设备
公开(公告)号：US06855132B2
公开(公告)日：2005-02-15
申请号：US10342023
申请日：2003-01-14
申请人： Robert A. VanTassel , David R. Holmes, Jr. , Robert S. Schwartz
发明人： Robert A. VanTassel , David R. Holmes, Jr. , Robert S. Schwartz
IPC分类号： C12N15/09 , A61K31/711 , A61K48/00 , A61M5/158 , A61M5/32 , A61M25/00 , A61M31/00 , A61P43/00
CPC分类号： A61M5/3286 , A61M5/3291 , A61M25/0068 , A61M2025/0057 , A61M2025/0073
摘要： The invention provides surgical needles with a porous distal portion from which a liquid injectate will weep or ooze multidirectionally under injection pressure while the porous distal portion of the needle is inserted into a body surface. The porous distal portion of the needle can be fabricated from a porous carbon, metal, ceramic or polymer and preferably has a decreasing gradient of impedance to fluid flowing to the point of the needle to compensate for the falling off of injection pressure as fluid moves towards the point, thereby ensuring uniform weeping of the injectate along the injection course. The needle is adapted for attachment to a catheter or syringe. In another embodiment, a surgical assemblage is provided wherein a porous distal portion having similar fluid flow characteristics is located along the distal end of a catheter, and a needle point is attached to the distal end of the catheter (e.g., a steerable catheter) for piercing tissue. A guidance catheter can be used to direct the invention devices to a remote internal injection site. The invention devices and methods can be used to inject fluids (including those containing nucleic acids for gene therapy) into interior body walls or tissue, such as a beating heart, without substantial loss of fluid and without substantial damage to tissue caused by injectate.
摘要翻译：本发明提供具有多孔远端部分的手术针头，其中注射的液体将在注射压力下多次地渗漏或渗出，同时针的多孔远端部分插入体表面。针的多孔远端部分可以由多孔碳，金属，陶瓷或聚合物制成，并且优选地具有减小的流向梯度的流体流向针的位置以补偿注射压力随着流体朝向这点，从而确保注射过程中注射剂的均匀渗漏。该针适于附接到导管或注射器。在另一个实施例中，提供了一种手术组合件，其中具有类似流体流动特征的多孔远侧部分沿着导管的远端定位，并且针尖附接到导管的远端（例如，可导向的导管），用于刺穿组织。引导导管可用于将本发明装置引导到远程内部注射部位。本发明的装置和方法可用于将流体（包括含有用于基因治疗的核酸的那些）注射到内部体壁或组织（例如打浆心脏）中，而没有明显的流体损失，并且对注射造成的组织没有实质的损害。

9. 发明授权

US06645143B2 Pressure/temperature/flow monitor device for vascular implantation 失效
公开(公告)号：US06645143B2
公开(公告)日：2003-11-11
申请号：US09961564
申请日：2001-09-20
申请人： Robert A. VanTassel , Robert S. Schwartz , David R. Holmes
发明人： Robert A. VanTassel , Robert S. Schwartz , David R. Holmes
IPC分类号： A61B500
CPC分类号： A61F2/82 , A61B5/0031 , A61B5/02055 , A61B5/0215 , A61B5/026 , A61B5/413 , A61B5/6882 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00623
摘要： A medical monitoring apparatus designed to be implanted in the vascular system is capable of sensing and transmitting via a telemetry link to an external monitor both pressure and temperature information. An internally or externally powered microcircuit component is supported on a stent-like structure and adapted to be placed in the vascular system. Placement in the ventricular septum permits measurement of pressure and temperature in the left ventricle without introducing thrombus generating materials in the left ventricle.

10. 发明授权

US06547769B2 Catheter apparatus with weeping tip and method of use 失效
标题翻译：导管器具有eping嘴和使用方法
公开(公告)号：US06547769B2
公开(公告)日：2003-04-15
申请号：US09829022
申请日：2001-04-09
申请人： Robert A. VanTassel , David R. Holmes, Jr. , Robert S. Schwartz
发明人： Robert A. VanTassel , David R. Holmes, Jr. , Robert S. Schwartz
IPC分类号： A61M532
CPC分类号： A61M5/3286 , A61M5/3291 , A61M25/0068 , A61M2025/0057 , A61M2025/0073
摘要： The invention provides surgical needles with a porous distal portion from which a liquid injectate will weep or ooze multidirectionally under injection pressure while the porous distal portion of the needle is inserted into a body surface. The porous distal portion of the needle can be fabricated from a porous carbon, metal, ceramic or polymer and preferably has a decreasing gradient of impedance to fluid flowing to the point of the needle to compensate for the falling off of injection pressure as fluid moves towards the point, thereby ensuring uniform weeping of the injectate along the injection course. The needle is adapted for attachment to a catheter or syringe. In another embodiment, a surgical assemblage is provided wherein a porous distal portion having similar fluid flow characteristics is located along the distal end of a catheter, and a needle point is attached to the distal end of the catheter (e.g., a steerable catheter) for piercing tissue. A guidance catheter can be used to direct the invention devices to a remote internal injection site. The invention devices and methods can be used to inject fluids (including those containing nucleic acids for gene therapy) into interior body walls or tissue, such as a beating heart, without substantial loss of fluid and without substantial damage to tissue caused by injectate.
摘要翻译：本发明提供具有多孔远端部分的手术针头，其中注射的液体将在注射压力下多次地渗漏或渗出，同时针的多孔远端部分插入体表面。针的多孔远端部分可以由多孔碳，金属，陶瓷或聚合物制成，并且优选地具有减小的流向梯度的流体流向针的位置以补偿注射压力随着流体朝向这点，从而确保注射过程中注射剂的均匀渗漏。该针适于附接到导管或注射器。在另一个实施例中，提供了一种手术组合件，其中具有类似流体流动特征的多孔远侧部分沿着导管的远端定位，并且针尖附接到导管的远端（例如，可导向的导管），用于刺穿组织。引导导管可用于将本发明装置引导到远程内部注射部位。本发明的装置和方法可用于将流体（包括含有用于基因治疗的核酸的那些）注射到内部体壁或组织（例如打浆心脏）中，而没有明显的流体损失，并且对注射造成的组织没有实质的损害。

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