专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20060069385A1 Methods and apparatus for tissue cryotherapy 审中-公开
标题翻译：组织冷冻治疗方法与装置
公开(公告)号：US20060069385A1
公开(公告)日：2006-03-30
申请号：US10954136
申请日：2004-09-28
申请人： Daniel Lafontaine , Boaz Avitall
发明人： Daniel Lafontaine , Boaz Avitall
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B90/39 , A61B2017/00101 , A61B2017/00243 , A61B2017/22051 , A61B2018/0022 , A61B2018/0212 , A61B2090/3954
摘要： A method for performing cryotherapy on a target tissue region in a body includes positioning a first cooling element in a first location in a body adjacent a target tissue region, positioning a second cooling element in a second location in the body adjacent the target tissue region, and cooling the respective first and second cooling elements so as to cool the target tissue region.
摘要翻译：用于在身体的目标组织区域上执行冷冻治疗的方法包括将第一冷却元件定位在邻近目标组织区域的身体的第一位置，将第二冷却元件定位在邻近目标组织区域的身体的第二位置，并冷却相应的第一和第二冷却元件以冷却目标组织区域。

2. 发明申请

US20060212027A1 Treating internal body tissue 有权
标题翻译：治疗内部身体组织
公开(公告)号：US20060212027A1
公开(公告)日：2006-09-21
申请号：US11082677
申请日：2005-03-17
申请人： Nassir Marrouche , Daniel Lafontaine
发明人： Nassir Marrouche , Daniel Lafontaine
IPC分类号： A61B18/02 , A61B18/04
CPC分类号： A61B18/02 , A61B18/04 , A61B2017/00243 , A61B2017/22069 , A61B2018/0022 , A61B2018/0212
摘要： Some embodiments of the invention relate to a system for treating tissue internal to a body, such as heart tissue. For example, the system may be used to ablate tissue as a treatment for atrial fibrillation. In certain embodiments, the system is capable of causing scar tissue to form in ostial areas of the atrium rather than inside the pulmonary vein. In such embodiments, the system may include a tissue treatment member that is operable to form an annular area of ablated tissue along the outer portion of the ostium in an area known as the antrum.
摘要翻译：本发明的一些实施方案涉及用于治疗身体内部的组织例如心脏组织的系统。例如，该系统可用于消融组织作为心房颤动的治疗。在某些实施方案中，该系统能够在心房的口部区域中形成瘢痕组织，而不是在肺静脉内部。在这样的实施例中，系统可以包括组织处理构件，其可操作以沿着称为窦的区域沿着口的外部部分形成消融组织的环形区域。

3. 发明申请

US20060173490A1 Filter system and method 审中-公开
标题翻译：过滤系统和方法
公开(公告)号：US20060173490A1
公开(公告)日：2006-08-03
申请号：US11049019
申请日：2005-02-01
申请人： Daniel Lafontaine , Mark Jenson , William Drasler
发明人： Daniel Lafontaine , Mark Jenson , William Drasler
IPC分类号： A61M29/00
CPC分类号： A61F2/2418 , A61F2/01 , A61F2/013 , A61F2/2433 , A61F2/958 , A61F2002/011 , A61F2002/016 , A61F2002/018 , A61F2210/0019 , A61F2220/005 , A61F2220/0066 , A61F2230/0006 , A61F2230/0069 , A61F2230/008
摘要： A filter system, comprising an elongate filter body defining a lumen and having a proximal end and a distal end. A valve can be provided defining a lumen and having a reversibly sealable opening for unidirectional flow of a fluid through the lumen. The valve can be adjoined proximal the distal end of the elongate filter body, wherein the elongate filter body filters the unidirectional flow of the fluid passing through the lumen of the valve and the lumen of the elongate filter body.
摘要翻译：一种过滤系统，包括限定内腔并具有近端和远端的细长过滤体。可以提供限定内腔的阀，并且具有可逆地密封的开口，用于流体通过内腔的单向流动。瓣膜可以在细长过滤体的远端附近邻接，其中细长的过滤器主体过滤通过阀的内腔和细长过滤体的内腔的单向流动。

4. 发明申请

US20060173475A1 Vascular catheter, system, and method 有权
标题翻译：血管导管，系统和方法
公开(公告)号：US20060173475A1
公开(公告)日：2006-08-03
申请号：US11049000
申请日：2005-02-01
申请人： Daniel Lafontaine , Mark Jenson , William Drasler
发明人： Daniel Lafontaine , Mark Jenson , William Drasler
IPC分类号： A61B17/22
CPC分类号： A61B17/32075 , A61B90/39 , A61B2017/00243 , A61B2017/22097 , A61F2/958
摘要： A catheter including an elongate body, a first cutting head and a second cutting head both having a blade, where the blades moves relative each other to provide a shearing action for cardiac tissue. The catheter can further include a stent positioned over an inflatable balloon, where the inflatable balloon can deploy the expandable stent over sheared cardiac tissue. The catheter can further be included in a system having a sheath, where at least a part of the catheter resides in the lumen of the sheath. The sheath further includes a cardiac valve and an expandable filter. The sheath can move relative the cardiac valve and the expandable filter to deploy the cardiac valve and at least a portion of the expandable filter proximal the inflatable balloon and the expandable stent.
摘要翻译：一种导管，其包括细长体，第一切割头和具有叶片的第二切割头，其中所述刀片相对于彼此移动以提供用于心脏组织的剪切动作。导管还可以包括定位在可膨胀气球上的支架，其中可充气球囊可以在可剪切的心脏组织上展开可扩张支架。导管可以进一步包括在具有护套的系统中，其中导管的至少一部分位于鞘的内腔中。护套还包括心脏瓣膜和可膨胀过滤器。护套可以相对于心脏瓣膜和可膨胀过滤器移动，以将心脏瓣膜部署，并且可扩张过滤器的至少一部分靠近可充气球囊和可扩张支架。

5. 发明申请

US20060047338A1 Cardiac valve, system, and method 有权
公开(公告)号：US20060047338A1
公开(公告)日：2006-03-02
申请号：US10933088
申请日：2004-09-02
申请人： Mark Jenson , William Drasler , Daniel Lafontaine
发明人： Mark Jenson , William Drasler , Daniel Lafontaine
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2412 , A61F2230/008
摘要： A cardiac valve with a support frame having a first end member and a second end member opposing the first end member in a substantially fixed distance relationship, and a cover extending over the support frame to allow for unidirectional flow of a liquid through the valve.

6. 发明申请

US20050257796A1 Percutaneous myocardial revascularization 失效
标题翻译：经皮心肌血运重建
公开(公告)号：US20050257796A1
公开(公告)日：2005-11-24
申请号：US11191056
申请日：2005-07-28
申请人： Louis Ellis , Daniel Lafontaine , Roger Hastings , Lauri DeVore
发明人： Louis Ellis , Daniel Lafontaine , Roger Hastings , Lauri DeVore
IPC分类号： A61B19/00 , A61B6/00 , A61B17/00 , A61B17/22 , A61B17/32 , A61B17/34 , A61B18/00 , A61B18/02 , A61B18/12 , A61B18/14 , A61B18/18
CPC分类号： A61B17/3207 , A61B18/1492 , A61B90/39 , A61B2017/00247 , A61B2017/22077 , A61B2017/3488 , A61B2018/00273 , A61B2018/00291 , A61B2018/00392 , A61B2018/144 , A61B2090/395 , A61M2210/125
摘要： Devices and methods for creating a series of percutaneous myocardial revascularization (PMR) channels in the heart. One method includes forming a pattern of channels in the myocardium leading from healthy tissue to hibernating tissue. Suitable channel patterns include lines and arrays. One method includes anchoring a radiopaque marker to a position in the ventricle wall, then using fluoroscopy repeatedly to guide positioning of a cutting tip in the formation of multiple channels. Another method uses radiopaque material injected into each channel formed, as a marker. Yet another method utilizes an anchorable, rotatable cutting probe for channel formation about an anchor member, where the cutting probe can vary in radial distance from the anchor. Still another method utilizes a multiple wire radio frequency burning probe, for formation of multiple channels simultaneously. Still another method utilizes liquid nitrogen to cause localized tissue death.
摘要翻译：在心脏中创建一系列经皮心肌血运重建（PMR）通道的装置和方法。一种方法包括在从健康组织导向冬眠组织的心肌中形成通道图案。合适的渠道模式包括线和阵列。一种方法包括将不透射线标记物固定在心室壁中的位置，然后重复使用荧光透视来引导切割尖端在形成多个通道中的定位。另一种方法使用注射到形成的每个通道中的不透射线材料作为标记。另一种方法利用可锚定的，可旋转的切割探针，用于围绕锚定构件的通道形成，其中切割探针可以与锚固件的径向距离变化。另一种方法是利用多线射频燃烧探头，同时形成多个通道。另一种方法利用液氮引起局部组织死亡。

7. 发明授权

US08282599B2 Therapeutic catheter with displacement sensing transducer 有权
标题翻译：带位移传感器的治疗导管
公开(公告)号：US08282599B2
公开(公告)日：2012-10-09
申请号：US11941472
申请日：2007-11-16
申请人： Alan Eskuri , Daniel Lafontaine
发明人： Alan Eskuri , Daniel Lafontaine
IPC分类号： A61M25/095
CPC分类号： A61B5/00 , A61B5/061 , A61B5/6848 , A61B8/12 , A61B17/3478 , A61B18/24 , A61B2017/0003 , A61B2017/00247 , A61B2018/00392 , A61B2090/062 , A61B2090/0811 , A61M5/46 , A61M25/0084
摘要： A catheter device having a proboscis, such as a needle, and a transducer which detects the axial displacement of the proboscis in relation to the distal tip of the catheter. The transducer is positioned at a distal portion of the catheter and may comprise an induction coil or a potentiometer. Axial displacement of the proboscis changes the amount of inductance or resistance in the transducer. This change in inductance or resistance can be calibrated to the amount of axial displacement of the proboscis and provided as feedback to the user.
摘要翻译：具有诸如针的长鼻子的导管装置和检测长鼻相对于导管的远端的轴向位移的换能器。换能器定位在导管的远端部分，并且可以包括感应线圈或电位计。长鼻子的轴向位移会改变传感器的电感或电阻。电感或电阻的这种变化可以校准到长鼻子的轴向位移量，并作为反馈提供给用户。

8. 发明申请

US20120122819A1 GUANINE RIBOSWITCH BINDING COMPOUNDS AND THEIR USE AS ANTIBIOTICS 审中-公开
标题翻译： GUANINE RIBOSWITCH BINDING化合物及其作为抗生素的用途
公开(公告)号：US20120122819A1
公开(公告)日：2012-05-17
申请号：US13377052
申请日：2010-06-14
申请人： Jérôme Mulhbacher , Daniel Lafontaine , François Malouin , Marianne Allard , Eric Marsault
发明人： Jérôme Mulhbacher , Daniel Lafontaine , François Malouin , Marianne Allard , Eric Marsault
IPC分类号： A61K31/675 , A61K31/513 , C07D279/06 , A61K31/54 , C07D265/06 , A61K31/535 , C07D213/73 , A61K31/4412 , A61K31/505 , C07F9/6533 , C07D487/04 , C07D498/04 , A61K31/519 , C07F9/6584 , A61K31/5383 , G01N33/50 , A61P31/04 , C12Q1/68 , C07D239/50
CPC分类号： A61K31/675 , A61K31/4412 , A61K31/505 , A61K31/513 , A61K31/519 , A61K31/535 , A61K31/5383 , A61K31/54 , A61K31/542 , C07D239/46 , C07D239/48 , C07D239/50 , C07D498/04 , C07D513/04 , Y10T436/141111 , Y10T436/143333
摘要： The present invention includes novel compounds and pharmaceutically acceptable formulations of said compounds which exhibit antibiotic activity against microorganisms bearing a guanine riboswitch that controls the expression of the guaA gene, including organisms which are resistant to certain antibiotic families, and which are useful as antibacterial agents for treatment or prophylaxis of bacterial infections in animals or in humans, in particular but not limited to infections of the mammary gland, or their use as antiseptics, agents for sterilization or disinfection.
摘要翻译：本发明包括所述化合物的新化合物和药学上可接受的制剂，其对具有控制guaA基因表达的鸟嘌呤核糖开关的微生物具有抗生素活性，包括对某些抗生素家族具有抗性的生物体，并且其可用作抗细菌剂治疗或预防动物或人类的细菌感染，特别是但不限于乳腺感染，或其作为防腐剂的用途，用于灭菌或消毒的试剂。

9. 发明申请

US20080140006A1 THERAPEUTIC CATHETER WITH DISPLACEMENT SENSING TRANSDUCER 有权
标题翻译：带位移感应传感器的治疗导管
公开(公告)号：US20080140006A1
公开(公告)日：2008-06-12
申请号：US11941472
申请日：2007-11-16
申请人： Alan Eskuri , Daniel Lafontaine
发明人： Alan Eskuri , Daniel Lafontaine
IPC分类号： A61M25/095
CPC分类号： A61B5/00 , A61B5/061 , A61B5/6848 , A61B8/12 , A61B17/3478 , A61B18/24 , A61B2017/0003 , A61B2017/00247 , A61B2018/00392 , A61B2090/062 , A61B2090/0811 , A61M5/46 , A61M25/0084
摘要： A catheter device having a proboscis, such as a needle, and a transducer which detects the axial displacement of the proboscis in relation to the distal tip of the catheter. The transducer is positioned at a distal portion of the catheter and may comprise an induction coil or a potentiometer. Axial displacement of the proboscis changes the amount of inductance or resistance in the transducer. This change in inductance or resistance can be calibrated to the amount of axial displacement of the proboscis and provided as feedback to the user.
摘要翻译：具有诸如针的长鼻子的导管装置和检测长鼻相对于导管的远端的轴向位移的换能器。换能器定位在导管的远端部分，并且可以包括感应线圈或电位计。长鼻子的轴向位移会改变传感器的电感或电阻。电感或电阻的这种变化可以校准到长鼻子的轴向位移量，并作为反馈提供给用户。

10. 发明授权

US07148044B1 Nucleic acid enzyme for RNA cleavage 失效
标题翻译：用于RNA切割的核酸酶
公开(公告)号：US07148044B1
公开(公告)日：2006-12-12
申请号：US09699667
申请日：2000-10-30
申请人： Jean-Pierre Perreault , Sirinart Ananvoranich , Daniel Lafontaine
发明人： Jean-Pierre Perreault , Sirinart Ananvoranich , Daniel Lafontaine
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/00 , C07H21/02 , C07H21/04
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/111 , C12N2310/123
摘要： A method is described for cleaving a nucleic acid substrate with a nucleic acid enzyme at a cleavage site comprising mixing the substrate with the enzyme, wherein the substrate includes a 7 nucleotide sequence with at least 6 nucleotides 3′ to the cleavage site and at least 1 nucleotide 5′ to the cleavage site and of formula: 5′-H′GNNHNN-3′ wherein each N is a nucleotide which may be the same or different, H is a nucleotide selected from the group consisting of A, U, C, and T, and is the site of cleavage, and H′ is a ribonucleotide selected from the group consisting of A, U, and C, wherein (i) the first nucleotide 3′ to the cleavage site is capable of forming a wobble pair with the enzyme, (ii) the second, third, fifth, and sixth nucleotides 3′ to the cleavage site are capable of forming conventional Watson-Crick base pairs with the enzyme, (iii) the fourth nucleotide 3′ to the cleavage site is capable of forming a non-conventional Watson-Crick base pair with the enzyme, and (iv) the first nucleotide 5′ to the cleavage site does not form a base pair with the enzyme; and the enzyme comprises a substrate binding portion which is capable of base pairing to the 6 nucleotides 3′ to the cleavage site of the substrate and which binding portion comprises the sequence: 3′-UNNXNN-5′ wherein each N is a nucleotide which may be the same or different, and X is a nucleotide selected from the group consisting of T, U, A, and G, whereby binding of the substrate to the enzyme effects cleavage of the substrate at the cleavage site.
摘要翻译：描述了一种用于在切割位点用核酸酶切割核酸底物的方法，包括将底物与酶混合，其中所述底物包含与切割位点具有至少6个核苷酸3'的7个核苷酸序列和至少1个核苷酸5'至切割位点，并具有下式：<？in-line-formula description =“In-line formula”end =“lead”？> 5'-H'GNNHNN-3'<？in-line-formula description =“内联式”末端=“尾”→其中每个N是可以相同或不同的核苷酸，H是选自A，U，C和T的核苷酸，并且是切割位点，H'是选自A，U和C的核糖核苷酸，其中（i）切割位点的第一个核苷酸3'能够与酶形成摆动对，（ii）切割位点的第二，第三，第五和第六核苷酸3'能够与酶形成常规的沃森 - 克里克碱基对，（iii）第四核到切割位点的3'能够与酶形成非常规的Watson-Crick碱基对，和（iv）切割位点的第一个核苷酸5'不与酶形成碱基对; 并且该酶包括能够与基底的切割位点的6'核苷酸3'碱基配对的底物结合部分，并且该结合部分包含以下序列：<？in-line-formula description =“In-line Formulas” end =“lead”？> 3'-UNNXNN-5'<？in-line-formula description =“In-line Formulas”end =“tail”？>其中每个N是可以相同或不同的核苷酸，并且X是选自T，U，A和G的核苷酸，由此底物与酶的结合在切割位点处影响底物的切割。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式