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1. 发明授权

US06847838B1 Apparatus and method for high dose rate brachytherapy radiation treatment 失效
标题翻译：用于高剂量率近距离放射治疗的装置和方法
公开(公告)号：US06847838B1
公开(公告)日：2005-01-25
申请号：US10247450
申请日：2002-09-19
申请人： Daniel J. Macey , Stanislaw Majewski , Andrew G. Weisenberger , Mark Frederick Smith , Brian James Kross
发明人： Daniel J. Macey , Stanislaw Majewski , Andrew G. Weisenberger , Mark Frederick Smith , Brian James Kross
IPC分类号： A61B19/00 , A61N5/10 , G01T1/161 , A61B5/05
CPC分类号： A61N5/1027 , A61B2090/392 , A61N5/1048 , G01T1/161
摘要： A method and apparatus for the in vivo location and tracking of a radioactive seed source during and after brachytherapy treatment. The method comprises obtaining multiple views of the seed source in a living organism using: 1) a single PSPMT detector that is exposed through a multiplicity of pinholes thereby obtaining a plurality of images from a single angle; 2) a single PSPMT detector that may obtain an image through a single pinhole or a plurality of pinholes from a plurality of angles through movement of the detector; or 3) a plurality of PSPMT detectors that obtain a plurality of views from different angles simultaneously or virtually simultaneously. The plurality of images obtained from these various techniques, through angular displacement of the various acquired images, provide the information required to generate the three dimensional images needed to define the location of the radioactive seed source within the body of the living organism.
摘要翻译：近距离放射治疗期间和之后的放射性种子源的体内定位和跟踪的方法和装置。该方法包括：使用以下方式获得活体中的种子源的多个视图：1）通过多个针孔暴露的单个PSPMT检测器，从而从单个角度获得多个图像; 2）单个PSPMT检测器，其可以通过检测器的移动从多个角度通过单个针孔或多个针孔获得图像; 或3）多个PSPMT检测器，其同时或实际上同时从不同角度获得多个视图。通过各种获取的图像的角位移获得的从这些各种技术获得的多个图像提供了生成在生物体的体内限定放射性种子源的位置所需的三维图像所需的信息。

2. 发明授权

US08049176B1 Method and apparatus for real time imaging and monitoring of radiotherapy beams 失效
标题翻译：放射线束实时成像和监测的方法和装置
公开(公告)号：US08049176B1
公开(公告)日：2011-11-01
申请号：US12316444
申请日：2008-12-12
申请人： Stanislaw Majewski , James Proffitt , Daniel J. Macey , Andrew G. Weisenberger
发明人： Stanislaw Majewski , James Proffitt , Daniel J. Macey , Andrew G. Weisenberger
IPC分类号： G01T1/16
CPC分类号： A61N5/1049 , A61N5/1071 , A61N2005/1052 , A61N2005/1054
摘要： A method and apparatus for real time imaging and monitoring of radiation therapy beams is designed to preferentially distinguish and image low energy radiation from high energy secondary radiation emitted from a target as the result of therapeutic beam deposition. A detector having low sensitivity to high energy photons combined with a collimator designed to dynamically image in the region of the therapeutic beam target is used.
摘要翻译：用于实时成像和监测放射治疗光束的方法和装置被设计为优先区分和成像低能量辐射与作为治疗光束沉积的结果从目标发射的高能二次辐射。使用与设计成在治疗束靶区域动态成像的准直仪结合的高能量光子的低灵敏度的检测器。

3. 发明授权

US06750456B1 Optical coupler 失效
标题翻译：光耦合器
公开(公告)号：US06750456B1
公开(公告)日：2004-06-15
申请号：US09577701
申请日：2000-05-23
申请人： Stanislaw Majewski , Andrew G. Weisenberger
发明人： Stanislaw Majewski , Andrew G. Weisenberger
IPC分类号： G01T120
CPC分类号： G01T1/2002 , G01T1/1644
摘要： In a camera or similar radiation sensitive device comprising a pixilated scintillation layer, a light guide and an array of position sensitive photomultiplier tubes, wherein there exists so-called dead space between adjacent photomultiplier tubes the improvement comprising a two part light guide comprising a first planar light spreading layer or portion having a first surface that addresses the scintillation layer and optically coupled thereto at a second surface that addresses the photomultiplier tubes, a second layer or portion comprising an array of trapezoidal light collectors defining gaps that span said dead space and are individually optically coupled to individual position sensitive photomultiplier tubes. According to a preferred embodiment, coupling of the trapezoidal light collectors to the position sensitive photomultiplier tubes is accomplished using an optical grease having about the same refractive index as the material of construction of the two part light guide.
摘要翻译：在包括像素化闪烁层，光导和位置敏感光电倍增管阵列的相机或类似的辐射敏感设备中，其中在相邻光电倍增管之间存在所谓的死空间，其改进包括两部分光导，包括第一平面光扩散层或具有第一表面的部分，其处理闪烁层并在寻址光电倍增管的第二表面处光学耦合到其上;第二层或部分包括限定跨越所述死空间的间隙的梯形光收集器阵列，并且分别光学耦合到单独的位置敏感光电倍增管。根据优选实施例，使用具有与两部分光导的结构材料大致相同的折射率的光学润滑脂来实现梯形光收集器与位置敏感光电倍增管的耦合。

4. 发明授权

US5864141A Compact, high-resolution, gamma ray imaging for scintimammography and other medical diagostic applications 失效
标题翻译：紧凑，高分辨率的γ射线成像，用于闪烁扫描和其他医学诊断应用
公开(公告)号：US5864141A
公开(公告)日：1999-01-26
申请号：US898731
申请日：1997-07-23
申请人： Stanislaw Majewski , Andrew G. Weisenberger , Randolph F. Wojcik , Daniela Steinbach
发明人： Stanislaw Majewski , Andrew G. Weisenberger , Randolph F. Wojcik , Daniela Steinbach
IPC分类号： G01T1/164 , G01T1/202 , G01T1/20
CPC分类号： G01T1/1644 , A61B6/4258 , G01T1/202
摘要： A high resolution gamma ray imaging device includes an aluminum housing, a lead screen collimator at an opened end of the housing, a crystal scintillator array mounted behind the lead screen collimator, a foam layer between the lead screen collimator and the crystal scintillator array, a photomultiplier window coupled to the crystal with optical coupling grease, a photomultiplier having a dynode chain body and a base voltage divider with anodes, anode wire amplifiers each connected to four anodes and a multi pin connector having pin connections to each anode wire amplifier. In one embodiment the crystal scintillator array includes a yttrium aluminum perovskite (YAP) crystal array. In an alternate embodiment, the crystal scintillator array includes a gadolinium oxyorthosilicate (GSO) crystal array.
摘要翻译：高分辨率伽马射线成像装置包括铝壳体，壳体开口端的引线屏准直器，安装在引线屏准直器后面的晶体闪烁体阵列，引线屏准直器和晶体闪烁体阵列之间的泡沫层，光电倍增器窗口，其耦合到具有光耦合润滑脂的晶体，具有倍增极链体的光电倍增管和具有阳极的基极分压器，每个连接到四个阳极的阳极线放大器和具有到每个阳极线放大器的引脚连接的多针连接器。在一个实施例中，晶体闪烁体阵列包括钇铝钙钛矿（YAP）晶体阵列。在替代实施例中，晶体闪烁体阵列包括氧化硅酸钆（GSO）晶体阵列。

5. 发明授权

US09784852B1 Surgical guidance system using hand-held probe with accompanying positron coincidence detector 有权
公开(公告)号：US09784852B1
公开(公告)日：2017-10-10
申请号：US11707579
申请日：2007-02-16
申请人： Stanislaw Majewski , Andrew G. Weisenberger
发明人： Stanislaw Majewski , Andrew G. Weisenberger
IPC分类号： A61B6/00 , G01T1/20 , G01T1/161 , G01T1/16 , A61N5/10
CPC分类号： G01T1/2008 , A61B6/4208 , A61B6/4258 , A61B6/4266 , A61B6/4405 , A61N5/103 , G01T1/1603 , G01T1/161 , G01T1/1642
摘要： A surgical guidance system offering different levels of imaging capability while maintaining the same hand-held convenient small size of light-weight intra-operative probes. The surgical guidance system includes a second detector, typically an imager, located behind the area of surgical interest to form a coincidence guidance system with the hand-held probe. This approach is focused on the detection of positron emitting biomarkers with gamma rays accompanying positron emissions from the radiolabeled nuclei.

6. 发明授权

US06271525B1 Mini gamma camera, camera system and method of use 有权
标题翻译：迷你伽马相机，相机系统及使用方法
公开(公告)号：US06271525B1
公开(公告)日：2001-08-07
申请号：US09159177
申请日：1998-09-23
申请人： Stanislaw Majewski , Andrew G. Weisenberger , Randolph F. Wojcik
发明人： Stanislaw Majewski , Andrew G. Weisenberger , Randolph F. Wojcik
IPC分类号： G01T1202
CPC分类号： G01T1/1642 , A61B6/4258 , G01T1/1644
摘要： A gamma camera comprising essentially and in order from the front outer or gamma ray impinging surface: 1) a collimator, 2) a scintillator layer, 3) a light guide, 4) an array of position sensitive, high resolution photomultiplier tubes, and 5) printed circuitry for receipt of the output of the photomultipliers. There is also described, a system wherein the output supplied by the high resolution, position sensitive photomultipiler tubes is communicated to: a) a digitizer and b) a computer where it is processed using advanced image processing techniques and a specific algorithm to calculate the center of gravity of any abnormality observed during imaging, and c) optional image display and telecommunications ports.
摘要翻译：一种伽马照相机，其基本上和从前外射线或伽马射线的入射面依次包括：1）准直器，2）闪烁体层，3）光导，4）阵列的位置敏感的高分辨率光电倍增管和5 ）印刷电路，用于接收光电倍增管的输出。还描述了一种系统，其中由高分辨率，位置敏感的光电多层管提供的输出被传送到：a）数字转换器和b）使用高级图像处理技术和特定算法来计算中心的计算机在成像期间观察到的任何异常的重力，以及c）可选的图像显示和电信端口。

7. 发明授权

US08183530B2 Positron emission tomography and optical tissue imaging 有权
标题翻译：正电子发射断层扫描和光学组织成像
公开(公告)号：US08183530B2
公开(公告)日：2012-05-22
申请号：US12319649
申请日：2009-01-09
申请人： Steven W. Falen , Richard A. Hoefer , Stanislaw Majewski , John McKisson , Brian Kross , James Proffitt , Alexander Stolin , Andrew G. Weisenberger
发明人： Steven W. Falen , Richard A. Hoefer , Stanislaw Majewski , John McKisson , Brian Kross , James Proffitt , Alexander Stolin , Andrew G. Weisenberger
IPC分类号： G01T1/166
CPC分类号： G01T1/2985 , A61B6/037 , G01N23/046 , G01N2223/419 , G01T1/1603
摘要： A mobile compact imaging system that combines both PET imaging and optical imaging into a single system which can be located in the operating room (OR) and provides faster feedback to determine if a tumor has been fully resected and if there are adequate surgical margins. While final confirmation is obtained from the pathology lab, such a device can reduce the total time necessary for the procedure and the number of iterations required to achieve satisfactory resection of a tumor with good margins.
摘要翻译：一种移动紧凑型成像系统，将PET成像和光学成像结合到可以位于手术室（OR）中的单个系统中，并提供更快的反馈，以确定肿瘤是否已被完全切除，以及是否有足够的手术切缘。虽然从病理实验室获得最终确认，但是这样的装置可以减少手术所需的总时间以及实现令人满意地切除具有良好边缘的肿瘤所需的迭代次数。

8. 发明授权

US07209579B1 Anatomic and functional imaging of tagged molecules in animals 失效
标题翻译：动物中标记分子的解剖和功能成像
公开(公告)号：US07209579B1
公开(公告)日：2007-04-24
申请号：US10341715
申请日：2003-01-14
申请人： Andrew G. Weisenberger , Stanislaw Majewski , Michael J. Paulus , Shaun S. Gleason
发明人： Andrew G. Weisenberger , Stanislaw Majewski , Michael J. Paulus , Shaun S. Gleason
IPC分类号： G06K9/00
CPC分类号： A61B6/032 , A61B5/1077 , A61B5/1127 , A61B6/037 , A61B6/08 , A61B6/5235 , A61B6/5247 , A61B2503/40
摘要： A novel functional imaging system for use in the imaging of unrestrained and non-anesthetized small animals or other subjects and a method for acquiring such images and further registering them with anatomical X-ray images previously or subsequently acquired. The apparatus comprises a combination of an IR laser profilometry system and gamma, PET and/or SPECT, imaging system, all mounted on a rotating gantry, that permits simultaneous acquisition of positional and orientational information and functional images of an unrestrained subject that are registered, i.e. integrated, using image processing software to produce a functional image of the subject without the use of restraints or anesthesia. The functional image thus obtained can be registered with a previously or subsequently obtained X-ray CT image of the subject. The use of the system described herein permits functional imaging of a subject in an unrestrained/non-anesthetized condition thereby reducing the stress on the subject and eliminating any potential interference with the functional testing that such stress might induce.
摘要翻译：用于无限制和非麻醉的小动物或其他受试者的成像中的新型功能成像系统以及用于获取这些图像并进一步将它们与先前或随后获得的解剖X射线图像对准的方法。该装置包括IR激光轮廓测量系统和全部安装在旋转台架上的伽马，PET和/或SPECT成像系统的组合，其允许同时获取被登记的无限制对象的位置和定向信息和功能图像，即集成的，使用图像处理软件来产生受试者的功能图像而不使用约束或麻醉。这样获得的功能图像可以与先前或随后获得的受试者的X射线CT图像对齐。本文描述的系统的使用允许受试者在无限制/非麻醉状态下进行功能成像，从而减少受试者的压力并消除对这种应激可能诱发的功能测试的任何潜在干扰。

9. 发明授权

US08295910B1 Imaging method for monitoring delivery of high dose rate brachytherapy 有权
标题翻译：用于监测高剂量率近距离放射治疗的成像方法
公开(公告)号：US08295910B1
公开(公告)日：2012-10-23
申请号：US11985680
申请日：2007-11-16
申请人： Andrew G. Weisenberger , Stanislaw Majewski
发明人： Andrew G. Weisenberger , Stanislaw Majewski
IPC分类号： A61B5/05
CPC分类号： A61B6/12 , A61B6/022 , A61B6/4258 , A61B6/482 , A61B6/5235 , A61N5/1015 , A61N2005/1052
摘要： A method for in-situ monitoring both the balloon/cavity and the radioactive source in brachytherapy treatment utilizing using at least one pair of miniature gamma cameras to acquire separate images of: 1) the radioactive source as it is moved in the tumor volume during brachytherapy; and 2) a relatively low intensity radiation source produced by either an injected radiopharmaceutical rendering cancerous tissue visible or from a radioactive solution filling a balloon surgically implanted into the cavity formed by the surgical resection of a tumor.
摘要翻译：一种使用至少一对微型γ照相机进行近距离放射治疗处理气囊/腔和放射源的现场监测方法，以获取单独的图像：1）放射源在近距离放射治疗期间在肿瘤体积中移动 ; 和2）由注射的放射性药物产生的相对低强度的辐射源，所述放射性药物使可见的癌组织或从外科手术植入通过手术切除肿瘤形成的腔中的放射性溶液的放射性溶液。

10. 发明申请

US20110089326A1 Positron emission tomography and optical tissue imaging 有权
标题翻译：正电子发射断层扫描和光学组织成像
公开(公告)号：US20110089326A1
公开(公告)日：2011-04-21
申请号：US12319649
申请日：2009-01-09
申请人： Steven W. Falen , Richard A. Hoefer , Stanislaw Majewski , John Mckisson , Brian Kross , James Proffitt , Alexander Stolin , Andrew G. Weisenberger
发明人： Steven W. Falen , Richard A. Hoefer , Stanislaw Majewski , John Mckisson , Brian Kross , James Proffitt , Alexander Stolin , Andrew G. Weisenberger
IPC分类号： G01T1/166
CPC分类号： G01T1/2985 , A61B6/037 , G01N23/046 , G01N2223/419 , G01T1/1603
摘要： A mobile compact imaging system that combines both of the imaging system of and optical imaging into a single system which can be located in the operating room (OR) and provides faster feedback to determine if a tumor has been fully resected and if there are adequate surgical margins. While final confirmation is obtained from the pathology lab, such a device can reduce the total time necessary for the procedure and the number of iterations required to achieve satisfactory resection of a tumor with good margins.
摘要翻译：一种移动式紧凑型成像系统，其将成像系统和光学成像系统结合到可以位于手术室（OR）中的单个系统中，并且提供更快的反馈以确定肿瘤是否已被完全切除，并且是否有足够的手术利润率虽然从病理实验室获得最终确认，但是这样的装置可以减少手术所需的总时间以及实现令人满意地切除具有良好边缘的肿瘤所需的迭代次数。

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