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    • 2. 发明授权
    • Anatomic and functional imaging of tagged molecules in animals
    • 动物中标记分子的解剖和功能成像
    • US07209579B1
    • 2007-04-24
    • US10341715
    • 2003-01-14
    • Andrew G. WeisenbergerStanislaw MajewskiMichael J. PaulusShaun S. Gleason
    • Andrew G. WeisenbergerStanislaw MajewskiMichael J. PaulusShaun S. Gleason
    • G06K9/00
    • A61B6/032A61B5/1077A61B5/1127A61B6/037A61B6/08A61B6/5235A61B6/5247A61B2503/40
    • A novel functional imaging system for use in the imaging of unrestrained and non-anesthetized small animals or other subjects and a method for acquiring such images and further registering them with anatomical X-ray images previously or subsequently acquired. The apparatus comprises a combination of an IR laser profilometry system and gamma, PET and/or SPECT, imaging system, all mounted on a rotating gantry, that permits simultaneous acquisition of positional and orientational information and functional images of an unrestrained subject that are registered, i.e. integrated, using image processing software to produce a functional image of the subject without the use of restraints or anesthesia. The functional image thus obtained can be registered with a previously or subsequently obtained X-ray CT image of the subject. The use of the system described herein permits functional imaging of a subject in an unrestrained/non-anesthetized condition thereby reducing the stress on the subject and eliminating any potential interference with the functional testing that such stress might induce.
    • 用于无限制和非麻醉的小动物或其他受试者的成像中的新型功能成像系统以及用于获取这些图像并进一步将它们与先前或随后获得的解剖X射线图像对准的方法。 该装置包括IR激光轮廓测量系统和全部安装在旋转台架上的伽马,PET和/或SPECT成像系统的组合,其允许同时获取被登记的无限制对象的位置和定向信息和功能图像, 即集成的,使用图像处理软件来产生受试者的功能图像而不使用约束或麻醉。 这样获得的功能图像可以与先前或随后获得的受试者的X射线CT图像对齐。 本文描述的系统的使用允许受试者在无限制/非麻醉状态下进行功能成像,从而减少受试者的压力并消除对这种应激可能诱发的功能测试的任何潜在干扰。
    • 3. 发明授权
    • Gamma-ray blind beta particle probe
    • 伽玛射线盲β粒子探针
    • US06317622B1
    • 2001-11-13
    • US09201178
    • 1998-11-30
    • Andrew G. Weisenberger
    • Andrew G. Weisenberger
    • A61B600
    • A61B6/4057A61B6/425A61B6/4258G01T1/161
    • An intra-operative beta particle probe is provided by placing a suitable photomultiplier tube (PMT), micro channel plate (MCP) or other electron multiplier device within a vacuum housing equipped with: 1) an appropriate beta particle permeable window; and 2) electron detection circuitry. Beta particles emitted in the immediate vicinity of the probe window will be received by the electron multiplier device and amplified to produce a detectable signal. Such a device is useful as a gamma insensitive, intra-operative, beta particle probe in surgeries where the patient has been injected with a beta emitting radiopharmaceutical. The method of use of such a device is also described, as is a position sensitive such device.
    • 通过将合适的光电倍增管(PMT),微通道板(MCP)或其他电子倍增器装置放置在配备有:1)适当的β粒子可渗透窗口的真空壳体内来提供术中β粒子探针。 和2)电子检测电路。 在探针窗口附近发射的β粒子将被电子倍增器装置接收并被放大以产生可检测的信号。 这种装置可用作手术中伽马不敏感,术中,β粒子探针,其中患者已经注射了β发射放射性药物。 还描述了使用这种装置的方法,以及对这种装置的位置敏感。
    • 7. 发明授权
    • Optical coupler
    • 光耦合器
    • US06750456B1
    • 2004-06-15
    • US09577701
    • 2000-05-23
    • Stanislaw MajewskiAndrew G. Weisenberger
    • Stanislaw MajewskiAndrew G. Weisenberger
    • G01T120
    • G01T1/2002G01T1/1644
    • In a camera or similar radiation sensitive device comprising a pixilated scintillation layer, a light guide and an array of position sensitive photomultiplier tubes, wherein there exists so-called dead space between adjacent photomultiplier tubes the improvement comprising a two part light guide comprising a first planar light spreading layer or portion having a first surface that addresses the scintillation layer and optically coupled thereto at a second surface that addresses the photomultiplier tubes, a second layer or portion comprising an array of trapezoidal light collectors defining gaps that span said dead space and are individually optically coupled to individual position sensitive photomultiplier tubes. According to a preferred embodiment, coupling of the trapezoidal light collectors to the position sensitive photomultiplier tubes is accomplished using an optical grease having about the same refractive index as the material of construction of the two part light guide.
    • 在包括像素化闪烁层,光导和位置敏感光电倍增管阵列的相机或类似的辐射敏感设备中,其中在相邻光电倍增管之间存在所谓的死空间,其改进包括两部分光导,包括第一平面 光扩散层或具有第一表面的部分,其处理闪烁层并在寻址光电倍增管的第二表面处光学耦合到其上;第二层或部分包括限定跨越所述死空间的间隙的梯形光收集器阵列,并且分别 光学耦合到单独的位置敏感光电倍增管。 根据优选实施例,使用具有与两部分光导的结构材料大致相同的折射率的光学润滑脂来实现梯形光收集器与位置敏感光电倍增管的耦合。