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1. 发明授权

US09564650B2 Methods for continuous direct carbon fuel cell operation with a circulating electrolyte slurry 有权
标题翻译：用循环电解质浆料连续直接燃料电池操作的方法
公开(公告)号：US09564650B2
公开(公告)日：2017-02-07
申请号：US13565376
申请日：2012-08-02
申请人： Daniel I. Harjes , D. Andrew Dineen, Jr. , Liang Guo , Joseph M. Calo , Valerie J. Bloomfield
发明人： Daniel I. Harjes , D. Andrew Dineen, Jr. , Liang Guo , Joseph M. Calo , Valerie J. Bloomfield
IPC分类号： H01M2/38 , H01M8/06 , H01M8/12 , H01M8/14 , H01M8/22 , H01M8/04
CPC分类号： H01M8/0668 , H01M8/04276 , H01M8/04291 , H01M8/0432 , H01M8/04388 , H01M8/04447 , H01M8/04619 , H01M8/04753 , H01M8/04761 , H01M8/0693 , H01M8/1233 , H01M8/143 , H01M8/145 , H01M8/146 , H01M8/225 , H01M2008/1293 , Y02E60/521 , Y02E60/525 , Y02E60/526
摘要： The present invention relates to methods and systems related to fuel cells, and in particular, to direct carbon fuel cells. The methods and systems relate to cleaning and removal of components utilized and produced during operation of the fuel cell, regeneration of components utilized during operation of the fuel cell, and generating power using the fuel cell.
摘要翻译：本发明涉及与燃料电池相关的方法和系统，特别涉及直接碳燃料电池。所述方法和系统涉及在燃料电池运行期间使用和产生的部件的清洁和去除，燃料电池运行期间使用的组件的再生以及使用燃料电池的发电。

2. 发明申请

US20130196238A1 METHODS FOR CONTINUOUS DIRECT CARBON FUEL CELL OPERATION WITH A CIRCULATING ELECTROLYTE SLURRY 有权
标题翻译：用循环电解质浆液连续直接燃料电池操作的方法
公开(公告)号：US20130196238A1
公开(公告)日：2013-08-01
申请号：US13565376
申请日：2012-08-02
申请人： Daniel I. Harjes , D. Andrew Dineen, JR. , Liang Guo , Joseph M. Calo , Valerie J. Bloomfield
发明人： Daniel I. Harjes , D. Andrew Dineen, JR. , Liang Guo , Joseph M. Calo , Valerie J. Bloomfield
IPC分类号： H01M8/06
CPC分类号： H01M8/0668 , H01M8/04276 , H01M8/04291 , H01M8/0432 , H01M8/04388 , H01M8/04447 , H01M8/04619 , H01M8/04753 , H01M8/04761 , H01M8/0693 , H01M8/1233 , H01M8/143 , H01M8/145 , H01M8/146 , H01M8/225 , H01M2008/1293 , Y02E60/521 , Y02E60/525 , Y02E60/526
摘要： The present invention relates to methods and systems related to fuel cells, and in particular, to direct carbon fuel cells. The methods and systems relate to cleaning and removal of components utilized and produced during operation of the fuel cell, regeneration of components utilized during operation of the fuel cell, and generating power using the fuel cell.
摘要翻译：本发明涉及与燃料电池相关的方法和系统，特别涉及直接碳燃料电池。所述方法和系统涉及在燃料电池运行期间使用和产生的部件的清洁和去除，燃料电池运行期间使用的组件的再生以及使用燃料电池的发电。

3. 发明授权

US08114662B2 Ion-selective quantum dots 有权
标题翻译：离子选择量子点
公开(公告)号：US08114662B2
公开(公告)日：2012-02-14
申请号：US11888663
申请日：2007-07-31
申请人： Heather A. Clark , Daniel I. Harjes , John M. Dubach
发明人： Heather A. Clark , Daniel I. Harjes , John M. Dubach
IPC分类号： G01N33/53 , C12M1/34 , B82B3/00 , C12Q1/02 , C12Q1/20
CPC分类号： G01N33/588 , B82Y5/00 , B82Y15/00 , G01N33/5005 , G01N33/54313 , G01N33/6872 , G01N33/84 , G01N2333/726 , Y10S977/774
摘要： The invention provides ion-selective sensors comprising quantum dots capable of selectively measuring ions, e.g., Na+, K+, Cl−, etc., in various environments, including in the cytosol of a living cell. Quantum dots are attractive probes for microscopy due to their photophysical advantages over fluorescent dyes, including prolonged photostability, brightness and quantum efficiency. In certain embodiments, a sensor comprises one or more quantum dots, a pH-sensitive dye, and optionally an ion-selective component such as an ionophore. These elements may, for example, be disposed in a polymer matrix. In certain embodiments, the sensors may detect ionic analytes by selective ion extraction by the polymer, thereby inducing a pH change within the sensor which in turn changes the absorbance of the pH-sensitive dye. The change of absorbance may in turn attenuate the intensity of detectable emissions, e.g., fluorescence, from the quantum dot by directly absorbing its fluorescence emission.
摘要翻译：本发明提供了离子选择性传感器，其包括量子点，其能够选择性地测量各种环境中的离子，例如Na +，K +，Cl-等，包括在活细胞的胞质溶胶中。量子点是显微镜的有吸引力的探针，因为它们比荧光染料的光物理优点，包括延长的光稳定性，亮度和量子效率。在某些实施方案中，传感器包括一个或多个量子点，pH敏感染料和任选的离子选择性组分，例如离子载体。这些元素可以例如被设置在聚合物基质中。在某些实施方案中，传感器可以通过聚合物的选择性离子提取来检测离子分析物，从而在传感器内引起pH变化，从而改变pH敏感染料的吸光度。吸光度的变化可以通过直接吸收其荧光发射来衰减来自量子点的可检测发射强度，例如荧光强度。

4. 发明申请

US20090142274A1 Intracellular nanosensors and methods for their introduction into cells 有权
标题翻译：细胞内纳米传感器及其引入细胞的方法
公开(公告)号：US20090142274A1
公开(公告)日：2009-06-04
申请号：US12287937
申请日：2008-10-14
申请人： Heather A. Clark , Daniel I. Harjes , John M. Dubach
发明人： Heather A. Clark , Daniel I. Harjes , John M. Dubach
IPC分类号： A61K49/00 , C12Q1/02 , C12M1/00 , G01N33/53
CPC分类号： G01N33/588 , B82Y5/00 , B82Y15/00 , G01N21/6458 , G01N27/3335 , G01N2021/6439
摘要： The invention provides ion-selective sensors capable of selectively measuring ions, e.g., Na+, K+, Cl−, etc., in the cytosol of a single living cell. The sensor comprises one or more quantum dots or a fluorescent dye, a pH-sensitive dye, and optionally an ion-selective component such as an ionophore. These elements may, for example, be disposed in a polymer matrix. The polymer matrix comprises an internalizing moiety which enables the sensor to localize within the cytosol of a cell. The internalizing moiety comprises a small molecule or peptide such as an amine, antepennepedia, mastoparan, or melittin that react under acidic conditions to release a sensor from the confines of a endosome. Once in the cytosol the sensors may detect ionic analytes by selective ion extraction by the polymer, thereby inducing a pH change within the sensor which in turn changes the absorbance of the pH-sensitive dye. The change of absorbance may in turn attenuate the intensity of detectable emissions, e.g., fluorescence, from the quantum dot or dye by directly absorbing its fluorescence emission.
摘要翻译：本发明提供能够选择性地测量单个活细胞的胞质溶胶中的离子，例如Na +，K +，Cl-等的离子选择性传感器。传感器包括一个或多个量子点或荧光染料，pH敏感染料和任选的离子选择性组分如离子载体。这些元素可以例如被设置在聚合物基质中。聚合物基质包括使得传感器能够定位在细胞的胞质溶胶内的内化部分。内化部分包含在酸性条件下反应以从内体的范围释放传感器的小分子或肽，例如胺，对映体，mastoparan或蜂毒素。一旦在细胞溶质中，传感器可以通过聚合物的选择性离子提取来检测离子分析物，从而在传感器内引起pH变化，从而改变pH敏感染料的吸光度。吸光度的变化可以通过直接吸收其荧光发射来衰减来自量子点或染料的可检测发射强度，例如荧光强度。

5. 发明授权

US08859225B2 Systems and methods of voltage-gated ion channel assays 有权
标题翻译：电压门控离子通道测定的系统和方法
公开(公告)号：US08859225B2
公开(公告)日：2014-10-14
申请号：US12579983
申请日：2009-10-15
申请人： Daniel I. Harjes , Heather A. Clark
发明人： Daniel I. Harjes , Heather A. Clark
IPC分类号： C12Q1/02 , C12Q1/04 , C12Q1/00 , C12N5/00 , C12N5/02 , C12Q1/18 , G01N21/80 , G01N33/84 , C12N13/00 , G01N21/64 , C12Q1/54 , G01N33/567 , G01N33/53
CPC分类号： G01N21/6428 , C12N13/00 , G01N21/6452 , G01N21/80 , G01N33/84 , Y10S435/808
摘要： Systems and methods are provided for optically measuring ion concentrations in biological samples. The systems and methods employ polymer-based optical ion sensors that include ion-selective ionophores and a pH sensitive chromionophore. Electrodes are providing for electrically stimulating the biological samples.
摘要翻译：提供了用于光学测量生物样品中离子浓度的系统和方法。该系统和方法采用基于聚合物的光离子传感器，其包括离子选择离子载体和pH敏感的发色团。电极提供电刺激生物样品。

6. 发明申请

US20100328001A1 Switchable Permanent Magnet and Related Methods 有权
标题翻译：可切换永磁体及相关方法
公开(公告)号：US20100328001A1
公开(公告)日：2010-12-30
申请号：US12797217
申请日：2010-06-09
申请人： Daniel I. Harjes
发明人： Daniel I. Harjes
IPC分类号： H01F7/04
CPC分类号： H01F7/0257 , H01F7/04
摘要： A mechanical linkage exerts a mechanical force on a permanent magnet to substantially counterbalance the magnetic force attracting the permanent magnet to a ferrous target surface.
摘要翻译：机械连杆在永久磁铁上施加机械力，以将吸附永磁体的磁力基本上平衡到亚铁目标表面。

7. 发明申请

US20100105075A1 SYSTEMS AND METHODS OF VOLTAGE-GATED ION CHANNEL ASSAYS 有权
标题翻译：电压离子通道测定系统及方法
公开(公告)号：US20100105075A1
公开(公告)日：2010-04-29
申请号：US12579983
申请日：2009-10-15
申请人： Daniel I. Harjes , Heather A. Clark
发明人： Daniel I. Harjes , Heather A. Clark
IPC分类号： C12Q1/02
CPC分类号： G01N21/6428 , C12N13/00 , G01N21/6452 , G01N21/80 , G01N33/84 , Y10S435/808
摘要： Systems and methods are provided for optically measuring ion concentrations in biological samples. The systems and methods employ polymer-based optical ion sensors that include ion-selective ionophores and a pH sensitive chromionophore. Electrodes are providing for electrically stimulating the biological samples.
摘要翻译：提供了用于光学测量生物样品中离子浓度的系统和方法。该系统和方法采用基于聚合物的光离子传感器，其包括离子选择离子载体和pH敏感的发色团。电极提供电刺激生物样品。

8. 发明授权

US08263358B2 Intracellular nanosensors and methods for their introduction into cells 有权
标题翻译：细胞内纳米传感器及其引入细胞的方法
公开(公告)号：US08263358B2
公开(公告)日：2012-09-11
申请号：US12287937
申请日：2008-10-14
申请人： Heather A. Clark , Daniel I. Harjes , John M. Dubach
发明人： Heather A. Clark , Daniel I. Harjes , John M. Dubach
IPC分类号： C12Q1/02 , C12M1/00 , G01N33/53 , G01N33/52 , A61K49/00 , B82B3/00
CPC分类号： G01N33/588 , B82Y5/00 , B82Y15/00 , G01N21/6458 , G01N27/3335 , G01N2021/6439
摘要： The invention provides ion-selective sensors capable of selectively measuring ions, e.g., Na+, K+, Cl−, etc., in the cytosol of a single living cell. The sensor comprises one or more quantum dots or a fluorescent dye, a pH-sensitive dye, and optionally an ion-selective component such as an ionophore. These elements may, for example, be disposed in a polymer matrix. The polymer matrix comprises an internalizing moiety which enables the sensor to localize within the cytosol of a cell. The internalizing moiety comprises a small molecule or peptide such as an amine, antepennepedia, mastoparan, or melittin that react under acidic conditions to release a sensor from the confines of a endosome. Once in the cytosol the sensors may detect ionic analytes by selective ion extraction by the polymer, thereby inducing a pH change within the sensor which in turn changes the absorbance of the pH-sensitive dye. The change of absorbance may in turn attenuate the intensity of detectable emissions, e.g., fluorescence, from the quantum dot or dye by directly absorbing its fluorescence emission.
摘要翻译：本发明提供能够选择性地测量单个活细胞的胞质溶胶中的离子，例如Na +，K +，Cl-等的离子选择性传感器。传感器包括一个或多个量子点或荧光染料，pH敏感染料和任选的离子选择性组分如离子载体。这些元素可以例如被设置在聚合物基质中。聚合物基质包括使得传感器能够定位在细胞的胞质溶胶内的内化部分。内化部分包含在酸性条件下反应以从内体的范围释放传感器的小分子或肽，例如胺，对映体，mastoparan或蜂毒素。一旦在细胞溶质中，传感器可以通过聚合物的选择性离子提取来检测离子分析物，从而在传感器内引起pH变化，从而改变pH敏感染料的吸光度。吸光度的变化可以通过直接吸收其荧光发射来衰减来自量子点或染料的可检测发射强度，例如荧光强度。

9. 发明申请

US20100176006A1 THREE-DIMENSIONAL METAL ION SENSOR ARRAYS ON PRINTED CIRCUIT BOARDS 有权
标题翻译：印刷电路板上的三维金属离子传感器阵列
公开(公告)号：US20100176006A1
公开(公告)日：2010-07-15
申请号：US12541454
申请日：2009-08-14
申请人： James A. Bickford , John R. Williams , Daniel I. Harjes , Andrew Reiter
发明人： James A. Bickford , John R. Williams , Daniel I. Harjes , Andrew Reiter
IPC分类号： G01N27/26 , B32B37/00
CPC分类号： G01N27/3335 , G01N27/333 , Y10T156/10
摘要： An electronic device includes a substrate and a plurality of sensors. Each sensor is disposed in a well over the substrate and includes a working electrode, an inner filling solution disposed thereover, and an ion-selective membrane. The working electrode is in contact with the substrate and the ion-selective membrane is disposed over the inner filling solution and substantially seals the well.
摘要翻译：电子设备包括基板和多个传感器。每个传感器设置在衬底上的井中，并且包括工作电极，设置在其上的内部填充溶液和离子选择性膜。工作电极与衬底接触，并且离子选择膜设置在内部填充溶液上并基本上密封阱。

10. 发明申请

US20080044879A1 Systems and methods of voltage-gated ion channel assays 审中-公开
标题翻译：电压门控离子通道测定的系统和方法
公开(公告)号：US20080044879A1
公开(公告)日：2008-02-21
申请号：US11507956
申请日：2006-08-22
申请人： Daniel I. Harjes , Heather A. Clark
发明人： Daniel I. Harjes , Heather A. Clark
IPC分类号： C12N13/00
CPC分类号： G01N21/6428 , C12N13/00 , G01N21/6452 , G01N21/80 , G01N33/84 , Y10S435/808
摘要： Systems and methods are provided for optically measuring ion concentrations in biological samples. The systems and methods employ polymer-based optical ion sensors that include ion-selective ionophores and a pH sensitive chromionophore. Electrodes are providing for electrically stimulating the biological samples.
摘要翻译：提供了用于光学测量生物样品中离子浓度的系统和方法。该系统和方法采用基于聚合物的光离子传感器，其包括离子选择离子载体和pH敏感的发色团。电极提供电刺激生物样品。

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