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1. 发明申请

US20160158330A1 METHODS OF PREPARATION AND COMPOSITION OF PEPTIDE CONSTRUCTS USEFUL FOR TREATMENT OF RHEUMATOID ARTHRITIS 审中-公开
标题翻译：用于治疗恶病质性肾炎的肽制剂的制备方法和组合物
公开(公告)号：US20160158330A1
公开(公告)日：2016-06-09
申请号：US14907520
申请日：2014-04-28
申请人： Daniel H. ZIMMERMAN , Roy CARAMBULA , Harold STEINER , Eyal TALOR , Tibor GLANT , Katalin MIKECZ , CEL-SCI CORPORATION
发明人： Daniel H. Zimmerman , Roy Carambula , Harold Steiner , Eyal Talor , Tibor Glant , Katalin Mikecz
IPC分类号： A61K39/00 , C07K7/08 , C12N5/0784 , C07K14/47
CPC分类号： A61K39/0008 , A61K2039/5154 , A61K2039/6031 , A61K2039/64 , C07K7/08 , C07K14/47 , C07K14/4713
摘要： The invention is related to peptide constructs, i.e., polypeptides obtained by linking together two or more peptides based on or derived from different molecules, which are useful in the treatment or prevention of autoimmune diseases, specifically rheumatoid arthritis (RA) and compositions containing same, methods for producing same and methods for using same; wherein the peptide constructs have the formula P1-x-P2 where P1 is a peptide associated with autoimmune disease such as rheumatoid arthritis myocarditis, diabetes, and immune-mediated disease, which binds to an antigen receptor on a set or subset of T cells; P2 is a peptide which will cause a Th2 directed immune response by the set or subset of T cells to which the peptide P1 is attached or which will bind to a T cell receptor which will cause the set or subset of T cells to which the peptide P1 is attached to initiate, but not complete, an immune response causing the set or subset of T cells to undergo immunomodulation including but not restricted to anergy and apoptosis; and x is a direct bond or linker for covalently bonding P1 and P2. Whereas said treatment being of the individual itself or of ex vivo treatment of isolated DC and or with further labeling with drug, dye or radioisotope and administration back into the patient of the activated and possibly modified DCs for detection, identification, localization and treatment thereof.
摘要翻译：本发明涉及肽构建体，即通过将两种或更多种基于或衍生自不同分子的肽连接在一起而获得的多肽，其可用于治疗或预防自身免疫疾病，特别是类风湿性关节炎（RA）和含有它们的组合物，生产方法及使用方法; 其中所述肽构建体具有式P1-x-P2，其中P1是与自身免疫疾病例如类风湿性关节炎心肌炎，糖尿病和免疫介导的疾病相关的肽，其结合T细胞的集合或亚群上的抗原受体; P2是通过肽P1所连接的T细胞的集合或子集引起Th2定向免疫应答的肽，或者将与T细胞受体结合，所述T细胞受体将导致肽 P1附着以引发但不完全的引起T细胞的集合或亚群进行免疫调节的免疫应答，包括但不限于无反应和凋亡; x是用于共价键合P1和P2的直接键或连接体。而所述治疗是个体本身或离体DC的离体处理，或者用药物，染料或放射性同位素进一步标记，并且向患者施用活化和可能改性的DC用于其检测，鉴定，定位和治疗。

2. 发明授权

US10179164B2 Method for inducing an immune response for treatment of cancer and autoimmune diseases or conditions 有权
公开(公告)号：US10179164B2
公开(公告)日：2019-01-15
申请号：US14122240
申请日：2012-05-24
申请人： Daniel H. Zimmerman , Eyal Talor , Kenneth Rosenthal
发明人： Daniel H. Zimmerman , Eyal Talor , Kenneth Rosenthal
IPC分类号： A61K38/00 , A61K39/00 , A61K38/16 , A61K35/12 , A61K51/02 , A61K47/64 , A61K47/68 , A61K47/69
摘要： The invention is related to peptide constructs, i.e., polypeptides obtained by linking together two or more peptides based on or derived from different molecules, which are useful in the treatment or prevention of cancer or the treatment of autoimmune diseases and compositions containing same, methods for producing same, and methods for using same; wherein the peptide constructs have the formula P1-x-P2 where P2 is a peptide associated with forms of cancer or an autoimmune condition and P1 is a peptide which will bind to a class of immune cells such as dendritic cells. The peptide construct can cause the maturation of immature dendritic cells to a more mature state. The peptide construct or the more mature dendritic cells can be administered to a subject to a modulate or to initiate an immune response against cancer cells, and can be used with dyes, radioisotopes, or therapeutic agents for detection of the immune target and/or treatment of cancer and autoimmune conditions.

3. 发明授权

US10179174B2 Method for inducing an immune response and formulations thereof 有权
公开(公告)号：US10179174B2
公开(公告)日：2019-01-15
申请号：US14122238
申请日：2012-05-24
申请人： Daniel H. Zimmerman , Eyal Talor , Kanta Subbarao , Kobporn Boonnak
发明人： Daniel H. Zimmerman , Eyal Talor , Kanta Subbarao , Kobporn Boonnak
IPC分类号： A61K39/00 , A61K39/395 , A61K39/145 , A61K39/385 , A61K38/00 , A61K47/48 , A61K39/12 , C07K14/005 , A61K47/65 , A61K47/64 , A61K47/68
摘要： The invention is related to peptide constructs, i.e., polypeptides obtained by linking together two or more peptides based on or derived from different molecules, which are useful in the treatment or prevention of influenza virus and other infectious diseases. Compositions containing the same, methods for producing the same, and methods for using the same are also disclosed, wherein the peptide constructs have the formula P1-x-P2, where P2 is a peptide associated with an infectious agent and P1 is a peptide that will bind to a class of immune cells, such as dendritic cells. The peptide construct can cause the maturation of immature dendritic cells to a more mature state. The peptide construct or the more mature dendritic cell can be administered to a subject to modulate or initiate an immune response against an infectious agent. Dyes, radioisotopes, or therapeutic agents conjugated with the dendritic cells can be used for localization of the immune target and/or prophylactic or therapeutic treatment of the disease.

4. 发明申请

US20210268101A1 NOVEL PEPTIDES FOR VACCINATION AND TREATMENT OF 2019-nCoV INFECTIONS 有权
公开(公告)号：US20210268101A1
公开(公告)日：2021-09-02
申请号：US17148266
申请日：2021-01-13
申请人： Cel-Sci Corporation
发明人： Daniel H. Zimmerman
IPC分类号： A61K39/215
摘要： The invention relates to novel peptide immunoconjugates for treatment, prevention, and diagnosis of coronaviral infections in animals and humans. The immunoconjugates can be used alone or in conjunction with vaccine adjuvants, immune system cells, or other immunomodulators.

5. 发明申请

US20150140065A1 METHOD FOR INDUCING AN IMMUNE RESPONSE AND FORMULATIONS THEREOF 审中-公开
标题翻译：诱导免疫应答的方法及其制剂
公开(公告)号：US20150140065A1
公开(公告)日：2015-05-21
申请号：US14122238
申请日：2012-05-24
申请人： CEL-SCI CORPORATION
发明人： Daniel H. Zimmerman , Eyal Talor , Kanta Subbarao , Kobporn Boonnak
IPC分类号： A61K47/48 , A61K39/00 , C07K14/005
CPC分类号： C07K14/005 , A61K39/0005 , A61K39/12 , A61K47/646 , A61K47/65 , A61K47/68 , A61K2039/5154 , A61K2039/5158 , A61K2039/6031 , A61K2039/645 , C12N2760/16134 , Y02A50/401
摘要： The invention is related to peptide constructs, i.e., polypeptides obtained by linking together two or more peptides based on or derived from different molecules, which are useful in the treatment or prevention of influenza virus and other infectious diseases. Compositions containing the same, methods for producing the same, and methods for using the same are also disclosed, wherein the peptide constructs have the formula P1-x-P2, where P2 is a peptide associated with an infectious agent and P1 is a peptide that will bind to a class of immune cells, such as dendritic cells. The peptide construct can cause the maturation of immature dendritic cells to a more mature state. The peptide construct or the more mature dendritic cell can be administered to a subject to modulate or initiate an immune response against an infectious agent. Dyes, radioisotopes, or therapeutic agents conjugated with the dendritic cells can be used for localization of the immune target and/or prophylactic or therapeutic treatment of the disease.
摘要翻译：本发明涉及肽构建体，即通过将两种或更多种基于或衍生自不同分子的肽连接在一起的多肽，其可用于治疗或预防流感病毒和其它感染性疾病。还公开了含有其的组合物，其制备方法及其使用方法，其中肽构建体具有式P1-x-P2，其中P2是与感染剂相关的肽，P1是肽将结合一类免疫细胞，如树突状细胞。肽结构可导致未成熟树突状细胞的成熟进入更成熟的状态。可以将肽构建体或更成熟的树突状细胞施用于受试者以调节或引发针对感染因子的免疫应答。与树突状细胞缀合的染料，放射性同位素或治疗剂可用于免疫靶的定位和/或疾病的预防或治疗性治疗。

6. 发明申请

US20140286858A1 METHOD FOR INDUCING AN IMMUNE RESPONSE FOR TREATMENT OF CANCER AND AUTOIMMUNE DISEASES OR CONDITIONS 审中-公开
标题翻译：诱导免疫反应治疗癌症和自身免疫性疾病或病症的方法
公开(公告)号：US20140286858A1
公开(公告)日：2014-09-25
申请号：US14122240
申请日：2012-05-24
申请人： CEL-SCI CORPORATION
发明人： Daniel H. Zimmerman , Eyal Talor , Kenneth Steven Rosenthal
IPC分类号： A61K47/48 , A61K51/02 , A61K39/00
CPC分类号： A61K39/00 , A61K35/12 , A61K38/162 , A61K39/0008 , A61K39/0011 , A61K47/646 , A61K47/68 , A61K47/6901 , A61K51/02 , A61K2039/5154
摘要： The invention is related to peptide constracts, i.e., polypeptides obtained by linking together two or more peptides based on or derived from different molecules, which are useful in the treatment or prevention of cancer or the treatment of autoimmune diseases and compositions containing same, methods for producing same, and methods for using same: wherein the peptide constructs have the formula P1-x-P2 where P2 is a peptide associated with forms of cancer or an autoimmune condition and P1 is a peptide which will bind to a class of immune cells such as dendritic cells. The peptide construct can cause the maturation of immature dendritic cells to a more mature state. The peptide construct or the more mature dendritic cells can be administered to a subject to a modulate or to initiate an immune response against cancer cells, and can be sued with dyes, radioisotopes, or therapeutic agents for detection of the immune target and/or treatment of cancer and autoimmune conditions.
摘要翻译：本发明涉及肽结构，即通过将两种或更多种基于或衍生自不同分子的肽连接在一起而获得的多肽，其可用于治疗或预防癌症或治疗自身免疫性疾病和含有其的组合物，方法制备其的方法及其使用方法：其中肽构建体具有式P1-x-P2，其中P2是与癌症形式或自身免疫病症相关的肽，P1是将结合一类免疫细胞的肽作为树突细胞。肽结构可导致未成熟树突状细胞的成熟进入更成熟的状态。肽构建体或更成熟的树突细胞可以施用于受试者以调节或引发针对癌细胞的免疫应答，并且可以用染料，放射性同位素或治疗剂起诉用于检测免疫靶和/或治疗的癌症和自身免疫病症。

7. 发明授权

US11041013B2 Methods of preparation and composition of peptide constructs useful for treatment of rheumatoid arthritis 有权
公开(公告)号：US11041013B2
公开(公告)日：2021-06-22
申请号：US12922687
申请日：2009-03-16
申请人： Daniel H. Zimmerman
发明人： Daniel H. Zimmerman
IPC分类号： A61K39/008 , C07K14/705 , A61K39/00 , A61K38/00 , A61K35/12
摘要： The invention is related to peptide constructs, i.e., polypeptides obtained by linking together two or more peptides based on or derived from different molecules, which are useful in the treatment or prevention of autoimmune diseases, specifically rheumatoid arthritis (RA) and compositions containing same, methods for producing same and methods for using same; wherein the peptide constructs have the formula P1-x-P2 where P1 is a peptide associated with autoimmune disease, allergy, asthma, host-versus-graft rejection, myocarditis, diabetes, and immune-mediated disease, which binds to an antigen receptor on a set or subset of T cells; P2 is a peptide which will cause a Th2 directed immune response by the set or subset of T cells to which the peptide P1 is attached or which will bind to a T cell receptor which will cause the set or subset of T cells to which the peptide P1 is attached to initiate, but not complete, an immune response causing the set or subset of T cells to undergo anergy and apoptosis; and x is a direct bond or linker for covalently bonding P1 and P2.

8. 发明授权

US06995237B1 Preparation and composition of peptides useful for treatment of autoimmune and transplant related graft versus host conditions 有权
标题翻译：用于治疗自身免疫和移植相关移植物与宿主条件的肽的制备和组合物
公开(公告)号：US06995237B1
公开(公告)日：2006-02-07
申请号：US10111645
申请日：2000-10-27
申请人： Daniel H. Zimmerman
发明人： Daniel H. Zimmerman
IPC分类号： A61K39/00 , C07K14/435
CPC分类号： C07K14/4713 , A61K39/0008 , A61K39/35 , A61K39/36 , C07K5/1008 , C07K14/435 , C07K2319/33 , C07K2319/40 , C07K2319/74
摘要： Peptide constructs including a first peptide segment which includes an amino acid sequence associated with autoimmune disease, asthma, allergy or xeno- or allograft transplantation rejections bonded directly or via a linker or spacer to a second peptide which binds to T cells and which will redirect the immune response from a harmful Th1 response to a less harmful Th2 response, or which will bind to T cells to initiate, but not complete, an immune response causing the T cells to which the first peptide binds, to undergo anergy and apoptosis, are useful in treating autoimmune conditions. For instance, the peptide construct NGQEEKAGVVSTGLIGGGDSAFDVLSFTAEEKAGVYK (SEQ ID NO:14) wherein Th2 stimulating Peptide G (SEQ ID NO:15) is covalently linked, via spacer GGG, to cardiac myosin molecule My1 (SEQ ID NO:16), can be used for treatment or prevention of myocarditis.
摘要翻译：包括第一肽段的肽构建体，其包括与自身免疫性疾病，哮喘，变态反应或异种或同种异体移植排斥相关的氨基酸序列，其直接或通过接头或间隔基键合至与T细胞结合的第二肽，并且将重定向有害的Th1应答对不太有害的Th2应答的免疫应答，或与T细胞结合以引发但不完全的引起第一个肽所结合的T细胞的免疫应答进行无反应和凋亡的免疫应答是有用的在治疗自身免疫性疾病。例如，可以使用其中Th2刺激肽G（SEQ ID NO：15）通过间隔基GGG共价连接到心肌肌球蛋白分子My1（SEQ ID NO：16）的肽构建体NGQEEKAGVVSTGLIGGGDSAFDVLSFTAEEKAGVYK（SEQ ID NO：14）用于治疗或预防心肌炎。

9. 发明授权

US10238747B2 Method for inducing an immune response against avian, swine, spanish, H1N1, H5N9 influenza viruses and formulations thereof 有权
公开(公告)号：US10238747B2
公开(公告)日：2019-03-26
申请号：US13994092
申请日：2011-12-13
申请人： Daniel H. Zimmerman
发明人： Daniel H. Zimmerman
IPC分类号： A61K47/48 , A61K39/12 , A61K39/145 , A61K45/06 , A61K47/64 , A61K39/00
摘要： A vaccine for immunization against Type A influenza virus is provided having an immunologically effective amount of peptide constructs obtained by linking together two or more peptides based on or derived from different molecules, and methods for producing the same. The peptide constructs have the formula P1-x-P2 or P2-x-P1 where P1 is associated with Type A influenza highly conserved protein such as but not limited to M2e matrix protein, NP1 nucleoprotein, HA2 core 1, and HA2 core 2, where P2 is a peptide construct causing a Th1 directed immune response by a set or subset of T cells to which the peptide P1 is attached or that binds to a dendritic cell or T cell receptor causing said set or subset of dendritic cell or T cells to which the peptide P1 is attached to initiate and complete, an immune response, and x is a direct bond or divalent linker for covalently bonding P1 and P2.

10. 发明申请

US20110098444A1 METHODS OF PREPARATION AND COMPOSITION OF PEPTIDE CONSTRUCTS USEFUL FOR TREATMENT OF RHEUMATOID ARTHRITIS 审中-公开
标题翻译：用于治疗恶病质性肾炎的肽制剂的制备方法和组合物
公开(公告)号：US20110098444A1
公开(公告)日：2011-04-28
申请号：US12922687
申请日：2009-03-16
申请人： Daniel H. Zimmerman
发明人： Daniel H. Zimmerman
IPC分类号： C07K19/00 , C07K7/08
CPC分类号： C07K14/7055 , A61K38/00
摘要： The invention is related to peptide constructs, i.e., polypeptides obtained by linking together two or more peptides based on or derived from different molecules, which are useful in the treatment or prevention of autoimmune diseases, specifically rheumatoid arthritis (RA) and compositions containing same, methods for producing same and methods for using same; wherein the peptide constructs have the formula P1-x-P2 where P1 is a peptide associated with autoimmune disease, allergy, asthma, host-versus-graft rejection, myocarditis, diabetes, and immune-mediated disease, which binds to an antigen receptor on a set or subset of T cells; P2 is a peptide which will cause a Th2 directed immune response by the set or subset of T cells to which the peptide P1 is attached or which will bind to a T cell receptor which will cause the set or subset of T cells to which the peptide P1 is attached to initiate, but not complete, an immune response causing the set or subset of T cells to undergo anergy and apoptosis; and x is a direct bond or linker for covalently bonding P1 and P2.
摘要翻译：本发明涉及肽构建体，即通过将两种或更多种基于或衍生自不同分子的肽连接在一起而获得的多肽，其可用于治疗或预防自身免疫疾病，特别是类风湿性关节炎（RA）和含有它们的组合物，生产方法及使用方法; 其中所述肽构建体具有式P1-x-P2，其中P1是与自身免疫疾病，过敏，哮喘，宿主对移植物排斥，心肌炎，糖尿病和免疫介导的疾病相关的肽，其结合抗原受体 T细胞的集合或子集; P2是通过肽P1所连接的T细胞的集合或子集引起Th2定向免疫应答的肽，或者将与T细胞受体结合，所述T细胞受体将导致肽 P1连接以引发但不完全的导致T细胞的集合或亚群进行无反应和凋亡的免疫应答; x是用于共价键合P1和P2的直接键或连接体。

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