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2. 发明申请

US20160158330A1 METHODS OF PREPARATION AND COMPOSITION OF PEPTIDE CONSTRUCTS USEFUL FOR TREATMENT OF RHEUMATOID ARTHRITIS 审中-公开
标题翻译：用于治疗恶病质性肾炎的肽制剂的制备方法和组合物
公开(公告)号：US20160158330A1
公开(公告)日：2016-06-09
申请号：US14907520
申请日：2014-04-28
申请人： Daniel H. ZIMMERMAN , Roy CARAMBULA , Harold STEINER , Eyal TALOR , Tibor GLANT , Katalin MIKECZ , CEL-SCI CORPORATION
发明人： Daniel H. Zimmerman , Roy Carambula , Harold Steiner , Eyal Talor , Tibor Glant , Katalin Mikecz
IPC分类号： A61K39/00 , C07K7/08 , C12N5/0784 , C07K14/47
CPC分类号： A61K39/0008 , A61K2039/5154 , A61K2039/6031 , A61K2039/64 , C07K7/08 , C07K14/47 , C07K14/4713
摘要： The invention is related to peptide constructs, i.e., polypeptides obtained by linking together two or more peptides based on or derived from different molecules, which are useful in the treatment or prevention of autoimmune diseases, specifically rheumatoid arthritis (RA) and compositions containing same, methods for producing same and methods for using same; wherein the peptide constructs have the formula P1-x-P2 where P1 is a peptide associated with autoimmune disease such as rheumatoid arthritis myocarditis, diabetes, and immune-mediated disease, which binds to an antigen receptor on a set or subset of T cells; P2 is a peptide which will cause a Th2 directed immune response by the set or subset of T cells to which the peptide P1 is attached or which will bind to a T cell receptor which will cause the set or subset of T cells to which the peptide P1 is attached to initiate, but not complete, an immune response causing the set or subset of T cells to undergo immunomodulation including but not restricted to anergy and apoptosis; and x is a direct bond or linker for covalently bonding P1 and P2. Whereas said treatment being of the individual itself or of ex vivo treatment of isolated DC and or with further labeling with drug, dye or radioisotope and administration back into the patient of the activated and possibly modified DCs for detection, identification, localization and treatment thereof.
摘要翻译：本发明涉及肽构建体，即通过将两种或更多种基于或衍生自不同分子的肽连接在一起而获得的多肽，其可用于治疗或预防自身免疫疾病，特别是类风湿性关节炎（RA）和含有它们的组合物，生产方法及使用方法; 其中所述肽构建体具有式P1-x-P2，其中P1是与自身免疫疾病例如类风湿性关节炎心肌炎，糖尿病和免疫介导的疾病相关的肽，其结合T细胞的集合或亚群上的抗原受体; P2是通过肽P1所连接的T细胞的集合或子集引起Th2定向免疫应答的肽，或者将与T细胞受体结合，所述T细胞受体将导致肽 P1附着以引发但不完全的引起T细胞的集合或亚群进行免疫调节的免疫应答，包括但不限于无反应和凋亡; x是用于共价键合P1和P2的直接键或连接体。而所述治疗是个体本身或离体DC的离体处理，或者用药物，染料或放射性同位素进一步标记，并且向患者施用活化和可能改性的DC用于其检测，鉴定，定位和治疗。

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