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1. 发明申请

US20150140065A1 METHOD FOR INDUCING AN IMMUNE RESPONSE AND FORMULATIONS THEREOF 审中-公开
标题翻译：诱导免疫应答的方法及其制剂
公开(公告)号：US20150140065A1
公开(公告)日：2015-05-21
申请号：US14122238
申请日：2012-05-24
申请人： CEL-SCI CORPORATION
发明人： Daniel H. Zimmerman , Eyal Talor , Kanta Subbarao , Kobporn Boonnak
IPC分类号： A61K47/48 , A61K39/00 , C07K14/005
CPC分类号： C07K14/005 , A61K39/0005 , A61K39/12 , A61K47/646 , A61K47/65 , A61K47/68 , A61K2039/5154 , A61K2039/5158 , A61K2039/6031 , A61K2039/645 , C12N2760/16134 , Y02A50/401
摘要： The invention is related to peptide constructs, i.e., polypeptides obtained by linking together two or more peptides based on or derived from different molecules, which are useful in the treatment or prevention of influenza virus and other infectious diseases. Compositions containing the same, methods for producing the same, and methods for using the same are also disclosed, wherein the peptide constructs have the formula P1-x-P2, where P2 is a peptide associated with an infectious agent and P1 is a peptide that will bind to a class of immune cells, such as dendritic cells. The peptide construct can cause the maturation of immature dendritic cells to a more mature state. The peptide construct or the more mature dendritic cell can be administered to a subject to modulate or initiate an immune response against an infectious agent. Dyes, radioisotopes, or therapeutic agents conjugated with the dendritic cells can be used for localization of the immune target and/or prophylactic or therapeutic treatment of the disease.
摘要翻译：本发明涉及肽构建体，即通过将两种或更多种基于或衍生自不同分子的肽连接在一起的多肽，其可用于治疗或预防流感病毒和其它感染性疾病。还公开了含有其的组合物，其制备方法及其使用方法，其中肽构建体具有式P1-x-P2，其中P2是与感染剂相关的肽，P1是肽将结合一类免疫细胞，如树突状细胞。肽结构可导致未成熟树突状细胞的成熟进入更成熟的状态。可以将肽构建体或更成熟的树突状细胞施用于受试者以调节或引发针对感染因子的免疫应答。与树突状细胞缀合的染料，放射性同位素或治疗剂可用于免疫靶的定位和/或疾病的预防或治疗性治疗。

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