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    • 10. 发明申请
    • COMPOSITIONS AND METHODS FOR MODULATION OF RORGAMMAT FUNCTIONS
    • 组合物和方法用于调制罗格玛函数
    • US20150218563A1
    • 2015-08-06
    • US14589336
    • 2015-01-05
    • Dan LittmanGerard EberlLiang ZhouIvaylo Ivanov
    • Dan LittmanGerard EberlLiang ZhouIvaylo Ivanov
    • C12N15/113
    • C12N15/1138A61K39/0011A61K39/39A61K2039/55522C07K16/2803C12N2310/14C12N2310/531
    • The present invention relates to expression of RORγt in cells and tissues and the effect of expression of this gene on proliferation of specific immune cells and in promotion of immune cell aggregates and in induction of IL17 producing cells. Furthermore, the invention relates to methods and agents that may decrease function of the gene product (the protein) or expression of this gene in individuals experiencing an inflammatory condition, an autoimmune disease or a food allergy, or any other condition whereby it is desirable to inhibit an immune response. In addition, methods and agents useful for enhancing the function of RORγt with agonists or expression of this gene are also considered for use whereby it is desirable to increase immunity to a pathogen or tumor cell, for example, for use in conjunction with a vaccine. Screening methods for identifying novel modulators (antagonists and agonists) of RORγt are also disclosed.
    • 本发明涉及细胞和组织中RORγt的表达以及该基因表达对特异性免疫细胞增殖和促进免疫细胞聚集和诱导IL17产生细胞的作用。 此外,本发明涉及可以减少经历炎症状况,自身免疫疾病或食物过敏的个体的基因产物(蛋白质)或该基因的表达或其他任何其它条件的功能的方法和试剂, 抑制免疫反应。 此外,还考虑用于增强RORγt与激动剂或该基因表达的功能的方法和试剂,因此期望提高对病原体或肿瘤细胞的免疫力,例如与疫苗结合使用。 还公开了用于鉴定RORγt的新型调节剂(拮抗剂和激动剂)的筛选方法。