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1. 发明授权

US09492439B2 Amido compounds as RORγt modulators and uses thereof 有权
标题翻译：酰胺化合物作为RORγt调节剂及其用途
公开(公告)号：US09492439B2
公开(公告)日：2016-11-15
申请号：US13634073
申请日：2011-03-11
申请人： Dan Littman , Jun R. Huh , Wenwei Huang , Ruili Huang , Erika Elaine Englund
发明人： Dan Littman , Jun R. Huh , Wenwei Huang , Ruili Huang , Erika Elaine Englund
IPC分类号： C07D211/06 , C07D401/10 , C07D403/14 , C07D405/06 , A61K31/4525 , A61K31/12 , A61K31/33 , A61K31/535 , C07C235/34 , C07C235/36 , C07D211/16 , C07D307/52 , C07D317/54 , C07D317/60 , A61K31/4453
CPC分类号： A61K31/55 , A61K31/12 , A61K31/33 , A61K31/4025 , A61K31/404 , A61K31/4453 , A61K31/451 , A61K31/4525 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/535 , A61K31/5377 , C07C235/34 , C07C235/36 , C07D211/06 , C07D211/16 , C07D307/52 , C07D307/81 , C07D317/54 , C07D317/60 , C07D401/10 , C07D403/14 , C07D405/06 , C07D413/06 , C07D413/14
摘要： Amido compounds are disclosed that have a formula represented by the following: and wherein n1, n2, R1a, R1b, R2, R3, R4, R5, and R6 are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, cancer, and graft-versus-host disease.
摘要翻译：公开了具有由以下表示的式的酰氨基化合物：其中n1，n2，R 1a，R 1b，R 2，R 3，R 4，R 5和R 6如本文所述。化合物可以制备成药物组合物，并且可以用于预防和治疗包括人在内的哺乳动物中的多种病症，包括作为非限制性实例，炎性病症，自身免疫疾病，癌症和移植物抗 - 宿主病。

2. 发明授权

US09765063B2 Amido compounds as RORγt modulators and uses thereof 有权
公开(公告)号：US09765063B2
公开(公告)日：2017-09-19
申请号：US14343410
申请日：2012-09-10
申请人： Dan Littman , Jun R. Huh , Ruili Huang , Wenwei Huang , Erika E. Englund
发明人： Dan Littman , Jun R. Huh , Ruili Huang , Wenwei Huang , Erika E. Englund
IPC分类号： C07D409/06 , C07D209/44 , C07D211/14 , C07D213/58 , C07D333/24 , C07D401/06 , C07D405/14 , A61K31/40 , A61K31/4025 , A61K31/445 , A61K31/4709 , A61K31/495 , A61K31/496 , A61K31/5375 , A61K31/5377
CPC分类号： C07D409/06 , A61K31/40 , A61K31/4025 , A61K31/445 , A61K31/4709 , A61K31/495 , A61K31/496 , A61K31/5375 , A61K31/5377 , C07D209/44 , C07D211/14 , C07D213/58 , C07D333/24 , C07D401/06 , C07D405/14
摘要： Amido compounds are disclosed that have a formula represented by the following: and wherein Cy1, Cy2, n1, n2, R1a, R1b, R2, R3, R4, R5, and R6 are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, cancer, and graft-versus-host disease.

3. 发明授权

US09101600B2 Compounds as RORγt modulators and uses thereof 有权
标题翻译：化合物作为RORγt调节剂及其用途
公开(公告)号：US09101600B2
公开(公告)日：2015-08-11
申请号：US13634102
申请日：2011-03-11
申请人： Dan Littman , Jun R. Huh , Wenwei Huang , Ruili Huang
发明人： Dan Littman , Jun R. Huh , Wenwei Huang , Ruili Huang
IPC分类号： A61K31/4188 , A61K31/7048 , A61K31/4439 , A61K31/519 , C07D495/04 , C07D471/04 , A61P1/04 , A61P19/02 , A61P29/00 , A61K31/33 , A61K31/41
CPC分类号： A61K31/33 , A61K31/41
摘要： Heterocyclic compounds, and pharmaceutical compositions thereof, are disclosed as RORγt modulators that have a formula represented by the following: and wherein n1, n2, R1, R2, R3, and R4 are as described herein. These compounds may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, cancer, and graft-versus-host disease.
摘要翻译：公开了杂环化合物及其药物组合物，其具有由下式表示的式RORγt调节剂：其中n1，n2，R1，R2，R3和R4如本文所述。这些化合物可用于预防和治疗包括人在内的哺乳动物中的多种病症，包括非限制性实例，炎性病症，自身免疫疾病，癌症和移植物抗宿主病。

4. 发明申请

US20150057278A1 AMIDO COMPOUNDS AS RORyT MODULATORS AND USES THEREOF 有权
标题翻译： AMIDO化合物作为RORYT调制剂及其用途
公开(公告)号：US20150057278A1
公开(公告)日：2015-02-26
申请号：US14343410
申请日：2012-09-10
申请人： Dan Littman , Jun R. Huh , Ruili Huang , Wenwei Huang , Erika E. Englund
发明人： Dan Littman , Jun R. Huh , Ruili Huang , Wenwei Huang , Erika E. Englund
IPC分类号： C07D409/06 , C07D209/44 , C07D211/14 , C07D401/06 , C07D405/14 , C07D213/58 , C07D333/24
CPC分类号： C07D409/06 , A61K31/40 , A61K31/4025 , A61K31/445 , A61K31/4709 , A61K31/495 , A61K31/496 , A61K31/5375 , A61K31/5377 , C07D209/44 , C07D211/14 , C07D213/58 , C07D333/24 , C07D401/06 , C07D405/14
摘要： Amido compounds are disclosed that have a formula represented by the following: and wherein Cy1, Cy2, n1, n2, R1a, R1b, R2, R3, R4, R5, and R6 are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, cancer, and graft-versus-host disease.
摘要翻译：公开了具有下列表示的式的酰氨基化合物：其中Cy1，Cy2，n1，n2，R1a，R1b，R2，R3，R4，R5和R6如本文所述。化合物可以制备成药物组合物，并且可以用于预防和治疗包括人在内的哺乳动物中的多种病症，包括作为非限制性实例，炎性病症，自身免疫疾病，癌症和移植物抗 - 宿主病。

5. 发明申请

US20130085162A1 AMIDO COMPOUNDS AS RORyT MODULATORS AND USES THEREOF 有权
标题翻译： AMIDO化合物作为RORYT调制剂及其用途
公开(公告)号：US20130085162A1
公开(公告)日：2013-04-04
申请号：US13634073
申请日：2011-03-11
申请人： Dan Littman , Jun R. Huh , Wenwei Huang , Ruili Huang , Erika Elaine Englund
发明人： Dan Littman , Jun R. Huh , Wenwei Huang , Ruili Huang , Erika Elaine Englund
IPC分类号： A61K31/4525 , A61K31/4453 , C07D211/06 , C07D401/10
CPC分类号： A61K31/55 , A61K31/12 , A61K31/33 , A61K31/4025 , A61K31/404 , A61K31/4453 , A61K31/451 , A61K31/4525 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/535 , A61K31/5377 , C07C235/34 , C07C235/36 , C07D211/06 , C07D211/16 , C07D307/52 , C07D307/81 , C07D317/54 , C07D317/60 , C07D401/10 , C07D403/14 , C07D405/06 , C07D413/06 , C07D413/14
摘要： Amido compounds are disclosed that have a formula represented by the following: and wherein n1, n2, R1a, R1b, R2, R3, R4, R5, and R6 are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, cancer, and graft-versus-host disease.
摘要翻译：公开了具有由以下表示的式的酰氨基化合物：其中n1，n2，R1a，R1b，R2，R3，R4，R5和R6如本文所述。化合物可以制备成药物组合物，并且可以用于预防和治疗包括人在内的哺乳动物中的多种病症，包括作为非限制性实例，炎性病症，自身免疫疾病，癌症和移植物抗 - 宿主病。

6. 发明申请

US20130065842A1 COMPOUNDS AS RORyT MODULATORS AND USES THEREOF 有权
标题翻译：作为RORYT调制器的化合物及其用途
公开(公告)号：US20130065842A1
公开(公告)日：2013-03-14
申请号：US13634102
申请日：2011-03-11
申请人： Dan Littman , Jun R. Huh , Wenwei Huang , Ruili Huang
发明人： Dan Littman , Jun R. Huh , Wenwei Huang , Ruili Huang
IPC分类号： A61K31/4188 , A61K31/7048 , A61K31/57 , A61K31/496 , A61K31/4439 , A61K31/4709 , A61K31/519 , A61K31/5377 , C07J17/00 , C07D495/04 , C07D471/04 , C07D413/12 , C07D401/12 , C07D417/14 , C07D403/06 , A61P29/00 , A61P37/00 , A61P19/02 , A61P3/10 , A61P25/00 , A61P17/06 , A61P11/00 , A61P9/10 , A61P11/06 , A61P11/02 , A61P37/08 , A61P1/04 , C07D491/147
CPC分类号： A61K31/33 , A61K31/41
摘要： Heterocyclic compounds, and pharmaceutical compositions thereof, are disclosed as RORγt modulators that have a formula represented by the following: and wherein n1, n2, R1, R2, R3, and R4 are as described herein. These compounds may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, cancer, and graft-versus-host disease.
摘要翻译：公开了杂环化合物及其药物组合物，其具有由下式表示的式RORγt调节剂：其中n1，n2，R1，R2，R3和R4如本文所述。这些化合物可用于预防和治疗包括人在内的哺乳动物中的多种病症，包括非限制性实例，炎性病症，自身免疫疾病，癌症和移植物抗宿主病。

7. 发明申请

US20130029983A1 AMINOTHIENOPYRIDAZINE INHIBITORS OF TAU ASSEMBLY 审中-公开
标题翻译：氨基酸亚胺嘧啶抑制剂
公开(公告)号：US20130029983A1
公开(公告)日：2013-01-31
申请号：US13497697
申请日：2010-09-22
申请人： Carlo Ballatore , Kurt R. Brunden , Alexander L. Crowe , Donna M. Huryn , Virginia M.Y. Lee , John Q. Trojanowski , Amos B. Smith, III , Ruili Huang , Wenwei Huang , Ronald L. Johnson , Francesco Piscitelli
发明人： Carlo Ballatore , Kurt R. Brunden , Alexander L. Crowe , Donna M. Huryn , Virginia M.Y. Lee , John Q. Trojanowski , Amos B. Smith, III , Ruili Huang , Wenwei Huang , Ronald L. Johnson , Francesco Piscitelli
IPC分类号： A61K31/5025 , C07D495/04 , A61K31/5377 , A61P25/28 , A61P25/16
CPC分类号： C07D495/04 , A61K31/5025 , A61K31/5377
摘要： The present invention is directed to methods of inhibiting a tauopathy in a patient by administration of a compound of formula I: Novel aminothienopyridazine compounds are also described.
摘要翻译：本发明涉及通过给药式I化合物来抑制患者的tau蛋白病变的方法：还描述了新的氨基噻吩并哒嗪化合物。

8. 发明授权

US07884561B2 Method and apparatus for speed control selection in electronically commutated motor 有权
标题翻译：电子换向电机速度控制选择方法及装置
公开(公告)号：US07884561B2
公开(公告)日：2011-02-08
申请号：US11623787
申请日：2007-01-17
申请人： Aiqian Peng , Maosen Zeng , Wenwei Huang
发明人： Aiqian Peng , Maosen Zeng , Wenwei Huang
IPC分类号： H02P6/06
CPC分类号： H02P6/08
摘要： This invention relates to a method of speed control selection for an electronically commutated motor comprising the following steps: (a) a motor controller receives an input signal T from a speed control selection circuit; (b) the motor controller retrieves a corresponding value for a motor running speed S from a comparison list correlating the input signal with the motor running speed, which list has been stored in the motor controller in advance, by searching the comparison list for the input signal T; and (c) the motor controller controlling a motor M to run at the motor running speed S, achieving the purpose of the speed selection. This method allows for from 2 to 256 speed choices with a single signal wire only. Such a circuit structure has the advantages of high integration, simple wiring, low cost, good performances, low failure rate, higher number of optional speeds, and simpler and more practical control.
摘要翻译：本发明涉及电子换向马达的速度控制选择方法，包括以下步骤：（a）马达控制器从速度控制选择电路接收输入信号T; （b）电动机控制器通过将比较列表与输入信号与电动机运行速度相关联的比较列表检索电动机运行速度S的相应值，该列表已预先存储在电动机控制器中，通过在比较列表中搜索输入信号T; 和（c）马达控制器控制马达M以马达运行速度S运行，达到速度选择的目的。该方法允许仅使用单个信号线从2到256个速度选择。这种电路结构具有集成度高，布线简单，成本低，性能好，故障率低，可选速度更高的数量，更简单实用的控制。

9. 发明授权

US07671551B2 Universal brushless DC motor 有权
标题翻译：通用无刷直流电机
公开(公告)号：US07671551B2
公开(公告)日：2010-03-02
申请号：US11764208
申请日：2007-06-17
申请人： Ronghua Bi , Aiqian Peng , Wenwei Huang , Maosen Zeng , Jianwei Jin
发明人： Ronghua Bi , Aiqian Peng , Wenwei Huang , Maosen Zeng , Jianwei Jin
IPC分类号： H02P6/00
CPC分类号： H02K11/00 , H02K11/33 , H02P6/18
摘要： The invention teaches a brushless DC motor, comprising a brushless DC motor unit and a controller unit, wherein the brushless DC motor unit comprises a stator assembly, a permanent magnet rotor assembly magnetically coupled with the stator assembly, an enclosure supporting the installation of stator assembly and the permanent magnet rotator assembly, an end shield installed at the end of the enclosure, the rotating shaft of the permanent magnet rotor assembly projecting out of the end shield; the controller unit comprises an integrated power module, a microprocessor unit, a rotor position sensing circuit, a power source circuit, an I/O interface circuit, a current-sensing circuit, and a controller box; and the controller unit is electrically connected to the brushless DC motor unit. The brushless DC motor of the invention has an ideal control circuit with a plurality of control units serving to control the motor operation characteristics stored in the microprocessor unit so that the brushless DC motor is broadly universal and can be operated under a plurality of control modes.
摘要翻译：本发明教导了一种无刷DC电动机，其包括无电刷DC电动机单元和控制器单元，其中无刷直流电动机单元包括定子组件，与定子组件磁耦合的永磁转子组件，支撑定子组件的安装的外壳永磁转子组件，安装在外壳端部的端盖，永磁转子组件的旋转轴突出端盖; 控制器单元包括集成电源模块，微处理器单元，转子位置感测电路，电源电路，I / O接口电路，电流感测电路和控制器盒; 并且控制器单元电连接到无刷直流电动机单元。本发明的无刷直流电动机具有理想的控制电路，其具有多个控制单元，用于控制微处理器单元中存储的电动机操作特性，使得无刷直流电动机广泛地通用并且可以在多种控制模式下操作。

10. 发明申请

US20120315217A1 INVERSE AGONISTS AND NEUTRAL ANTAGONISTS FOR THE TSH RECEPTOR 有权
标题翻译：反向激动剂和TSH受体的中性拮抗剂
公开(公告)号：US20120315217A1
公开(公告)日：2012-12-13
申请号：US13579251
申请日：2011-04-08
申请人： Marvin Gershengorn , Susanne Neumann , Wenwei Huang , Craig J. Thomas
发明人： Marvin Gershengorn , Susanne Neumann , Wenwei Huang , Craig J. Thomas
IPC分类号： A61K31/517 , C07D405/06 , A61K51/00 , A61P5/14 , A61P35/00 , C07D401/06 , C07D239/91
CPC分类号： C07D401/06 , A61K31/517 , C07D239/91 , C07D405/06
摘要： TSHR inverse agonists and neutral antagonists that are useful for treating Graves' orbitopathy, Graves' hyperthyroidism and/or thyroid cancer.
摘要翻译： TSHR反向激动剂和中枢拮抗剂，可用于治疗格雷夫斯眶前病变，格雷夫斯甲状腺功能亢进症和/或甲状腺癌。

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