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1. 发明授权

US07844331B2 Method and apparatus for controlling anti-tachyarrhythmia pacing using hemodynamic sensor 有权
标题翻译：使用血液动力学传感器控制抗心律失调起搏的方法和装置
公开(公告)号：US07844331B2
公开(公告)日：2010-11-30
申请号：US11312082
申请日：2005-12-20
申请人： Dan Li , Gerrard M. Carlson , Stephen J. Hahn
发明人： Dan Li , Gerrard M. Carlson , Stephen J. Hahn
IPC分类号： A61N1/365
CPC分类号： A61N1/3622 , A61N1/36514
摘要： A cardiac rhythm management (CRM) system includes an implantable medical device that delivers anti-tachyarrhythmia therapies including anti-tachyarrhythmia pacing (ATP) and at least one hemodynamic sensor that senses a hemodynamic signal. When a tachyarrhythmia episode is detected, the CRM system analyzes the hemodynamic signal to determine whether and/or when to deliver an ATP. In one embodiment, a hemodynamic parameter extracted from the hemodynamic signal is used to predict the potential effectiveness of ATP in terminating the detected tachyarrhythmia episode. In another embodiment, a characteristic feature detected from the hemodynamic signal is used to determine an ATP window during which a delivery of ATP is initiated.
摘要翻译：心律管理（CRM）系统包括可植入的医疗装置，其传递抗慢性心律失常疗法，包括抗快速性心律失常起搏（ATP）和至少一种感测血液动力学信号的血液动力学传感器。当检测到快速性心律失常发作时，CRM系统分析血液动力学信号，以确定是否和/或何时递送ATP。在一个实施例中，使用从血液动力学信号提取的血液动力学参数来预测ATP终止检测到的快速性心律失常发作的潜在有效性。在另一个实施例中，使用从血液动力学信号检测到的特征特征来确定在其中开始ATP递送的ATP窗口。

2. 发明申请

US20130158621A1 ECTOPIC-TRIGGERED PARA-HIS STIMULATION 审中-公开
公开(公告)号：US20130158621A1
公开(公告)日：2013-06-20
申请号：US13716810
申请日：2012-12-17
申请人： Jiang Ding , Allan C. Shuros , Dan Li , Yinghong Yu , Stephen J. Hahn
发明人： Jiang Ding , Allan C. Shuros , Dan Li , Yinghong Yu , Stephen J. Hahn
IPC分类号： A61N1/365
CPC分类号： A61N1/36592 , A61B5/02152 , A61B5/0464 , A61B5/0468 , A61N1/365 , A61N1/37 , A61N1/371
摘要： Ectopic cardiac activity can be detected, such as in the absence of a diagnosed tachyarrhythmia episode. In response to the detected ectopic activity, electrostimulation can be provided to a para-Hisian region, such as to activate natural cardiac contraction mechanisms or to interrupt re-entrant cardiac activity. Subsequent ectopic cardiac activity can be detected, and subsequent electrostimulation can be provided to the para-Hisian region, such as according to one or more adjustable electrostimulation parameters.
摘要翻译：可以检测异位心脏活动，例如在没有诊断的快速性心律失常发作时。响应于检测到的异位活动，可以向对等神经区域提供电刺激，例如激活自然心脏收缩机制或中断再入心脏活动。可以检测随后的异位心脏活动，并且可以根据一个或多个可调节的电刺激参数来向对 - Hisian区域提供随后的电刺激。

3. 发明申请

US20120143286A1 SYSTEMS AND METHODS FOR INCREASING STIMULATION DOSE 有权
标题翻译：用于增加刺激剂量的系统和方法
公开(公告)号：US20120143286A1
公开(公告)日：2012-06-07
申请号：US13306745
申请日：2011-11-29
申请人： Stephen J. Hahn , Jason J. Hamann , David J. Ternes
发明人： Stephen J. Hahn , Jason J. Hamann , David J. Ternes
IPC分类号： A61N1/372
CPC分类号： A61N1/37282 , A61N1/0556 , A61N1/36132 , A61N1/3615 , A61N1/36178 , A61N1/36185 , A61N1/37252
摘要： According to an embodiment of a method performed by an implantable medical device to deliver a neural stimulation therapy to a patient, a lower dose of the neural stimulation therapy is delivered to the patient. The dose of the neural stimulation therapy is automatically increased from the lower dose to a higher dose, and the higher dose of the neural stimulation therapy is delivered to the patient. A trigger that is controlled by the patient is detected, and the dose of the neural stimulation therapy is automatically returned from the higher dose back to the lower dose in response to detecting the trigger.
摘要翻译：根据由可植入医疗装置执行以向患者递送神经刺激疗法的方法的实施例，将较低剂量的神经刺激疗法递送给患者。神经刺激治疗的剂量自动从较低剂量增加到较高剂量，而较高剂量的神经刺激疗法则传递给患者。检测由患者控制的触发器，并且响应于检测到触发，神经刺激治疗的剂量自动从较高剂量返回到较低剂量。

4. 发明授权

US5468254A Method and apparatus for defibrillation using a multiphasic truncated exponential waveform 失效
标题翻译：使用多相截断指数波形除颤的方法和装置
公开(公告)号：US5468254A
公开(公告)日：1995-11-21
申请号：US97463
申请日：1993-07-26
申请人： Stephen J. Hahn , David K. Swanson
发明人： Stephen J. Hahn , David K. Swanson
IPC分类号： A61N1/39
CPC分类号： A61N1/3956 , A61N1/3906
摘要： A method and apparatus for converting an arrhythmia of a heart using a biphasic truncated exponential waveform wherein the first phase is of shorter duration than the second phase.
摘要翻译：一种使用双相截短指数波形转换心脏心律失常的方法和装置，其中第一阶段的持续时间比第二阶段短。

5. 发明授权

US5230337A Process for implanting subcutaneous defibrillation electrodes 失效
标题翻译：植入皮下除颤电极的方法
公开(公告)号：US5230337A
公开(公告)日：1993-07-27
申请号：US912950
申请日：1992-07-14
申请人： Roger W. Dahl , David K. Swanson , Stephen J. Hahn , Douglas J. Lang , John E. Heil
发明人： Roger W. Dahl , David K. Swanson , Stephen J. Hahn , Douglas J. Lang , John E. Heil
IPC分类号： A61N1/05
CPC分类号： A61N1/05
摘要： Implantable electrodes for defibrillation are formed of pluralities of electrode segments. Each of the segments is relatively long and narrow. The electrode segments can be parallel and spaced apart from one another a distance at least ten times the nominal width, with one end of each segment mounted to a transverse distal portion of an electrically conductive lead coupling the electrode to a defibrillation pulse generator. Alternatively, segments can branch or radiate outwardly from a common junction. In yet another arrangement, electrode segments are portions of a single conductive path at the distal end of a lead from a pulse generator, arranged in either a spiral configuration or a serpentine configuration which can align electrode segments side by side, parallel and spaced apart. The electrode segments can be formed of composite conductors in the form of titanium ribbons or wires with a sputtered outer layer of platinum, or a silver core in a stainless steel tube, with a platinum layer formed onto the tube. The electrodes are highly compliant yet can provide large effective areas for defibrillation, enabling a transthoracic pulsing arrangement of two electrodes on opposite sides of the heart, implanted subcutaneously outside of the thoracic region.
摘要翻译：用于除颤的可植入电极由多个电极段形成。每个段都相对长而窄。电极段可以彼此平行和间隔至少十倍于标称宽度的距离，每个段的一端安装到将电极耦合到除颤脉冲发生器的导电引线的横向远端部分。或者，片段可以从公共接头向外分支或辐射。在另一种布置中，电极段是在来自脉冲发生器的引线的远端处的单个导电路径的部分，其布置成螺旋构造或蛇形结构，其可以并排并排隔离电极段。电极段可以由具有溅射的铂外层或不锈钢管中的银芯的钛带或电线形式的复合导体形成，铂层形成在管上。电极是高度依从性的，但可以为除颤提供大的有效区域，使得能够在心脏外侧皮下植入心脏两侧的两个电极的经胸部脉冲排列。

6. 发明申请

US20130053926A1 SYSTEMS TO DETECT VAGUS CAPTURE 有权
标题翻译：检测VAGUS捕获的系统
公开(公告)号：US20130053926A1
公开(公告)日：2013-02-28
申请号：US13586432
申请日：2012-08-15
申请人： Juan Gabriel Hincapie Ordonez , Stephen J. Hahn , David J. Ternes , Shantha Arcot-Krishnamurthy , Jason J. Hamann
发明人： Juan Gabriel Hincapie Ordonez , Stephen J. Hahn , David J. Ternes , Shantha Arcot-Krishnamurthy , Jason J. Hamann
IPC分类号： A61N1/36
CPC分类号： A61B5/0492 , A61B5/0488 , A61B5/4035 , A61N1/0556 , A61N1/36053 , A61N1/36114
摘要： Some embodiments provide a system for delivering neurostimulation. Some system embodiments comprise a lead configured to be implanted in the body, a stimulation output circuit configured to deliver neurostimulation pulses to the vagus nerve through the lead, an EMG sensing circuit configured to use the lead to sense EMG signals from laryngeal muscle activity, and an evoked muscular response detection circuit configured to use the EMG signals sensed by the EMG sensing circuit to detect evoked laryngeal muscle activity evoked by the neurostimulation pulse.
摘要翻译：一些实施例提供用于递送神经刺激的系统。一些系统实施例包括被配置为植入体内的引线，刺激输出电路，其经配置以通过引线将神经刺激脉冲输送到迷走神经; EMG感测电路，被配置为使用引线来感测来自喉部肌肉活动的EMG信号;以及诱发肌肉反应检测电路，被配置为使用由EMG感测电路感测的EMG信号来检测由神经刺激脉冲诱发的诱发喉部肌肉活动。

7. 发明申请

US20130053914A1 METHOD AND APPARATUS FOR ADAPTIVE CONTROL OF NEUROSTIMULATION USING CARDIAC RESTITUTION 有权
标题翻译：使用心脏衰竭治疗神经病学自适应控制的方法和装置
公开(公告)号：US20130053914A1
公开(公告)日：2013-02-28
申请号：US13586503
申请日：2012-08-15
申请人： Shibaji Shome , Stephen Ruble , Jason J. Hamann , Stephen J. Hahn , Arjun D. Sharma
发明人： Shibaji Shome , Stephen Ruble , Jason J. Hamann , Stephen J. Hahn , Arjun D. Sharma
IPC分类号： A61N1/365
CPC分类号： A61N1/36114 , A61N1/36139
摘要： A neurostimulation system measures a cardiac parameter at various cardiac intervals and analyzes its restitution, including computing a restitution slope being a rate of change of the restitution parameter with respect to change in the cardiac interval. In various embodiments, the system uses the restitution slope to provide for adaptive control of neurostimulation. In various embodiments, one or more cardiac parameters such as action potential duration (APD), conduction velocity (CV), QT interval (QT), and/or T-wave morphology (TM) parameter are measured and analyzed for restitution of each parameter, which is then used to control the delivery of the neurostimulation.
摘要翻译：神经刺激系统以各种心脏间隔测量心脏参数并分析其恢复，包括计算相对于心脏间隔变化的恢复参数的变化率的恢复斜率。在各种实施例中，系统使用恢复斜率来提供神经刺激的自适应控制。在各种实施例中，测量并分析一个或多个心脏参数，例如动作电位持续时间（APD），传导速度（CV），QT间期（QT）和/或T波形态（TM）参数，以分析每个参数的恢复，然后用于控制神经刺激的递送。

8. 发明申请

US20120303086A1 SYSTEMS AND METHODS FOR COLLECTING PATIENT EVENT INFORMATION 有权
标题翻译：收集患者事件信息的系统和方法
公开(公告)号：US20120303086A1
公开(公告)日：2012-11-29
申请号：US13568958
申请日：2012-08-07
申请人： Stephen J. Hahn , Yanting Dong , Haresh G. Sachanandani , Kenneth P. Hoyme , James O. Gilkerson
发明人： Stephen J. Hahn , Yanting Dong , Haresh G. Sachanandani , Kenneth P. Hoyme , James O. Gilkerson
IPC分类号： A61N1/362
CPC分类号： A61N1/37247 , A61N1/37258 , A61N1/3962
摘要： A method of and system for collecting patient event information is described, where the system includes an implantable medical (IMD) and an external interface device. The external interface device is remote from the IMD and includes a communication module, a display device adapted to prompt a user of the system to select a reason for a particular transmission session and a user input device adopted to accept input indicating a selected reason.
摘要翻译：描述了收集患者事件信息的方法和系统，其中系统包括可植入医疗（IMD）和外部接口装置。外部接口设备远离IMD，并且包括通信模块，适于提示系统的用户选择特定传输会话的原因的显示设备和用于接受指示所选理由的输入的用户输入设备。

9. 发明申请

US20080086175A1 METHOD AND APPARATUS FOR REDUCING DEFIBRILLATION THRESHOLD 审中-公开
标题翻译：减少破坏阈值的方法和装置
公开(公告)号：US20080086175A1
公开(公告)日：2008-04-10
申请号：US11760987
申请日：2007-06-11
申请人： Imad Libbus , Avram Scheiner , Stephen J. Hahn
发明人： Imad Libbus , Avram Scheiner , Stephen J. Hahn
IPC分类号： A61N1/39
CPC分类号： A61N1/36114 , A61N1/0504 , A61N1/3956
摘要： An antitachyarrhythmia system uses vagal nerve stimulation in combination with one or more additional techniques to lower the defibrillation threshold (DFT). Examples of such additional techniques include using electrical shock waveforms each including a plurality of pulses and using defibrillation electrode configurations each including an electrode placed in the coronary sinus or coronary vein.
摘要翻译：抗心律失常系统使用迷走神经刺激与一种或多种额外技术相结合来降低除颤阈值（DFT）。这种附加技术的实例包括使用每个包括多个脉冲的电击波形，并且使用每个包括放置在冠状静脉或冠状静脉中的电极的除颤电极构造。

10. 发明授权

US08260423B2 Systems and methods for collecting patient event information 有权
标题翻译：用于收集患者事件信息的系统和方法
公开(公告)号：US08260423B2
公开(公告)日：2012-09-04
申请号：US12504450
申请日：2009-07-16
申请人： Stephen J. Hahn , Yanting Dong , Haresh G. Sachanandani , Kenneth P. Hoyme , James O. Gilkerson
发明人： Stephen J. Hahn , Yanting Dong , Haresh G. Sachanandani , Kenneth P. Hoyme , James O. Gilkerson
IPC分类号： A61N1/00
CPC分类号： A61N1/37247 , A61N1/37258 , A61N1/3962
摘要： A method of collecting patient event information from a cardiac rhythm management system (CRM system) is described, where the CRM system includes a cardiac rhythm management device (CRM device) and an external interface device. The method includes the steps of initiating a transmission session wherein the interface device communicates with the CRM device, prompting a user of the CRM system to select a reason for the transmission session, inputting the selected reason for the transmission session to the interface device, and storing the selected reason for the transmission session and timestamp information for the transmission session.
摘要翻译：描述了从心律管理系统（CRM系统）收集患者事件信息的方法，其中CRM系统包括心律管理装置（CRM装置）和外部接口装置。该方法包括以下步骤：启动传输会话，其中接口设备与CRM设备通信，提示CRM系统的用户选择传输会话的原因，向接口设备输入传输会话的选择原因;以及存储用于传输会话的选择原因和用于传输会话的时间戳信息。

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