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1. 发明申请

US20080086175A1 METHOD AND APPARATUS FOR REDUCING DEFIBRILLATION THRESHOLD 审中-公开
标题翻译：减少破坏阈值的方法和装置
公开(公告)号：US20080086175A1
公开(公告)日：2008-04-10
申请号：US11760987
申请日：2007-06-11
申请人： Imad Libbus , Avram Scheiner , Stephen J. Hahn
发明人： Imad Libbus , Avram Scheiner , Stephen J. Hahn
IPC分类号： A61N1/39
CPC分类号： A61N1/36114 , A61N1/0504 , A61N1/3956
摘要： An antitachyarrhythmia system uses vagal nerve stimulation in combination with one or more additional techniques to lower the defibrillation threshold (DFT). Examples of such additional techniques include using electrical shock waveforms each including a plurality of pulses and using defibrillation electrode configurations each including an electrode placed in the coronary sinus or coronary vein.
摘要翻译：抗心律失常系统使用迷走神经刺激与一种或多种额外技术相结合来降低除颤阈值（DFT）。这种附加技术的实例包括使用每个包括多个脉冲的电击波形，并且使用每个包括放置在冠状静脉或冠状静脉中的电极的除颤电极构造。

2. 发明授权

US08473076B2 Lead for stimulating the baroreceptors in the pulmonary artery 有权
标题翻译：用于刺激肺动脉中的压力感受器的铅
公开(公告)号：US08473076B2
公开(公告)日：2013-06-25
申请号：US13225769
申请日：2011-09-06
申请人： Imad Libbus , Ronald W. Heil, Jr. , Avram Scheiner
发明人： Imad Libbus , Ronald W. Heil, Jr. , Avram Scheiner
IPC分类号： A61N1/05 , A61N1/04
CPC分类号： A61N1/0476 , A61N1/05 , A61N1/056 , A61N1/057 , A61N1/36117
摘要： An apparatus includes a flexible lead body extending from a proximal end to a distal end, an expandable electrode coupled proximate the distal end, the expandable electrode having an expanded diameter dimensioned to abut a wall of a pulmonary artery, and an implantable pulse generator electrically coupled to the expandable electrode. The expandable electrode includes a plurality of electrode zones. The plurality of zones can be tested to determine which zone delivers the best baroreflex response. At least one of the electrode zones can be selected to deliver a stimulation signal based on the testing. The implantable pulse generator is adapted to deliver a baroreflex stimulation signal to a baroreceptor in the pulmonary artery via the electrode.
摘要翻译：一种装置包括从近端延伸到远端的柔性引线主体，靠近远端连接的可扩张电极，所述可扩张电极具有尺寸设计成邻接肺动脉壁的扩张直径，以及电耦合的可植入脉冲发生器到可膨胀电极。可膨胀电极包括多个电极区。可以测试多个区域以确定哪个区域提供最佳的压力反射响应。可以选择至少一个电极区域以基于测试传递刺激信号。可植入脉冲发生器适于通过电极将压力反射刺激信号传递给肺动脉中的压力感受器。

3. 发明申请

US20100076511A1 BAROREFLEX STIMULATION SYSTEM TO REDUCE HYPERTENSION 有权
标题翻译： BAROREFLEX刺激系统降低高血压
公开(公告)号：US20100076511A1
公开(公告)日：2010-03-25
申请号：US12627562
申请日：2009-11-30
申请人： Ronald W. Heil, JR. , Avram Scheiner , Imad Libbus
发明人： Ronald W. Heil, JR. , Avram Scheiner , Imad Libbus
IPC分类号： A61N1/08 , A61N1/362
CPC分类号： A61N1/36117 , A61N1/3627 , A61N1/36564
摘要： Various aspects of the present subject matter provide an implantable medical device. In various embodiments, the device comprises a pulse generator, a lead, a sensor, and a controller. The pulse generator generates a baroreflex stimulation signal as part of a baroreflex therapy. The lead is adapted to be electrically connected to the pulse generator and to be intravascularly fed into a heart. The lead includes an electrode to be positioned in or proximate to the heart to deliver the baroreflex signal to a baroreceptor region in or proximate to the heart. The sensor senses a physiological parameter regarding an efficacy of the baroreflex therapy and provides a signal indicative of the efficacy. The controller is connected to the pulse generator to control the baroreflex stimulation signal and to the sensor to receive the signal indicative of the efficacy of the baroreflex therapy. Other aspects are provided herein.
摘要翻译：本主题的各个方面提供可植入医疗装置。在各种实施例中，该装置包括脉冲发生器，引线，传感器和控制器。脉冲发生器产生压力反射刺激信号作为压力反射治疗的一部分。引线适于电连接到脉冲发生器并且被血管内馈送到心脏中。引线包括位于心脏中或靠近心脏的电极，以将压力反射信号传递到心脏中或心脏附近的压力感受器区域。传感器感测关于压力反射治疗的功效的生理参数，并提供指示功效的信号。控制器连接到脉冲发生器以控制压力反射刺激信号和传感器以接收指示压力反射治疗功效的信号。本文提供了其他方面。

4. 发明申请

US20080243196A1 UNIDIRECTIONAL NEURAL STIMULATION SYSTEMS, DEVICES AND METHODS 有权
标题翻译：非线性神经刺激系统，设备和方法
公开(公告)号：US20080243196A1
公开(公告)日：2008-10-02
申请号：US11695189
申请日：2007-04-02
申请人： Imad Libbus , Avram Scheiner
发明人： Imad Libbus , Avram Scheiner
IPC分类号： A61N1/00
CPC分类号： A61N1/36057 , A61B5/021 , A61B5/024 , A61N1/0551 , A61N1/36114 , A61N1/36135 , A61N1/37217 , A61N1/37282 , A61N1/37288
摘要： An embodiment relates to a method for delivering a unidirectional afferent nerve stimulation treatment. A test neural stimulation is delivered, and a physiologic response to the test neural stimulation is monitored. At least one neural stimulation parameter for the test neural stimulation is adjusted if the test neural stimulation does not elicit a desired physiologic response. If the test neural stimulation does elicit the desired physiologic response, at least one treatment parameter for a unidirectional afferent nerve stimulation is determined using the at least one neural stimulation parameter for the test neural stimulation that provided the desired physiologic response. The unidirectional afferent nerve stimulation is delivered using the at least one treatment parameter.
摘要翻译：一个实施方案涉及用于递送单向传入神经刺激治疗的方法。传递测试神经刺激，并监测对测试神经刺激的生理反应。如果测试神经刺激不引起所需的生理反应，则调整用于测试神经刺激的至少一个神经刺激参数。如果测试神经刺激确实引起所需的生理反应，则使用提供所需生理反应的测试神经刺激的至少一个神经刺激参数确定单向传入神经刺激的至少一个治疗参数。使用至少一个治疗参数递送单向传入神经刺激。

5. 发明授权

US07643875B2 Baroreflex stimulation system to reduce hypertension 有权
标题翻译： Baroreflex刺激系统可以降低高血压
公开(公告)号：US07643875B2
公开(公告)日：2010-01-05
申请号：US10746134
申请日：2003-12-24
申请人： Ronald W. Heil, Jr. , Avram Scheiner , Imad Libbus
发明人： Ronald W. Heil, Jr. , Avram Scheiner , Imad Libbus
IPC分类号： A61N1/36
CPC分类号： A61N1/36117 , A61N1/3627 , A61N1/36564
摘要： Various aspects of the present subject matter provide an implantable medical device. In various embodiments, the device comprises a pulse generator, a lead, a sensor, and a controller. The pulse generator generates a baroreflex stimulation signal as part of a baroreflex therapy. The lead is adapted to be electrically connected to the pulse generator and to be intravascularly fed into a heart. The lead includes an electrode to be positioned in or proximate to the heart to deliver the baroreflex signal to a baroreceptor region in or proximate to the heart. The sensor senses a physiological parameter regarding an efficacy of the baroreflex therapy and provides a signal indicative of the efficacy. The controller is connected to the pulse generator to control the baroreflex stimulation signal and to the sensor to receive the signal indicative of the efficacy of the baroreflex therapy. Other aspects are provided herein.
摘要翻译：本主题的各个方面提供可植入医疗装置。在各种实施例中，装置包括脉冲发生器，引线，传感器和控制器。脉冲发生器产生压力反射刺激信号作为压力反射治疗的一部分。引线适于电连接到脉冲发生器并且被血管内馈送到心脏中。引线包括位于心脏中或靠近心脏的电极，以将压力反射信号传递到心脏中或心脏附近的压力感受器区域。传感器感测关于压力反射治疗的功效的生理参数，并提供指示功效的信号。控制器连接到脉冲发生器以控制压力反射刺激信号和传感器以接收指示压力反射治疗功效的信号。本文提供了其他方面。

6. 发明申请

US20120239099A1 SYSTEM AND METHOD FOR DELIVERING MYOCARDIAL AND AUTONOMIC NEURAL STIMULATION 有权
标题翻译：用于输送心肌和自主神经刺激的系统和方法
公开(公告)号：US20120239099A1
公开(公告)日：2012-09-20
申请号：US13484060
申请日：2012-05-30
申请人： Ronald W. Heil, JR. , Avram Scheiner , Imad Libbus
发明人： Ronald W. Heil, JR. , Avram Scheiner , Imad Libbus
IPC分类号： A61N1/365 , A61N1/39 , A61N1/362
CPC分类号： A61N1/36117 , A61N1/3627 , A61N1/36564
摘要： Various aspects of the present subject matter provide an implantable medical device. In various embodiments, the device comprises a pulse generator, a lead, a sensor, and a controller. The pulse generator generates a baroreflex stimulation signal as part of a baroreflex therapy. The lead is adapted to be electrically connected to the pulse generator and to be intravascularly fed into a heart. The lead includes an electrode to be positioned in or proximate to the heart to deliver the baroreflex signal to a baroreceptor region in or proximate to the heart. The sensor senses a physiological parameter regarding an efficacy of the baroreflex therapy and provides a signal indicative of the efficacy. The controller is connected to the pulse generator to control the baroreflex stimulation signal and to the sensor to receive the signal indicative of the efficacy of the baroreflex therapy. Other aspects are provided herein.
摘要翻译：本主题的各个方面提供可植入医疗装置。在各种实施例中，该装置包括脉冲发生器，引线，传感器和控制器。脉冲发生器产生压力反射刺激信号作为压力反射治疗的一部分。引线适于电连接到脉冲发生器并且被血管内馈送到心脏中。引线包括位于心脏中或靠近心脏的电极以将压力反射信号传递到心脏中或心脏附近的压力感受器区域。传感器感测关于压力反射治疗的功效的生理参数，并提供指示功效的信号。控制器连接到脉冲发生器以控制压力反射刺激信号和传感器以接收指示压力反射治疗功效的信号。本文提供了其他方面。

7. 发明授权

US08639322B2 System and method for delivering myocardial and autonomic neural stimulation 有权
标题翻译：用于输送心肌和自主神经刺激的系统和方法
公开(公告)号：US08639322B2
公开(公告)日：2014-01-28
申请号：US13484060
申请日：2012-05-30
申请人： Ronald W. Heil, Jr. , Avram Scheiner , Imad Libbus
发明人： Ronald W. Heil, Jr. , Avram Scheiner , Imad Libbus
IPC分类号： A61N1/36
CPC分类号： A61N1/36117 , A61N1/3627 , A61N1/36564
摘要： Various aspects of the present subject matter provide an implantable medical device. In various embodiments, the device comprises a pulse generator, a lead, a sensor, and a controller. The pulse generator generates a baroreflex stimulation signal as part of a baroreflex therapy. The lead is adapted to be electrically connected to the pulse generator and to be intravascularly fed into a heart. The lead includes an electrode to be positioned in or proximate to the heart to deliver the baroreflex signal to a baroreceptor region in or proximate to the heart. The sensor senses a physiological parameter regarding an efficacy of the baroreflex therapy and provides a signal indicative of the efficacy. The controller is connected to the pulse generator to control the baroreflex stimulation signal and to the sensor to receive the signal indicative of the efficacy of the baroreflex therapy. Other aspects are provided herein.
摘要翻译：本主题的各个方面提供可植入医疗装置。在各种实施例中，该装置包括脉冲发生器，引线，传感器和控制器。脉冲发生器产生压力反射刺激信号作为压力反射治疗的一部分。引线适于电连接到脉冲发生器并且被血管内馈送到心脏中。引线包括位于心脏中或靠近心脏的电极以将压力反射信号传递到心脏中或心脏附近的压力感受器区域。传感器感测关于压力反射治疗的功效的生理参数，并提供指示功效的信号。控制器连接到脉冲发生器以控制压力反射刺激信号和传感器以接收指示压力反射治疗功效的信号。本文提供了其他方面。

8. 发明申请

US20120265273A1 UNIDIRECTIONAL NEURAL STIMULATION SYSTEMS, DEVICES AND METHODS 有权
标题翻译：非线性神经刺激系统，设备和方法
公开(公告)号：US20120265273A1
公开(公告)日：2012-10-18
申请号：US13532469
申请日：2012-06-25
申请人： Imad Libbus , Avram Scheiner
发明人： Imad Libbus , Avram Scheiner
IPC分类号： A61N1/36
CPC分类号： A61N1/36057 , A61B5/021 , A61B5/024 , A61N1/0551 , A61N1/36114 , A61N1/36135 , A61N1/37217 , A61N1/37282 , A61N1/37288
摘要： An embodiment relates to a method for delivering a unidirectional afferent nerve stimulation treatment. A test neural stimulation is delivered, and a physiologic response to the test neural stimulation is monitored. At least one neural stimulation parameter for the test neural stimulation is adjusted if the test neural stimulation does not elicit a desired physiologic response. If the test neural stimulation does elicit the desired physiologic response, at least one treatment parameter for a unidirectional afferent nerve stimulation is determined using the at least one neural stimulation parameter for the test neural stimulation that provided the desired physiologic response. The unidirectional afferent nerve stimulation is delivered using the at least one treatment parameter.
摘要翻译：一个实施方案涉及用于递送单向传入神经刺激治疗的方法。传递测试神经刺激，并监测对测试神经刺激的生理反应。如果测试神经刺激不引起所需的生理反应，则调整用于测试神经刺激的至少一个神经刺激参数。如果测试神经刺激确实引起所需的生理反应，则使用提供所需生理反应的测试神经刺激的至少一个神经刺激参数确定单向传入神经刺激的至少一个治疗参数。使用至少一个治疗参数递送单向传入神经刺激。

9. 发明授权

US08224436B2 Unidirectional neural stimulation systems, devices and methods 有权
标题翻译：单向神经刺激系统，装置和方法
公开(公告)号：US08224436B2
公开(公告)日：2012-07-17
申请号：US11695189
申请日：2007-04-02
申请人： Imad Libbus , Avram Scheiner
发明人： Imad Libbus , Avram Scheiner
IPC分类号： A61N1/36
CPC分类号： A61N1/36057 , A61B5/021 , A61B5/024 , A61N1/0551 , A61N1/36114 , A61N1/36135 , A61N1/37217 , A61N1/37282 , A61N1/37288
摘要： An embodiment relates to a method for delivering a unidirectional afferent nerve stimulation treatment. A test neural stimulation is delivered, and a physiologic response to the test neural stimulation is monitored. At least one neural stimulation parameter for the test neural stimulation is adjusted if the test neural stimulation does not elicit a desired physiologic response. If the test neural stimulation does elicit the desired physiologic response, at least one treatment parameter for a unidirectional afferent nerve stimulation is determined using the at least one neural stimulation parameter for the test neural stimulation that provided the desired physiologic response. The unidirectional afferent nerve stimulation is delivered using the at least one treatment parameter.
摘要翻译：一个实施方案涉及用于递送单向传入神经刺激治疗的方法。传递测试神经刺激，并监测对测试神经刺激的生理反应。如果测试神经刺激不引起所需的生理反应，则调整用于测试神经刺激的至少一个神经刺激参数。如果测试神经刺激确实引起所需的生理反应，则使用提供所需生理反应的测试神经刺激的至少一个神经刺激参数确定单向传入神经刺激的至少一个治疗参数。使用至少一个治疗参数递送单向传入神经刺激。

10. 发明授权

US08195289B2 Baroreflex stimulation system to reduce hypertension 有权
标题翻译： Baroreflex刺激系统可以降低高血压
公开(公告)号：US08195289B2
公开(公告)日：2012-06-05
申请号：US12627562
申请日：2009-11-30
申请人： Ronald W. Heil, Jr. , Avram Scheiner , Imad Libbus
发明人： Ronald W. Heil, Jr. , Avram Scheiner , Imad Libbus
IPC分类号： A61N1/36
CPC分类号： A61N1/36117 , A61N1/3627 , A61N1/36564
摘要： Various aspects of the present subject matter provide an implantable medical device. In various embodiments, the device comprises a pulse generator, a lead, a sensor, and a controller. The pulse generator generates a baroreflex stimulation signal as part of a baroreflex therapy. The lead is adapted to be electrically connected to the pulse generator and to be intravascularly fed into a heart. The lead includes an electrode to be positioned in or proximate to the heart to deliver the baroreflex signal to a baroreceptor region in or proximate to the heart. The sensor senses a physiological parameter regarding an efficacy of the baroreflex therapy and provides a signal indicative of the efficacy. The controller is connected to the pulse generator to control the baroreflex stimulation signal and to the sensor to receive the signal indicative of the efficacy of the baroreflex therapy. Other aspects are provided herein.
摘要翻译：本主题的各个方面提供可植入医疗装置。在各种实施例中，该装置包括脉冲发生器，引线，传感器和控制器。脉冲发生器产生压力反射刺激信号作为压力反射治疗的一部分。引线适于电连接到脉冲发生器并且被血管内馈送到心脏中。引线包括位于心脏中或靠近心脏的电极以将压力反射信号传递到心脏中或心脏附近的压力感受器区域。传感器感测关于压力反射治疗的功效的生理参数，并提供指示功效的信号。控制器连接到脉冲发生器以控制压力反射刺激信号和传感器以接收指示压力反射治疗功效的信号。本文提供了其他方面。

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