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1. 发明授权

US09993205B2 Cardiac response classification using retriggerable classification windows 有权
公开(公告)号：US09993205B2
公开(公告)日：2018-06-12
申请号：US12818066
申请日：2010-06-17
申请人： Scott A. Meyer , Yanting Dong , Jeremy Maniak , Doug Birholz , John Voegele
发明人： Scott A. Meyer , Yanting Dong , Jeremy Maniak , Doug Birholz , John Voegele
IPC分类号： A61N1/08 , A61B5/00 , A61N1/37 , A61B5/0452
CPC分类号： A61B5/7264 , A61B5/04525 , A61B5/7217 , A61N1/371
摘要： Methods and devices for classifying a cardiac response to pacing involve establishing a retriggerable cardiac response classification window. A first cardiac response classification window is established subsequent to delivery of a pacing pulse. A cardiac signal following the pacing stimulation is sensed in the first classification window. A second cardiac response classification may be triggered if a trigger characteristic is detected in the first classification window. The cardiac signal is sensed in the second classification window if the second classification window is established. The cardiac response to the pacing stimulation is determined based on characteristics of the cardiac signal. The cardiac response may be determined to be one of a captured response, a non-captured response, a non-captured response added to an intrinsic beat, and a fusion/pseudofusion beat, for example.

2. 发明授权

US09020596B2 Management of fusion beat detection during capture threshold determination 有权
标题翻译：捕获阈值确定期间融合搏动检测的管理
公开(公告)号：US09020596B2
公开(公告)日：2015-04-28
申请号：US13546820
申请日：2012-07-11
申请人： Shibaji Shome , Yanting Dong , Aaron R. McCabe
发明人： Shibaji Shome , Yanting Dong , Aaron R. McCabe
IPC分类号： A61N1/37
CPC分类号： A61N1/3712
摘要： An improved technique is described for dealing with the detection of fusion beats when capture verification is performed by a cardiac pacing device such as during a capture threshold determination procedure. Schemes for classifying heart beats may misclassify beats as fusion beats due to feature/morphology changes in the test electrogram waveform that may occur even when capture is achieved.
摘要翻译：描述了一种改进的技术，用于处理在心脏起搏装置执行捕获验证时，例如在捕获阈值确定过程期间的融合节拍的检测。分类心脏跳动的方案可能由于测试电描记图波形中的特征/形态变化而将节拍错误分类为融合节拍，即使实现捕获也可能发生。

3. 发明授权

US08805497B2 Titrated intermittent pacing therapy 有权
标题翻译：滴定间歇起搏治疗
公开(公告)号：US08805497B2
公开(公告)日：2014-08-12
申请号：US12573533
申请日：2009-10-05
申请人： Yanting Dong , Shantha Arcot-Krishnamurthy , Allan C. Shuros , David L. Whitehouse
发明人： Yanting Dong , Shantha Arcot-Krishnamurthy , Allan C. Shuros , David L. Whitehouse
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/3688
摘要： Cardioprotective pre-excitation pacing may be applied to stress or de-stress a particular myocardial region delivering of pacing pulses in a manner that causes a dyssynchronous contraction. Such dyssynchronous contractions are responsible for the desired cardioprotective effects of pre-excitation pacing but may also be hazardous. Described herein is a method and system that uses measures of a patient's heart rate or exertion level to control the duty cycles of intermittent pre-excitation pacing.
摘要翻译：心脏保护性预激发起搏可用于以导致同步收缩的方式对起搏脉冲递送的特定心肌区域应力或去应激。这种异常收缩负责预激励起搏的所需心脏保护作用，但也可能是危险的。这里描述了一种方法和系统，其使用患者心率或运动水平的测量来控制间歇性预激发起搏的占空比。

4. 发明授权

US08725255B2 Cardiac resynchronization therapy optimization using cardiac activation sequence information 有权
标题翻译：心脏再同步治疗优化使用心脏激活序列信息
公开(公告)号：US08725255B2
公开(公告)日：2014-05-13
申请号：US11601216
申请日：2006-11-17
申请人： Shantha Arcot-Krishnamurthy , Yi Zhang , Jiang Ding , Yinghong Yu , Yanting Dong
发明人： Shantha Arcot-Krishnamurthy , Yi Zhang , Jiang Ding , Yinghong Yu , Yanting Dong
IPC分类号： A61N1/365 , A61N1/362
CPC分类号： A61N1/3627 , A61B5/04011 , A61B5/0452 , A61N1/365 , A61N1/36535 , A61N1/36542
摘要： Systems and methods provide for pacing a heart to improve pumping efficiency of the heart, such as by producing a cardiac fusion response for patient's subject to cardiac resynchronization therapy. A pacing parameter, such as an A-V delay, V-V delay, lead/electrode configuration or vector, is adjusted and a cardiac signal vector representative of all or a portion of one or more cardiac activation sequences is monitored during pacing parameter adjustment. A change in a characteristic of the cardiac signal vector is detected in response to an adjusted pacing parameter, the change indicative of a cardiac fusion response. A pacing therapy may be delivered to produce the cardiac fusion response using the adjusted pacing parameter.
摘要翻译：系统和方法提供心脏起搏以改善心脏的泵送效率，例如通过为患者进行心脏再同步治疗产生心脏融合反应。调整起搏参数，例如A-V延迟，V-V延迟，引线/电极配置或载体，并且在起搏参数调整期间监测表示一个或多个心脏激活序列的全部或一部分的心脏信号载体。响应于调整的起搏参数，指示心脏融合反应的变化来检测心脏信号载体的特性变化。可以使用调整的起搏参数来递送起搏治疗以产生心脏融合反应。

5. 发明申请

US20130261688A1 DETERMINATION OF PHRENIC NERVE STIMULATION THRESHOLD 有权
标题翻译：确定神经刺激阈值
公开(公告)号：US20130261688A1
公开(公告)日：2013-10-03
申请号：US13781042
申请日：2013-02-28
申请人： Yanting Dong , Sunipa Saha , Holly Rockweiler
发明人： Yanting Dong , Sunipa Saha , Holly Rockweiler
IPC分类号： A61N1/37
CPC分类号： A61N1/371 , A61B5/1107 , A61B5/4029 , A61B5/7264 , A61B5/7282 , A61B2562/0219 , A61N1/36542
摘要： In an example of a method, the method includes testing for phrenic nerve stimulation (PS) threshold. If PS beats are detected at the pacing output level, analyzing the detected PS beats using criteria to determine if the pacing output level can be declared to be the PS threshold. If the pacing output level cannot be declared to be the PS threshold based on the analysis of the PS beat at the pacing output level, performing a PS beat confirmation procedure. The PS beat confirmation procedure may include delivering additional cardiac paces at the pacing output level to generate additional PS beats, and analyzing the detected PS beats using other criteria to determine if the pacing output level can be confirmed as the PS threshold.
摘要翻译：在方法的示例中，该方法包括测试膈神经刺激（PS）阈值。如果在起搏输出电平检测到PS节拍，则使用标准分析检测到的PS节拍，以确定起搏输出电平是否可以声明为PS阈值。如果起搏输出电平不能根据起搏输出电平下PS搏动的分析声明为PS阈值，则执行PS跳动确认程序。 PS节拍确认程序可以包括在起搏输出电平上递送额外的心脏搏动以产生额外的PS节拍，并且使用其他标准来分析检测到的PS节拍，以确定起搏输出电平是否可以被确认为PS阈值。

6. 发明授权

US08403830B2 Rhythm discrimination enhancement—AV drive 有权
标题翻译：节奏辨别增强 - AV驱动
公开(公告)号：US08403830B2
公开(公告)日：2013-03-26
申请号：US13196491
申请日：2011-08-02
申请人： Deepa Mahajan , Yanting Dong , David L. Perschbacher
发明人： Deepa Mahajan , Yanting Dong , David L. Perschbacher
IPC分类号： A61B1/00
CPC分类号： A61N1/3621 , A61B5/0464 , A61N1/3622 , A61N1/3624 , A61N1/3704 , A61N1/3962
摘要： An apparatus comprises an implantable cardiac signal sensing circuit and a controller circuit. The implantable cardiac signal sensing circuit provides a sensed depolarization signal from a ventricle and a sensed depolarization signal from an atrium. The controller circuit includes a one-to-one detector circuit and a tachyarrhythmia discrimination circuit. The one-to-one detector circuit measures cardiac depolarization intervals of the atrium and the ventricle and determines whether a relationship of atrial depolarizations to ventricular depolarizations is substantially one-to-one. The tachyarrhythmia discrimination circuit increments a counter when detecting a shortening or prolonging of a V-V interval that immediately precedes the same shortening or prolonging of an A-A interval, classifies the episode as VT according to the counter, and provides the classification of the tachyarrhythmia episode to a user or process.
摘要翻译：一种装置包括可植入心脏信号感测电路和控制器电路。可植入心脏信号感测电路提供来自心室的感测去极化信号和来自心房的感测去极化信号。控制器电路包括一对一检测器电路和快速心律失常鉴别电路。一对一检测器电路测量心房和心室的心脏去极化间隔，并确定心房去极化与心室去极化的关系是否基本上是一对一的。快速性心律失常辨别电路在检测到在AA间隔的相同缩短或延长之前的VV间期的缩短或延长时增加计数器，根据计数器将发作分类为VT，并将快速性心律失常发作的分类提供给用户或进程。

7. 发明申请

US20130013020A1 Methods and Systems for Managing Fusion and Noise in Cardiac Pacing Response Classification 有权
标题翻译：心脏起搏反应分类融合与噪声管理方法与系统
公开(公告)号：US20130013020A1
公开(公告)日：2013-01-10
申请号：US13618486
申请日：2012-09-14
申请人： Kevin John Stalsberg , Yanting Dong , Scott A. Meyer , John Michael Voegele , Derek Daniel Bohn , Eric Keith Enrooth , Clayton Scott Foster , David William Yost
发明人： Kevin John Stalsberg , Yanting Dong , Scott A. Meyer , John Michael Voegele , Derek Daniel Bohn , Eric Keith Enrooth , Clayton Scott Foster , David William Yost
IPC分类号： A61N1/37
CPC分类号： A61N1/371 , A61B5/0452 , A61B5/7203 , A61B5/7217 , A61B5/7264
摘要： Methods and systems for detecting noise in cardiac pacing response classification processes involve determining that a cardiac response classification is possibly erroneous if unexpected signal content is detected. The unexpected signal content may comprise signal peaks that have polarity opposite to the polarity of peaks used to determine the cardiac response to pacing. Fusion/noise management processes include pacing at a relatively high energy level until capture is detected after a fusion, indeterminate, or possibly erroneous pacing response classification is made. The relatively high energy pacing pulses may be delivered until capture is detected or until a predetermined number of paces are delivered.
摘要翻译：用于检测心脏起搏反应分类过程中的噪声的方法和系统涉及如果检测到意外的信号内容，则确定心脏反应分类可能是错误的。意想不到的信号内容可以包括具有与用于确定对起搏的心脏反应的峰的极性相反的极性的信号峰。融合/噪声管理过程包括在相对高的能量级别进行起搏，直到在融合之后检测到捕获，不确定或可能错误的起搏响应分类。可以递送相对高的能量起搏脉冲，直到检测到捕获或直到传送预定数量的步数。

8. 发明授权

US08311631B2 Systems and methods for improving heart rate kinetics in heart failure patients 有权
标题翻译：改善心力衰竭患者心率动力学的系统和方法
公开(公告)号：US08311631B2
公开(公告)日：2012-11-13
申请号：US12545676
申请日：2009-08-21
申请人： Donald Hopper , Yinghong Yu , Yanting Dong
发明人： Donald Hopper , Yinghong Yu , Yanting Dong
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36542
摘要： Adaptive rate pacing for improving heart rate kinetics in heart failure patients involves determining onset and sustaining of patient activity. The patient's heart rate response to the sustained activity is evaluated during a time window defined between onset of the activity and a steady-state exercise level. If the patient's heart rate response to the sustained activity is determined to be slow, a pacing therapy is delivered at a rate greater than the patient's intrinsic heart rate based on a profile of the patient's heart rate response to varying workloads. If determined not to be slow, the pacing therapy is withheld. Monitoring-only configurations provide for acquisition and organization of physiological data for heart failure patients. These data can be acquired on a per-patient basis and used to assess the HF status of the patient.
摘要翻译：用于改善心力衰竭患者心率动力学的适应性起搏速率包括确定患者活动的发病和持续时间。在活动开始和稳态运动水平之间定义的时间窗口期间评估患者对持续活动的心率反应。如果患者对持续活动的心率反应被确定为缓慢，则基于患者对不同工作负荷的心率反应的简档，起搏治疗以大于患者内在心率的速率递送。如果确定不要慢，起搏疗法就被扣留。仅监测配置提供心脏病患者生理数据的采集和组织。这些数据可以在每个患者的基础上获得，并用于评估患者的HF状态。

9. 发明授权

US08306622B2 Left atrial sense or capture detection from coronary sinus 有权
标题翻译：左心房感或冠状窦的捕获检测
公开(公告)号：US08306622B2
公开(公告)日：2012-11-06
申请号：US12892378
申请日：2010-09-28
申请人： Shantha Arcot-Krishnamurthy , Shibaji Shome , Yanting Dong
发明人： Shantha Arcot-Krishnamurthy , Shibaji Shome , Yanting Dong
IPC分类号： A61N1/00
CPC分类号： A61N1/371 , A61N1/3627 , A61N1/3684
摘要： A method and device to detect and compare changes in atrial rate and morphology can be used to identify left atrial sense and capture, such as from a quadripolar or other lead located in or around the coronary sinus.
摘要翻译：用于检测和比较心房率和形态变化的方法和装置可用于鉴定左心房感和捕获，例如来自位于冠状窦内或周围的四极或其他导联。

10. 发明申请

US20120226328A1 CARDIAC RESYNCHRONIZATION THERAPY PARAMETER OPTIMIZATION 审中-公开
标题翻译： CARDIAC RESYNCHRONIZATION治疗参数优化
公开(公告)号：US20120226328A1
公开(公告)日：2012-09-06
申请号：US13466431
申请日：2012-05-08
申请人： Yanting Dong , Yinghong Yu , Jiang Ding , Scott A. Meyer , Xuan Wei , Michael John Stucky
发明人： Yanting Dong , Yinghong Yu , Jiang Ding , Scott A. Meyer , Xuan Wei , Michael John Stucky
IPC分类号： A61N1/365 , A61N1/37
CPC分类号： A61N1/3627 , A61N1/36585 , A61N1/3684
摘要： Systems and methods involve determination of CRT parameters using a number of CRT optimization processes. Each CRT optimization process attempts to return recommended parameters. The CRT parameters are determined based on the recommended parameters returned by one or more of the CRT optimization processes. The CRT optimization processes may be sequentially implemented and the CRT parameters may be determined based on the recommended parameters returned by a first CRT optimization process to return recommended parameters. The CRT parameters may be determined based on a combination of the recommended parameters returned. The CRT optimization processes implemented may be selected from available CRT optimization processes based on patient conditions.
摘要翻译：系统和方法涉及使用多个CRT优化过程来确定CRT参数。每个CRT优化过程都会尝试返回推荐的参数。 CRT参数根据一个或多个CRT优化过程返回的推荐参数来确定。可以顺序地实施CRT优化过程，并且可以基于由第一CRT优化过程返回的推荐参数来返回推荐参数来确定CRT参数。可以基于返回的推荐参数的组合来确定CRT参数。可以根据患者条件从可用的CRT优化过程中选择实现的CRT优化处理。

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