专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20120142557A1 SLIDE CONDITIONING SYSTEMS AND METHODS 审中-公开
标题翻译：滑动调节系统和方法
公开(公告)号：US20120142557A1
公开(公告)日：2012-06-07
申请号：US13257483
申请日：2010-03-17
申请人： Dale B. Emery , Nils B. Adey
发明人： Dale B. Emery , Nils B. Adey
IPC分类号： C40B40/00 , C40B60/00
CPC分类号： G01N35/00029 , B01L9/52 , B01L2200/025 , B01L2200/141 , B01L2300/0636 , B01L2300/0822 , B01L2400/0409 , B01L2400/0487 , G01N2035/00089 , G01N2035/00158
摘要： A slide-loader system for preparing a microarray slide having a hybridized reaction area for washing, and which includes an immersion tray which contains a volume of wash buffer fluid, and a stripping jig that holds the microarray slide during removal of a reaction chamber housing that is mounted about the hybridized reaction area.
摘要翻译：一种用于制备具有用于洗涤的杂交反应区域的微阵列载玻片的载玻片装载器系统，其包括含有一定体积的洗涤缓冲液的浸渍托盘和在移除反应室时保持微阵列载玻片的剥离夹具，围绕杂交反应区安装。

2. 发明授权

US06637463B1 Multi-channel microfluidic system design with balanced fluid flow distribution 失效
标题翻译：具有平衡流体流量分布的多通道微流体系统设计
公开(公告)号：US06637463B1
公开(公告)日：2003-10-28
申请号：US10142555
申请日：2002-05-10
申请人： Ming Lei , Nils B. Adey , Michael R. McNeely
发明人： Ming Lei , Nils B. Adey , Michael R. McNeely
IPC分类号： F15B2100
CPC分类号： B01F5/0403 , B01F5/064 , B01F5/0642 , B01F13/0059 , B01F15/0232 , B01F2015/0221 , B01F2215/0037 , B01J19/0093 , B01J2219/00837 , B01J2219/00891 , B01J2219/00995 , B01L3/502723 , B01L3/502738 , B01L3/502746 , B01L99/00 , B01L2200/025 , B01L2200/0621 , B01L2200/0684 , B01L2200/10 , B01L2200/12 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/0883 , B01L2300/0887 , B01L2300/165 , B01L2300/18 , B01L2400/0406 , B01L2400/0487 , B01L2400/0688 , B01L2400/0694 , B01L2400/086 , F15C1/14 , F15C1/146 , F28F2210/02 , F28F2245/04 , F28F2260/02 , G01N35/08 , G01N35/1004 , G01N2035/00237 , G01N2035/00366 , G01N2035/00544 , Y10T137/206 , Y10T137/2076 , Y10T137/2267
摘要： Methods and apparatus are presented for controlling fluid flow through flow paths with pressure gradient fluid control. Passive fluid flow barriers may be used to act as valves, thereby allowing the flow of fluids through flow paths to be regulated so as to allow fluids to be introduced via a single channel and subsequently split into multiple channels. Flow through the flow paths can be regulated to allow a series of sister wells or chambers to all fill prior to the fluid flowing beyond any one of the sister wells or chambers. Each flow path may have multiple segments, at least one of which is designed to balance the pressure drops of the flow paths to provide uniform flow of fluids through the flow paths. The configurations of the wells may also be modified by adding vents or flow dividers to enhance fluid flushing and gas removal capability.
摘要翻译：提出了通过压力梯度流体控制来控制通过流动路径的流体流动的方法和装置。被动流体阻流层可以用作阀门，从而允许流体通过流动路径的流动被调节，以允许流体经由单个通道被引入并随后被分成多个通道。可以调节通过流路的流动，以允许一系列姐妹井或腔室在流体流过任何一个姐妹井或腔室之前全部填充。每个流动路径可以具有多个段，其中至少一个被设计成平衡流动路径的压降以提供流体通过流动路径的均匀流动。也可以通过添加通风口或分流器来改进孔的构造，以增强流体冲洗和气体去除能力。

3. 发明授权

US10866170B2 Devices, systems, and methods for extracting a material from a material sample 有权
公开(公告)号：US10866170B2
公开(公告)日：2020-12-15
申请号：US13981541
申请日：2011-11-16
申请人： Nils B. Adey , Katherine B. Geiersbach , Mark Herrmann , Robert J. Parry
发明人： Nils B. Adey , Katherine B. Geiersbach , Mark Herrmann , Robert J. Parry
IPC分类号： G01N1/31 , G01N1/04 , G01N1/28 , G01N1/38
CPC分类号： G01N1/31 , G01N1/04 , G01N2001/2873 , G01N2001/383
摘要： Devices, systems, and associated methods for selectively extracting a material from a sample are provided. In one aspect, for example, a method for selectively extracting biological material from a biological sample can include identifying a region of biological material to be extracted from a biological sample disposed on a substantially planar surface, applying an extraction tool to the region of biological material to disrupt biological material from the biological sample, and dispensing a liquid at the region of biological material. The method can also include aspirating the liquid and the disrupted biological material from the biological sample.

4. 发明申请

US20130048089A1 Analytical System For Performing Laboratory Protocols and Associated Methods 审中-公开
标题翻译：执行实验室协议和相关方法的分析系统
公开(公告)号：US20130048089A1
公开(公告)日：2013-02-28
申请号：US13695081
申请日：2011-04-29
申请人： Nils B. Adey , Rob Parry , James Kelland , Kevin Sullivan
发明人： Nils B. Adey , Rob Parry , James Kelland , Kevin Sullivan
IPC分类号： G01N1/28 , F17D1/00 , C40B40/00
摘要： Systems, devices, and methods for automating laboratory protocols utilizing cooperative efforts between differing components including fluidics, agitation and thermal control for processing a wide variety of disparate laboratory protocols are provided. In one aspect, a sample processing module is provided, including a housing configured to accommodate a pre-identified sample process, a temperature input capable of interfacing with a temperature controller, a fluid input capable of interfacing with an input fluid controller, a fluid output capable of interfacing with an output fluid controller, and a standardized agitation connector capable of interfacing with an agitator. A control system interfaces with the temperature input, fluid input, fluid output, and agitation connector to enable the system to perform laboratory protocols that require complex, sequential fluidic steps in association with the temperature and agitation control.
摘要翻译：提供了使用不同组件之间的协作努力自动化实验室协议的系统，设备和方法，包括用于处理各种不同实验室协议的流体学，搅拌和热控制。在一个方面，提供了一种样品处理模块，其包括被配置为容纳预先识别的样品过程的壳体，能够与温度控制器接口的温度输入，能够与输入流体控制器接口的流体输入，流体输出能够与输出流体控制器接口，以及能够与搅拌器接口的标准化搅拌连接器。控制系统与温度输入，流体输入，流体输出和搅拌连接器接口，使系统能够执行实验室协议，这些实验室协议需要与温度和搅拌控制相关联的复杂的，顺序的流程步骤。

5. 发明授权

US5747334A Random peptide library 失效
标题翻译：随机肽库
公开(公告)号：US5747334A
公开(公告)日：1998-05-05
申请号：US189331
申请日：1994-01-31
申请人： Brian K Kay , Dana M. Fowlkes , Nils B. Adey , Andrew B. Sparks
发明人： Brian K Kay , Dana M. Fowlkes , Nils B. Adey , Andrew B. Sparks
IPC分类号： G01N33/566 , A61K38/00 , C07H21/04 , C07K14/47 , C07K16/00 , C07K16/18 , C07K16/30 , C07K16/40 , C07K16/44 , C12N1/21 , C12N15/09 , C12N15/10 , C12N15/62 , C12N15/70 , C12P21/02 , C12P21/04 , C12P21/08 , C12R1/19 , C40B40/02 , C12N5/10
CPC分类号： C40B40/02 , C07K14/47 , C07K16/00 , C07K16/18 , C07K16/3007 , C07K16/3069 , C07K16/40 , C07K16/44 , C12N15/1037 , C12N15/1048 , C12N15/1062 , C12N15/1075 , C12N15/62 , C12N15/70 , C07K2319/00 , C07K2319/20 , C07K2319/50 , C07K2319/61 , C07K2319/705 , C07K2319/72 , C07K2319/73 , C07K2319/735
摘要： A novel method for producing novel and/or improved heterofunctional binding fusion proteins termed Totally Synthetic Affinity Reagents (TSARs) is disclosed. TSARs are concatenated heterofunctional proteins, polypeptides or peptides comprising at least two functional regions: a binding domain with affinity for a ligand and a second effector peptide portion that is chemically or biologically active. In one embodiment, the heterofunctional proteins, polypeptides or peptides further comprise a linker peptide portion between the binding domain and the second active peptide portion. The linker peptide can be either susceptible or not susceptible to cleavage by enzymatic or chemical means. Novel and/or improved heterofunctional binding reagents as well as methods for using the reagents for a variety of in vitro and in vivo applications are also disclosed.
摘要翻译：公开了一种用于产生称为全合成亲和试剂（TSAR）的新型和/或改进的异功能结合融合蛋白的新方法。 TSAR是连接的异功能蛋白质，多肽或肽，其包含至少两个功能区：对配体具有亲和性的结合结构域和化学或生物活性的第二效应肽部分。在一个实施方案中，杂多功能蛋白质，多肽或肽还包含结合结构域和第二活性肽部分之间的接头肽部分。接头肽可以是敏感的或不易于通过酶促或化学方式切割。还公开了新型和/或改进的异型结合试剂以及用于多种体外和体内应用的方法。

6. 发明授权

US10697990B2 Analytical system for performing laboratory protocols and associated methods 有权
公开(公告)号：US10697990B2
公开(公告)日：2020-06-30
申请号：US13695081
申请日：2011-04-29
申请人： Nils B. Adey , Rob Perry
发明人： Nils B. Adey , Rob Perry
IPC分类号： G01N1/31 , G01N35/00 , G01N35/10
摘要： Systems, devices, and methods for automating laboratory protocols utilizing cooperative efforts between differing components including fluidics, agitation and thermal control for processing a wide variety of disparate laboratory protocols are provided. In one aspect, a sample processing module is provided, including a housing configured to accommodate a pre-identified sample process, a temperature input capable of interfacing with a temperature controller, a fluid input capable of interfacing with an input fluid controller, a fluid output capable of interfacing with an output fluid controller, and a standardized agitation connector capable of interfacing with an agitator. A control system interfaces with the temperature input, fluid input, fluid output, and agitation connector to enable the system to perform laboratory protocols that require complex, sequential fluidic steps in association with the temperature and agitation control.

7. 发明授权

US5948635A Totally Synthetic Affinity Reagents 失效
标题翻译：全合成亲和试剂
公开(公告)号：US5948635A
公开(公告)日：1999-09-07
申请号：US471068
申请日：1995-06-06
申请人： Brian K Kay , Dana M. Fowlkes , Nils B. Adey , Andrew B. Sparks
发明人： Brian K Kay , Dana M. Fowlkes , Nils B. Adey , Andrew B. Sparks
IPC分类号： G01N33/566 , A61K38/00 , C07H21/04 , C07K14/47 , C07K16/00 , C07K16/18 , C07K16/30 , C07K16/40 , C07K16/44 , C12N1/21 , C12N15/09 , C12N15/10 , C12N15/62 , C12N15/70 , C12P21/02 , C12P21/04 , C12P21/08 , C12R1/19 , C40B40/02
CPC分类号： C40B40/02 , C07K14/47 , C07K16/00 , C07K16/18 , C07K16/3007 , C07K16/3069 , C07K16/40 , C07K16/44 , C12N15/1037 , C12N15/1048 , C12N15/1062 , C12N15/1075 , C12N15/62 , C12N15/70 , C07K2319/00 , C07K2319/20 , C07K2319/50 , C07K2319/61 , C07K2319/705 , C07K2319/72 , C07K2319/73 , C07K2319/735
摘要： A novel method for producing novel and/or improved heterofunctional binding fusion proteins termed Totally Synthetic Affinity Reagents (TSARs) is disclosed. TSARs are concatenated heterofunctional proteins, polypeptides or peptides comprising at least two functional regions: a binding domain with affinity for a ligand and a second effector peptide portion that is chemically or biologically active. In one embodiment, the heterofunctional proteins, polypeptides or peptides further comprise a linker peptide portion between the binding domain and the second active peptide portion. The linker peptide can be either susceptible or not susceptible to cleavage by enzymatic or chemical means. Novel and/or improved heterofunctional binding reagents as well as methods for using the reagents for a variety of in vitro and in vivo applications are also disclosed.
摘要翻译：公开了一种用于产生称为全合成亲和试剂（TSAR）的新型和/或改进的异功能结合融合蛋白的新方法。 TSAR是连接的异功能蛋白质，多肽或肽，其包含至少两个功能区：对配体具有亲和性的结合结构域和化学或生物活性的第二效应肽部分。在一个实施方案中，杂多功能蛋白质，多肽或肽还包含结合结构域和第二活性肽部分之间的接头肽部分。接头肽可以是敏感的或不易于通过酶促或化学方式切割。还公开了新型和/或改进的异型结合试剂以及用于多种体外和体内应用的方法。

8. 发明授权

US5852167A Totally synthetic affinity reagents 失效
公开(公告)号：US5852167A
公开(公告)日：1998-12-22
申请号：US471800
申请日：1995-06-06
申请人： Brian K. Kay , Nils B. Adey
发明人： Brian K. Kay , Nils B. Adey
IPC分类号： C07K14/47 , C07K16/00 , C07K16/18 , C07K16/30 , C07K16/40 , C07K16/44 , C12N15/10 , C12N15/62 , C12N15/70 , C12P21/04 , C40B40/02 , C07K14/00
CPC分类号： C07K14/47 , C07K16/00 , C07K16/18 , C07K16/3007 , C07K16/3069 , C07K16/40 , C07K16/44 , C12N15/1037 , C12N15/1048 , C12N15/1062 , C12N15/1075 , C12N15/62 , C12N15/70 , C40B40/02 , C07K2317/34 , C07K2319/00 , C07K2319/20 , C07K2319/50 , C07K2319/61 , C07K2319/705 , C07K2319/72 , C07K2319/73 , C07K2319/735
摘要： A novel method for producing novel and/or improved heterofunctional binding fusion proteins termed Totally Synthetic Affinity Reagents (TSARs) is disclosed. TSARs are concatenated heterofunctional proteins, polypeptides or peptides comprising at least two functional regions: a binding domain with affinity for a ligand and a second effector peptide portion that is chemically or biologically active. In one embodiment, the heterofunctional proteins, polypeptides or peptides further comprise a linker peptide portion between the binding domain and the second active peptide portion. The linker peptide can be either susceptible or not susceptible to cleavage by enzymatic or chemical means. Novel and/or improved heterofunctional binding reagents as well as methods for using the reagents for a variety of in vitro and in vivo applications are also disclosed.

9. 发明申请

US20140329269A1 DEVICES, SYSTEMS, AND METHODS FOR EXTRACTING A MATERIAL FROM A MATERIAL SAMPLE 审中-公开
标题翻译：用于从材料样品中提取材料的装置，系统和方法
公开(公告)号：US20140329269A1
公开(公告)日：2014-11-06
申请号：US13981541
申请日：2011-11-16
申请人： Nils B. Adey , Katherine B. Geiersbach , Mark Herrmann , Robert J. Parry
发明人： Nils B. Adey , Katherine B. Geiersbach , Mark Herrmann , Robert J. Parry
IPC分类号： G01N1/31
CPC分类号： G01N1/31 , G01N1/04 , G01N2001/2873 , G01N2001/383
摘要： Devices, systems, and associated methods for selectively extracting a material from a sample are provided. In one aspect, for example, a method for selectively extracting biological material from a biological sample can include identifying a region of biological material to be extracted from a biological sample disposed on a substantially planar surface, applying an extraction tool to the region of biological material to disrupt biological material from the biological sample, and dispensing a liquid at the region of biological material. The method can also include aspirating the liquid and the disrupted biological material from the biological sample.
摘要翻译：提供了用于从样品中选择性提取材料的装置，系统和相关方法。在一个方面，例如，用于从生物样品中选择性提取生物材料的方法可以包括鉴定要从设置在基本上平坦的表面上的生物样品中提取的生物材料的区域，将提取工具施加到生物材料区域从生物样品中破坏生物材料，并在生物材料区域分配液体。该方法还可以包括从生物样品吸入液体和破坏的生物材料。

10. 发明授权

US07235400B2 Laminated microarray interface device 失效
标题翻译：层压微阵列接口装置
公开(公告)号：US07235400B2
公开(公告)日：2007-06-26
申请号：US10211503
申请日：2002-08-02
申请人： Nils B. Adey
发明人： Nils B. Adey
IPC分类号： C12M1/34
CPC分类号： B01F5/10 , B01F11/0045 , B01F11/0266 , B01F13/0059 , B01J19/0093 , B01J2219/00351 , B01J2219/0043 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00659 , B01L3/0293 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L3/5085 , B01L9/52 , B01L9/527 , B01L2200/025 , B01L2200/026 , B01L2200/0689 , B01L2300/0636 , B01L2300/0819 , B01L2300/0822 , B01L2300/0877 , B01L2300/0883 , B01L2300/0887 , C40B60/14 , G01N33/543 , G01N35/00 , G01N35/025 , G01N35/028 , G01N2035/00158 , G01N2035/00237 , G01N2035/00544
摘要： A device for forming a low volume reaction chamber on a substrate such as a microarray slide and its method of use is disclosed. The reaction chamber forming device has an adhesive laminate design that permits it to be manufactured as a disposable device. A preferred embodiment of the device includes pneumatically actuatable mixing bladders, which can be inflated or deflated to produce deflection of a wall of the reaction chamber in and out with respect to the reaction chamber to generate movement and mixing of fluid within the reaction chamber.
摘要翻译：公开了一种用于在诸如微阵列载玻片的基板上形成低体积反应室的装置及其使用方法。反应室形成装置具有允许其被制造为一次性装置的粘合层压板设计。该装置的优选实施例包括气动致动的混合气囊，其可被充气或放气以产生反应室的壁相对于反应室进出的偏转，以产生反应室内的流体的运动和混合。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式