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1. 发明授权

US08450279B2 Cell permeable Nm23 recombinant proteins, polynucleotides encoding the same, and anti-metastatic composition comprising the same 有权
标题翻译：细胞可渗透的Nm23重组蛋白，编码它们的多核苷酸和包含其的抗转移组合物
公开(公告)号：US08450279B2
公开(公告)日：2013-05-28
申请号：US12676182
申请日：2008-09-04
申请人： Daewoong Jo , Thi Thuy Nga Do , Kisuk Park
发明人： Daewoong Jo , Thi Thuy Nga Do , Kisuk Park
IPC分类号： C12N15/12
CPC分类号： C12N9/12 , A61K38/1709 , C07K2319/00 , C07K2319/09 , C07K2319/10
摘要： The present invention discloses cell permeable Nm23 recombinant proteins where a macromolecule transduction domain (MTD) is fused to a metastasis suppressor Nm23. Also disclosed are polynucleotides encoding the cell permeable Nm23 recombinant proteins, an expression vector containing the cell permeable Nm23 recombinant protein, and a pharmaceutical composition for preventing metastasis which contains the cell permeable Nm23 recombinant protein as an effective ingredient. The cell permeable Nm23 recombinant proteins of the present invention can induce KSR phosphorylation and inactivation and inhibit Ras-mediated MAPK cascade by efficiently introducing a metastasis suppressor Nm23 into a cell. Therefore, the cell permeable Nm23 recombinant proteins of the present invention can be effectively used as an anti-metastatic agent capable of preventing cancer metastasis by inhibiting the proliferation, differentiation and migration of cancer cells.
摘要翻译：本发明公开了一种细胞渗透性的Nm23重组蛋白，其中大分子转导结构域（MTD）与转移抑制基因Nm23融合。还公开了编码细胞可渗透性的Nm23重组蛋白质的多核苷酸，含有细胞可渗透性的Nm23重组蛋白质的表达载体，以及含有细胞可渗透性的Nm23重组蛋白质作为有效成分的用于预防转移的药物组合物。本发明的细胞可渗透的Nm23重组蛋白可以通过有效地将转移抑制基因Nm23引入细胞来诱导KSR磷酸化和失活并抑制Ras介导的MAPK级联。因此，通过抑制癌细胞的增殖，分化和迁移，本发明的细胞可渗透的Nm23重组蛋白可以有效地用作能够预防癌转移的抗转移剂。

2. 发明申请

US20100323971A1 CELL PERMEABLE NM23 RECOMBINANT PROTEINS, POLYNUCLEOTIDES ENCODING THE SAME, AND ANTI-METASTATIC COMPOSITION COMPRISING THE SAME 有权
标题翻译：细胞渗透性NM23重组蛋白，编码其的多核苷酸和包含其的抗细胞组成
公开(公告)号：US20100323971A1
公开(公告)日：2010-12-23
申请号：US12676182
申请日：2008-09-04
申请人： Daewoong Jo , Thi Thuy Nga Do , Kisuk Park
发明人： Daewoong Jo , Thi Thuy Nga Do , Kisuk Park
IPC分类号： A61K38/16 , C12P21/04 , C12N1/21 , C12N15/63 , C07K14/435 , C07H21/04 , A61P35/04
CPC分类号： C12N9/12 , A61K38/1709 , C07K2319/00 , C07K2319/09 , C07K2319/10
摘要： The present invention discloses cell permeable Nm23 recombinant proteins where a macromolecule transduction domain (MTD) is fused to a metastasis suppressor Nm23. Also disclosed are polynucleotides encoding the cell permeable Nm23 recombinant proteins, an expression vector containing the cell permeable Nm23 recombinant protein, and a pharmaceutical composition for preventing metastasis which contains the cell permeable Nm23 recombinant protein as an effective ingredient. The cell permeable Nm23 recombinant proteins of the present invention can induce KSR phosphorylation and inactivation and inhibit Ras-mediated MAPK cascade by efficiently introducing a metastasis suppressor Nm23 into a cell. Therefore, the cell permeable Nm23 recombinant proteins of the present invention can be effectively used as an anti-metastatic agent capable of preventing cancer metastasis by inhibiting the proliferation, differentiation and migration of cancer cells.
摘要翻译：本发明公开了一种细胞渗透性的Nm23重组蛋白，其中大分子转导结构域（MTD）与转移抑制基因Nm23融合。还公开了编码细胞可渗透性的Nm23重组蛋白质的多核苷酸，含有细胞可渗透性的Nm23重组蛋白质的表达载体，以及含有细胞可渗透性的Nm23重组蛋白质作为有效成分的用于预防转移的药物组合物。本发明的细胞可渗透的Nm23重组蛋白可以通过有效地将转移抑制基因Nm23引入细胞来诱导KSR磷酸化和失活并抑制Ras介导的MAPK级联。因此，通过抑制癌细胞的增殖，分化和迁移，本发明的细胞可渗透的Nm23重组蛋白可以有效地用作能够预防癌转移的抗转移剂。

3. 发明申请

US20100197598A1 NOVEL MACROMOLECULE TRANSDUCTION DOMAINS AND METHODS FOR IDENTIFICATION AND USES THEREOF 有权
标题翻译：新型MACROMOLECULE传输域及其识别方法及其应用
公开(公告)号：US20100197598A1
公开(公告)日：2010-08-05
申请号：US12524935
申请日：2008-01-29
申请人： Dae Woong Jo , Jae Sun Ko , Jin Sook Kim , Kyung Mi Park , Jin Kyung Song , Jung Hee Lim , Thi Thuy Nga Do , Thi Lan Phuong Do , Minh Tam Duong
发明人： Dae Woong Jo , Jae Sun Ko , Jin Sook Kim , Kyung Mi Park , Jin Kyung Song , Jung Hee Lim , Thi Thuy Nga Do , Thi Lan Phuong Do , Minh Tam Duong
IPC分类号： A61K38/10 , C07K7/06 , C07K7/08 , C07H21/04 , C12N9/00 , A61K38/08
CPC分类号： A61K47/48246 , A61K39/39 , A61K48/0041 , C07K7/06 , C07K7/08 , C07K14/195 , C07K14/47
摘要： The present invention discloses novel macromolecule transduction domain (MTD) peptides which facilitate the traverse of a biologically active molecule across the cell membrane. Also disclosed are polynucleotides encoding the MTD peptides, methods of identifying the MTD peptides; methods of genetically engineering a biologically active molecule to have cell permeability by using the MTD peptides, methods of importing a biologically active molecule into a cell by using the MTD peptides, and uses thereof.
摘要翻译：本发明公开了促进细胞膜上生物活性分子穿越的新型大分子转导结构域（MTD）肽。还公开了编码MTD肽的多核苷酸，鉴定MTD肽的方法; 通过使用MTD肽将生物活性分子遗传工程化以具有细胞渗透性的方法，通过使用MTD肽将生物活性分子导入细胞的方法及其用途。

4. 发明授权

US08629097B2 Macromolecule transduction domains and methods for identification and uses thereof 有权
标题翻译：大分子转导结构域及其鉴定及应用的方法
公开(公告)号：US08629097B2
公开(公告)日：2014-01-14
申请号：US12524935
申请日：2008-01-29
申请人： Dae Woong Jo , Jae Sun Ko , Jin Sook Kim , Kyung Mi Park , Jin Kyung Song , Jung Hee Lim , Thi Thuy Nga Do , Thi Lan Phuong Do , Minh Tam Duong
发明人： Dae Woong Jo , Jae Sun Ko , Jin Sook Kim , Kyung Mi Park , Jin Kyung Song , Jung Hee Lim , Thi Thuy Nga Do , Thi Lan Phuong Do , Minh Tam Duong
IPC分类号： C07K7/04 , C07K7/08 , C07K7/06
CPC分类号： A61K47/48246 , A61K39/39 , A61K48/0041 , C07K7/06 , C07K7/08 , C07K14/195 , C07K14/47
摘要： The present invention discloses novel macromolecule transduction domain (MTD) peptides which facilitate the traverse of a biologically active molecule across the cell membrane. Also disclosed are polynucleotides encoding the MTD peptides, methods of identifying the MTD peptides; methods of genetically engineering a biologically active molecule to have cell permeability by using the MTD peptides, methods of importing a biologically active molecule into a cell by using the MTD peptides, and uses thereof.
摘要翻译：本发明公开了促进细胞膜上生物活性分子穿越的新型大分子转导结构域（MTD）肽。还公开了编码MTD肽的多核苷酸，鉴定MTD肽的方法; 通过使用MTD肽将生物活性分子遗传工程化以具有细胞渗透性的方法，通过使用MTD肽将生物活性分子导入细胞的方法及其用途。

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