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1. 发明申请

US20120095188A1 ESTABLISHMENT OF INDUCED PLURIPOTENT STEM CELL USING CELL-PERMEABLE REPROGRAMMING TRANSCRIPTION FACTOR FOR CUSTOMIZED STEM CELL THERAPY 审中-公开
标题翻译：使用细胞渗透性重组转录因子建立诱导型肺细胞干细胞治疗自定义干细胞治疗
公开(公告)号：US20120095188A1
公开(公告)日：2012-04-19
申请号：US13263955
申请日：2010-03-12
申请人： Daewoong Jo , Jung-Hee Lim , Jungeun Kim , Sooyoung Jeong , Inhee Jung
发明人： Daewoong Jo , Jung-Hee Lim , Jungeun Kim , Sooyoung Jeong , Inhee Jung
IPC分类号： C07K19/00 , C12P21/02 , C12N1/21 , C12N15/62 , C12N15/70
CPC分类号： C07K14/4702 , C07K2319/09 , C07K2319/10
摘要： The present invention relates to a reprogramming transcription factor recombinant protein in which a macromolecule transduction domain (MTD) is fused to a reprogramming transcription factor to obtain cell permeability. The present invention also relates to a polynucleotide for coding said reprogramming transcription factor recombinant protein and to an expression vector of said cell-permeable reprogramming transcription factor recombinant protein. Treating a somatic cell with the cell-permeable reprogramming transcription factor recombinant protein induces the reprogramming of the stem cell-specific gene of the somatic cell, and thus can be effectively used in the establishment of an induced pluripotent stem cell (iPS cell) having characteristics similar to those of an embryonic stem cell in terms of morphology and genetics.
摘要翻译：本发明涉及重编程转录因子重组蛋白，其中大分子转导结构域（MTD）与重编程转录因子融合以获得细胞渗透性。本发明还涉及用于编码所述重编程转录因子重组蛋白的多核苷酸和所述细胞可透过重编程转录因子重组蛋白的表达载体。用细胞可渗透的重编程转录因子重组蛋白处理体细胞诱导体细胞干细胞特异性基因的重新编程，因此可以有效地用于建立具有特征的诱导多能干细胞（iPS细胞）类似于胚胎干细胞在形态学和遗传学方面。

2. 发明申请

US20100197598A1 NOVEL MACROMOLECULE TRANSDUCTION DOMAINS AND METHODS FOR IDENTIFICATION AND USES THEREOF 有权
标题翻译：新型MACROMOLECULE传输域及其识别方法及其应用
公开(公告)号：US20100197598A1
公开(公告)日：2010-08-05
申请号：US12524935
申请日：2008-01-29
申请人： Dae Woong Jo , Jae Sun Ko , Jin Sook Kim , Kyung Mi Park , Jin Kyung Song , Jung Hee Lim , Thi Thuy Nga Do , Thi Lan Phuong Do , Minh Tam Duong
发明人： Dae Woong Jo , Jae Sun Ko , Jin Sook Kim , Kyung Mi Park , Jin Kyung Song , Jung Hee Lim , Thi Thuy Nga Do , Thi Lan Phuong Do , Minh Tam Duong
IPC分类号： A61K38/10 , C07K7/06 , C07K7/08 , C07H21/04 , C12N9/00 , A61K38/08
CPC分类号： A61K47/48246 , A61K39/39 , A61K48/0041 , C07K7/06 , C07K7/08 , C07K14/195 , C07K14/47
摘要： The present invention discloses novel macromolecule transduction domain (MTD) peptides which facilitate the traverse of a biologically active molecule across the cell membrane. Also disclosed are polynucleotides encoding the MTD peptides, methods of identifying the MTD peptides; methods of genetically engineering a biologically active molecule to have cell permeability by using the MTD peptides, methods of importing a biologically active molecule into a cell by using the MTD peptides, and uses thereof.
摘要翻译：本发明公开了促进细胞膜上生物活性分子穿越的新型大分子转导结构域（MTD）肽。还公开了编码MTD肽的多核苷酸，鉴定MTD肽的方法; 通过使用MTD肽将生物活性分子遗传工程化以具有细胞渗透性的方法，通过使用MTD肽将生物活性分子导入细胞的方法及其用途。

3. 发明授权

US08470971B2 Cell permeable p53 recombinant protein, polynucleotide encoding the same, and anti-cancer composition containing the same as active ingredient 有权
标题翻译：细胞可渗透的p53重组蛋白，编码它们的多核苷酸以及含有与活性成分相同的抗癌组合物
公开(公告)号：US08470971B2
公开(公告)日：2013-06-25
申请号：US13132202
申请日：2009-12-02
申请人： Daewoong Jo , Jung-Hee Lim
发明人： Daewoong Jo , Jung-Hee Lim
IPC分类号： C07K7/00
CPC分类号： C07K14/4746 , A61K38/00 , C07K2319/10
摘要： Disclosed are a cell-permeable p53 recombinant protein in which a macromolecule transduction domain (MTD) is fused to the tumor suppressor p53, a polynucleotide encoding the same, a recombinant expression vector for producing the same, and a pharmaceutical composition of the treatment of cancer, comprising the same. Having high cell permeability, the p53 recombinant protein is effectively transduced into cells so that the tumor suppressor p53 can be translocated into cell nuclei. Within nuclei, p53 inhibits the formation of cyclin-CDK complexes to halt the cell cycle, thus suppressing excessive cell proliferation and inducing apoptosis of tumor cells. Therefore, the p53 recombinant protein can be useful as an anticancer agent in the treatment of various cancers.
摘要翻译：公开了一种细胞可渗透的p53重组蛋白，其中大分子转导结构域（MTD）与肿瘤抑制基因p53融合，编码该多核苷酸的多核苷酸，用于制备该多核苷酸的重组表达载体，以及治疗癌症的药物组合物，包括它们。具有高细胞通透性，p53重组蛋白有效转导入细胞，使肿瘤抑制基因p53能够转位入细胞核。在核内，p53抑制细胞周期蛋白CDK复合物的形成，以阻止细胞周期，从而抑制过量的细胞增殖并诱导肿瘤细胞凋亡。因此，p53重组蛋白可用作治疗各种癌症的抗癌剂。

4. 发明申请

US20110021442A1 CELL PREAMBLE RUNX3 RECOMBINANT PROTEINS, POLYNUCLEOTIDES ENCODING THE SAME, AND ANTICANCER COMPOSITIONS INCLUDING THE SAME 审中-公开
标题翻译：细胞前体RUNX3重组蛋白，编码其的多核苷酸和包括其的抗体组合物
公开(公告)号：US20110021442A1
公开(公告)日：2011-01-27
申请号：US12741138
申请日：2008-11-06
申请人： Daewoong Jo , Eun Kyung Hong , Jung-Hee Lim , Se-Eun Kang , Lihua Che
发明人： Daewoong Jo , Eun Kyung Hong , Jung-Hee Lim , Se-Eun Kang , Lihua Che
IPC分类号： A61K38/00 , C07K14/00 , C07H21/04 , C12N15/63 , C12N1/21 , C12P21/06 , A61P35/00 , A61P35/04
CPC分类号： C07K14/4702 , C07K2319/09 , C07K2319/10 , C07K2319/21
摘要： The present invention discloses cell permeable RUNX3 recombinant proteins where a Macromolecule Transduction Domain (MTD) is fused to a tumor and metastasis suppressor RUNX3. Also disclosed are polynucleotides encoding the cell permeable RUNX3 recombinant proteins, an expression vector containing the cell permeable RUNX3 recombinant protein, and a pharmaceutical composition for preventing metastasis which contains the cell permeable RUNX3 recombinant protein as an effective ingredient. The cell permeable RUNX3 recombinant proteins of the present invention can induce the reactivation of TGF-β signal transduction pathway which causes cell cycle arrest by efficiently introducing a tumor and metastasis suppressor RUNX3 into a cell. Therefore, the cell permeable RUNX3 recombinant proteins of the present invention can be effectively used as an anticancer agent capable of preventing cancer growth and metastasis by suppressing the proliferation, differentiation, and migration of cancer cells.
摘要翻译：本发明公开了细胞渗透性RUNX3重组蛋白，其中大分子转导结构域（MTD）与肿瘤融合，转移抑制因子RUNX3。还公开了编码细胞可渗透性RUNX3重组蛋白的多核苷酸，含有细胞可渗透性RUNX3重组蛋白的表达载体和用于预防转移的药物组合物，其含有可透过细胞的RUNX3重组蛋白作为有效成分。本发明的细胞渗透性RUNX3重组蛋白可以诱导TGF- 信号转导途径，通过有效地将肿瘤和转移抑制剂RUNX3引入细胞而引起细胞周期阻滞。因此，通过抑制癌细胞的增殖，分化和迁移，本发明的细胞可渗透的RUNX3重组蛋白可以有效地用作能够预防癌症生长和转移的抗癌剂。

5. 发明授权

US08445443B2 Cell permeable p18 recombinant proteins, polynucleotides encoding the same, and anticancer composition comprising the same 有权
标题翻译：细胞可渗透性p18重组蛋白，编码其的多核苷酸和包含其的抗癌组合物
公开(公告)号：US08445443B2
公开(公告)日：2013-05-21
申请号：US12676491
申请日：2008-09-04
申请人： Daewoong Jo , Seolhwa Kim , Jung-Hee Lim , Kisuk Park , Se-Eun Kang
发明人： Daewoong Jo , Seolhwa Kim , Jung-Hee Lim , Kisuk Park , Se-Eun Kang
IPC分类号： C12N15/62
CPC分类号： C07K14/4703 , C07K14/50 , C07K2319/033
摘要： The present invention discloses cell permeable p18 recombinant proteins where a macromolecule transduction domain (MTD) is fused to a tumor suppressor p18. Also disclosed are polynucleotides encoding the cell permeable p18 recombinant proteins, an expression vector containing the cell permeable p18 recombinant protein, and a pharmaceutical composition for treating p18 deficiency or failure which contains the cell permeable p18 recombinant protein as an effective ingredient. The cell permeable p18 recombinant proteins of the present invention are capable of efficiently introducing a haploinsufficient tumor suppressor p18 into a cell, and thus, can activate cell signaling mechanisms involved in the activation of ATM and p53 that induce cell cycle arrest and apoptosis in response to DNA damage or oncogenic signals. Therefore, the cell permeable p18 recombinant proteins of the present invention can be effectively used as an anticancer agent.
摘要翻译：本发明公开了一种细胞渗透性p18重组蛋白，其中大分子转导结构域（MTD）与肿瘤抑制基因p18融合。还公开了编码细胞可渗透性p18重组蛋白质的多核苷酸，含有细胞可渗透性p18重组蛋白质的表达载体和含有细胞可渗透性p18重组蛋白质作为有效成分的p18缺陷或失败的药物组合物。本发明的细胞可渗透性p18重组蛋白能够有效地将不充分的单倍体肿瘤抑制基因p18引入细胞，从而可以激活参与ATM和p53激活的细胞信号传导机制，诱导细胞周期停滞和凋亡，以响应于 DNA损伤或致癌信号。因此，本发明的细胞可渗透性p18重组蛋白质可以有效地用作抗癌剂。

6. 发明申请

US20100305041A1 CELL PERMEABLE P18 RECOMBINANT PROTEINS, POLYNUCLEOTIDES ENCODING THE SAME, AND ANTICANCER COMPOSITION COMPRISING THE SAME 有权
标题翻译：细胞渗透性P18重组蛋白，编码其的多核苷酸和包含其的抗体组合物
公开(公告)号：US20100305041A1
公开(公告)日：2010-12-02
申请号：US12676491
申请日：2008-09-04
申请人： Daewoong Jo , Seolhwa Kim , Jung-Hee Lim , Kisuk Park , Se-Eun Kang
发明人： Daewoong Jo , Seolhwa Kim , Jung-Hee Lim , Kisuk Park , Se-Eun Kang
IPC分类号： A61K38/17 , C07K14/435 , C07H21/04 , C12N15/63 , C12N1/21 , C12P21/02 , A61P35/00
CPC分类号： C07K14/4703 , C07K14/50 , C07K2319/033
摘要： The present invention discloses cell permeable p18 recombinant proteins where a macromolecule transduction domain (MTD) is fused to a tumor suppressor p18. Also disclosed are polynucleotides encoding the cell permeable p18 recombinant proteins, an expression vector containing the cell permeable p18 recombinant protein, and a pharmaceutical composition for treating p18 deficiency or failure which contains the cell permeable p18 recombinant protein as an effective ingredient. The cell permeable p18 recombinant proteins of the present invention are capable of efficiently introducing a haploinsufficient tumor suppressor p18 into a cell, and thus, can activate cell signaling mechanisms involved in the activation of ATM and p53 that induce cell cycle arrest and apoptosis in response to DNA damage or oncogenic signals. Therefore, the cell permeable p18 recombinant proteins of the present invention can be effectively used as an anticancer agent.
摘要翻译：本发明公开了一种细胞渗透性p18重组蛋白，其中大分子转导结构域（MTD）与肿瘤抑制基因p18融合。还公开了编码细胞可渗透性p18重组蛋白质的多核苷酸，含有细胞可渗透性p18重组蛋白质的表达载体和含有细胞可渗透性p18重组蛋白质作为有效成分的p18缺陷或失败的药物组合物。本发明的细胞可渗透性p18重组蛋白能够有效地将不充分的单倍体肿瘤抑制基因p18引入细胞，从而可以激活参与ATM和p53激活的细胞信号传导机制，诱导细胞周期停滞和凋亡，以响应于 DNA损伤或致癌信号。因此，本发明的细胞可渗透性p18重组蛋白质可以有效地用作抗癌剂。

7. 发明授权

US08629097B2 Macromolecule transduction domains and methods for identification and uses thereof 有权
标题翻译：大分子转导结构域及其鉴定及应用的方法
公开(公告)号：US08629097B2
公开(公告)日：2014-01-14
申请号：US12524935
申请日：2008-01-29
申请人： Dae Woong Jo , Jae Sun Ko , Jin Sook Kim , Kyung Mi Park , Jin Kyung Song , Jung Hee Lim , Thi Thuy Nga Do , Thi Lan Phuong Do , Minh Tam Duong
发明人： Dae Woong Jo , Jae Sun Ko , Jin Sook Kim , Kyung Mi Park , Jin Kyung Song , Jung Hee Lim , Thi Thuy Nga Do , Thi Lan Phuong Do , Minh Tam Duong
IPC分类号： C07K7/04 , C07K7/08 , C07K7/06
CPC分类号： A61K47/48246 , A61K39/39 , A61K48/0041 , C07K7/06 , C07K7/08 , C07K14/195 , C07K14/47
摘要： The present invention discloses novel macromolecule transduction domain (MTD) peptides which facilitate the traverse of a biologically active molecule across the cell membrane. Also disclosed are polynucleotides encoding the MTD peptides, methods of identifying the MTD peptides; methods of genetically engineering a biologically active molecule to have cell permeability by using the MTD peptides, methods of importing a biologically active molecule into a cell by using the MTD peptides, and uses thereof.
摘要翻译：本发明公开了促进细胞膜上生物活性分子穿越的新型大分子转导结构域（MTD）肽。还公开了编码MTD肽的多核苷酸，鉴定MTD肽的方法; 通过使用MTD肽将生物活性分子遗传工程化以具有细胞渗透性的方法，通过使用MTD肽将生物活性分子导入细胞的方法及其用途。

8. 发明申请

US20120122796A1 CELL PERMEABLE P53 RECOMBINANT PROTEIN, POLYNUCLEOTIDE ENCODING THE SAME, AND ANTI-CANCER COMPOSITION CONTAINING THE SAME AS ACTIVE INGREDIENT 有权
标题翻译：细胞渗透性P53重组蛋白，编码其的多核苷酸和含有该成分的抗癌组合物作为活性成分
公开(公告)号：US20120122796A1
公开(公告)日：2012-05-17
申请号：US13132202
申请日：2009-12-02
申请人： Daewoong Jo , Jung-Hee Lim
发明人： Daewoong Jo , Jung-Hee Lim
IPC分类号： A61K38/16 , C12N15/62 , C12N1/21 , C12P21/02 , A61P35/00 , C07K19/00 , C12N15/70
CPC分类号： C07K14/4746 , A61K38/00 , C07K2319/10
摘要： Disclosed are a cell-permeable p53 recombinant protein in which a macromolecule transduction domain (MTD) is fused to the tumor suppressor p53, a polynucleotide encoding the same, a recombinant expression vector for producing the same, and a pharmaceutical composition of the treatment of cancer, comprising the same. Having high cell permeability, the p53 recombinant protein is effectively transduced into cells so that the tumor suppressor p53 can be translocated into cell nuclei. Within nuclei, p53 inhibits the formation of cyclin-CDK complexes to halt the cell cycle, thus suppressing excessive cell proliferation and inducing apoptosis of tumor cells. Therefore, the p53 recombinant protein can be useful as an anticancer agent in the treatment of various cancers.
摘要翻译：公开了一种细胞可渗透的p53重组蛋白，其中大分子转导结构域（MTD）与肿瘤抑制基因p53融合，编码该多核苷酸的多核苷酸，用于制备该多核苷酸的重组表达载体，以及治疗癌症的药物组合物，包括它们。具有高细胞通透性，p53重组蛋白有效转导入细胞，使肿瘤抑制基因p53能够转位入细胞核。在核内，p53抑制细胞周期蛋白CDK复合物的形成，以阻止细胞周期，从而抑制过量的细胞增殖并诱导肿瘤细胞凋亡。因此，p53重组蛋白可用作治疗各种癌症的抗癌剂。

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