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1. 发明申请

US20080089905A1 COMPOUNDS FOR STIMULATING STEM CELL PROLIFERATION INCLUDING AFA-OMEGA (EtOH) 审中-公开
标题翻译：用于刺激包括AFA-OMEGA（EtOH）的干细胞增殖的化合物
公开(公告)号：US20080089905A1
公开(公告)日：2008-04-17
申请号：US11757251
申请日：2007-06-01
申请人： Cyndy Davis Sanberg , Paula Bickford , Paul Sanberg , Jun Tan , R. Shytle , Jerry Anderson
发明人： Cyndy Davis Sanberg , Paula Bickford , Paul Sanberg , Jun Tan , R. Shytle , Jerry Anderson
IPC分类号： A61K36/05 , A61K36/45 , A61K36/82 , A61P43/00
CPC分类号： A61K31/205 , A61K31/59 , A61K35/748 , A61K36/45 , A61K36/82 , A61K2300/00
摘要： A method and composition for stimulating the proliferation and differentiation of stem cells is used to self-repair injury in mammals. A supplement is administered having an effective dose of substances selected from blueberry, carnosine, catechin, green tea extract, VitaBlue, Vitamin D3, Spirulina, AFA or effective combinations and derivatives of these. For example, a supplement comprising wild blueberry, green tea extract, carnosine, vitamin D3, and AFA-Omega (EtOH) or Spirulina and AFA-Omega (EtOH) exhibits a synergistic and unexpected association with substantially increased proliferation of bone marrow stem cells and CD34+. A therapeutic amount of a substance that is associated with a substantial increase in stem cells may be used to prevent and repair damaged tissues of the brain, due to stroke, the heart, due to coronary artery disease or a heart attack.
摘要翻译：用于刺激干细胞增殖和分化的方法和组合物用于自我修复哺乳动物的损伤。施用补充物，其具有选自蓝莓，肌肽，儿茶素，绿茶提取物，维生素B，维生素D3，螺旋藻，AFA中的有效剂量的物质或这些的有效组合和衍生物。例如，包含野生蓝莓，绿茶提取物，肌肽，维生素D3和AFA-Omega（EtOH）或螺旋藻和AFA-Omega（EtOH）的补充物显示出与骨髓干细胞的增殖显着增加的协同和意想不到的关联， CD34 +。可以使用与干细胞显着增加相关的物质的治疗量来预防和修复由于冠状动脉疾病或心脏病发作引起的脑中风，心脏的受损组织。

2. 发明申请

US20080085330A1 COMPOUNDS FOR STIMULATING STEM CELL PROLIFERATION INCLUDING SPIRULINA 审中-公开
标题翻译：用于刺激包括螺旋体的干细胞增殖的化合物
公开(公告)号：US20080085330A1
公开(公告)日：2008-04-10
申请号：US11757266
申请日：2007-06-01
申请人： Cyndy Davis Sanberg , Paula Bickford , Paul Sanberg , Jun Tan , R. Shytle
发明人： Cyndy Davis Sanberg , Paula Bickford , Paul Sanberg , Jun Tan , R. Shytle
IPC分类号： A61K36/82 , A61K36/45 , A61P43/00
CPC分类号： A61K31/205 , A61K31/59 , A61K35/748 , A61K36/45 , A61K36/82 , A61K2300/00
摘要： A method and composition for stimulating the proliferation and differentiation of stem cells is used to self-repair injury in mammals. A supplement is administered having an effective dose of substances selected from blueberry, carnosine, catechin, green tea extract, VitaBlue, Vitamin D3, Spirulina, AFA or effective combinations and derivatives of these. For example, a supplement comprising wild blueberry, green tea extract, carnosine, vitamin D3, and a Spirulina and/or an AFA-Omega (EtOH) exhibited a synergistic and unexpected association with substantially increased proliferation of bone marrow stem cells and CD34+. A therapeutic amount of a substance that is associated with a substantial increase in stem cells may be used to prevent and repair damages tissues of the brain, due to stroke, the heart, due to coronary artery disease or a heart attack.
摘要翻译：用于刺激干细胞增殖和分化的方法和组合物用于自我修复哺乳动物的损伤。施用补充剂，其具有选自蓝莓，肌肽，儿茶素，绿茶提取物，维生素B，维生素D 3，螺旋藻，AFA或其有效组合和衍生物的有效剂量的物质。例如，包含野生蓝莓，绿茶提取物，肌肽，维生素D 3和螺旋藻和/或AFA-Omega（EtOH）的补充物显示与骨髓干细胞和CD34的增加的显着增加的协同和意想不到的关联 +。可以使用治疗量的与干细胞显着增加相关的物质来预防和修复由于冠状动脉疾病或心脏病发作引起的脑中风，心脏损伤的组织。

3. 发明申请

US20060275512A1 Combined effects of nutrients on proliferation of stem cells 有权
公开(公告)号：US20060275512A1
公开(公告)日：2006-12-07
申请号：US11415907
申请日：2006-05-02
申请人： Cyndy Davis Sanberg , Paul Sanberg , Paula Bickford , R. Shytle , Jun Tan
发明人： Cyndy Davis Sanberg , Paul Sanberg , Paula Bickford , R. Shytle , Jun Tan
IPC分类号： A61K36/82 , A61K36/45 , A61K31/59 , A61K31/205
CPC分类号： A61K31/59 , A61K31/205 , A61K36/45 , A61K36/82 , A61K2300/00
摘要： A method and composition for stimulating the proliferation and differentiation of stem cells is used to self-repair injury in mammals. A supplement is administered having an effective dose of blueberry, carnosine, catechin, green tea extract, VitaBlue, Vitamin D3 or combinations of these. For example, a therapeutic amount of two or more of the supplements may be selected having a synergistic effect, allowing a lower dose to achieve the same or greater effective protection as a higher dose of any one of the supplements.

4. 发明授权

US08574640B2 Combined effects of nutrients on proliferation of stem cells 有权
公开(公告)号：US08574640B2
公开(公告)日：2013-11-05
申请号：US12901329
申请日：2010-10-08
申请人： Cyndy Davis Sanberg , Paula Bickford , Paul Sanberg , Jun Tan , R. Douglas Shytle
发明人： Cyndy Davis Sanberg , Paula Bickford , Paul Sanberg , Jun Tan , R. Douglas Shytle
IPC分类号： A61K36/82 , A61K36/45 , A61K38/00 , A23L1/30
CPC分类号： A61K31/59 , A61K31/205 , A61K36/45 , A61K36/82 , A61K2300/00
摘要： A method and composition for stimulating the proliferation and differentiation of stem cells is used to self-repair injury in mammals. A supplement is administered having an effective dose of blueberry, carnosine, catechin, green tea extract, VitaBlue, Vitamin D3 or combinations of these. For example, a therapeutic amount of two or more of the supplements may be selected having a synergistic effect, allowing a lower dose to achieve the same or greater effective protection as a higher dose of any one of the supplements.

5. 发明申请

US20110038963A1 COMBINED EFFECTS OF NUTRIENTS ON PROLIFERATION OF STEM CELLS 有权
标题翻译：营养素对干细胞增殖的组合作用
公开(公告)号：US20110038963A1
公开(公告)日：2011-02-17
申请号：US12901329
申请日：2010-10-08
申请人： Cyndy Davis Sanberg , Paul Sanberg , Paula Bickford , R. Douglas Shytle , Jun Tan
发明人： Cyndy Davis Sanberg , Paul Sanberg , Paula Bickford , R. Douglas Shytle , Jun Tan
IPC分类号： A61K36/82 , A61K36/45 , C12N5/071 , A61P43/00
CPC分类号： A61K31/59 , A61K31/205 , A61K36/45 , A61K36/82 , A61K2300/00
摘要： A method and composition for stimulating the proliferation and differentiation of stem cells is used to self-repair injury in mammals. A supplement is administered having an effective dose of blueberry, carnosine, catechin, green tea extract, VitaBlue, Vitamin D3 or combinations of these. For example, a therapeutic amount of two or more of the supplements may be selected having a synergistic effect, allowing a lower dose to achieve the same or greater effective protection as a higher dose of any one of the supplements.
摘要翻译：用于刺激干细胞增殖和分化的方法和组合物用于自我修复哺乳动物的损伤。施用补充剂具有有效剂量的蓝莓，肌肽，儿茶素，绿茶提取物，维生素B，维生素D3或它们的组合。例如，可以选择治疗量的两种或更多种补充剂，其具有协同作用，允许较低剂量实现与任何一种补充剂的较高剂量相同或更高的有效保护。

6. 发明授权

US07442394B2 Combined effects of nutrients on proliferation of stem cells 有权
标题翻译：营养物质对干细胞增殖的综合作用
公开(公告)号：US07442394B2
公开(公告)日：2008-10-28
申请号：US11415907
申请日：2006-05-02
申请人： Cyndy Davis Sanberg , Paul Sanberg , Paula Bickford , R. Douglas Shytle , Jun Tan
发明人： Cyndy Davis Sanberg , Paul Sanberg , Paula Bickford , R. Douglas Shytle , Jun Tan
IPC分类号： A01N65/00 , A01N37/18 , A23L1/30 , A61K38/00
CPC分类号： A61K31/59 , A61K31/205 , A61K36/45 , A61K36/82 , A61K2300/00
摘要： A method and composition for stimulating the proliferation and differentiation of stem cells is used to self-repair injury in mammals. A supplement is administered having an effective dose of blueberry, carnosine, catechin, green tea extract, VITABLUE® blueberry extract, Vitamin D3 or combinations of these. For example, a therapeutic amount of two or more of the supplements may be selected having a synergistic effect, allowing a lower dose to achieve the same or greater effective protection as a higher dose of any one of the supplements.
摘要翻译：用于刺激干细胞增殖和分化的方法和组合物用于自我修复哺乳动物的损伤。施用补充剂具有有效剂量的蓝莓，肌肽，儿茶素，绿茶提取物，蓝莓提取物，维生素D3或它们的组合。例如，可以选择治疗量的两种或更多种补充剂，其具有协同作用，允许较低剂量实现与任何一种补充剂的较高剂量相同或更高的有效保护。

7. 发明申请

US20090280198A1 Combined effects of nutrients on proliferation of stem cells 审中-公开
标题翻译：营养物质对干细胞增殖的综合作用
公开(公告)号：US20090280198A1
公开(公告)日：2009-11-12
申请号：US12288848
申请日：2008-10-23
申请人： Cyndy Davis Sanberg , Paul Sanberg , Paula Bickford , R. Douglas Shytle , Jun Tan
发明人： Cyndy Davis Sanberg , Paul Sanberg , Paula Bickford , R. Douglas Shytle , Jun Tan
IPC分类号： A61K36/82 , A61K36/45 , A61K38/05 , A61K31/59 , A61K31/35
CPC分类号： A61K31/59 , A61K31/205 , A61K36/45 , A61K36/82 , A61K2300/00
摘要： A method and composition for stimulating the proliferation and differentiation of stem cells is used to self-repair injury in mammals. A supplement is administered having an effective dose of blueberry, carnosine, catechin, green tea extract, VitaBlue, Vitamin D3 or combinations of these. For example, a therapeutic amount of two or more of the supplements may be selected having a synergistic effect, allowing a lower dose to achieve the same or greater effective protection as a higher dose of any one of the supplements.
摘要翻译：用于刺激干细胞增殖和分化的方法和组合物用于自我修复哺乳动物的损伤。施用补充剂具有有效剂量的蓝莓，肌肽，儿茶素，绿茶提取物，维生素B，维生素D3或它们的组合。例如，可以选择治疗量的两种或更多种补充剂，其具有协同作用，允许较低剂量实现与任何一种补充剂的较高剂量相同或更高的有效保护。

8. 发明申请

US20050249708A1 Cerebral Intraventricular Transplantation as Method of Treating Amyotrophic Lateral Sclerosis (ALS) 有权
标题翻译：脑室内移植作为治疗肌萎缩性侧索硬化症（ALS）的方法
公开(公告)号：US20050249708A1
公开(公告)日：2005-11-10
申请号：US10908322
申请日：2005-05-06
申请人： Svitlana Garbuzova-Davis , Andrew Balber , Cyndy Davis-Sanberg , Tracy Gentry , Nicole Kuzmin-Nichols , Paul Sanberg , Alison Willing
发明人： Svitlana Garbuzova-Davis , Andrew Balber , Cyndy Davis-Sanberg , Tracy Gentry , Nicole Kuzmin-Nichols , Paul Sanberg , Alison Willing
IPC分类号： A61K31/203 , A61K35/12 , A61K35/14 , A61K35/28 , A61K35/51 , A61K45/00 , A61K45/06 , C12N5/074 , C12N5/0789 , C12N5/08
CPC分类号： A61K35/28 , A61K9/0085 , A61K31/203 , A61K35/30 , A61K35/50 , A61K35/51 , A61K45/06 , A61K2035/124 , C12N5/0607 , C12N5/0647 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N2501/13 , C12N2501/385 , C12N2506/11 , A61K2300/00
摘要： A method of treating a patient with a neurodegenerative disease, such as ALS, using progenitor cells isolated from human umbilical cord blood. Non-invasive transplantation of aldehyde dehydrogenase (ALDH+) expressing progenitor cells provides cell replacement and protection of motor neurons.
摘要翻译：使用从人脐带血分离的祖细胞来治疗患有神经变性疾病的患者（例如ALS）的方法。表达祖细胞的醛脱氢酶（ALDH + +）表达的非侵入性移植提供了运动神经元的细胞替代和保护。

9. 发明申请

US20100150882A1 HUCBC TREATMENT OF AMYLOID ASSOCIATED DISEASE 有权
标题翻译：乳腺癌相关疾病的治疗
公开(公告)号：US20100150882A1
公开(公告)日：2010-06-17
申请号：US12706510
申请日：2010-02-16
申请人： Jun Tan , Paul Sanberg
发明人： Jun Tan , Paul Sanberg
IPC分类号： A61K35/14 , A61K35/16 , A61P25/28 , A61P3/10 , A61P7/00
CPC分类号： A61K35/16 , A61K35/44 , A61K2035/122
摘要： Administration of human umbilical cord blood cells (HUCBC) or HUCBC-derived plasma is used to treat amyloid-based diseases, such as Alzheimer's disease, Huntington's disease, cerebral amyloid antigopathy, and type-II diabetes. Modulating inflammatory reactions by infusing HUCBC resulted in a marked reduction of amyloid plaques and immune-associated cellular damage. HUCBC infusion also significantly reduced cerebral amyloid angiopathy in mice models. These effects were associated with suppression of the CD40-CD40L interaction and a reduction in surface expressed CD-40 was observed on immune cells. Further, Aβ phagocytic activity was increased and soluble and insoluble Aβ protein levels were modulated by treatment. HUCBC-infused sera also significantly increased phagocytosis of Aβ1-42 peptide and inhibited immune cell CD40 expression and reduced cerebral amyloid angiopathy.
摘要翻译：使用人脐带血细胞（HUCBC）或HUCBC衍生血浆来治疗淀粉样蛋白病，如阿尔茨海默氏病，亨廷顿舞蹈病，脑淀粉样蛋白病和II型糖尿病。通过输注HUCBC调节炎症反应导致淀粉样蛋白斑块和免疫相关细胞损伤的显着减少。 HUCBC输注也显着降低了小鼠模型中的脑淀粉样血管病变。这些作用与CD40-CD40L相互作用的抑制有关，并且在免疫细胞上观察到表达CD-40的表达减少。此外，A＆bgr 吞噬活性增加，可溶性和不溶性A＆bgr; 蛋白质水平通过治疗调节。 HUCBC输注的血清也显着增加了Aβ1-42肽的吞噬作用，抑制了免疫细胞CD40的表达，降低了脑淀粉样血管病变。

10. 发明授权

US09402870B2 HUCBC treatment of amyloid associated disease 有权
标题翻译： HUCBC治疗淀粉样蛋白相关疾病
公开(公告)号：US09402870B2
公开(公告)日：2016-08-02
申请号：US12706510
申请日：2010-02-16
申请人： Jun Tan , Paul Sanberg
发明人： Jun Tan , Paul Sanberg
IPC分类号： A61K35/12 , A61K35/16 , A61K35/44
CPC分类号： A61K35/16 , A61K35/44 , A61K2035/122
摘要： Administration of human umbilical cord blood cells (HUCBC) or HUCBC-derived plasma is used to treat amyloid-based diseases, such as Alzheimer's disease, Huntington's disease, cerebral amyloid antigopathy, and type-II diabetes. Modulating inflammatory reactions by infusing HUCBC resulted in a marked reduction of amyloid plaques and immune-associated cellular damage. HUCBC infusion also significantly reduced cerebral amyloid angiopathy in mice models. These effects were associated with suppression of the CD40-CD40L interaction and a reduction in surface expressed CD-40 was observed on immune cells. Further, Aβ phagocytic activity was increased and soluble and insoluble Aβ protein levels were modulated by treatment. HUCBC-infused sera also significantly increased phagocytosis of Aβ1-42 peptide and inhibited immune cell CD40 expression and reduced cerebral amyloid angiopathy.
摘要翻译：使用人脐带血细胞（HUCBC）或HUCBC衍生血浆来治疗淀粉样蛋白病，如阿尔茨海默氏病，亨廷顿舞蹈病，脑淀粉样蛋白病防治病和II型糖尿病。通过输注HUCBC调节炎症反应导致淀粉样蛋白斑块和免疫相关细胞损伤的显着减少。 HUCBC输注也显着降低了小鼠模型中的脑淀粉样血管病变。这些作用与CD40-CD40L相互作用的抑制有关，并且在免疫细胞上观察到表达CD-40的表达减少。此外，Aβ吞噬活性增加，可溶性和不溶性Aβ蛋白水平通过治疗调节。 HUCBC输注的血清也显着增加了Aβ1-42肽的吞噬作用，抑制了免疫细胞CD40表达，降低了脑淀粉样血管病变。

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