专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20100040558A1 GREEN TEA POLYPHENOL ALPHA SECRETASE ENHANCERS AND METHODS OF USE 审中-公开
标题翻译：绿茶聚苯乙烯ALPHA秘密增强剂及其使用方法
公开(公告)号：US20100040558A1
公开(公告)日：2010-02-18
申请号：US11919444
申请日：2006-04-26
申请人： R. Douglas Shytle , Jun Tan
发明人： R. Douglas Shytle , Jun Tan
IPC分类号： A61K9/12 , C12Q1/37 , C12N5/02 , A61K31/35 , A61K31/05
CPC分类号： A61K31/353 , A61K45/06 , C12Q1/37 , G01N33/5058 , G01N33/6896
摘要： The subject invention concerns materials and methods for treating or preventing a neurodegenerative condition or disease associated with β-amyloid peptide deposition in neural tissue in a person or animal by administering a therapeutically effective amount of a polyphenol, or an analog, isomer, metabolite, or prodrug thereof, that increases expression or activity of a protein that exhibits α-secretase activity. The subject invention also provides methods to increase α-secretase expression and/or activity in cells by administering polyphenol flavonoids like (−)-epigallocatechin-3-gallate (EGCG) and epicatechin (EC), two polyphenols derived from green tea and other plants and that can be produced synthetically. Furthermore, there are provided methods to decrease or inhibit the production of Aβ1-40 or Aβ1-42 by administering the EGCG and EC compounds, their analogs, metabolites, and prodrugs.
摘要翻译：本发明涉及通过施用治疗有效量的多酚或类似物，异构体，代谢产物，治疗或预防与人或动物的神经组织中淀粉样肽沉积相关的神经变性病症或疾病的材料和方法，或前药，其增加表现出α-分泌酶活性的蛋白质的表达或活性。本发明还提供了通过施用多酚类黄酮如（ - ） - 表没食子儿茶-3-没食子酸酯（EGCG）和表儿茶素（EC），来自绿茶和其他植物的两种多酚来增加细胞中α-分泌酶表达和/或活性的方法并且可以综合生成。此外，通过施用EGCG和EC化合物，它们的类似物，代谢物和前药，提供了减少或抑制Aβ1-40或A-bgr 1-42的生产的方法。

2. 发明授权

US09744189B1 Compositions of lithium salts and methods of use 有权
公开(公告)号：US09744189B1
公开(公告)日：2017-08-29
申请号：US14539411
申请日：2014-11-12
申请人： Adam J. Smith , R. Douglas Shytle
发明人： Adam J. Smith , R. Douglas Shytle
IPC分类号： A61K33/00 , A61K47/12
CPC分类号： A61K33/00 , A61K9/145 , A61K47/12
摘要： Lithium is regarded as the gold standard comparator and benchmark treatment for mania. One of the problems associated with Lithium is its narrow therapeutic window. Recent attempts to find new drugs with similar therapeutic activities have yielded new chemical entities. However, these potential new drugs have yet to match the many bioactivities attributable to lithium's efficacy for the treatment of neuropsychiatric diseases. Consequently, an intense effort for re-engineering lithium therapeutics using cocrystallization is currently underway. The evaluation of pharmacokinetics of previously unexplored lithium salts with organic anions (lithium salicylate and lithium lactate) has found that these lithium salts exhibit profoundly different pharmacokinetics compared to the more common FDA approved salt, lithium carbonate, in rats. Remarkably, lithium salicylate produced elevated blood and brain levels of lithium beyond 48 hours post-dose without the sharp peak that contributes to the toxicity problems of current lithium therapeutics.

3. 发明申请

US20090280198A1 Combined effects of nutrients on proliferation of stem cells 审中-公开
标题翻译：营养物质对干细胞增殖的综合作用
公开(公告)号：US20090280198A1
公开(公告)日：2009-11-12
申请号：US12288848
申请日：2008-10-23
申请人： Cyndy Davis Sanberg , Paul Sanberg , Paula Bickford , R. Douglas Shytle , Jun Tan
发明人： Cyndy Davis Sanberg , Paul Sanberg , Paula Bickford , R. Douglas Shytle , Jun Tan
IPC分类号： A61K36/82 , A61K36/45 , A61K38/05 , A61K31/59 , A61K31/35
CPC分类号： A61K31/59 , A61K31/205 , A61K36/45 , A61K36/82 , A61K2300/00
摘要： A method and composition for stimulating the proliferation and differentiation of stem cells is used to self-repair injury in mammals. A supplement is administered having an effective dose of blueberry, carnosine, catechin, green tea extract, VitaBlue, Vitamin D3 or combinations of these. For example, a therapeutic amount of two or more of the supplements may be selected having a synergistic effect, allowing a lower dose to achieve the same or greater effective protection as a higher dose of any one of the supplements.
摘要翻译：用于刺激干细胞增殖和分化的方法和组合物用于自我修复哺乳动物的损伤。施用补充剂具有有效剂量的蓝莓，肌肽，儿茶素，绿茶提取物，维生素B，维生素D3或它们的组合。例如，可以选择治疗量的两种或更多种补充剂，其具有协同作用，允许较低剂量实现与任何一种补充剂的较高剂量相同或更高的有效保护。

4. 发明授权

US08574640B2 Combined effects of nutrients on proliferation of stem cells 有权
公开(公告)号：US08574640B2
公开(公告)日：2013-11-05
申请号：US12901329
申请日：2010-10-08
申请人： Cyndy Davis Sanberg , Paula Bickford , Paul Sanberg , Jun Tan , R. Douglas Shytle
发明人： Cyndy Davis Sanberg , Paula Bickford , Paul Sanberg , Jun Tan , R. Douglas Shytle
IPC分类号： A61K36/82 , A61K36/45 , A61K38/00 , A23L1/30
CPC分类号： A61K31/59 , A61K31/205 , A61K36/45 , A61K36/82 , A61K2300/00
摘要： A method and composition for stimulating the proliferation and differentiation of stem cells is used to self-repair injury in mammals. A supplement is administered having an effective dose of blueberry, carnosine, catechin, green tea extract, VitaBlue, Vitamin D3 or combinations of these. For example, a therapeutic amount of two or more of the supplements may be selected having a synergistic effect, allowing a lower dose to achieve the same or greater effective protection as a higher dose of any one of the supplements.

5. 发明申请

US20110038963A1 COMBINED EFFECTS OF NUTRIENTS ON PROLIFERATION OF STEM CELLS 有权
标题翻译：营养素对干细胞增殖的组合作用
公开(公告)号：US20110038963A1
公开(公告)日：2011-02-17
申请号：US12901329
申请日：2010-10-08
申请人： Cyndy Davis Sanberg , Paul Sanberg , Paula Bickford , R. Douglas Shytle , Jun Tan
发明人： Cyndy Davis Sanberg , Paul Sanberg , Paula Bickford , R. Douglas Shytle , Jun Tan
IPC分类号： A61K36/82 , A61K36/45 , C12N5/071 , A61P43/00
CPC分类号： A61K31/59 , A61K31/205 , A61K36/45 , A61K36/82 , A61K2300/00
摘要： A method and composition for stimulating the proliferation and differentiation of stem cells is used to self-repair injury in mammals. A supplement is administered having an effective dose of blueberry, carnosine, catechin, green tea extract, VitaBlue, Vitamin D3 or combinations of these. For example, a therapeutic amount of two or more of the supplements may be selected having a synergistic effect, allowing a lower dose to achieve the same or greater effective protection as a higher dose of any one of the supplements.
摘要翻译：用于刺激干细胞增殖和分化的方法和组合物用于自我修复哺乳动物的损伤。施用补充剂具有有效剂量的蓝莓，肌肽，儿茶素，绿茶提取物，维生素B，维生素D3或它们的组合。例如，可以选择治疗量的两种或更多种补充剂，其具有协同作用，允许较低剂量实现与任何一种补充剂的较高剂量相同或更高的有效保护。

6. 发明授权

US07442394B2 Combined effects of nutrients on proliferation of stem cells 有权
标题翻译：营养物质对干细胞增殖的综合作用
公开(公告)号：US07442394B2
公开(公告)日：2008-10-28
申请号：US11415907
申请日：2006-05-02
申请人： Cyndy Davis Sanberg , Paul Sanberg , Paula Bickford , R. Douglas Shytle , Jun Tan
发明人： Cyndy Davis Sanberg , Paul Sanberg , Paula Bickford , R. Douglas Shytle , Jun Tan
IPC分类号： A01N65/00 , A01N37/18 , A23L1/30 , A61K38/00
CPC分类号： A61K31/59 , A61K31/205 , A61K36/45 , A61K36/82 , A61K2300/00
摘要： A method and composition for stimulating the proliferation and differentiation of stem cells is used to self-repair injury in mammals. A supplement is administered having an effective dose of blueberry, carnosine, catechin, green tea extract, VITABLUE® blueberry extract, Vitamin D3 or combinations of these. For example, a therapeutic amount of two or more of the supplements may be selected having a synergistic effect, allowing a lower dose to achieve the same or greater effective protection as a higher dose of any one of the supplements.
摘要翻译：用于刺激干细胞增殖和分化的方法和组合物用于自我修复哺乳动物的损伤。施用补充剂具有有效剂量的蓝莓，肌肽，儿茶素，绿茶提取物，蓝莓提取物，维生素D3或它们的组合。例如，可以选择治疗量的两种或更多种补充剂，其具有协同作用，允许较低剂量实现与任何一种补充剂的较高剂量相同或更高的有效保护。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式