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1. 发明申请

US20070134234A1 Immunomodulatory compositions and uses therefor 审中-公开
标题翻译：免疫调节组合物及其用途
公开(公告)号：US20070134234A1
公开(公告)日：2007-06-14
申请号：US11541449
申请日：2006-09-29
申请人： Craig Smith , Steven Wiley , Ajamete Kaykas , Jalal Vakili , Peter Probst
发明人： Craig Smith , Steven Wiley , Ajamete Kaykas , Jalal Vakili , Peter Probst
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C07K16/46 , C12N5/06 , C12P21/08
CPC分类号： C12N9/16 , A61K38/162 , C07K14/005 , C07K14/70539 , C07K16/2803 , C07K2319/30 , C12N2710/24022 , C12N2710/24122
摘要： The poxvirus proteins designated A41L and 130L bind to three receptor-like protein tyrosine phosphatases (RPTP), leukocyte common antigen related protein (LAR), RPTP-δ, and RPTP-σ, that are present on the cell surface of immune cells. When a host is infected with the poxvirus, binding of A41L to cell surface proteins on the host cells results in suppression of the immune response. The present invention provides agents such as antibodies, and antigen-binding fragments thereof, small molecules, aptamers, small interfering RNAs, and peptide-IgFc fusion polypeptides that interact with one or more of LAR, RPTP-δ, and RPTP-σ expressed by immune cells or interact with a polynucleotide encoding the RPTP. Also provided are RPTP Ig domain oligomers and Fc fusion polypeptides. Such agents are useful for treating an immunological disorder in a subject according to the methods described herein.
摘要翻译：命名为A41L和130L的痘病毒蛋白与存在于免疫细胞的细胞表面上的三种受体样蛋白酪氨酸磷酸酶（RPTP），白细胞常见抗原相关蛋白（LAR），RPTP-delta和RPTP-sigma结合。当宿主感染痘病毒时，A41L与宿主细胞上的细胞表面蛋白的结合导致免疫应答的抑制。本发明提供诸如抗体及其抗原结合片段，小分子，适体，小干扰RNA和肽-IgFc融合多肽的试剂，其与LAR，RPTP-δ和RPTP-sigma中的一种或多种相互作用，免疫细胞或与编码RPTP的多核苷酸相互作用。还提供了RPTP Ig结构域寡聚体和Fc融合多肽。根据本文所述的方法，这样的试剂可用于治疗受试者的免疫学障碍。

2. 发明申请

US20090117112A1 IMMUNOMODULATORY COMPOSITIONS AND USES THEREFOR 审中-公开
标题翻译：免疫组化及其用途
公开(公告)号：US20090117112A1
公开(公告)日：2009-05-07
申请号：US12246291
申请日：2008-10-06
申请人： Craig A. Smith , Steven Wiley , Ajamete Kaykas , Jalal Vakili , Peter Probst
发明人： Craig A. Smith , Steven Wiley , Ajamete Kaykas , Jalal Vakili , Peter Probst
IPC分类号： A61K39/395 , C07K16/00 , A61P37/02
CPC分类号： C12N9/16 , A61K38/162 , C07K14/005 , C07K14/70539 , C07K16/2803 , C07K2319/30 , C12N2710/24022 , C12N2710/24122
摘要： The poxvirus proteins designated A41L and 130L bind to three receptor-like protein tyrosine phosphatases (RPTP), leukocyte common antigen related protein (LAR), RPTP-δ, and RPTP-σ, that are present on the cell surface of immune cells. When a host is infected with the poxvirus, binding of A41L to cell surface proteins on the host cells results in suppression of the immune response. The present invention provides agents such as antibodies, and antigen-binding fragments thereof, small molecules, aptamers, small interfering RNAs, and peptide-IgFc fusion polypeptides that interact with one or more of LAR, RPTP-δ, and RPTP-σ expressed by immune cells or interact with a polynucleotide encoding the RPTP. Also provided are RPTP Ig domain oligomers and Fc fusion polypeptides. Such agents are useful for treating an immunological disorder in a subject according to the methods described herein.
摘要翻译：命名为A41L和130L的痘病毒蛋白与存在于免疫细胞的细胞表面上的三种受体样蛋白酪氨酸磷酸酶（RPTP），白细胞常见抗原相关蛋白（LAR），RPTP-delta和RPTP-sigma结合。当宿主感染痘病毒时，A41L与宿主细胞上的细胞表面蛋白的结合导致免疫应答的抑制。本发明提供诸如抗体及其抗原结合片段，小分子，适体，小干扰RNA和肽-IgFc融合多肽的试剂，其与LAR，RPTP-δ和RPTP-sigma中的一种或多种相互作用，免疫细胞或与编码RPTP的多核苷酸相互作用。还提供了RPTP Ig结构域寡聚体和Fc融合多肽。根据本文所述的方法，这样的试剂可用于治疗受试者的免疫学障碍。

3. 发明申请

US20100239579A1 CD47 Related Compositions and Methods for Treating Immunological Diseases and Disorders 有权
标题翻译： CD47相关组合物和治疗免疫疾病和疾病的方法
公开(公告)号：US20100239579A1
公开(公告)日：2010-09-23
申请号：US12687334
申请日：2010-01-14
申请人： Craig A. Smith , Steven Wiley , Ajamete Kaykas , Peter Probst
发明人： Craig A. Smith , Steven Wiley , Ajamete Kaykas , Peter Probst
IPC分类号： A61K39/395 , C07K16/08 , C07H21/04 , C12N15/63 , C12N5/10 , G01N33/53 , A61P37/00 , C12N1/19
CPC分类号： C07K14/70596 , C07K2319/30
摘要： Provide herein are fusion polypeptides that comprise a CD47 extracellular domain or a variant thereof that is fused to a Fc polypeptide. The fusion polypeptides are useful for treating an immunological disease or disorder in a subject according to the methods described herein. The fusion polypeptides are capable of suppressing immunoresponsiveness of an immune cell, inhibiting production of proinflammatory cytokines, including inhibiting immune complex-induced production of cytokines.
摘要翻译：本文提供的是融合多肽，其包含与Fc多肽融合的CD47细胞外结构域或其变体。根据本文所述的方法，融合多肽可用于治疗受试者的免疫疾病或病症。融合多肽能够抑制免疫细胞的免疫反应性，抑制促炎细胞因子的产生，包括抑制免疫复合物诱导的细胞因子产生。

4. 发明授权

US08377448B2 CD47 related compositions and methods for treating immunological diseases and disorders 有权
标题翻译： CD47相关组合物和治疗免疫疾病和病症的方法
公开(公告)号：US08377448B2
公开(公告)日：2013-02-19
申请号：US12687334
申请日：2010-01-14
申请人： Craig A. Smith , Steven Wiley , Ajamete Kaykas , Peter Probst
发明人： Craig A. Smith , Steven Wiley , Ajamete Kaykas , Peter Probst
IPC分类号： A61K39/00
CPC分类号： C07K14/70596 , C07K2319/30
摘要： Provide herein are fusion polypeptides that comprise a CD47 extracellular domain or a variant thereof that is fused to a Fc polypeptide. The fusion polypeptides are useful for treating an immunological disease or disorder in a subject according to the methods described herein. The fusion polypeptides are capable of suppressing immunoresponsiveness of an immune cell, inhibiting production of proinflammatory cytokines, including inhibiting immune complex-induced production of cytokines.
摘要翻译：本文提供的是包含与Fc多肽融合的CD47细胞外结构域或其变体的融合多肽。根据本文所述的方法，融合多肽可用于治疗受试者的免疫疾病或病症。融合多肽能够抑制免疫细胞的免疫反应性，抑制促炎细胞因子的产生，包括抑制免疫复合物诱导的细胞因子产生。

5. 发明申请

US20080131431A1 CD47 related compositions and methods for treating immunological diseases and disorders 审中-公开
标题翻译： CD47相关组合物和治疗免疫疾病和病症的方法
公开(公告)号：US20080131431A1
公开(公告)日：2008-06-05
申请号：US11804992
申请日：2007-05-15
申请人： Craig A. Smith , Steven Wiley , Ajamete Kaykas , Peter Probst
发明人： Craig A. Smith , Steven Wiley , Ajamete Kaykas , Peter Probst
IPC分类号： A61K39/00 , C07K16/00 , C07H21/04 , C12N5/06 , G01N33/53 , C12N5/10 , C12N15/00 , C12N5/00
CPC分类号： C07K14/70596 , A61K38/00 , A61K38/177 , C07K2319/30 , C07K2319/32
摘要： Provide herein are fusion polypeptides that comprise a CD47 extracellular domain or a variant thereof that is fused to a Fc polypeptide. The fusion polypeptides are useful for treating an immunological disease or disorder in a subject according to the methods described herein. The fusion polypeptides are capable of suppressing immunoresponsiveness of an immune cell, inhibiting production of proinflammatory cytokines, including inhibiting immune complex-induced production of cytokines.
摘要翻译：本文提供的是包含与Fc多肽融合的CD47细胞外结构域或其变体的融合多肽。根据本文所述的方法，融合多肽可用于治疗受试者的免疫疾病或病症。融合多肽能够抑制免疫细胞的免疫反应性，抑制促炎细胞因子的产生，包括抑制免疫复合物诱导的细胞因子产生。

6. 发明申请

US20070264654A1 Methods for identifying polypeptide targets and uses thereof for treating immunological diseases 失效
标题翻译：用于鉴定多肽靶标的方法及其用于治疗免疫疾病的用途
公开(公告)号：US20070264654A1
公开(公告)日：2007-11-15
申请号：US11728329
申请日：2007-03-22
申请人： Steven Wiley , Craig Smith , Ajamete Kaykas
发明人： Steven Wiley , Craig Smith , Ajamete Kaykas
IPC分类号： G01N33/53 , C12Q1/68
CPC分类号： G01N33/6845 , A61K39/3955 , C12Q1/18 , C12Q1/70 , G01N33/5008 , G01N33/56983 , G01N2500/02
摘要： The present invention provides methods for identifying viral virulence factors and for identifying cellular polypeptides to which the viral polypeptides bind. The cellular polypeptide is useful as a therapeutic target or as a therapeutic agent for treating diseases and disorders, including immunological diseases or disorders.
摘要翻译：本发明提供用于鉴定病毒毒力因子和鉴定病毒多肽结合的细胞多肽的方法。细胞多肽可用作治疗靶点或用作治疗疾病和病症（包括免疫疾病或病症）的治疗剂。

7. 发明授权

US08293500B2 Methods for identifying polypeptide targets and uses thereof for treating immunological diseases 失效
标题翻译：用于鉴定多肽靶标的方法及其用于治疗免疫疾病的用途
公开(公告)号：US08293500B2
公开(公告)日：2012-10-23
申请号：US11728329
申请日：2007-03-22
申请人： Steven Wiley , Craig A Smith , Ajamete Kaykas
发明人： Steven Wiley , Craig A Smith , Ajamete Kaykas
IPC分类号： C12P21/04
CPC分类号： G01N33/6845 , A61K39/3955 , C12Q1/18 , C12Q1/70 , G01N33/5008 , G01N33/56983 , G01N2500/02
摘要： The present invention provides methods for identifying viral virulence factors and for identifying cellular polypeptides to which the viral polypeptides bind. The cellular polypeptide is useful as a therapeutic target or as a therapeutic agent for treating diseases and disorders, including immunological diseases or disorders.
摘要翻译：本发明提供用于鉴定病毒毒力因子和鉴定病毒多肽结合的细胞多肽的方法。细胞多肽可用作治疗靶点或用作治疗疾病和病症（包括免疫疾病或病症）的治疗剂。

8. 发明申请

US20130129748A1 METHODS FOR IDENTIFYING POLYPEPTIDE TARGETS AND USES THEREOF FOR TREATING IMMUNOLOGICAL DISEASES 审中-公开
标题翻译：识别多肽目标的方法及其用于治疗免疫缺陷病毒的方法
公开(公告)号：US20130129748A1
公开(公告)日：2013-05-23
申请号：US13616694
申请日：2012-09-14
申请人： Steven Wiley , Craig A. Smith , Ajamete Kaykas
发明人： Steven Wiley , Craig A. Smith , Ajamete Kaykas
IPC分类号： G01N33/68 , A61K39/395 , C12Q1/70
CPC分类号： G01N33/6845 , A61K39/3955 , C12Q1/18 , C12Q1/70 , G01N33/5008 , G01N33/56983 , G01N2500/02
摘要： The present invention provides methods for identifying viral virulence factors and for identifying cellular polypeptides to which the viral polypeptides bind. The cellular polypeptide is useful as a therapeutic target or as a therapeutic agent for treating diseases and disorders, including immunological diseases or disorders.
摘要翻译：本发明提供用于鉴定病毒毒力因子和鉴定病毒多肽结合的细胞多肽的方法。细胞多肽可用作治疗靶点或用作治疗疾病和病症（包括免疫疾病或病症）的治疗剂。

9. 发明申请

US20210123016A1 REGULATORS OF HUMAN PLURIPOTENT STEM CELLS AND USES THEREOF 有权
公开(公告)号：US20210123016A1
公开(公告)日：2021-04-29
申请号：US17052041
申请日：2019-05-01
申请人： Robert John Ihry , Ajamete Kaykas , Marc Horst Peter Hild , Novartis AG
发明人： Robert John Ihry , Ajamete Kaykas , Marc Horst Peter Hild
IPC分类号： C12N5/0735 , C12N5/074
摘要： Disclosed herein are regulators, e.g., inhibitors or promoters, of human pluripotent stem cells (hPSCs), and methods of using the same. Also provided herein are methods of manufacturing hPSCs, and methods of modifying hPSCs comprising contacting the hPSCs with the regulators, e.g., inhibitors or promoters, of hPSCs, and uses thereof.

10. 发明申请

US20050233994A1 Methods and vectors for expressing siRNA 审中-公开
标题翻译：用于表达siRNA的方法和载体
公开(公告)号：US20050233994A1
公开(公告)日：2005-10-20
申请号：US10826130
申请日：2004-04-16
申请人： Ajamete Kaykas , Randall Moon
发明人： Ajamete Kaykas , Randall Moon
IPC分类号： A61K48/00 , C12N15/09 , C12N15/63 , C12N15/85 , C12Q1/68
CPC分类号： C12N15/85 , C12N15/63
摘要： In a first aspect, the invention provides expression vectors comprising: (a) a first RNA polymerase III promoter operably associated with a first RNA polymerase III termination signal and (b) a second RNA polymerase III promoter operably associated with a second RNA polymerase III termination signal, wherein the first and second RNA polymerase III promoters are oriented to promote bidirectional transcription of an insert disposed between the first and the second RNA polymerase III termination signals. In other aspects, the invention provide methods for using these expression vectors for inhibiting expression of target genes, for determining the effect of siRNAs on biological processes, and for identifying siRNAs that affect biological processes.
摘要翻译：在第一方面，本发明提供表达载体，其包含：（a）可操作地与第一RNA聚合酶III终止信号相关的第一RNA聚合酶III启动子和（b）与第二RNA聚合酶III终止子可操作地相关的第二RNA聚合酶III启动子信号，其中所述第一和第二RNA聚合酶III启动子被定向以促进设置在所述第一和第二RNA聚合酶III终止信号之间的插入物的双向转录。在其它方面，本发明提供了使用这些表达载体抑制靶基因表达，确定siRNA对生物学过程的影响以及鉴定影响生物学过程的siRNA的方法。

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