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1. 发明申请

US20050233994A1 Methods and vectors for expressing siRNA 审中-公开
标题翻译：用于表达siRNA的方法和载体
公开(公告)号：US20050233994A1
公开(公告)日：2005-10-20
申请号：US10826130
申请日：2004-04-16
申请人： Ajamete Kaykas , Randall Moon
发明人： Ajamete Kaykas , Randall Moon
IPC分类号： A61K48/00 , C12N15/09 , C12N15/63 , C12N15/85 , C12Q1/68
CPC分类号： C12N15/85 , C12N15/63
摘要： In a first aspect, the invention provides expression vectors comprising: (a) a first RNA polymerase III promoter operably associated with a first RNA polymerase III termination signal and (b) a second RNA polymerase III promoter operably associated with a second RNA polymerase III termination signal, wherein the first and second RNA polymerase III promoters are oriented to promote bidirectional transcription of an insert disposed between the first and the second RNA polymerase III termination signals. In other aspects, the invention provide methods for using these expression vectors for inhibiting expression of target genes, for determining the effect of siRNAs on biological processes, and for identifying siRNAs that affect biological processes.
摘要翻译：在第一方面，本发明提供表达载体，其包含：（a）可操作地与第一RNA聚合酶III终止信号相关的第一RNA聚合酶III启动子和（b）与第二RNA聚合酶III终止子可操作地相关的第二RNA聚合酶III启动子信号，其中所述第一和第二RNA聚合酶III启动子被定向以促进设置在所述第一和第二RNA聚合酶III终止信号之间的插入物的双向转录。在其它方面，本发明提供了使用这些表达载体抑制靶基因表达，确定siRNA对生物学过程的影响以及鉴定影响生物学过程的siRNA的方法。

2. 发明申请

US20060263791A1 Methods for diagnosis of Alzheimer disease 有权
标题翻译：阿尔茨海默病诊断方法
公开(公告)号：US20060263791A1
公开(公告)日：2006-11-23
申请号：US11133918
申请日：2005-05-20
申请人： Randall Moon , Giancarlo De Ferrari
发明人： Randall Moon , Giancarlo De Ferrari
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172
摘要： Methods for diagnosis or prognosis of late onset Alzheimer disease in an individual are provided which comprise detecting at least one polymorphism of a low-density lipoprotein receptor related protein 6 gene.
摘要翻译：提供个体中迟发性阿尔茨海默病的诊断或预后的方法，其包括检测低密度脂蛋白受体相关蛋白6基因的至少一个多态性。

3. 发明申请

US20060147435A1 Methods for regulation of stem cells 有权
公开(公告)号：US20060147435A1
公开(公告)日：2006-07-06
申请号：US11026399
申请日：2004-12-30
申请人： Randall Moon , Mickie Bhatia , Jennifer Trowbridge
发明人： Randall Moon , Mickie Bhatia , Jennifer Trowbridge
IPC分类号： A61K48/00 , C12N5/08 , C12N15/87
CPC分类号： A61K35/14 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K48/005 , C07K14/46 , C07K14/475 , C07K14/705 , C12N9/1205 , G01N33/5041 , G01N33/5073
摘要： Methods are provided for increasing stem cells, hematopoietic progenitor/stem cells, mesenchymal progenitor/stem cells, mesodermal progenitor/stem cells, muscle progenitor/stem cells, or neural progenitor/stem cells in vivo in a mammalian subject. Methods are also provided for treating an immune related disease, a mesenchymal/mesoderm degenerative disease, or a neurodegenerative disease in a mammalian subject in need thereof.

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