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1. 发明申请

US20080206316A1 Chromium-Fatty Acid Compounds and Methods of Making and Using Thereof 审中-公开
标题翻译：铬 - 脂肪酸化合物及其制备和使用方法
公开(公告)号：US20080206316A1
公开(公告)日：2008-08-28
申请号：US10575204
申请日：2006-01-26
申请人： Colin Barrow , Jaroslav A. Kralovec , Harry Stephen Ewart
发明人： Colin Barrow , Jaroslav A. Kralovec , Harry Stephen Ewart
IPC分类号： A61K9/127 , C07F11/00 , C07F3/06 , A61K9/48 , A61P3/00 , A61K9/50 , A61K31/28
CPC分类号： C07C57/12 , C07C51/412 , C07C57/03 , C07F11/005
摘要： Disclosed are compounds comprising one or more chromium atoms bonded to one or more fatty acids. Also disclosed are nutritional supplements, pharmaceutical formulations, delivery devices, and foodstuffs comprising the disclosed compounds. Methods of using the disclosed compounds and compositions to improve health are also disclosed.
摘要翻译：公开了包含一个或多个与一种或多种脂肪酸键合的铬原子的化合物。还公开了营养补充剂，药物制剂，递送装置和包含所公开的化合物的食品。还公开了使用所公开的化合物和组合物改善健康的方法。

2. 发明申请

US20090182050A1 Salts of Fatty Acids and Methods of Making and Using thereof 审中-公开
标题翻译：脂肪酸盐及其制备和使用方法
公开(公告)号：US20090182050A1
公开(公告)日：2009-07-16
申请号：US12083276
申请日：2006-10-03
申请人： Colin Barrow , Jaroslav A. Kralovec
发明人： Colin Barrow , Jaroslav A. Kralovec
IPC分类号： A61K31/20 , A61K31/202 , A61K31/201
CPC分类号： A23K20/158 , A23L33/12 , A61K31/201 , A61K31/202
摘要： Disclosed are methods of making salts of fatty acids (e.g., marine oils) and to salts prepared by the disclosed methods. Methods of using the disclosed salts are also disclosed.
摘要翻译：公开了制备脂肪酸盐（例如海洋油）的盐和通过所公开的方法制备的盐的方法。还公开了使用所公开的盐的方法。

3. 发明授权

US06998501B1 Nutritional supplement for lowering serum triglyceride and cholesterol levels 失效
标题翻译：降低血清甘油三酯和胆固醇水平的营养补充剂
公开(公告)号：US06998501B1
公开(公告)日：2006-02-14
申请号：US10070181
申请日：2000-08-30
申请人： Jeffrey L. C. Wright , Jaroslav A. Kralovec
发明人： Jeffrey L. C. Wright , Jaroslav A. Kralovec
IPC分类号： C07C69/74
CPC分类号： C07J9/00
摘要： Triglycerides and cholesterol in the bloodstream are important factors in the development of cardiovascular disease. The present invention discloses a nutritional supplement comprising a sterol and an omega-3 fatty acid, or an ester thereof, for lowering cholesterol and triglyceride levels in the bloodstream of a subject. Preferably, the sterol and omega-3 fatty acid are together in the form of an ester.
摘要翻译：血液中的甘油三酯和胆固醇是心血管疾病发展的重要因素。本发明公开了一种营养补充剂，其包含用于降低受试者血液中的胆固醇和甘油三酯水平的甾醇和ω-3脂肪酸或其酯。优选地，甾醇和ω-3脂肪酸一起是酯的形式。

4. 发明申请

US20080139649A1 Fatty Acid-Benzenediol Derivatives and Methods of Making and Using Thereof 审中-公开
标题翻译：脂肪酸 - 苯二酚衍生物及其制备和使用方法
公开(公告)号：US20080139649A1
公开(公告)日：2008-06-12
申请号：US11795934
申请日：2006-01-17
申请人： Colin J. Barrow , Jaroslav A. Kralovec
发明人： Colin J. Barrow , Jaroslav A. Kralovec
IPC分类号： A61K31/22 , C07C69/618 , A61K9/48
CPC分类号： C07C69/587 , A23L33/30 , C07C67/307
摘要： Disclosed are compounds comprising a benzenediol derivative bound to one or more fatty acids. Also disclosed are nutritional supplements, pharmaceutical formulations, delivery devices, and foodstuffs comprising the disclosed compounds. Methods of using the disclosed compounds and compositions to improve health are also disclosed.
摘要翻译：公开了包含与一种或多种脂肪酸结合的苯二酚衍生物的化合物。还公开了营养补充剂，药物制剂，递送装置和包含所公开的化合物的食品。还公开了使用所公开的化合物和组合物改善健康的方法。

5. 发明授权

US06977076B2 Methods for obtaining from Chlorella extract polysaccharides having immunomodulating properties 失效
标题翻译：获得具有免疫调节特性的小球藻提取物多糖的方法
公开(公告)号：US06977076B2
公开(公告)日：2005-12-20
申请号：US10367795
申请日：2003-02-19
申请人： Jaroslav A. Kralovec
发明人： Jaroslav A. Kralovec
IPC分类号： A23L1/30 , A23L1/48 , A61K31/715 , A61K36/05 , A61K39/145 , A61K39/39 , A61P31/04 , A61P31/10 , A61P31/16 , A61P37/02 , A61P37/04 , A61P43/00 , C07G99/00 , C08B37/00 , C12N1/12 , A61K39/00 , A01N63/00 , A61K39/35 , A61K39/36 , A61K47/00
CPC分类号： A61K31/715 , A61K36/05 , Y10S435/946
摘要： Chlorella extracts containing high molecular weight Chlorella polysaccharide and polysaccharide complexes show immune modulatory, specifically immune stimulatory, activity. The polysaccharide and polysaccharide complexes contain glucose and any combination of: galactose, rhamnose, mannose and arabinose, as well as N-acetyl glucosamine and N-acetyl galactosamine. The extracts may be treated with pronase, DNAse, RNAse and proteases to remove unassociated nucleic acids, ribonucleic acids and proteins. The extracts may also undergo treatment to effect cleavage of specific glycosidic linkages, the linkages being defined by their susceptibility to cleavage by amylase, amyloglucosidase, cellulase or neuraminidase. Chlorella extracts may be administered to a mammal to increase proliferation of splenocytes and increase production of cytokines such as IL-6, IL-10, INF-γ and TNF-α. They may be used as a supplement to a vaccination regimen.
摘要翻译：含有高分子量小球藻多糖和多糖复合物的小球藻提取物显示免疫调节，特别是免疫刺激活性。多糖和多糖配合物含有葡萄糖和以下任何组合：半乳糖，鼠李糖，甘露糖和阿拉伯糖，以及N-乙酰氨基葡萄糖和N-乙酰半乳糖胺。可以用链霉蛋白酶，DNA酶，RNA酶和蛋白酶处理提取物以除去未缔合的核酸，核糖核酸和蛋白质。提取物也可以进行治疗以实现特定糖苷键的切割，所述连接通过它们对淀粉酶，淀粉葡糖苷酶，纤维素酶或神经氨酸酶切割的易感性来定义。可以向哺乳动物施用小球藻提取物以增加脾细胞的增殖并增加诸如IL-6，IL-10，INF-γ和TNF-α的细胞因子的产生。它们可以用作疫苗接种方案的补充。

6. 发明授权

US06974576B2 Chlorella composition having high molecular weight polysaccharides and polysaccharide complexes 失效
标题翻译：具有高分子量多糖和多糖配合物的小球藻组合物
公开(公告)号：US06974576B2
公开(公告)日：2005-12-13
申请号：US10728943
申请日：2003-12-08
申请人： Jaroslav A. Kralovec
发明人： Jaroslav A. Kralovec
IPC分类号： A23L1/30 , A23L1/48 , A61K31/715 , A61K36/05 , A61K39/145 , A61K39/39 , A61P31/04 , A61P31/10 , A61P31/16 , A61P37/02 , A61P37/04 , A61P43/00 , C07G99/00 , C08B37/00 , C12N1/12 , A61K35/80 , A61K47/00
CPC分类号： A61K31/715 , A61K36/05 , Y10S435/946
摘要： Chlorella extracts containing high molecular weight Chlorella polysaccharide and polysaccharide complexes show immune modulatory, specifically immune stimulatory, activity. The polysaccharide and polysaccharide complexes contain glucose and any combination of: galactose, rhamnose, mannose and arabinose, as well as N-acetyl glucosamine and N-acetyl galactosamine. The extracts may be treated with pronase, DNAse, RNAse and proteases to remove unassociated nucleic acids, ribonucleic acids and proteins. The extracts may also undergo treatment to effect cleavage of specific glycosidic linkages, the linkages being defined by their susceptibility to cleavage by amylase, amyloglucosidase, cellulase or neuraminidase. Chlorella extracts may be administered to a mammal to increase proliferation of splenocytes and increase production of cytokines such as IL-6, IL-10, INF-γ and TNF-α. They may be used as a supplement to a vaccination regimen.
摘要翻译：含有高分子量小球藻多糖和多糖复合物的小球藻提取物显示免疫调节，特别是免疫刺激活性。多糖和多糖配合物含有葡萄糖和以下任何组合：半乳糖，鼠李糖，甘露糖和阿拉伯糖，以及N-乙酰氨基葡萄糖和N-乙酰半乳糖胺。可以用链霉蛋白酶，DNA酶，RNA酶和蛋白酶处理提取物以除去未缔合的核酸，核糖核酸和蛋白质。提取物也可以进行治疗以实现特定糖苷键的切割，所述连接通过它们对淀粉酶，淀粉葡糖苷酶，纤维素酶或神经氨酸酶切割的易感性来定义。可以向哺乳动物施用小球藻提取物以增加脾细胞的增殖并增加诸如IL-6，IL-10，INF-γ和TNF-α的细胞因子的产生。它们可以用作疫苗接种方案的补充。

7. 发明授权

US06551596B2 Fractions of Chlorella extract containing polysaccharide having immunomodulating properties 失效
标题翻译：含有具有免疫调节性质的多糖的小球藻提取物级分
公开(公告)号：US06551596B2
公开(公告)日：2003-04-22
申请号：US09925953
申请日：2001-08-10
申请人： Jaroslav A. Kralovec
发明人： Jaroslav A. Kralovec
IPC分类号： A61K3580
CPC分类号： A61K31/715 , A61K36/05 , Y10S435/946
摘要： Chlorella fractionated extracts containing high molecular weight Chlorella polysaccharide and polysaccharide complexes show immune modulatory, specifically immune stimulatory activity. The fractionated extracts are obtained by size fractionation of an extract of Chlorella and selecting fractions containing high molecular weight polysaccharides and polysaccharide complexes of about 1×104 Da to about 1×107 Da. A fraction of about 4×106 Da to about 1×107 Da is preferably obtained by size fractionation. The polysaccharide and polysaccharide complexes contain glucose and any combination of: galactose, rhamnose, mannose and arabinose, as well as N-acetyl glucosamine and N-acetyl galactosamine. The extracts may be treated with pronase, DNAse, RNAse and proteases to remove unassociated nucleic acids, ribonucleic acids and proteins. The extracts may also undergo treatment to effect cleavage of specific glycosidic linkages, the linkages being defined by their susceptibility to cleavage by amylase, amyloglucosidase, cellulase or neuraminidase. Chlorella extracts may be administered to a mammal to increase proliferation of splenocytes and increase production of cytokines such as IL-6, IL-10, INF-&ggr; and TNF-&agr;. They may be used as a supplement to a vaccination regimen.
摘要翻译：含有高分子量小球藻多糖和多糖配合物的小球藻分馏提取物显示免疫调节，特别是免疫刺激活性。分级提取物通过小球藻提取物的大小分级获得并选择含有约1×104Da至约1×10 7 Da的高分子量多糖和多糖复合物的级分。优选通过尺寸分级分离获得约4×10 6 Da至约1×10 7 Da的分数。多糖和多糖配合物含有葡萄糖和以下任何组合：半乳糖，鼠李糖，甘露糖和阿拉伯糖，以及N-乙酰氨基葡萄糖和N-乙酰半乳糖胺。可以用链霉蛋白酶，DNA酶，RNA酶和蛋白酶处理提取物以除去未缔合的核酸，核糖核酸和蛋白质。提取物也可以进行治疗以实现特定糖苷键的切割，所述连接通过它们对淀粉酶，淀粉葡糖苷酶，纤维素酶或神经氨酸酶切割的易感性来定义。可以向哺乳动物施用小球藻提取物以增加脾细胞的增殖并增加诸如IL-6，IL-10，INF-γ和TNF-α的细胞因子的产生。它们可以用作疫苗接种方案的补充。

8. 发明授权

US08420349B2 Enzymatic modification of oil 有权
标题翻译：油的酶改性
公开(公告)号：US08420349B2
公开(公告)日：2013-04-16
申请号：US12668533
申请日：2008-07-11
申请人： Jaroslav A. Kralovec , Weijie Wang , Colin James Barrow
发明人： Jaroslav A. Kralovec , Weijie Wang , Colin James Barrow
IPC分类号： C12P1/00 , C12P7/64 , C12P7/62
CPC分类号： C12P7/6409 , C11C1/045 , C12P7/6418 , C12P7/6445 , C12P7/6472 , C12P7/649 , Y02E50/13
摘要： The disclosed subject matter relates generally to a method for modifying oil, and specifically to a process for increasing the concentration of polyunsaturated fatty acid in an oil composition.
摘要翻译：所公开的主题一般涉及用于改性油的方法，具体涉及提高油组合物中多不饱和脂肪酸浓度的方法。

9. 发明申请

US20100041111A9 Immobilized Enzymes and Methods of Using Thereof 有权
标题翻译：固定化酶及其使用方法
公开(公告)号：US20100041111A9
公开(公告)日：2010-02-18
申请号：US11918150
申请日：2006-06-13
申请人： Jaroslav A. Kralovec , Weijie Wang
发明人： Jaroslav A. Kralovec , Weijie Wang
IPC分类号： C12P7/64 , C12N11/00
CPC分类号： C12P7/6472 , C12N9/20 , C12N11/06 , C12N11/08 , C12P7/6436 , C12P7/6454
摘要： The disclosed matter relates to immobilized enzymes and methods of use thereof.
摘要翻译：所公开的事项涉及固定的酶及其使用方法。

10. 发明申请

US20090042263A1 Immobilized Enzymes and Methods of Using Thereof 有权
标题翻译：固定化酶及其使用方法
公开(公告)号：US20090042263A1
公开(公告)日：2009-02-12
申请号：US11918150
申请日：2006-06-13
申请人： Jaroslav A. Kralovec , Weijie Wang
发明人： Jaroslav A. Kralovec , Weijie Wang
IPC分类号： C12P7/64 , C12N11/00
CPC分类号： C12P7/6472 , C12N9/20 , C12N11/06 , C12N11/08 , C12P7/6436 , C12P7/6454
摘要： The disclosed matter relates to immobilized enzymes and methods of use thereof.
摘要翻译：所公开的事项涉及固定的酶及其使用方法。

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