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1. 发明授权

US06878746B2 Carbamate and thiocarbamate podophyllotoxin derivatives, preparation method and pharmaceutical compositions containing them 失效
标题翻译：氨基甲酸酯和硫代氨基甲酸酯鬼臼毒素衍生物，制备方法和含有它们的药物组合物
公开(公告)号：US06878746B2
公开(公告)日：2005-04-12
申请号：US10312175
申请日：2001-06-19
申请人： Claude Monneret , Emmanuel Bertounesque , Philippe Meresse , Ghanem Atassi , Alain Pierre , John Hickman , Bruno Pfeiffer , Pierre Renard
发明人： Claude Monneret , Emmanuel Bertounesque , Philippe Meresse , Ghanem Atassi , Alain Pierre , John Hickman , Bruno Pfeiffer , Pierre Renard
IPC分类号： A61K31/36 , A61P35/00 , C07D493/04 , A61K31/365
CPC分类号： C07D493/04 , Y02P20/55
摘要： A compound selected from these of formula (I): wherein: R1 represents hydrogen, alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkoxycarbonyl, aryloxycarbonyl, arylalkoxycarbonyl, heterocycloalkoxycarbonyl, alkylsulfonyl, arylsulfonyl, arylalkylsulfonyl or phosphono, R2 represents oxygen or sulphur, R3 represents hydrogen or alkyl, cycloalkyl or arylalkyl, X represents linear or branched (C1-C6)alkylene, R4 represents a group selected from amino optionally substituted by one or two groups, —N(R3)—X1—OR5 wherein R3, X1 and R5 are as defined in the description, —N(R3)—X1—NR6R7 wherein R3, X1, R6 and R7 are as defined in the description, hydroxy, alkoxy, aryloxy, —O—X1—OR5 wherein R5 and X1 are as defined in the description, and —O—X1—NR6R7 wherein R6, R7 and X1 are as defined in the description, its isomers, and also addition salts thereof with a pharmaceutically acceptable acid or base, and medical products containing the same which are useful in the treatment of cancer.
摘要翻译：选自这些式（I）的化合物：其中：R1表示氢，烷基，芳基，芳基烷基，杂芳基，杂芳基烷基，烷氧基羰基，芳氧基羰基，芳基烷氧基羰基，杂环烷氧基羰基，烷基磺酰基，芳基磺酰基，芳基烷基磺酰基或膦酰基，R2表示氧或硫，R3 表示氢或烷基，环烷基或芳基烷基，X表示直链或支链（C1-C6）亚烷基，R4表示选自任选被一个或两个基团取代的氨基的基团-N（R3）-X1-OR5，其中R3，X1和 R 5如说明书中所定义，-N（R3）-X1-NR6R7，其中R3，X1，R6和R7如说明书中所定义，羟基，烷氧基，芳氧基，-O-X1-OR5，其中R5和X1为和-O-X 1 -NR 6 R 7，其中R 6，R 7和X 1如说明书中所定义，其异构体及其与药学上可接受的酸或碱的加成盐，以及含有它们的医药产品可用在治疗癌症。

2. 发明授权

US06281198B1 9-(3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydrofuro-[3′,4′:6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one compounds 失效
标题翻译： 9-（3,5-二甲氧基苯基）-5,8,8a，9-四氢呋喃（3'，4'：6,7）萘并（2,3-d）（1,3）二氧杂环戊烯-6（5aH）一种化合物
公开(公告)号：US06281198B1
公开(公告)日：2001-08-28
申请号：US09697248
申请日：2000-10-26
申请人： Claude Monneret , Emmanuel Bertounesque , Philippe Meresse , Ghanem Atassi , Alain Pierre , Bruno Pfeiffer , Pierre Renard
发明人： Claude Monneret , Emmanuel Bertounesque , Philippe Meresse , Ghanem Atassi , Alain Pierre , Bruno Pfeiffer , Pierre Renard
IPC分类号： A61K31365
CPC分类号： C07D493/04 , Y02P20/55
摘要： Compound of formula (I): wherein: R represents: a group of formula (i): wherein X, Y and W are as defined in the description, or a group of formula (ii): —A—G (ii) wherein: A represents a single bond or an optionally substituted alkylene chain, G represents a group selected from hydrogen, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, —OR2, —O—T1—NR3R4, —O—T1—NR2—T′1—NR3R4, —NR3R4, —NR2—T1—NR3R4, —NR2—T1—OR5, —NR2—T1—CO2R6, —NR2—T1—C(O)R6, —C(O)—NR3R4, —C(O)—NR2—T2, —O—C(O)T2, —O—C(S)—T2, —NR2—C(O)—T2, —NR2—C(S)—T2, —O—C(O)—O—T2, —O—C(O)—NR2—T2, —O—C(S)—O—T2, —O—C(S)—NR2—T2, —NR2—C(O)—O—T2, —NR2—C(O)—NR—T2, —NR2—C(S)—O—T2, —NR2—C(S)—NR6—T2 and —NR2—SO2—T3, wherein R2, R3, R4, R5, R6, T1, T′1, T2 and T3 are as defined in the description, R1 represents a group selected from hydrogen, alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkylcarbonyl, arylcarbonyl, arylalkylcarbonyl, heterocycloalkylcarbonyl, alkylsulphonyl, arylsulphonyl, arylalkylsulphonyl, phosphono, aryloxycarbonyl, alkoxycarbonyl and arylalkoxycarbonyl, its isomers, and also addition salts thereof with a pharmaceutically acceptable acid or base. Medicinal products containing the same which are useful in the treatment of cancer.
摘要翻译：式（I）的化合物：其中：R表示：式（ⅰ）的基团：其中X，Y和W如说明书中所定义，或式（ⅱ）的基团：其中：A表示单键或任选取代的亚烷基链，G表示选自氢，环烷基，杂环烷基，芳基，杂芳基，-OR2，-O-T1-NR3R4，-O-T1-NR2-T'1-NR3R4，-NR3R4，-NR2 -T 1 -NR 3 R 4，-NR 2 -T 1 -OR 5，-NR 2 -T 1 -CO 2 R 6，-NR 2 -T 1 -C（O）R 6，-C（O）-NR 3 R 4，-C（O）-NR 2 -T 2，-OC （O）T 2，-OC（S）-T 2，-NR 2 -C（O）-T 2，-NR 2 -C（S）-T 2，-OC（O）-O-T 2，-OC（O） -T 2，-OC（S）-O-T2，-OC（S）-NR2-T2，-NR2-C（O）-O-T2，-NR2-C（O）-NR-T2， C（S）-O-T2，-NR2-C（S）-NR6-T2和-NR2-SO2-T3，其中R2，R3，R4，R5，R6，T1，T'1，T2和T3为 R 1表示选自氢，烷基，芳基，芳基烷基，杂芳基，杂芳基烷基，烷基羰基，芳基羰基，芳基烷基羰基，杂环烷基羰基，烷基磺酰基，芳基磺酰基，芳基烷基磺酰基，膦酰基，芳氧基羰基，烷氧基羰基和芳基烷氧基羰基，其异构体，以及其与药学上可接受的酸或碱的加成盐。含有该化合物的药物可用于治疗癌症。

3. 发明授权

US06548515B1 Dihydrofuro[3,4-b]quinolin-1-one compounds 失效
标题翻译：二氢呋喃并[3,4-b]喹啉-1-酮化合物
公开(公告)号：US06548515B1
公开(公告)日：2003-04-15
申请号：US09718917
申请日：2000-11-22
申请人： Henri-Philippe Husson , Sylviane Giorgi-Renault , Christophe Tratrat , Ghanem Atassi , Alain Pierre , Pierre Renard , Bruno Pfeiffer
发明人： Henri-Philippe Husson , Sylviane Giorgi-Renault , Christophe Tratrat , Ghanem Atassi , Alain Pierre , Pierre Renard , Bruno Pfeiffer
IPC分类号： A61K314741
CPC分类号： C07D491/04 , C07D219/06 , C07D221/16 , C07D221/18 , C07D491/14 , C07D495/04
摘要： The invention relates to compound of formula (I): wherein: represents a single or double bond, R0 represents hydrogen or hydroxy or alkoxy, R1 and R2, which are identical or different, each represents hydrogen or halogen or alkyl, alkoxy, hydroxy, polyhaloalkyl, nitro or optionally substituted amino or wherein m represents an integer such that 1≦m≦4, or form together with the carbon atoms carrying them an aromatic or non-aromatic, mono- or bi-cyclic group having from 5 to 12 ring members and optionally containing 1 or 2 hetero atoms selected from O, S and N, R3 represents hydrogen or aryl, heteroaryl, cycloalkyl, optionally substituted alkyl or a group of formula COR7 wherein R7 represents aryl, optionally substituted alkyl, optionally substituted amino or OR10 wherein R10 represents aryl or optionally substituted alkyl, X represents oxygen or sulphur or —CH2— or —CH2—CH2—, Ar represents aryl, heteroaryl or arylalkyl, its optical isomers, its hydrates, solvates, and also its addition salts with a pharmaceutically acceptable acid. Medicinal products containing the same are useful in the treatment of cancer.
摘要翻译：本发明涉及式（I）的化合物：其中：表示单键或双键，R 0表示氢或羟基或烷氧基，R 1和R 2相同或不同，各自表示氢或卤素或烷基，烷氧基，羟基，多卤代烷基，硝基或任选取代的氨基或其中m表示1≤= m = 4的整数，或与带有带有5至12个环成员的芳族或非芳族单环或双环基团的碳原子一起形成，并且任选地含有1或 2个选自O，S和N的杂原子，R 3表示氢或芳基，杂芳基，环烷基，任选取代的烷基或式COR7基团，其中R7表示芳基，任选取代的烷基，任选取代的氨基或OR 10，其中R 10表示芳基或任选地取代的烷基，X表示氧或硫或-CH 2 - 或-CH 2-CH 2 - ，Ar表示芳基，杂芳基或芳基烷基，其光学异构体，其水合物，溶剂合物，以及其与药学上可接受的酸的加成盐。含有它们的医药产品可用于治疗癌症。

4. 发明授权

US06569858B2 12,13-(pyranosyl)-indolo[2,3-a]pyrrolo[3,4-c]carbazole and 12,13-(pyranosyl)-furo[3,4-c]indolo[2,3-a]carbazoles 失效
标题翻译： 12,13-（吡喃糖基） - 吲哚并[2,3-a]吡咯并[3,4-c]咔唑和12,13-（吡喃糖基） - 呋喃并[3,4-c]吲哚并[2,3-a] 咔唑
公开(公告)号：US06569858B2
公开(公告)日：2003-05-27
申请号：US10010379
申请日：2001-11-05
申请人： Michelle Prudhomme , Pascale Moreau , Fabrice Anizon , Christelle Marminon , Ghanem Atassi , Alain Pierre , Bruno Pfeiffer , Pierre Renard
发明人： Michelle Prudhomme , Pascale Moreau , Fabrice Anizon , Christelle Marminon , Ghanem Atassi , Alain Pierre , Bruno Pfeiffer , Pierre Renard
IPC分类号： C07D49044
CPC分类号： C07H19/23
摘要： A compound selected from those of formula (I): wherein: R1 and R2, which may be identical or different, represent a group of formula U-V wherein U represents single bond, or alkylene which is optionally substituted and/or unsaturated, and V is as defined in the description, G represents oxygen, or NR3 wherein R3 is as defined in the description, X represents hydrogen, hydroxy, alkoxy, mercapto or alkylthio, Y represents hydrogen, or X+Y represents carbonyl, X1 represents hydrogen, hydroxy, alkoxy, mercapto or alkylthio, Y1 represents hydrogen, or X1+Y1 represents carbonyl, R4, R5, and R6 are as defined in the description, its isomers, and pharmaceutically-acceptable acid or base addition salts thereof, and medicinal products containing the same are useful in the treatment of cancer.
摘要翻译：选自式（I）的化合物：其中：R 1和R 2可以相同或不同，表示其中U表示单键的式UV基团，或任选被取代和/或不饱和的亚烷基，V是 G表示氧或NR 3，其中R3如说明书中所定义，X表示氢，羟基，烷氧基，巯基或烷硫基，Y表示氢，或X + Y表示羰基，X1表示氢，羟基，烷氧基，巯基或烷硫基，Y1表示氢，或X1 + Y1表示羰基，R4，R5和R6如说明书中所定义，其异构体及其药学上可接受的酸或碱加成盐，以及含有它们的药物可用于治疗癌症。

5. 发明授权

US06503919B1 Compounds of 7-oxo-2,3,7,14-tetrahydro-1H-benzo[b]pyrano[3,2-h]acridin carboxylate 失效
标题翻译： 7-氧代-2,3,7,14-四氢-1H-苯并[b]吡喃并[3,2-h]吖啶羧酸酯的化合物
公开(公告)号：US06503919B1
公开(公告)日：2003-01-07
申请号：US09594853
申请日：2000-06-15
申请人： Michel Koch , François Tillequin , Sylvie Michel , Ghanem Atassi , Alain Pierre , Pierre Renard , Bruno Pfeiffer
发明人： Michel Koch , François Tillequin , Sylvie Michel , Ghanem Atassi , Alain Pierre , Pierre Renard , Bruno Pfeiffer
IPC分类号： C07D491052
CPC分类号： C07D491/04
摘要： A compound selected from those of formula (I): wherein: X and Y represent hydrogen, halogen, hydroxy, mercapto, cyano, nitro, alkyl, alkoxy, trihaloalkyl, optionally substituted amino, methylenedioxy, or ethylenedioxy, R1 represents hydrogen, or alkyl, R2 represents hydrogen, hydroxy, alkyl, alkoxy, alkylcarbonyloxy, or optionally substituted amino, R3 and R4 represent hydrogen, or alkyl, R5 and R6 represent —O—CO—U—V wherein U and V are as defined in the description, or Z as defined in the description, it being understood that at least one of the R5 and R6 groups represents —O—CO—U—V, their isomers, N-oxides, and pharmaceutically-acceptable acid or base addition salts thereof, and medicinal products containing the same which are useful in the treatment of cancer.
摘要翻译：选自式（I）的化合物：其中：X和Y表示氢，卤素，羟基，巯基，氰基，硝基，烷基，烷氧基，三卤代烷基，任选取代的氨基，亚甲二氧基或亚乙二氧基，，R 2表示氢，羟基，烷基，烷氧基，烷基羰基氧基或任选取代的氨基，R 3和R 4表示氢或烷基，R 5和R 6表示-O-CO-UV，其中U和V如说明书中所定义，或Z 可以理解的是，R 5和R 6基团中的至少一个表示-O-CO-UV，它们的异构体，N-氧化物及其药学上可接受的酸或碱加成盐，以及含有相同的可用于治疗癌症。

6. 发明授权

US06288073B1 Acronycine derivatives, preparation method and pharmaceutical compositions 失效
标题翻译： Acronycine衍生物，制备方法和药物组合物
公开(公告)号：US06288073B1
公开(公告)日：2001-09-11
申请号：US09581853
申请日：2000-06-19
申请人： Michel Koch , François Tillequin , Sylvie Michel , Ghanem Atassi , Alain Pierre , Bruno Pfeiffer , Pierre Renard
发明人： Michel Koch , François Tillequin , Sylvie Michel , Ghanem Atassi , Alain Pierre , Bruno Pfeiffer , Pierre Renard
IPC分类号： A61K314741
CPC分类号： C07D491/04 , C07D491/14
摘要： A compound selected from those of formula (I): in which: X and Y represent hydrogen, halogen, hydroxy, mercapto, cyano, nitro, alkyl, alkoxy, trihaloalkyl, optionally substituted amino, methylenedioxy, or ethylenedioxy, R1 represents hydrogen, or alkyl, R2 represents hydrogen, hydroxy, alkyl, alkoxy, alkylcarbonyloxy, or optionally substituted ammo, R3 and R4 represent hydrogen, or alkyl, A represents —CH═CH—, or —CH(R5)—CH(R6)— wherein R5 and R6 are as defined in the description, their isomers, N-oxides, and pharmaceutically-acceptable acid or base addition salts thereof, and medicinal products containing the same which are useful in the treatment of cancer.
摘要翻译：选自式（I）的化合物：其中：X和Y表示氢，卤素，羟基，巯基，氰基，硝基，烷基，烷氧基，三卤代烷基，任选取代的氨基，亚甲二氧基或亚乙二氧基，烷基，R 2表示氢，羟基，烷基，烷氧基，烷基羰基氧基或任选取代的氨基，R3和R4表示氢或烷基，A表示-CH = CH-或-CH（R5）-CH（R6） - ，其中R5 和R6如说明书中所定义，它们的异构体，N-氧化物及其药学上可接受的酸或碱加成盐，以及其可用于治疗癌症的药物。

7. 发明授权

US6127369A 5,10-dihydrodipyrido[2,3-b:2,3-e]pyrazin and 5,10-dihydrodipyrido[2,3-b:3,2-e]pyrazin compounds 失效
标题翻译： 5,10-二氢二吡啶并[2,3-b：2,3-e]吡嗪和5,10-二氢二吡啶并[2,3-b：3,2-e]吡嗪化合物
公开(公告)号：US6127369A
公开(公告)日：2000-10-03
申请号：US330496
申请日：1999-06-11
申请人： Paul Caubere , Gerald Guillaumet , Ivan Rodriguez , Karine Vinter-Pasquier , Catherine Kuehm-Caubere , Stephanie Blanchard , Ghanem Atassi , Alain Pierre , Bruno Pfeiffer , Pierre Renard
发明人： Paul Caubere , Gerald Guillaumet , Ivan Rodriguez , Karine Vinter-Pasquier , Catherine Kuehm-Caubere , Stephanie Blanchard , Ghanem Atassi , Alain Pierre , Bruno Pfeiffer , Pierre Renard
IPC分类号： A61K31/00 , A61K31/495 , A61K31/4985 , A61P35/00 , A61P35/02 , C07D471/14
CPC分类号： C07D471/14
摘要： A compound selected from those of formula (I): ##STR1## wherein: X represents N, C or CH,Y represents N when X represents C or CH, or Y represents C or CH when X represents N,R.sub.1 represents an optionally substituted alkyl,R.sub.2 and R.sub.3, which may be identical or different, represent Z or W, as defined in the description,their isomers and addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.
摘要翻译：选自式（I）的化合物：其中：X表示N，C或CH，Y表示N，当X表示C或CH时，或Y表示C或CH，当X表示N时，R 1表示任选取代的烷基，R 2 和可以相同或不同的R 3表示如说明书中所定义的Z或W，其与药学上可接受的酸或碱的异构体及其加成盐，以及含有该Z可以用于治疗癌症的药物。

8. 发明授权

US07378419B2 9-amino-podophyllotoxin derivatives, method for the production thereof and pharmaceutical compositions containing said derivatives 失效
标题翻译： 9-氨基鬼臼毒素衍生物，其制备方法和含有所述衍生物的药物组合物
公开(公告)号：US07378419B2
公开(公告)日：2008-05-27
申请号：US10576201
申请日：2004-09-01
申请人： Claude Monneret , Daniel Dauzonne , John Hickman , Alain Pierre , Laurence Kraus-Berthier , Bruno Pfeiffer , Pierre Benard
发明人： Claude Monneret , Daniel Dauzonne , John Hickman , Alain Pierre , Laurence Kraus-Berthier , Bruno Pfeiffer , Pierre Benard
IPC分类号： C07D405/00 , A61K31/50 , A01N43/36
CPC分类号： C07D493/04
摘要： The invention relates to compounds of formula (I), wherein R1 is a group selected from hydrogen, alkyl, aryl, aryalkil, heteroaryl, heteroarylalkyl, alkylcarbonyl, arylcarbonyl, arylalkylcarbonyl, alkoxycarbonyl, aryloxycarbonyl, arylalkoxycarbonyl, heterocycloalkoxycarbonyl, alkylsulfonyl, arylsulfonyl, arylalkylsulfonyl, phosphonic and Si(Ra)2Rb, Y is a group selected from HN—NH and N—R2, R3 is a hydrogen atom, an alkyl, cycloalkyl, aryl, arylalkyl group, R4 is hydrogen atom or an alkyl group, enantiomers, diastereoisomers and the salts thereof
摘要翻译：本发明涉及式（I）化合物，其中R 1是选自氢，烷基，芳基，芳亚烷基，杂芳基，杂芳基烷基，烷基羰基，芳基羰基，芳基烷基羰基，烷氧基羰基，芳氧基羰基，芳基烷氧基羰基，杂环烷氧基羰基，烷基磺酰基，芳基磺酰基，芳基烷基磺酰基，膦酸和Si（R a）2 R b，Y是选自HN-NH和NR 2 R 3是氢原子，烷基，环烷基，芳基，芳基烷基，R 4是氢原子或烷基，对映异构体，非对映异构体及其盐

9. 发明申请

US20060247246A1 9-Amino-podophyllotoxin derivatives, method for the production thereof and pharmaceutical compositions containing said derivatives 失效
标题翻译： 9-氨基鬼臼毒素衍生物，其制备方法和含有所述衍生物的药物组合物
公开(公告)号：US20060247246A1
公开(公告)日：2006-11-02
申请号：US10576201
申请日：2004-09-01
申请人： Claude Monneret , Daniel Dauzonne , John Hickman , Alain Pierre , Laurence Kraus-Berthier , Bruno Pfeiffer , Pierre Benard
发明人： Claude Monneret , Daniel Dauzonne , John Hickman , Alain Pierre , Laurence Kraus-Berthier , Bruno Pfeiffer , Pierre Benard
IPC分类号： A61K31/506 , A61K31/501 , A61K31/497 , A61K31/4439 , A61K31/426 , A61K31/421 , A61K31/405 , A61K31/4025 , C07D493/02
CPC分类号： C07D493/04
摘要： The invention relates to compounds of formula (I), wherein R1 is a group selected from hydrogen, alkyl, aryl, aryalkil, heteroaryl, heteroarylalkyl, alkylcarbonyl, arylcarbonyl, arylalkylcarbonyl, alkoxycarbonyl, aryloxycarbonyl, arylalkoxycarbonyl, heterocycloalkoxycarbonyl, alkylsulfonyl, arylsulfonyl, arylalkylsulfonyl, phosphonic and Si(Ra)2Rb, Y is a group selected from HN—NH and N—R2, R3 is a hydrogen atom, an alkyl, cycloalkyl, aryl, arylalkyl group, R4 is hydrogen atom or an alkyl group, enantiomers, diastereoisomers and the salts thereof.
摘要翻译：本发明涉及式（I）化合物，其中R 1是选自氢，烷基，芳基，芳亚烷基，杂芳基，杂芳基烷基，烷基羰基，芳基羰基，芳基烷基羰基，烷氧基羰基，芳氧基羰基，芳基烷氧基羰基，杂环烷氧基羰基，烷基磺酰基，芳基磺酰基，芳基烷基磺酰基，膦酸和Si（R a）2 R b，Y是选自HN-NH和NR 2 R 3是氢原子，烷基，环烷基，芳基，芳基烷基，R 4是氢原子或烷基，对映异构体，非对映异构体及其盐。

10. 发明授权

US07276512B2 Benzo[a]pyrano[3,2-h]acridin-7-one compounds 失效
公开(公告)号：US07276512B2
公开(公告)日：2007-10-02
申请号：US10872060
申请日：2004-06-18
申请人： Michel Koch , François Tillequin , Sylvie Michel , John Hickman , Alain Pierre , Stéphane Leonce , Bruno Pfeiffer , Pierre Renard
发明人： Michel Koch , François Tillequin , Sylvie Michel , John Hickman , Alain Pierre , Stéphane Leonce , Bruno Pfeiffer , Pierre Renard
IPC分类号： A61K31/44
CPC分类号： C07D491/04 , C07D491/14
摘要： A compound selected from those of formula (I): wherein: X and Y represent a group selected from hydrogen, halogen, hydroxy, alkoxy, nitro, cyano, alkyl, trihaloalkyl and NRaRb, wherein Ra and Rb are as defined in the description R1 represents hydrogen or alkyl R2 represents a group selected from hydrogen, alkyl, —OR″a, —NR′aR′b, —O-Ta-OR″a, —NR″a-Ta-NR′aR′b, —NR″a—C(O)-TaH, —O—C(O)-TaH, —O-Ta-NR′aR′b, —NR″a-Ta-OR″a, —NR″a-Ta-CO2R″a and —NR″a—C(O)-Ta-NR′aR′b, wherein R′a, R″a, R′b and Ta are as defined in the description R3 and R4 represent hydrogen or alkyl A represents a group of formula —CH(R5)—CH(R6)—, —CH═C(R7)—, —C(R7)═CH—, —C(O)—CH(R8) or —CH(R8)—C(O), wherein R5, R6, R7 and R8 are as defined in the description its isomers, N-oxides, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.

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