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1. 发明授权

US07144891B2 Benzo[b ]pyrano[3,2- h ]acridin-7-one cinnamate compounds 失效
标题翻译：苯并[b]吡喃并[3,2-h]吖啶-7-酮肉桂酸酯化合物
公开(公告)号：US07144891B2
公开(公告)日：2006-12-05
申请号：US11313386
申请日：2005-12-21
申请人： Michel Koch , François Tillequin , Sylvie Michel , John Hickman , Alain Pierre , Stéphane Leonce , Bruno Pfeiffer , Laurence Kraus-Berthier
发明人： Michel Koch , François Tillequin , Sylvie Michel , John Hickman , Alain Pierre , Stéphane Leonce , Bruno Pfeiffer , Laurence Kraus-Berthier
IPC分类号： A61K31/4741 , C07D491/02
CPC分类号： C07D491/04
摘要： A compound selected from those of formula (I): wherein: X and Y represent a group selected from hydrogen, halogen, alkoxy, nitro, cyano, alkyl, alkenyl, polyhaloalkyl and —NRaRb wherein Ra and Rb are as defined in the description, Z represents oxygen or NRc wherein Rc is as defined in the description, Ar represents aryl or heteroaryl, R1 represents hydrogen or alkyl, R2 represents a group selected from hydrogen, alkyl, —ORa and —NRaRb wherein Ra and Rb are as defined in the description, R3 and R4 represent hydrogen or alkyl, R5 represents hydrogen, ORc, NRcRd, W1—C(W2)—U—V, W1—C(W2)—W3-T1 or Z-CO—CH═CHAr wherein Rc, Rd, W1, W2, W3, U, V, T, Z and Ar are as defined in the description, its isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.
摘要翻译：选自式（I）的化合物：其中：X和Y表示选自氢，卤素，烷氧基，硝基，氰基，烷基，烯基，多卤代烷基和-NR a R 其中R a a和R b b如说明书中所定义，Z表示氧或NR C c，其中R _{- >如说明书中所定义，Ar表示芳基或杂芳基，R 1表示氢或烷基，R 2表示选自氢，烷基其中R a a和R b都是 - ， - - - - - - - - >如说明书中所定义，R 3和R 4代表氢或烷基，R 5表示氢，或C 1-4烷基， R 1，R 2，R 2，R 2，R 2，R 2，（W 2）-W 3 -T 1或Z-CO-CH-CHAr其中R R 1，R 2，W 3，W 2，W 3，U 3，，V，T，Z和Ar定义如下在其描述中，其异构体及其与药学上可接受的酸或碱的加成盐，以及含有该物质的药物可用于治疗癌症。}

2. 发明授权

US5389644A 1,4-dihydropyridine compounds 失效
标题翻译： 1,4-二氢吡啶化合物
公开(公告)号：US5389644A
公开(公告)日：1995-02-14
申请号：US13297
申请日：1993-02-04
申请人： Jean-Louis Peglion , Ghanem Aasssi , Alain Pierre , Laurence Kraus-Berthier , Nicolas Guilbaud , Jean-Paul Vilaine
发明人： Jean-Louis Peglion , Ghanem Aasssi , Alain Pierre , Laurence Kraus-Berthier , Nicolas Guilbaud , Jean-Paul Vilaine
IPC分类号： A61K31/455 , A61K31/4427 , A61K31/4433 , A61P35/00 , A61P43/00 , C07D211/90 , C07D401/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , A61K31/44
CPC分类号： C07D211/90 , C07D401/12 , C07D409/12 , C07D413/10 , C07D417/12
摘要： The compounds are 2,4-disubstituted 3-ethoxycarbonyl 5-methoxycarbonyl 6-methyl 1,4-dihydropyridines in their dextrorotatory form, useful to potentiate the activity of cytotoxic agents and to increase the sensitivity of tumor cells to antitumor agents.A compound disclosed is d-2-{[2-(2-(N-p-nitrobenzylamino)ethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine.
摘要翻译：化合物是它们的右旋形式的2,4-二取代的3-乙氧基羰基5-甲氧基羰基-6-甲基1,4-二氢吡啶，可用于增强细胞毒性剂的活性并增加肿瘤细胞对抗肿瘤剂的敏感性。所公开的化合物是d-2 - {[2-（2-（N-硝基苄基氨基）乙氧基）乙氧基]甲基} -4-（2,3-二氯苯基）-3-乙氧基羰基-5-甲氧基羰基-6-甲基-1 ，4-二氢吡啶。

3. 发明授权

US6162822A Bisimide compounds 失效
标题翻译：双酰亚胺化合物
公开(公告)号：US6162822A
公开(公告)日：2000-12-19
申请号：US221904
申请日：1998-12-28
申请人： Gilbert Lavielle , Patrick Hautefaye , Ghanem Atassi , Alain Pierre , Laurence Kraus-Berthier , Stephane Leonce
发明人： Gilbert Lavielle , Patrick Hautefaye , Ghanem Atassi , Alain Pierre , Laurence Kraus-Berthier , Stephane Leonce
IPC分类号： C07D221/10 , A61K31/435 , A61K31/47 , A61K31/473 , A61K31/55 , A61P35/00 , C07D209/80 , C07D401/12 , C07D403/12 , C07D519/00 , A01N43/38 , C07D487/00 , C07D487/02 , C07D491/00 , A61R31/40
CPC分类号： C07D209/80 , C09B57/08
摘要： A compound of formula (I) ##STR1## in which: m, and n, which may be identical or different, represent 0 or 1,X and Y, which may be identical or different, represent hydrogen or halogen or alky, trihaloalkyl, alkoxy, hydroxyl, cyano, nitro, amino, alkylamino or dialkylamino,Z represent a linear or branched C.sub.4 to C.sub.12 alkylene chain in which one or more --CH.sub.2 -- are optionally replaced by any one of the following atoms or groups: --NR--, --O--, --S--, --SO--, --SO.sub.2 --, or --CONH--, or by a substituted or unsubstituted heterocylcic,A forms, with two adjacent carbon atoms of the phenyl ring, a phenyl, naphthyl or tetrahydronaphthyl ring or a heterocycle, ##STR2## and medicinal products containing the same are useful as anticancer agent.
摘要翻译：式（I）化合物，其中m和n可以相同或不同，表示0或1，X和Y可以相同或不同，表示氢或卤素或烷基，三卤代烷基，烷氧基，羟基，氰基，硝基，氨基，烷基氨基或二烷基氨基，Z表示直链或支链的C 4至C 12亚烷基链，其中一个或多个-CH 2 - 任选被以下任何一个原子或基团取代：-NR-，-O- ，-S-，-SO-，-SO 2 - 或-CONH-，或通过取代或未取代的杂环A形式与苯环的两个相邻碳原子，苯基，萘基或四氢萘基环或杂环，含有该药物的药物可用作抗癌剂。

4. 发明申请

US20060003997A1 Substituted benzo[e] [1,4] oxazino [3,2-g] isoindole compounds 失效
标题翻译：取代的苯并[e] [1,4]恶嗪并[3,2-g]异吲哚化合物
公开(公告)号：US20060003997A1
公开(公告)日：2006-01-05
申请号：US10531648
申请日：2003-10-17
申请人： Gerard Coudert , Franck Lepifre , Daniel-Henri Caignard , Pierre Renard , John Hickman , Alain Pierre , Laurence Kraus-Berthier
发明人： Gerard Coudert , Franck Lepifre , Daniel-Henri Caignard , Pierre Renard , John Hickman , Alain Pierre , Laurence Kraus-Berthier
IPC分类号： A61K31/5383 , C07D491/14
CPC分类号： C07D497/04 , C07D497/14
摘要： A compound selected from those of formula (I): wherein: W1, with the carbon atoms to which it is bonded, represents phenyl or pyridyl, Z represents a group selected from hydrogen, halogen, linear or branched (C1-C6)alkyl, aryl, aryl-(C1-C6)alkyl, aryloxy, aryl-(C1-C6)alkoxy, hydroxy and linear or branched (C1-C6)alkoxy, R1 is as defined in the description, R2 represents hydrogen or —CH2CH2O—R8, R3 and R4 each represents hydrogen, linear or branched (C1-C6)alkyl, aryl or aryl-(C1-C6)alkyl, n represents an integer of from 1 to 6 inclusive, its isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.
摘要翻译：选自式（I）的化合物的化合物：其中：W 1与其键合的碳原子代表苯基或吡啶基，Z表示选自氢，卤素，直链或支链（C 1 -C 6 -C 6）烷基，芳基，芳基 - （C 1 -C 6 -C 6）烷基，芳氧基，芳基 - （C 1 -C 6 -C 6）烷氧基，羟基和直链或支链（C 1 -C 6 - R 1和R 2如在说明书中所定义，R 2表示氢或-CH 2 CH 2， R 3，R 3和R 4各自表示直链或支链（C 1 -C 4）烷基的氢， C 6 -C 6烷基，芳基或芳基 - （C 1 -C 6）烷基，n表示1〜6的整数，其异构体及其与药学上可接受的酸或碱的加成盐，以及含有该物质的药物，可用于治疗癌症。

5. 发明授权

US07378419B2 9-amino-podophyllotoxin derivatives, method for the production thereof and pharmaceutical compositions containing said derivatives 失效
标题翻译： 9-氨基鬼臼毒素衍生物，其制备方法和含有所述衍生物的药物组合物
公开(公告)号：US07378419B2
公开(公告)日：2008-05-27
申请号：US10576201
申请日：2004-09-01
申请人： Claude Monneret , Daniel Dauzonne , John Hickman , Alain Pierre , Laurence Kraus-Berthier , Bruno Pfeiffer , Pierre Benard
发明人： Claude Monneret , Daniel Dauzonne , John Hickman , Alain Pierre , Laurence Kraus-Berthier , Bruno Pfeiffer , Pierre Benard
IPC分类号： C07D405/00 , A61K31/50 , A01N43/36
CPC分类号： C07D493/04
摘要： The invention relates to compounds of formula (I), wherein R1 is a group selected from hydrogen, alkyl, aryl, aryalkil, heteroaryl, heteroarylalkyl, alkylcarbonyl, arylcarbonyl, arylalkylcarbonyl, alkoxycarbonyl, aryloxycarbonyl, arylalkoxycarbonyl, heterocycloalkoxycarbonyl, alkylsulfonyl, arylsulfonyl, arylalkylsulfonyl, phosphonic and Si(Ra)2Rb, Y is a group selected from HN—NH and N—R2, R3 is a hydrogen atom, an alkyl, cycloalkyl, aryl, arylalkyl group, R4 is hydrogen atom or an alkyl group, enantiomers, diastereoisomers and the salts thereof
摘要翻译：本发明涉及式（I）化合物，其中R 1是选自氢，烷基，芳基，芳亚烷基，杂芳基，杂芳基烷基，烷基羰基，芳基羰基，芳基烷基羰基，烷氧基羰基，芳氧基羰基，芳基烷氧基羰基，杂环烷氧基羰基，烷基磺酰基，芳基磺酰基，芳基烷基磺酰基，膦酸和Si（R a）2 R b，Y是选自HN-NH和NR 2 R 3是氢原子，烷基，环烷基，芳基，芳基烷基，R 4是氢原子或烷基，对映异构体，非对映异构体及其盐

6. 发明授权

US07312213B2 Substituted benzo[e][1,4]oxazino[3,2-g]isoindole compounds 失效
标题翻译：取代的苯并[e] [1,4]恶嗪并[3,2-g]异吲哚化合物
公开(公告)号：US07312213B2
公开(公告)日：2007-12-25
申请号：US10531648
申请日：2003-10-17
申请人： Gérard Coudert , Franck Lepifre , Daniel-Henri Caignard , Pierre Renard , John Hickman , Alain Pierre , Laurence Kraus-Berthier
发明人： Gérard Coudert , Franck Lepifre , Daniel-Henri Caignard , Pierre Renard , John Hickman , Alain Pierre , Laurence Kraus-Berthier
IPC分类号： C07D498/04 , A61K31/5383
CPC分类号： C07D497/04 , C07D497/14
摘要： A compound selected from those of formula (I): wherein: W1, with the carbon atoms to which it is bonded, represents phenyl or pyridyl, Z represents a group selected from hydrogen, halogen, linear or branched (C1-C6)alkyl, aryl, aryl-(C1-C6)alkyl, aryloxy, aryl-(C1-C6)alkoxy, hydroxy and linear or branched (C1-C6)alkoxy, R1 is as defined in the description, R2 represents hydrogen or —CH2CH2O—R8, R3 and R4 each represents hydrogen, linear or branched (C1-C6)alkyl, aryl or aryl-(C1-C6)alkyl, n represents an integer of from 1 to 6 inclusive, its isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.
摘要翻译：选自式（I）的化合物的化合物：其中：W 1与其键合的碳原子代表苯基或吡啶基，Z表示选自氢，卤素，直链或支链（C 1 -C 6 -C 6）烷基，芳基，芳基 - （C 1 -C 6 -C 6）烷基，芳氧基，芳基 - （C 1 -C 6 -C 6）烷氧基，羟基和直链或支链（C 1 -C 6 - R 1和R 2如在说明书中所定义，R 2表示氢或-CH 2 CH 2， R 3，R 3和R 4各自表示直链或支链（C 1 -C 4）烷基的氢， C 6 -C 6烷基，芳基或芳基 - （C 1 -C 6）烷基，n表示1〜6的整数，其异构体及其与药学上可接受的酸或碱的加成盐，以及含有该物质的药物，可用于治疗癌症。

7. 发明申请

US20060247246A1 9-Amino-podophyllotoxin derivatives, method for the production thereof and pharmaceutical compositions containing said derivatives 失效
标题翻译： 9-氨基鬼臼毒素衍生物，其制备方法和含有所述衍生物的药物组合物
公开(公告)号：US20060247246A1
公开(公告)日：2006-11-02
申请号：US10576201
申请日：2004-09-01
申请人： Claude Monneret , Daniel Dauzonne , John Hickman , Alain Pierre , Laurence Kraus-Berthier , Bruno Pfeiffer , Pierre Benard
发明人： Claude Monneret , Daniel Dauzonne , John Hickman , Alain Pierre , Laurence Kraus-Berthier , Bruno Pfeiffer , Pierre Benard
IPC分类号： A61K31/506 , A61K31/501 , A61K31/497 , A61K31/4439 , A61K31/426 , A61K31/421 , A61K31/405 , A61K31/4025 , C07D493/02
CPC分类号： C07D493/04
摘要： The invention relates to compounds of formula (I), wherein R1 is a group selected from hydrogen, alkyl, aryl, aryalkil, heteroaryl, heteroarylalkyl, alkylcarbonyl, arylcarbonyl, arylalkylcarbonyl, alkoxycarbonyl, aryloxycarbonyl, arylalkoxycarbonyl, heterocycloalkoxycarbonyl, alkylsulfonyl, arylsulfonyl, arylalkylsulfonyl, phosphonic and Si(Ra)2Rb, Y is a group selected from HN—NH and N—R2, R3 is a hydrogen atom, an alkyl, cycloalkyl, aryl, arylalkyl group, R4 is hydrogen atom or an alkyl group, enantiomers, diastereoisomers and the salts thereof.
摘要翻译：本发明涉及式（I）化合物，其中R 1是选自氢，烷基，芳基，芳亚烷基，杂芳基，杂芳基烷基，烷基羰基，芳基羰基，芳基烷基羰基，烷氧基羰基，芳氧基羰基，芳基烷氧基羰基，杂环烷氧基羰基，烷基磺酰基，芳基磺酰基，芳基烷基磺酰基，膦酸和Si（R a）2 R b，Y是选自HN-NH和NR 2 R 3是氢原子，烷基，环烷基，芳基，芳基烷基，R 4是氢原子或烷基，对映异构体，非对映异构体及其盐。

8. 发明申请

US20060135545A1 Benzo[b]pyrano[3,2-h]acridin-7-one cinnamate compounds 失效
标题翻译：苯并[b]吡喃并[3,2-h]吖啶-7-酮肉桂酸酯化合物
公开(公告)号：US20060135545A1
公开(公告)日：2006-06-22
申请号：US11313386
申请日：2005-12-21
申请人： Michel Koch , Francois Tillequin , Sylvie Michel , John Hickman , Alain Pierre , Stephane Leonce , Bruno Pfeiffer , Laurence Kraus-Berthier
发明人： Michel Koch , Francois Tillequin , Sylvie Michel , John Hickman , Alain Pierre , Stephane Leonce , Bruno Pfeiffer , Laurence Kraus-Berthier
IPC分类号： A61K31/4741 , C07D491/02
CPC分类号： C07D491/04
摘要： A compound selected from those of formula (I): wherein: X and Y represent a group selected from hydrogen, halogen, alkoxy, nitro, cyano, alkyl, alkenyl, polyhaloalkyl and —NRaRb wherein Ra and Rb are as defined in the description, Z represents oxygen or NRc wherein Rc is as defined in the description, Ar represents aryl or heteroaryl, R1 represents hydrogen or alkyl, R2 represents a group selected from hydrogen, alkyl, —ORa and —NRaRb wherein Ra and Rb are as defined in the description, R3 and R4 represent hydrogen or alkyl, R5 represents hydrogen, ORc, NRcRd, W1—C(W2)—U—V, W1—C(W2)—W3-T1 or Z-CO—CH═CHAr wherein Rc, Rd, W1, W2, W3, U, V, T, Z and Ar are as defined in the description, its isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.
摘要翻译：选自式（I）的化合物：其中：X和Y表示选自氢，卤素，烷氧基，硝基，氰基，烷基，烯基，多卤代烷基和-NR a R 其中R a a和R b b如说明书中所定义，Z表示氧或NR C c，其中R _{- >如说明书中所定义，Ar表示芳基或杂芳基，R 1表示氢或烷基，R 2表示选自氢，烷基其中R a a和R b都是 - ， - - - - - - - - >如说明书中所定义，R 3和R 4代表氢或烷基，R 5表示氢，或C 1-4烷基， R 1，R 2，R 2，R 2，R 2，R 2，（W 2）-W 3 -T 1或Z-CO-CH-CHAr其中R R 1，R 2，W 3，W 2，W 3，U 3，，V，T，Z和Ar定义如下在其描述中，其异构体及其与药学上可接受的酸或碱的加成盐，以及含有该物质的药物可用于治疗癌症。}

9. 发明授权

US06627650B2 Indenoindolone compounds 失效
标题翻译：茚并吲哚酮化合物
公开(公告)号：US06627650B2
公开(公告)日：2003-09-30
申请号：US10171191
申请日：2002-06-13
申请人： Michel Wierzbicki , Marie-Françoise Boussard , Anne Rousseau , Ghanem Atassi , John Hickman , Alain Pierre , Stéphane Leonce , Nicolas Guilbaut , Laurence Kraus-Berthier
发明人： Michel Wierzbicki , Marie-Françoise Boussard , Anne Rousseau , Ghanem Atassi , John Hickman , Alain Pierre , Stéphane Leonce , Nicolas Guilbaut , Laurence Kraus-Berthier
IPC分类号： A61K3140
CPC分类号： C07D401/12 , C07D209/94 , C07D405/12 , C07D409/12 , C07D491/04
摘要： A compound of formula (I): wherein: R represents hydrogen, optionally substituted alkyl or alkenyl, R1 to R8, which may be identical or different, each represents hydrogen, optionally substituted alkyl, hydroxy, acyloxy, optionally substituted amino, carboxy, optionally substituted alkoxy, or alkenyloxy, or one of R1 to R8 forms, with another of R1 to R8 that is adjacent, an alkylenedioxy group, X represents oxygen or NR16 wherein R16 represents hydrogen, alkyl, aryl or arylalkyl, R9 represents hydrogen, aryl, heteroaryl, or optionally substituted, saturated or unsaturated alkyl, an isomer thereof, or an addition salt thereof with a pharmaceutically acceptable acid or base. Medicinal products containing the same which are useful as anti-cancer agents.
摘要翻译：式（I）的化合物：其中：R表示氢，任选取代的烷基或烯基，可以相同或不同的R 1至R 8各自表示氢，任选取代的烷基，羟基，酰氧基，任选取代的氨基，羧基，任选地取代的烷氧基或烯氧基，或R 1至R 8中的一个与相邻的R 1至R 8中的另一个相邻，亚烷基二氧基，X表示氧或NR 16，其中R16表示氢，烷基，芳基或芳烷基，R9表示氢，杂芳基或任选取代的饱和或不饱和的烷基，其异构体或其加成盐与药学上可接受的酸或碱的混合物。含有该化合物的药物可用作抗癌剂。

10. 发明授权

US06300340B1 Bisimide compounds 失效
标题翻译：双酰亚胺化合物
公开(公告)号：US06300340B1
公开(公告)日：2001-10-09
申请号：US09616857
申请日：2000-07-14
申请人： Gilbert Lavielle , Patrick Hautefaye , Ghanem Atassi , Alain Pierre , Laurence Kraus-Berthier , Stéphane Leonce
发明人： Gilbert Lavielle , Patrick Hautefaye , Ghanem Atassi , Alain Pierre , Laurence Kraus-Berthier , Stéphane Leonce
IPC分类号： C07D48704
CPC分类号： C07D209/80 , C09B57/08
摘要： A compound of formula (I) in which: m, and n, which may be identical or different, represent 0 or 1, X and Y, which may be identical or different, represent hydrogen or halogen or alkyl, trihaloalkyl, alkoxy, hydroxyl, cyano, nitro, amino, alkylamino, or dialkylamino, Z represent a linear or branched C4 to C12 alkylene chain in which one or more —CH2— are optionally replaced by any one of the following atoms or groups: —NR—, —O—, —S—, —SO—, SO2—, or —CONH—, or by a substituted or unsubstituted heterocylcic, A forms, with two adjacent carbon atoms of the phenyl ring, a phenyl, naphthyl or tetrahydronaphthyl ring or a heterocycle, represents any one of the groups as defined in the description, its optical isomers and its addition salts with a pharamaceutically and acceptable acid or base, and medicinal products containing the same which are useful as anticancer agents.
摘要翻译：式（I）化合物，其中m和n可以相同或不同，表示0或1，X和Y可以相同或不同，表示氢或卤素或烷基，三卤代烷基，烷氧基，羟基，氰基，硝基，氨基，烷基氨基或二烷基氨基，Z表示直链或支链的C 4至C 12亚烷基链，其中一个或多个-CH 2 - 任选被以下任何一个原子或基团取代：-NR-，-O - ， - S - ， - SO - ，SO2-或-CONH-，或通过取代或未取代的杂环A形式与苯环的两个相邻碳原子，苯基，萘基或四氢萘基环或杂环，表示在描述中定义的任何一个基团，其光学异构体及其与药物和可接受的酸或碱的加成盐，以及含有该组的药物，其可用作抗癌剂。

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