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1. 发明授权

US07378419B2 9-amino-podophyllotoxin derivatives, method for the production thereof and pharmaceutical compositions containing said derivatives 失效
标题翻译： 9-氨基鬼臼毒素衍生物，其制备方法和含有所述衍生物的药物组合物
公开(公告)号：US07378419B2
公开(公告)日：2008-05-27
申请号：US10576201
申请日：2004-09-01
申请人： Claude Monneret , Daniel Dauzonne , John Hickman , Alain Pierre , Laurence Kraus-Berthier , Bruno Pfeiffer , Pierre Benard
发明人： Claude Monneret , Daniel Dauzonne , John Hickman , Alain Pierre , Laurence Kraus-Berthier , Bruno Pfeiffer , Pierre Benard
IPC分类号： C07D405/00 , A61K31/50 , A01N43/36
CPC分类号： C07D493/04
摘要： The invention relates to compounds of formula (I), wherein R1 is a group selected from hydrogen, alkyl, aryl, aryalkil, heteroaryl, heteroarylalkyl, alkylcarbonyl, arylcarbonyl, arylalkylcarbonyl, alkoxycarbonyl, aryloxycarbonyl, arylalkoxycarbonyl, heterocycloalkoxycarbonyl, alkylsulfonyl, arylsulfonyl, arylalkylsulfonyl, phosphonic and Si(Ra)2Rb, Y is a group selected from HN—NH and N—R2, R3 is a hydrogen atom, an alkyl, cycloalkyl, aryl, arylalkyl group, R4 is hydrogen atom or an alkyl group, enantiomers, diastereoisomers and the salts thereof
摘要翻译：本发明涉及式（I）化合物，其中R 1是选自氢，烷基，芳基，芳亚烷基，杂芳基，杂芳基烷基，烷基羰基，芳基羰基，芳基烷基羰基，烷氧基羰基，芳氧基羰基，芳基烷氧基羰基，杂环烷氧基羰基，烷基磺酰基，芳基磺酰基，芳基烷基磺酰基，膦酸和Si（R a）2 R b，Y是选自HN-NH和NR 2 R 3是氢原子，烷基，环烷基，芳基，芳基烷基，R 4是氢原子或烷基，对映异构体，非对映异构体及其盐

2. 发明申请

US20060247246A1 9-Amino-podophyllotoxin derivatives, method for the production thereof and pharmaceutical compositions containing said derivatives 失效
标题翻译： 9-氨基鬼臼毒素衍生物，其制备方法和含有所述衍生物的药物组合物
公开(公告)号：US20060247246A1
公开(公告)日：2006-11-02
申请号：US10576201
申请日：2004-09-01
申请人： Claude Monneret , Daniel Dauzonne , John Hickman , Alain Pierre , Laurence Kraus-Berthier , Bruno Pfeiffer , Pierre Benard
发明人： Claude Monneret , Daniel Dauzonne , John Hickman , Alain Pierre , Laurence Kraus-Berthier , Bruno Pfeiffer , Pierre Benard
IPC分类号： A61K31/506 , A61K31/501 , A61K31/497 , A61K31/4439 , A61K31/426 , A61K31/421 , A61K31/405 , A61K31/4025 , C07D493/02
CPC分类号： C07D493/04
摘要： The invention relates to compounds of formula (I), wherein R1 is a group selected from hydrogen, alkyl, aryl, aryalkil, heteroaryl, heteroarylalkyl, alkylcarbonyl, arylcarbonyl, arylalkylcarbonyl, alkoxycarbonyl, aryloxycarbonyl, arylalkoxycarbonyl, heterocycloalkoxycarbonyl, alkylsulfonyl, arylsulfonyl, arylalkylsulfonyl, phosphonic and Si(Ra)2Rb, Y is a group selected from HN—NH and N—R2, R3 is a hydrogen atom, an alkyl, cycloalkyl, aryl, arylalkyl group, R4 is hydrogen atom or an alkyl group, enantiomers, diastereoisomers and the salts thereof.
摘要翻译：本发明涉及式（I）化合物，其中R 1是选自氢，烷基，芳基，芳亚烷基，杂芳基，杂芳基烷基，烷基羰基，芳基羰基，芳基烷基羰基，烷氧基羰基，芳氧基羰基，芳基烷氧基羰基，杂环烷氧基羰基，烷基磺酰基，芳基磺酰基，芳基烷基磺酰基，膦酸和Si（R a）2 R b，Y是选自HN-NH和NR 2 R 3是氢原子，烷基，环烷基，芳基，芳基烷基，R 4是氢原子或烷基，对映异构体，非对映异构体及其盐。

3. 发明授权

US07144891B2 Benzo[b ]pyrano[3,2- h ]acridin-7-one cinnamate compounds 失效
标题翻译：苯并[b]吡喃并[3,2-h]吖啶-7-酮肉桂酸酯化合物
公开(公告)号：US07144891B2
公开(公告)日：2006-12-05
申请号：US11313386
申请日：2005-12-21
申请人： Michel Koch , François Tillequin , Sylvie Michel , John Hickman , Alain Pierre , Stéphane Leonce , Bruno Pfeiffer , Laurence Kraus-Berthier
发明人： Michel Koch , François Tillequin , Sylvie Michel , John Hickman , Alain Pierre , Stéphane Leonce , Bruno Pfeiffer , Laurence Kraus-Berthier
IPC分类号： A61K31/4741 , C07D491/02
CPC分类号： C07D491/04
摘要： A compound selected from those of formula (I): wherein: X and Y represent a group selected from hydrogen, halogen, alkoxy, nitro, cyano, alkyl, alkenyl, polyhaloalkyl and —NRaRb wherein Ra and Rb are as defined in the description, Z represents oxygen or NRc wherein Rc is as defined in the description, Ar represents aryl or heteroaryl, R1 represents hydrogen or alkyl, R2 represents a group selected from hydrogen, alkyl, —ORa and —NRaRb wherein Ra and Rb are as defined in the description, R3 and R4 represent hydrogen or alkyl, R5 represents hydrogen, ORc, NRcRd, W1—C(W2)—U—V, W1—C(W2)—W3-T1 or Z-CO—CH═CHAr wherein Rc, Rd, W1, W2, W3, U, V, T, Z and Ar are as defined in the description, its isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.
摘要翻译：选自式（I）的化合物：其中：X和Y表示选自氢，卤素，烷氧基，硝基，氰基，烷基，烯基，多卤代烷基和-NR a R 其中R a a和R b b如说明书中所定义，Z表示氧或NR C c，其中R _{- >如说明书中所定义，Ar表示芳基或杂芳基，R 1表示氢或烷基，R 2表示选自氢，烷基其中R a a和R b都是 - ， - - - - - - - - >如说明书中所定义，R 3和R 4代表氢或烷基，R 5表示氢，或C 1-4烷基， R 1，R 2，R 2，R 2，R 2，R 2，（W 2）-W 3 -T 1或Z-CO-CH-CHAr其中R R 1，R 2，W 3，W 2，W 3，U 3，，V，T，Z和Ar定义如下在其描述中，其异构体及其与药学上可接受的酸或碱的加成盐，以及含有该物质的药物可用于治疗癌症。}

4. 发明申请

US20060135545A1 Benzo[b]pyrano[3,2-h]acridin-7-one cinnamate compounds 失效
标题翻译：苯并[b]吡喃并[3,2-h]吖啶-7-酮肉桂酸酯化合物
公开(公告)号：US20060135545A1
公开(公告)日：2006-06-22
申请号：US11313386
申请日：2005-12-21
申请人： Michel Koch , Francois Tillequin , Sylvie Michel , John Hickman , Alain Pierre , Stephane Leonce , Bruno Pfeiffer , Laurence Kraus-Berthier
发明人： Michel Koch , Francois Tillequin , Sylvie Michel , John Hickman , Alain Pierre , Stephane Leonce , Bruno Pfeiffer , Laurence Kraus-Berthier
IPC分类号： A61K31/4741 , C07D491/02
CPC分类号： C07D491/04
摘要： A compound selected from those of formula (I): wherein: X and Y represent a group selected from hydrogen, halogen, alkoxy, nitro, cyano, alkyl, alkenyl, polyhaloalkyl and —NRaRb wherein Ra and Rb are as defined in the description, Z represents oxygen or NRc wherein Rc is as defined in the description, Ar represents aryl or heteroaryl, R1 represents hydrogen or alkyl, R2 represents a group selected from hydrogen, alkyl, —ORa and —NRaRb wherein Ra and Rb are as defined in the description, R3 and R4 represent hydrogen or alkyl, R5 represents hydrogen, ORc, NRcRd, W1—C(W2)—U—V, W1—C(W2)—W3-T1 or Z-CO—CH═CHAr wherein Rc, Rd, W1, W2, W3, U, V, T, Z and Ar are as defined in the description, its isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.
摘要翻译：选自式（I）的化合物：其中：X和Y表示选自氢，卤素，烷氧基，硝基，氰基，烷基，烯基，多卤代烷基和-NR a R 其中R a a和R b b如说明书中所定义，Z表示氧或NR C c，其中R _{- >如说明书中所定义，Ar表示芳基或杂芳基，R 1表示氢或烷基，R 2表示选自氢，烷基其中R a a和R b都是 - ， - - - - - - - - >如说明书中所定义，R 3和R 4代表氢或烷基，R 5表示氢，或C 1-4烷基， R 1，R 2，R 2，R 2，R 2，R 2，（W 2）-W 3 -T 1或Z-CO-CH-CHAr其中R R 1，R 2，W 3，W 2，W 3，U 3，，V，T，Z和Ar定义如下在其描述中，其异构体及其与药学上可接受的酸或碱的加成盐，以及含有该物质的药物可用于治疗癌症。}

5. 发明授权

US06878746B2 Carbamate and thiocarbamate podophyllotoxin derivatives, preparation method and pharmaceutical compositions containing them 失效
标题翻译：氨基甲酸酯和硫代氨基甲酸酯鬼臼毒素衍生物，制备方法和含有它们的药物组合物
公开(公告)号：US06878746B2
公开(公告)日：2005-04-12
申请号：US10312175
申请日：2001-06-19
申请人： Claude Monneret , Emmanuel Bertounesque , Philippe Meresse , Ghanem Atassi , Alain Pierre , John Hickman , Bruno Pfeiffer , Pierre Renard
发明人： Claude Monneret , Emmanuel Bertounesque , Philippe Meresse , Ghanem Atassi , Alain Pierre , John Hickman , Bruno Pfeiffer , Pierre Renard
IPC分类号： A61K31/36 , A61P35/00 , C07D493/04 , A61K31/365
CPC分类号： C07D493/04 , Y02P20/55
摘要： A compound selected from these of formula (I): wherein: R1 represents hydrogen, alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkoxycarbonyl, aryloxycarbonyl, arylalkoxycarbonyl, heterocycloalkoxycarbonyl, alkylsulfonyl, arylsulfonyl, arylalkylsulfonyl or phosphono, R2 represents oxygen or sulphur, R3 represents hydrogen or alkyl, cycloalkyl or arylalkyl, X represents linear or branched (C1-C6)alkylene, R4 represents a group selected from amino optionally substituted by one or two groups, —N(R3)—X1—OR5 wherein R3, X1 and R5 are as defined in the description, —N(R3)—X1—NR6R7 wherein R3, X1, R6 and R7 are as defined in the description, hydroxy, alkoxy, aryloxy, —O—X1—OR5 wherein R5 and X1 are as defined in the description, and —O—X1—NR6R7 wherein R6, R7 and X1 are as defined in the description, its isomers, and also addition salts thereof with a pharmaceutically acceptable acid or base, and medical products containing the same which are useful in the treatment of cancer.
摘要翻译：选自这些式（I）的化合物：其中：R1表示氢，烷基，芳基，芳基烷基，杂芳基，杂芳基烷基，烷氧基羰基，芳氧基羰基，芳基烷氧基羰基，杂环烷氧基羰基，烷基磺酰基，芳基磺酰基，芳基烷基磺酰基或膦酰基，R2表示氧或硫，R3 表示氢或烷基，环烷基或芳基烷基，X表示直链或支链（C1-C6）亚烷基，R4表示选自任选被一个或两个基团取代的氨基的基团-N（R3）-X1-OR5，其中R3，X1和 R 5如说明书中所定义，-N（R3）-X1-NR6R7，其中R3，X1，R6和R7如说明书中所定义，羟基，烷氧基，芳氧基，-O-X1-OR5，其中R5和X1为和-O-X 1 -NR 6 R 7，其中R 6，R 7和X 1如说明书中所定义，其异构体及其与药学上可接受的酸或碱的加成盐，以及含有它们的医药产品可用在治疗癌症。

6. 发明授权

US06281198B1 9-(3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydrofuro-[3′,4′:6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one compounds 失效
标题翻译： 9-（3,5-二甲氧基苯基）-5,8,8a，9-四氢呋喃（3'，4'：6,7）萘并（2,3-d）（1,3）二氧杂环戊烯-6（5aH）一种化合物
公开(公告)号：US06281198B1
公开(公告)日：2001-08-28
申请号：US09697248
申请日：2000-10-26
申请人： Claude Monneret , Emmanuel Bertounesque , Philippe Meresse , Ghanem Atassi , Alain Pierre , Bruno Pfeiffer , Pierre Renard
发明人： Claude Monneret , Emmanuel Bertounesque , Philippe Meresse , Ghanem Atassi , Alain Pierre , Bruno Pfeiffer , Pierre Renard
IPC分类号： A61K31365
CPC分类号： C07D493/04 , Y02P20/55
摘要： Compound of formula (I): wherein: R represents: a group of formula (i): wherein X, Y and W are as defined in the description, or a group of formula (ii): —A—G (ii) wherein: A represents a single bond or an optionally substituted alkylene chain, G represents a group selected from hydrogen, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, —OR2, —O—T1—NR3R4, —O—T1—NR2—T′1—NR3R4, —NR3R4, —NR2—T1—NR3R4, —NR2—T1—OR5, —NR2—T1—CO2R6, —NR2—T1—C(O)R6, —C(O)—NR3R4, —C(O)—NR2—T2, —O—C(O)T2, —O—C(S)—T2, —NR2—C(O)—T2, —NR2—C(S)—T2, —O—C(O)—O—T2, —O—C(O)—NR2—T2, —O—C(S)—O—T2, —O—C(S)—NR2—T2, —NR2—C(O)—O—T2, —NR2—C(O)—NR—T2, —NR2—C(S)—O—T2, —NR2—C(S)—NR6—T2 and —NR2—SO2—T3, wherein R2, R3, R4, R5, R6, T1, T′1, T2 and T3 are as defined in the description, R1 represents a group selected from hydrogen, alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkylcarbonyl, arylcarbonyl, arylalkylcarbonyl, heterocycloalkylcarbonyl, alkylsulphonyl, arylsulphonyl, arylalkylsulphonyl, phosphono, aryloxycarbonyl, alkoxycarbonyl and arylalkoxycarbonyl, its isomers, and also addition salts thereof with a pharmaceutically acceptable acid or base. Medicinal products containing the same which are useful in the treatment of cancer.
摘要翻译：式（I）的化合物：其中：R表示：式（ⅰ）的基团：其中X，Y和W如说明书中所定义，或式（ⅱ）的基团：其中：A表示单键或任选取代的亚烷基链，G表示选自氢，环烷基，杂环烷基，芳基，杂芳基，-OR2，-O-T1-NR3R4，-O-T1-NR2-T'1-NR3R4，-NR3R4，-NR2 -T 1 -NR 3 R 4，-NR 2 -T 1 -OR 5，-NR 2 -T 1 -CO 2 R 6，-NR 2 -T 1 -C（O）R 6，-C（O）-NR 3 R 4，-C（O）-NR 2 -T 2，-OC （O）T 2，-OC（S）-T 2，-NR 2 -C（O）-T 2，-NR 2 -C（S）-T 2，-OC（O）-O-T 2，-OC（O） -T 2，-OC（S）-O-T2，-OC（S）-NR2-T2，-NR2-C（O）-O-T2，-NR2-C（O）-NR-T2， C（S）-O-T2，-NR2-C（S）-NR6-T2和-NR2-SO2-T3，其中R2，R3，R4，R5，R6，T1，T'1，T2和T3为 R 1表示选自氢，烷基，芳基，芳基烷基，杂芳基，杂芳基烷基，烷基羰基，芳基羰基，芳基烷基羰基，杂环烷基羰基，烷基磺酰基，芳基磺酰基，芳基烷基磺酰基，膦酰基，芳氧基羰基，烷氧基羰基和芳基烷氧基羰基，其异构体，以及其与药学上可接受的酸或碱的加成盐。含有该化合物的药物可用于治疗癌症。

7. 发明授权

US07276512B2 Benzo[a]pyrano[3,2-h]acridin-7-one compounds 失效
公开(公告)号：US07276512B2
公开(公告)日：2007-10-02
申请号：US10872060
申请日：2004-06-18
申请人： Michel Koch , François Tillequin , Sylvie Michel , John Hickman , Alain Pierre , Stéphane Leonce , Bruno Pfeiffer , Pierre Renard
发明人： Michel Koch , François Tillequin , Sylvie Michel , John Hickman , Alain Pierre , Stéphane Leonce , Bruno Pfeiffer , Pierre Renard
IPC分类号： A61K31/44
CPC分类号： C07D491/04 , C07D491/14
摘要： A compound selected from those of formula (I): wherein: X and Y represent a group selected from hydrogen, halogen, hydroxy, alkoxy, nitro, cyano, alkyl, trihaloalkyl and NRaRb, wherein Ra and Rb are as defined in the description R1 represents hydrogen or alkyl R2 represents a group selected from hydrogen, alkyl, —OR″a, —NR′aR′b, —O-Ta-OR″a, —NR″a-Ta-NR′aR′b, —NR″a—C(O)-TaH, —O—C(O)-TaH, —O-Ta-NR′aR′b, —NR″a-Ta-OR″a, —NR″a-Ta-CO2R″a and —NR″a—C(O)-Ta-NR′aR′b, wherein R′a, R″a, R′b and Ta are as defined in the description R3 and R4 represent hydrogen or alkyl A represents a group of formula —CH(R5)—CH(R6)—, —CH═C(R7)—, —C(R7)═CH—, —C(O)—CH(R8) or —CH(R8)—C(O), wherein R5, R6, R7 and R8 are as defined in the description its isomers, N-oxides, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.

8. 发明授权

US07056929B2 Benzo[b]pyrano[3,2-h]acridin-7-one compounds 失效
公开(公告)号：US07056929B2
公开(公告)日：2006-06-06
申请号：US10627463
申请日：2003-07-26
申请人： Michel Koch , Francois Tillequin , Sylvie Michel , Elisabeth Seguin , Abdelhakim El Omri , John Hickman , Alain Pierre , Bruno Pfeiffer , Pierre Renard
发明人： Michel Koch , Francois Tillequin , Sylvie Michel , Elisabeth Seguin , Abdelhakim El Omri , John Hickman , Alain Pierre , Bruno Pfeiffer , Pierre Renard
IPC分类号： A61K31/44
CPC分类号： C07D491/04
摘要： A method for treating a living body afflicted with a cancer selected from lung and ovarian carcinoma, comprising the step of administering to the living animal body an amount of a compound selected from those of formula (I): wherein: X and Y represent group selected from hydrogen, halogen, mercapto, cyano, nitro, alkyl, trihaloalkyl, trihaloalkylcarbonylamino, —ORa, —NRaRb, —NRa—C(O)-T1, —O—C(O)-T1, —O-T2-NRaRb, —O-T2-ORa, —NRa-T2-NRaRb, —NRa-T2-ORa and —NRa-T2-CO2Ra wherein Ra, Rb, T1, T2 are as defined in the description, or X and Y together form a methylenedioxy or ethylenedioxy, R1 represents hydrogen or alkyl, R2 represents a group selected from hydrogen, —ORa, —NRaRb, —NRa—C(O)-T1, —O—C(O)-T1, —O-T2-NRaRb, —O-T2-ORa, —NRa-T2-NRaRb, —NRa-T2-ORa and —NRa-T2-CO2Ra wherein Ra, Rb, T1 and T2 are as defined hereinbefore, R3 and R4 represent hydrogen or alkyl, W represents a group of formula —CH(R5)—CH(R6)—, —CH═C(R7)—, —C(R7)═CH— or —C(O)—CH(R8)— wherein R5, R6, R7 and R8 are as defined in the description, their isomers and N-oxides, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same are useful in the treatment of cancer.

9. 发明授权

US07001906B2 Pyrido-pyrido-pyrrolo pyrrolo-indole and pyrido-pyrrolo pyrrolo carbazole derivatives, method for the production thereof and pharmaceutical compositions containing said derivatives 失效
标题翻译：吡啶并吡咯并吡咯并吡咯并吲哚和吡啶并吡咯并吡咯衍生物，其制备方法和含有所述衍生物的药物组合物
公开(公告)号：US07001906B2
公开(公告)日：2006-02-21
申请号：US10481991
申请日：2002-06-28
申请人： Michelle Prudhomme , Christelle Marminon , Sylvain Routier , Gérard Coudert , Jean-Yves Merour , John Hickman , Alain Pierre , Pierre Renard , Bruno Pfeiffer
发明人： Michelle Prudhomme , Christelle Marminon , Sylvain Routier , Gérard Coudert , Jean-Yves Merour , John Hickman , Alain Pierre , Pierre Renard , Bruno Pfeiffer
IPC分类号： A61K31/4985 , A61K31/437 , C07D491/22 , C07D405/14
CPC分类号： C07H15/252
摘要： Compounds of formula (I): wherein: W1 and W2, together with the carbon atoms to which they are bonded, represent a phenyl group or a pyridyl group, and at least one of the groups W1 or W2 represents a pyridyl group, R1 and R2 each represent a group of formula U-V as defined in the description, X and X1 each represent a hydrogen atom or a hydroxy, alkoxy, mercapto or alkylthio group, Y and Y1 each represent a hydrogen atom, or X and Y, X1 and Y1, together with the carbon atom carrying them, represent a carbonyl or thiocarbonyl group, R4 and R5 are as defined in the description, Q1, Q2 represent a hydrogen atom, or Q1 and Q2, together with the carbon atoms carrying them, form an aromatic bond. Medicaments.
摘要翻译：式（I）化合物：化学式id =“CHEM-US-00001”num =“000

10. 发明申请

US20060004428A1 Pyrrolo (3,4-c) carbazole and pyrido (2,3-b) pyrrolo (3,4-e) indole derivatives, preparation method and pharmaceutical compositions containing same 审中-公开
标题翻译：吡咯并（3,4-c）咔唑和吡啶并（2,3-b）吡咯并（3,4-e）吲哚衍生物，制备方法和含有它们的药物组合物
公开(公告)号：US20060004428A1
公开(公告)日：2006-01-05
申请号：US10531620
申请日：2003-10-14
申请人： Michelle Prudhomme , Bernadette Hugon , Fabrice Anizon , John Hickman , Alain Pierre , Roy Golsteyn , Pierre Renard , Bruno Pfeiffer
发明人： Michelle Prudhomme , Bernadette Hugon , Fabrice Anizon , John Hickman , Alain Pierre , Roy Golsteyn , Pierre Renard , Bruno Pfeiffer
IPC分类号： A61N1/00
CPC分类号： C07D487/14
摘要： A compound selected from those of formula (I): wherein: Z represents a group of the formula U-V as defined in the description, W1 represents together with carbon to which it is bonded, phenyl, pyridyl, W2 is as defined in the description, X1, X2 each represents hydrogen, hydroxy, alkoxy, mercapto or alkylthio, Y1, Y2 each represents hydrogen, or X1 and Y1, X2 and Y2 with carbon carrying them, together form carbonyl or thiocarbonyl, R1 is as defined in the description, Q represents oxygen, a group NR2 as defined in the description, its isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.
摘要翻译：选自式（I）的化合物：其中：Z表示如说明书中所定义的式UV基团，W 1代表与其键合的碳，苯基，吡啶基， W 2 2如说明书中所定义，X 1，X 2各自表示氢，羟基，烷氧基，巯基或烷硫基，Y _{1，Y 2各自表示氢，或X 1和Y 1，X 2，和Y 2带有带有它们的碳，一起形成羰基或硫代羰基，R 1如说明书中所定义，Q表示氧，NR 2基团， SUB>，其异构体及其与药学上可接受的酸或碱的加成盐，以及含有该物质的药物可用于治疗癌症。}

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