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1. 发明申请

US20080318310A1 Method and Apparatus for Automatically Isolating Microbial Species 审中-公开
标题翻译：自动分离微生物物种的方法和装置
公开(公告)号：US20080318310A1
公开(公告)日：2008-12-25
申请号：US11664486
申请日：2005-10-07
申请人： Claude Dufresne , Gary S. Kath , Gregory W. King , Prakash S. Masurekar , Salvatore J. Siciliano , Janet M. Sigmund , Neal R. Simpson , Stephen Skwish
发明人： Claude Dufresne , Gary S. Kath , Gregory W. King , Prakash S. Masurekar , Salvatore J. Siciliano , Janet M. Sigmund , Neal R. Simpson , Stephen Skwish
IPC分类号： C12M1/26
CPC分类号： G01N35/028 , G01N2035/1037
摘要： This invention relates to an apparatus for streaking a sample on a media-coated (agar) plate in a predefined pattern utilizing a plate carousel system to house and retrieve a plate to a fixed location, a streaking mechanism having a floating stylus having a tip capable of gliding over the agar surface and depositing a sample onto the surface of the agar, a sample dispensing system and an optional wash station.
摘要翻译：本发明涉及一种利用板转盘系统以预定图案将样品划到介质涂覆（琼脂）板上以将板固定到固定位置的装置，具有浮动触针的条纹机构具有尖端能力在琼脂表面上滑动并将样品沉积在琼脂表面上，样品分配系统和可选的洗涤台。

2. 发明授权

US5310949A Cholesterol lowering compounds 失效
标题翻译：胆固醇降低化合物
公开(公告)号：US5310949A
公开(公告)日：1994-05-10
申请号：US939258
申请日：1992-09-02
申请人： Claude Dufresne , Prakash S. Masurekar , Leslie A. Ferrell , Deborah L. Zink , Margaret S. Sosa
发明人： Claude Dufresne , Prakash S. Masurekar , Leslie A. Ferrell , Deborah L. Zink , Margaret S. Sosa
IPC分类号： C07D493/08 , C07D319/04
CPC分类号： C07D493/08
摘要： New Zaragozic acids have been isolated from a culture of MF5465. These compounds and their derivatives are active as squalene synthetase inhibitors and are useful in the treatment of hypercholesterolemia.
摘要翻译：已经从MF5465的培养物中分离出新的萨拉哥酸。这些化合物及其衍生物作为角鲨烯合成酶抑制剂是有活性的，可用于治疗高胆固醇血症。

3. 发明授权

US5578581A Active avermectin analogue 失效
标题翻译：活性除虫菌素类似物
公开(公告)号：US5578581A
公开(公告)日：1996-11-26
申请号：US233489
申请日：1994-04-26
申请人： Prakash S. Masurekar , Wesley L. Shoop , Michael A. Wallace , Richard L. Monaghan
发明人： Prakash S. Masurekar , Wesley L. Shoop , Michael A. Wallace , Richard L. Monaghan
IPC分类号： C07H19/01 , A61K31/70 , C07H17/08
CPC分类号： A61K31/7048 , C07H19/01
摘要： An active avermectin analogue which can be produced by directed biosynthesis is described. The compound, named 26-R-Avermectin B.sub.1 a, is active in the Haemonchus egg to L3 assay and has the following structure: ##STR1##
摘要翻译：描述了可以通过定向生物合成产生的活性除虫菌素类似物。命名为26-R-阿维菌素B1a的化合物在血红蛋卵至L3测定中有活性，具有以下结构： + TR

4. 发明授权

US5306708A Antibiotic agent 失效
标题翻译：抗生素
公开(公告)号：US5306708A
公开(公告)日：1994-04-26
申请号：US630457
申请日：1990-12-19
申请人： Robert E. Schwartz , David F. Sesin , Prakash S. Masurekar , Jerrold M. Liesch , Thomas C. Hallada , Otto D. Hensens
发明人： Robert E. Schwartz , David F. Sesin , Prakash S. Masurekar , Jerrold M. Liesch , Thomas C. Hallada , Otto D. Hensens
IPC分类号： A61K38/00 , A61P31/04 , A61P31/10 , A61P33/02 , C07K7/56 , C07K14/37 , C07K14/41 , C12N1/14 , C12P21/04 , C12R1/645 , A61K37/02 , C07K7/54
CPC分类号： C07K7/56 , A61K38/00
摘要： A new antibiotic cyclic lipopeptide having the formula ##STR1## wherein R is H SEQ ID NO:1 or OH SEQ ID NO:2 and a method of producing is described. The agent has very high activity against human pathogens and is of very low mammalian toxicity.
摘要翻译：描述了具有式（*化学结构*）（*化学结构*）的新型抗生素环状脂肽，其中R为H SEQ ID NO：1或OH SEQ ID NO：2及其制备方法。该药剂对人类病原体的活性非常高，哺乳动物的毒性非常低。

5. 发明授权

US4072568A Method for the preparation of cholesterol oxidase 失效
标题翻译：胆固醇氧化酶的制备方法
公开(公告)号：US4072568A
公开(公告)日：1978-02-07
申请号：US739379
申请日：1976-11-05
申请人： Prakash S. Masurekar , Charles T. Goodhue
发明人： Prakash S. Masurekar , Charles T. Goodhue
IPC分类号： C12N9/04 , C12D13/10
CPC分类号： C12N9/0006 , Y10S435/83 , Y10S435/843 , Y10S435/866 , Y10S435/872
摘要： A method for preparing cholesterol oxidase, comprising the steps of:(a) growing a cholesterol oxidase producing microorganism in a medium comprising a nontoxic concentration of nonionic surfactant to yield extracellular cholesterol oxidase; and(b) separating the extracellular cholesterol oxidase from the medium.Preferably, cholesterol oxidase is prepared from a growth medium of Nocardia cholesterolicum species NRRL 5767 or 5768 which contains cholesterol, a suitable derivative of cholesterol or a 3-.beta.-hydroxy sterol as a cholesterol oxidase inducer and a nonionic surfactant in a concentration which is not toxic to said bacterium, which does not produce decomposition products in concentrations sufficient to be toxic to said bacterium, and in sufficient concentration to produce extracellular enzyme.
摘要翻译：一种制备胆固醇氧化酶的方法，包括以下步骤：

6. 发明授权

US5426038A Process for production of an antibiotic compound with Zalerion arboricola 失效
标题翻译：用Zalerion arboricola生产抗生素化合物的方法
公开(公告)号：US5426038A
公开(公告)日：1995-06-20
申请号：US195426
申请日：1994-02-14
申请人： Jimmy M. Fountoulakis , Prakash S. Masurekar , Louis Kaplan
发明人： Jimmy M. Fountoulakis , Prakash S. Masurekar , Louis Kaplan
IPC分类号： A61K38/00 , C07K7/56 , C12P21/00
CPC分类号： C07K7/56 , A61K38/00 , Y10S435/911
摘要： A process for producing an antibiotic compound which is normally a minor component in the cultivation of Z. arboricola to be the major product is described.
摘要翻译：本发明描述了一种制备抗生素化合物的方法，该抗生素化合物通常作为主要产品的培养中的次要成分。

7. 发明授权

US4276377A Creatinine iminohydrolase free from urease activity 失效
标题翻译：肌酸酐亚氨基水解酶不含脲酶活性
公开(公告)号：US4276377A
公开(公告)日：1981-06-30
申请号：US91218
申请日：1979-11-05
申请人： Charles T. Goodhue , Theodore W. Esders , Prakash S. Masurekar
发明人： Charles T. Goodhue , Theodore W. Esders , Prakash S. Masurekar
IPC分类号： C12N9/78 , C12N9/80 , C12Q1/34 , C12R1/20
CPC分类号： C12N9/78 , C12Q1/34 , G01N2333/978 , Y10S435/85
摘要： A urease-free creatinine iminohydrolase enzyme preparation obtained from an aerobic soil microorganism. The enzyme of the preparation preferably has a molecular weight of from about 250,000 to 300,000; a maximum activity at a pH between 7 and 8 as measured at 37.degree. C.; a K.sub.m of about 3 to 5 mM for creatinine as measured at 37.degree. C., pH 7.5; and a specific activity for creatinine of at least about 1.0 unit per milligram of protein in the preparation as measured at 37.degree. C., pH 7.5. The preferred enzyme preparation is derived from the aerobic soil microorganism ATCC 31,546. Assay methods, compositions, and elements containing the aforementioned urease-free creatinine iminohydrolase for the determination of creatinine in an aqueous liquid are also disclosed.
摘要翻译：从需氧土壤微生物获得的无脲酶肌酐亚氨基水解酶制剂。制剂的酶优选具有约25万至30万的分子量; 在37℃下测量的pH在7和8之间的最大活性。在37℃，pH7.5下测量的肌酸酐的Km为约3至5mM; 并且在37℃，pH7.5下测定，所述制剂中肌酸酐的比活性为至少约1.0单位/毫克蛋白质。优选的酶制剂来自需氧土壤微生物ATCC 31,546。还公开了含有上述无脲酶肌酐亚氨基水解酶的测定方法，组合物和元件，用于测定水性液体中的肌酐。

8. 发明授权

US4275164A Process and nutrient medium for growing microorganism 失效
标题翻译：生长微生物的过程和营养培养基
公开(公告)号：US4275164A
公开(公告)日：1981-06-23
申请号：US91216
申请日：1979-11-05
申请人： Prakash S. Masurekar
发明人： Prakash S. Masurekar
IPC分类号： C12N1/00 , C12N1/20 , C12N9/78 , C12N9/80 , C12R1/20
CPC分类号： C12N9/78 , Y10S435/85
摘要： A fermentation process and improved aqueous nutrient medium is used for the production of urease-free creatinine iminohydrolase from an aerobic soil microorganism. In the process, a fresh sample of the microorganism grown on a creatinine-containing maintenance medium is transferred to a microbial growth medium to grow the microorganism, the growing microorganism is then transferred to a production medium to produce microorganism in which creatinine iminohydrolase production has been induced, and the desired enzyme is then extracted from the microorganism. An improved aqueous nutrient medium for use as the aforementioned production medium is disclosed.
摘要翻译：发酵过程和改进的含水营养培养基用于从需氧土壤微生物生产不含脲酶的肌酐亚氨基水解酶。在此过程中，将含有肌酸酐的维持培养基上生长的微生物的新鲜样品转移到微生物生长培养基中以生长微生物，然后将生长的微生物转移到生产培养基中以产生其中肌酐亚氨基水解酶生产已经产生的微生物然后从微生物中提取所需的酶。公开了用作上述生产介质的改进的水性营养培养基。

9. 发明授权

US4166005A Process for the production of .alpha.-glycerophosphate oxidase 失效
标题翻译：生产{60-甘油磷酸氧化酶的方法
公开(公告)号：US4166005A
公开(公告)日：1979-08-28
申请号：US866734
申请日：1978-01-03
申请人： Prakash S. Masurekar , Charles T. Goodhue
发明人： Prakash S. Masurekar , Charles T. Goodhue
IPC分类号： C12N9/04 , C12D13/10
CPC分类号： C12N9/0006 , Y10S435/822 , Y10S435/853 , Y10S435/856 , Y10S435/857 , Y10S435/885
摘要： An improved process for producing .alpha.-glycerophosphate oxidase provides yields of more than 1500 U per liter. The enzyme is produced by growing a member of the family Lactobacillaceae in a medium comprising pyruvate and an inducer for .alpha.-glycerophosphate oxidase. In the preferred embodiment, a medium comprising a mixture of glucose and pyruvate as carbon sources provides a synergistic effect on the production of .alpha.-glycerophosphate oxidase.
摘要翻译：用于生产α-甘油磷酸氧化酶的改进方法提供超过1500U /升的产量。该酶通过在含丙酮酸盐和α-甘油磷酸酯氧化酶诱导剂的培养基中培养家族乳杆菌科的成员而产生。在优选的实施方案中，包含作为碳源的葡萄糖和丙酮酸盐的混合物的培养基对α-甘油磷酸酯氧化酶的产生提供协同效应。

10. 发明授权

US5366880A Antibiotic agent 失效
标题翻译：抗生素
公开(公告)号：US5366880A
公开(公告)日：1994-11-22
申请号：US66282
申请日：1993-05-21
申请人： Robert E. Schwartz , Prakash S. Masurekar , David F. Sesin , Jerrold M. Liesch , Thomas C. Hallada , Otto D. Hensens
发明人： Robert E. Schwartz , Prakash S. Masurekar , David F. Sesin , Jerrold M. Liesch , Thomas C. Hallada , Otto D. Hensens
IPC分类号： C07K7/56 , C12P17/18 , C12P7/02 , C12P7/24 , C12P13/00
CPC分类号： C07K7/56
摘要： A new antibiotic cyclic lipopeptide having the formula ##STR1## wherein R is H or OH and a method of producing is described. The agent has very high activity against human pathogens and is of very low mammalian toxicity.
摘要翻译：描述了具有式“IMAGE”的新型抗生素环状脂肽，其中R是H或OH，并描述了制备方法。该药剂对人类病原体的活性非常高，哺乳动物的毒性非常低。

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