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1. 发明授权

US5139948A Strain of Trichostrongylus colubriformis with ivermectin and thiabendazole resistance 失效
标题翻译： Trichostrongylus colubriformis菌株与伊维菌素和噻菌灵抗性
公开(公告)号：US5139948A
公开(公告)日：1992-08-18
申请号：US506311
申请日：1990-04-09
申请人： Wesley L. Shoop , John R. Egerton
发明人： Wesley L. Shoop , John R. Egerton
IPC分类号： A01K67/033
CPC分类号： A01K67/033
摘要： A novel strain of Trichostrongylus colubriformis has the unique characteristics of being significantly resistant to the effect of antihelmintic drugs, in particular the antihelmintic drugs ivermectin and thiabendazole. The novel strain of T. colubriformis was prepared by the serial passage of the helminth through sheep. Twenty passages of the helminth through sheep were adequate to impart resistance to oral therapy of 20 times that normally expected with ivermectin. The highly resistant parasite is useful to screen for antihelmintic agents with different modes of action than that of ivermectin or thiabendazole which represent two of the three major classes of modern, broad spectrum anthelmintics.
摘要翻译： Trichostrongylus colubriformis的新型菌株具有显着抵抗抗肠内索药物，特别是抗凝血药物伊维菌素和噻菌灵的作用的独特特征。通过蠕虫连续通过绵羊制备T.colubriformis的新菌株。蠕虫通过绵羊的二十次传代足以赋予对伊维菌素通常预期的20倍的口服治疗耐药性。高度耐药的寄生虫可用于筛选具有不同于伊维菌素或噻替达唑的不同作用模式的抗栓剂，其代表三种主要的广谱驱虫药物中的两种。

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